Journal of the American College of Cardiology最新文献

{"title":"Misclassification of Myocardial Infarction Subtypes in Administrative Claims","authors":"Andrea Martinez MD , Muhammad Etiwy MD , James L. Januzzi Jr. MD , Cian P. McCarthy MB, BCh, BAO, SM , David Cheng PhD , Erika Shults MS , Sarah K. Gustus MS, ATC , John Hsu MD, MBA , Jason H. Wasfy MD, MPhil","doi":"10.1016/j.jacc.2025.05.036","DOIUrl":"10.1016/j.jacc.2025.05.036","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages 284-286"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Mass Index, Central Adiposity, and HFpEF","authors":"Klara R. Klein MD, PhD , Jaime P. Almandoz MD, MBA , Darren K. McGuire MD, MHSc , Ildiko Lingvay MD, MPH, MSCS","doi":"10.1016/j.jacc.2025.05.043","DOIUrl":"10.1016/j.jacc.2025.05.043","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages 256-258"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Benefits of Early Ezetimibe Conferred by its Effect on LDL-C?","authors":"Anshul Yadav MBBS , Neelesh Gupta MD , Rajeev Gupta DM (Cardiology)","doi":"10.1016/j.jacc.2025.04.072","DOIUrl":"10.1016/j.jacc.2025.04.072","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages e33-e34"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responder Thresholds and Multiplicity Concerns in HELIOS-B","authors":"Anshul Yadav MBBS , Ojus Yadav MBBS , Neelesh Gupta MD , Rajeev Gupta DM (Cardiology)","doi":"10.1016/j.jacc.2025.04.075","DOIUrl":"10.1016/j.jacc.2025.04.075","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages e37-e38"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JACC: A New Look, A Larger Vision","authors":"Harlan M. Krumholz MD, SM (Editor-in-Chief, JACC; Harold H. Hines, Jr Professor)","doi":"10.1016/j.jacc.2025.06.023","DOIUrl":"10.1016/j.jacc.2025.06.023","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages 223-224"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes in Older Patients Undergoing Surgical Aortic Valve Replacement With Concomitant Procedures","authors":"Harun Kundi MD, MMSc , Jeffrey J. Popma MD , Juan F. Granada MD , Martin B. Leon MD , Afek Kodesh MD , Guido Ascione MD , Isaac George MD , Azeem Latib MD , Julia B. Thompson MS , Alexandra Popma MD , Maria C. Alu MS , David J. Cohen MD, MSc","doi":"10.1016/j.jacc.2025.05.021","DOIUrl":"10.1016/j.jacc.2025.05.021","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages 280-283"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Body Mass Index, Central Adiposity, and Weight Loss on the Benefits of Tirzepatide in HFpEF","authors":"Barry A. Borlaug MD , Michael R. Zile MD , Christopher M. Kramer MD , Wenyu Ye PhD , Yang Ou PhD , Karla Hurt BSN, MBA , Masahiro Murakami MD, PhD , Milton Packer MD , SUMMIT Trial Study Group","doi":"10.1016/j.jacc.2025.04.059","DOIUrl":"10.1016/j.jacc.2025.04.059","url":null,"abstract":"<div><h3>Background</h3><div>The SUMMIT trial showed that the long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide 1 receptor agonist tirzepatide decreased the risk of cardiovascular death or worsening heart failure (HF) in patients with obesity-related heart failure with preserved ejection fraction (HFpEF). Effects may differ by baseline obesity severity, distribution, or magnitude of weight loss.</div></div><div><h3>Objectives</h3><div>In this analysis, the authors compared baseline characteristics and effects of tirzepatide on primary and other endpoints according to baseline obesity severity and distribution, and we explored relationships between degree of weight loss achieved and outcomes.</div></div><div><h3>Methods</h3><div>In the SUMMIT trial, 731 patients with NYHA functional class II-IV HFpEF and body mass index (BMI) ≥30 kg/m<sup>2</sup> were randomly assigned to tirzepatide (n = 364) or placebo (n = 367). The primary outcomes were time to cardiovascular death or worsening HF and change in Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS) at 52 weeks. Key secondary outcomes included changes in 6-minute walk distance (6MWD), C-reactive protein (CRP), and body weight (BW) at 52 weeks. In this secondary analysis, primary and secondary endpoints were analyzed based on obesity severity (BMI) and distribution (waist-height ratio [WHR]). Time-to-event endpoints were analyzed with the use of a Cox regression model, and continuous endpoints were assessed with the use of a mixed-effects model for repeated measures. Relationships between changes in BW and waist circumference (WC) on treatment with tirzepatide and changes in key endpoints also were evaluated.</div></div><div><h3>Results</h3><div>Patients with obesity-related HFpEF and higher BMI were younger and more likely to be female, with more severe HF symptoms and physical limitations, greater volume expansion despite higher diuretic use and lower natriuretic peptide levels, and more severe systemic inflammation compared with patients with lower BMI. These findings were largely similar when contrasting patients by baseline WHR, but those with higher WHR also had poorer exercise capacity and more severe kidney disease. There was no evidence of heterogeneity in the effect of tirzepatide on the risk of worsening HF or cardiovascular death by BMI or WHR tertile. However, with increasing tertiles of baseline BMI, there were greater improvements in 6MWD (estimated treatment difference [ETD]: 9.9 vs 26.3 vs 37.5 m; <em>P</em> = 0.025), and greater decreases in BW (ETD: −10.7% vs −11.8% vs −14.4%; <em>P</em> = 0.006) and systolic blood pressure (ETD: −1.00 vs −6.65 vs −6.62 mm Hg; <em>P</em> = 0.035) with tirzepatide compared with placebo, with a trend for greater improvement in KCCQ-CSS (<em>P</em> = 0.097). Among those randomized to tirzepatide, greater weight loss at 52 weeks was associated with larger improvements in 6MWD, KCCQ-CSS,","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages 242-255"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stent Frame Underexpansion","authors":"Michael Joner MD, Tobias Rheude MD","doi":"10.1016/j.jacc.2025.05.059","DOIUrl":"10.1016/j.jacc.2025.05.059","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages 239-241"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amara Yad Image: Interior View of the Right Atrium and Right Ventricle","authors":"Kalyanam Shivkumar MD, PhD","doi":"10.1016/j.jacc.2025.05.055","DOIUrl":"10.1016/j.jacc.2025.05.055","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages 314-316"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Aortic Balloon Pump in Heart Failure–Related Cardiogenic Shock","authors":"Luca Baldetti MD , Silvia Ajello MD , Mario Gramegna MD , Corstiaan A. Den Uil MD , Anna Mara Scandroglio MD","doi":"10.1016/j.jacc.2025.04.030","DOIUrl":"10.1016/j.jacc.2025.04.030","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"86 4","pages":"Pages e45-e46"},"PeriodicalIF":21.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}