Journal of the American College of Cardiology最新文献

{"title":"The Reducer Is a Novel, Safe, and Effective Therapy to Optimize the Management of Patients With Stable Angina","authors":"Shmuel Banai MD , Amir Lerman MD , Stefan Verheye MD, PhD","doi":"10.1016/j.jacc.2024.08.083","DOIUrl":"10.1016/j.jacc.2024.08.083","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 24","pages":"Page e337"},"PeriodicalIF":21.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audio Summary","authors":"","doi":"10.1016/S0735-1097(24)10360-9","DOIUrl":"10.1016/S0735-1097(24)10360-9","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 24","pages":"Page e331"},"PeriodicalIF":21.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major Bleeding and Mortality After Revascularization of Left Main Disease","authors":"Gennaro Giustino MD ,&nbsp;Joseph F. Sabik III MD ,&nbsp;Patrick W. Serruys MD, PhD ,&nbsp;John D. Puskas MD ,&nbsp;Dimitri Karmpaliotis MD ,&nbsp;David E. Kandzari MD ,&nbsp;Marie-Claude Morice MD ,&nbsp;Michael Ragosta III MD ,&nbsp;Zixuan Zhang MS ,&nbsp;Ovidiu Dressler MD ,&nbsp;Bjorn Redfors MD, PhD ,&nbsp;Ori Ben-Yehuda MD ,&nbsp;Samin K. Sharma MD ,&nbsp;Arie Pieter Kappetein MD, PhD ,&nbsp;Gregg W. Stone MD","doi":"10.1016/j.jacc.2024.07.065","DOIUrl":"10.1016/j.jacc.2024.07.065","url":null,"abstract":"<div><h3>Background</h3><div>The incidence and prognostic impact of major bleeding (MB) after percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) are unknown.</div></div><div><h3>Objectives</h3><div>The goal of this study was to investigate the rates and outcomes of MB after LMCAD revascularization.</div></div><div><h3>Methods</h3><div>In the EXCEL (Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial, 1,905 patients with unprotected LMCAD were randomized to undergo PCI (n = 948) or CABG (n = 957) and followed up for 5 years. MB was defined as TIMI major or minor bleeding, BARC (Bleeding Academic Research Consortium) types 3 to 5 bleeding, or any overt bleeding requiring blood transfusion. The association between MB and subsequent mortality was assessed in time-adjusted Cox regression models.</div></div><div><h3>Results</h3><div>At 5 years, 217 patients (11.4%) had at least 1 MB event. Rates of 5-year MB were 7.9% after PCI vs 14.8% after CABG (OR: 0.48; 95% CI: 0.36-0.65; <em>P</em> &lt; 0.0001). However, in-hospital MB was lower after PCI (3.8% vs 13.5%; OR: 0.25; 95% CI: 0.17-0.37), whereas postdischarge MB was lower after CABG (4.5% vs 2.0%; OR: 2.33; 95% CI: 1.33-3.09; <em>P</em>_interaction &lt; 0.0001). All 41 postdischarge MB events after PCI occurred in patients receiving dual antiplatelet therapy. MB events within 5 years were associated with a higher subsequent risk of all-cause mortality (adjusted HR: 2.71; 95% CI: 1.95-3.77; <em>P</em> &lt; 0.0001), whether in-hospital or postdischarge (<em>P</em>_interaction = 1.00) and after both PCI and CABG (<em>P</em>_interaction = 0.95), driven both by increased cardiovascular and non-cardiovascular mortality.</div></div><div><h3>Conclusions</h3><div>In the EXCEL trial, CABG resulted in higher 5-year rates of all MB and in-hospital MB, although postdischarge MB was more frequent after PCI. MB after both procedures was associated with increased cardiovascular and noncardiovascular mortality within 5 years. (Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization [EXCEL]; <span><span>NCT01205776</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 24","pages":"Pages 2335-2346"},"PeriodicalIF":21.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Self-Reported Race, Social Determinants of Health, and Polygenic Risk With Coronary Heart Disease","authors":"Kristjan Norland MSc ,&nbsp;Daniel J. Schaid PhD ,&nbsp;Mohammadreza Naderian MD ,&nbsp;Jie Na MSc ,&nbsp;Iftikhar J. Kullo MD","doi":"10.1016/j.jacc.2024.06.052","DOIUrl":"10.1016/j.jacc.2024.06.052","url":null,"abstract":"<div><h3>Background</h3><div>Social determinants of health (SDOH) influence the risk of common diseases such as coronary heart disease (CHD).</div></div><div><h3>Objectives</h3><div>This study sought to test the associations of self-reported race/ethnicity, SDOH, and a polygenic risk score (PRS), with CHD in a large and diverse U.S. cohort.</div></div><div><h3>Methods</h3><div>In 67,256 All of Us (AoU) participants with available SDOH and whole-genome sequencing data, we ascertained self-reported race/ethnicity and 22 SDOH measures across 5 SDOH domains, and we calculated a PRS for CHD (PRS_CHD, PGS004696). We developed an SDOH score for CHD (SDOH_CHD). We tested the associations of SDOH and PRS_CHD with CHD in regression models that included clinical risk factors.</div></div><div><h3>Results</h3><div>SDOH across 5 domains, including food insecurity, income, educational attainment, health literacy, neighborhood disorder, and loneliness, were associated with CHD. SDOH_CHD was highest in self-reported Black and Hispanic people. Self-reporting as Blacks had higher odds of having CHD than Whites but not after adjustment for SDOH_CHD. SDOH_CHD and PRS_CHD were weakly correlated. In the test set (n = 33,628), 1-SD increases in SDOH_CHD and PRS_CHD were associated with CHD in models that adjusted for clinical risk factors (OR: 1.32; 95% CI: 1.23-1.41 and OR: 1.36; 95% CI: 1.28-1.44, respectively). SDOH_CHD and PRS_CHD were associated with incident CHD events (n = 52) over a median follow-up of 214 days (Q1-Q3: 88 days).</div></div><div><h3>Conclusions</h3><div>Increased odds of CHD in people who self-report as Black are likely due to a higher SDOH burden. SDOH and PRS were independently associated with CHD. Our findings suggest that including both PRS and SDOH in CHD risk models could improve their accuracy.</div></div>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 22","pages":"Pages 2157-2166"},"PeriodicalIF":21.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considering Social and Genetic Factors in Cardiovascular Disease Risk","authors":"Nilay S. Shah MD, MPH","doi":"10.1016/j.jacc.2024.07.059","DOIUrl":"10.1016/j.jacc.2024.07.059","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 22","pages":"Pages 2167-2169"},"PeriodicalIF":21.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AS-1004 Associations of B Vitamins Intake With Physical Dysfunction and Cognitive Impairment Among Patients With Valvular Diseases","authors":"Ningjing Qian ,&nbsp;Xianbao Liu ,&nbsp;Jian’an Wang","doi":"10.1016/j.jacc.2024.10.039","DOIUrl":"10.1016/j.jacc.2024.10.039","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 22","pages":"Page C13"},"PeriodicalIF":21.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AS-0365 Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized and Placebo-Controlled Clinical Trial","authors":"Xiaofan Yu","doi":"10.1016/j.jacc.2024.10.043","DOIUrl":"10.1016/j.jacc.2024.10.043","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 22","pages":"Page C14"},"PeriodicalIF":21.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AS-0104 U-Shaped Association Between Ankle-Ankle Index and Coronary Artery Calcification Progression: The Multi-Ethnic Study of Atherosclerosis (MESA)","authors":"Jikai Song ,&nbsp;Da Teng ,&nbsp;Qingwen Huang ,&nbsp;Lei Gong ,&nbsp;Chunxiao Wang ,&nbsp;Haibin Dong ,&nbsp;Hua Wang ,&nbsp;Lin Zhong ,&nbsp;Jun Yang","doi":"10.1016/j.jacc.2024.10.060","DOIUrl":"10.1016/j.jacc.2024.10.060","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 22","pages":"Page C21"},"PeriodicalIF":21.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AS-0032 Serum Uric Acid Change Pattern in Relation to the Risk of Decline in Kidney Function in Patients With Hypertension","authors":"Zeya Li ,&nbsp;Yu Zhao ,&nbsp;Weihua Chen ,&nbsp;Dongjie Du ,&nbsp;Xianzhong Gu ,&nbsp;Rongchong Huang","doi":"10.1016/j.jacc.2024.10.030","DOIUrl":"10.1016/j.jacc.2024.10.030","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 22","pages":"Page C10"},"PeriodicalIF":21.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AS-0227 The Net Clinical Benefit of Fondaparinux vs LMWH in Chinese Non–ST-Segment Elevation Acute Coronary Syndrome Patients: The REFOCAS Nonrandomized Controlled Trial","authors":"Dandan Li ,&nbsp;Xiaodan Tuo MS ,&nbsp;Yani Yu ,&nbsp;Genshan Ma ,&nbsp;Chuanyu Gao ,&nbsp;Wei Mao ,&nbsp;Peng Qu ,&nbsp;Limin Liu ,&nbsp;Zhuo Shang ,&nbsp;Xunli Yin ,&nbsp;Guozhen Wang ,&nbsp;Aifen Liu ,&nbsp;Yundai Chen","doi":"10.1016/j.jacc.2024.10.045","DOIUrl":"10.1016/j.jacc.2024.10.045","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"84 22","pages":"Page C15"},"PeriodicalIF":21.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}