Journal of the American College of Cardiology最新文献

{"title":"Diagnostic Performance and Clinical Impact of Photon-Counting Detector Computed Tomography in Coronary Artery Disease.","authors":"Koshiro Sakai, Doosup Shin, Mandeep Singh, Sarah Malik, Ali Dakroub, Zainab Sami, Jonathan Weber, J Jane Cao, Roosha Parikh, Lu Chen, Fernando Sosa, David J Cohen, Jeffrey W Moses, Richard A Shlofmitz, Carlos Collet, Evan Shlofmitz, Allen Jeremias, Omar K Khalique, Ziad A Ali","doi":"10.1016/j.jacc.2024.10.069","DOIUrl":"10.1016/j.jacc.2024.10.069","url":null,"abstract":"<p><strong>Background: </strong>Photon-counting detector-computed tomography (PCD-CT) has emerged as a promising technology, offering improved spatial resolution.</p><p><strong>Objectives: </strong>This study aimed to evaluate the clinical impact and diagnostic performance of PCD-CT vs conventional energy-integrating detector computed tomography (EID-CT) for obstructive coronary artery disease (CAD).</p><p><strong>Methods: </strong>From 2022 to 2023, we retrospectively identified 7,833 consecutive patients who underwent clinically indicated coronary computed tomography angiography (CCTA) at a single center, with either PCD-CT (n = 3,876; NAEOTOM Alpha [Siemens Healthineers]) or EID-CT (n = 3,957; Revolution Apex 256 [GE HealthCare] or Aquilion ONE ViSION 320 [Canon Medical Systems]) scanners. Subsequent invasive coronary angiography (ICA) and percutaneous or surgical revascularization were performed as part of routine clinical care. Among those referred for ICA after coronary CTA, the presence of obstructive CAD in each vessel was determined by coronary CTA (severe stenosis on visual assessment per the Coronary Artery Disease Reporting and Data System) and ICA (≥50% diameter stenosis on quantitative coronary angiography) in a blinded fashion. The diagnostic performance of EID-CT and PCD-CT was compared by using quantitative coronary angiography as the reference standard.</p><p><strong>Results: </strong>Patients who underwent PCD-CT were less frequently referred to subsequent ICA than those undergoing EID-CT (9.9% vs 13.1%; P < 0.001). Among those who underwent ICA, revascularization was more frequently performed in the PCD-CT group than in the EID-CT group (43.4% vs 35.5%; P = 0.02). In the vessel-level analysis (n = 1,686), specificity (98.0% vs 93.0%; P < 0.001), positive predictive value (83.3% vs 63.0%; P = 0.002), and diagnostic accuracy (97.2% vs 92.8%; P < 0.001) were improved by PCD-CT. Sensitivity (90.9% vs 90.7%; P = 0.95) and negative predictive value (98.9% vs 98.7%; P = 0.83) for obstructive CAD were similar between the PCD-CT and EID-CT groups, respectively.</p><p><strong>Conclusions: </strong>PCD-CT exhibited excellent diagnostic performance for detecting obstructive CAD. Compared with patients undergoing conventional EID-CT, fewer patients were referred to ICA after PCD-CT, but those referred were more likely to undergo revascularization.</p>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":"339-348"},"PeriodicalIF":21.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering the Profession: The ACC’s Commitment to Cutting-Edge Clinical Guidance","authors":"Cathleen Biga, Ana Barac, Nicole Bhave","doi":"10.1016/j.jacc.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.01.006","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"14 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Valve Repair for Tricuspid Regurgitation: 1-Year Results From a Large European Real-World Registry.","authors":"Mirjam G Wild, Lukas Stolz, Sebastian Rosch, Felix Rudolph, Björn Goebel, Benedikt Köll, Philipp von Stein, Wolfgang Rottbauer, Tienush Rassaf, Harald Beucher, Martin Kraus, Mohammad Kassar, Tobias Geisler, Andreas Rück, Joao Ferreira-Martins, Stefan Toggweiler, Paula Sagmeister, Dirk Westermann, Thomas J Stocker, Ludwig T Weckbach, Michael Näbauer, Magnus Settergren, Sam Dawkins, Tobias Kister, Fabien Praz, Marc Vorpahl, Mathias H Konstandin, Peter Lüdike, Mirjam Keßler, Christos Iliadis, Daniel Kalbacher, Philip Lauten, Muhammed Gerçek, Christian Besler, Philipp Lurz, Jörg Hausleiter","doi":"10.1016/j.jacc.2024.10.068","DOIUrl":"10.1016/j.jacc.2024.10.068","url":null,"abstract":"<p><strong>Background: </strong>Tricuspid valve transcatheter edge-to-edge repair has emerged as a valuable treatment option for patients with severe tricuspid regurgitation (TR).</p><p><strong>Objectives: </strong>This study aims to investigate the safety and effectiveness of the PASCAL transcatheter valve repair system in treating severe TR in a real-world patient population.</p><p><strong>Methods: </strong>The PASTE (PASCAL for Tricuspid Regurgitation-a European registry) study is an investigator-initiated, multicenter, retrospective, and prospective observational cohort analysis conducted across 16 European heart valve centers including consecutive patients treated with the PASCAL transcatheter valve repair system from February 2019 to November 2023. Echocardiographic assessments were performed at baseline, discharge, and follow-up, and were subjected to centralized analysis.</p><p><strong>Results: </strong>The study included 1,059 high-risk patients (mean age 79 ± 9 years; 53% female; TRI-SCORE risk 23% ± 18%; 87% NYHA functional class III/IV) with multiple comorbidities. Severe or higher graded TR was observed in 96% of patients. Intraprocedural success according to Tricuspid Valve Academic Research Consortium criteria was achieved in 85%, and TR reduced to ≤moderate in 87%. Independent predictors for a postprocedure residual TR of >moderate were coaptation gaps ≥8 mm (OR: 1.67; 95% CI: 1.03-2.72; P = 0.038), tenting height ≥10 mm (OR: 2.18; CI: 1.30-3.65; P = 0.003), the presence of a transvalvular lead (OR: 1.91; 95% CI: 1.19-3.05; P = 0.007), right ventricular dilatation >42 mm (OR: 3.35; 95% CI: 1.37-9.1; P = 0.009) and massive/torrential TR at baseline (OR: 4.59; 95% CI: 2.35-8.96; P < 0.001). At 1 year, 83% of patients showed ≤moderate TR. Significant clinical improvements included enhanced NYHA functional class (66% class I/II vs 17% at baseline; P < 0.001). Patients treated with the first-generation PASCAL system (n = 570) and with the new PASCAL Precision system (n = 489) had similar clinical profiles and TR severity at baseline. However, the Precision cohort showed greater TR reduction to trace/mild (63% vs 49%; P < 0.001), shorter procedure times (median 93 minutes [Q1-Q3: 69-130 minutes] vs 120 minutes [Q1-Q3: 82-165 minutes]; P < 0.001), and higher clinical success rates according to the Tricuspid Valve Academic Research Consortium at 30 days and 1 year (87% vs 81% [P = 0.021] and 56% vs 50% [P = 0.044], respectively). Higher center experience (≥21 patients/year) resulted in higher intraprocedural and clinical success.</p><p><strong>Conclusions: </strong>The PASCAL system effectively treats severe TR in high-risk patients, offering sustained TR reduction and significant clinical improvements at 1-year follow-up. (PASCAL for Tricuspid Regurgitation-a European registry [PASTE]; NCT05328284).</p>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":"220-231"},"PeriodicalIF":21.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Recurrent Ischemic Stroke After PFO Closure: Unconsidered Low RoPE Score and Thrombophilia","authors":"Kasper Bonnesen, Asger Andersen, Claus Ziegler Simonsen, Jens Erik Nielsen-Kudsk, Morten Schmidt","doi":"10.1016/j.jacc.2024.11.036","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.11.036","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"18 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Dialogue on Atrial Fibrillation in the United States","authors":"Connor G. Oltman, Taehyung P. Kim, James W.Y. Lee, John D. Lupu, Issam D. Moussa","doi":"10.1016/j.jacc.2024.11.038","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.11.038","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"113 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: What Is the Diagnostic and Prognostic Value of the Electrocardiographic QRS Attenuation in Myocarditis?","authors":"Benedikt Bernhard, Christoph Gräni","doi":"10.1016/j.jacc.2024.11.037","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.11.037","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"34 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Plasma Triglyceride Reduction and Cardiovascular Risk in ODYSSEY Outcomes Trial: Interpret With Caution","authors":"Doron Zahger, Gregory G. Schwartz, Michael Szarek, Sergio Fazio, P. Gabriel Steg","doi":"10.1016/j.jacc.2024.11.039","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.11.039","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"150 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Publishing: Your Paper, Your Way at JACC","authors":"Harlan M. Krumholz","doi":"10.1016/j.jacc.2024.12.015","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.12.015","url":null,"abstract":"&lt;h2&gt;Section snippets&lt;/h2&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;The Central Tenets of YPYW&lt;/h2&gt;Our YPYW policy is simple: authors should submit their manuscripts in whatever formatting style they find easiest and clearest. Initial submissions are evaluated for content, not formatting requirements. Our key principles include the following:&lt;ul&gt;&lt;li&gt;&lt;span&gt;1.&lt;/span&gt;&lt;span&gt;&lt;strong&gt;Focus on Content&lt;/strong&gt;: The quality of the research, clarity of the message, and significance of the findings are our sole focus during the initial review. Formatting adjustments come only after the initial round of peer review if the editors offer acceptance&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;What This Means for You&lt;/h2&gt;The &lt;em&gt;JACC&lt;/em&gt; YPYW approach transforms our submission process in tangible ways. It is a part of our more comprehensive author-centric system, and our deep respect for authors. This approach should translate into the following:&lt;ul&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;strong&gt;Less Stress:&lt;/strong&gt; Submit your manuscript as it is. Spend your time refining your science, not your formatting.&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;strong&gt;More Speed:&lt;/strong&gt; Submit faster and receive decisions quickly, allowing you to spend more time advancing your research.&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;strong&gt;Greater Collaboration:&lt;/strong&gt; Work with us to refine your&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;The Essential Requirements&lt;/h2&gt;For clarity, exactly what we expect at each stage for an Original Research paper is detailed in Table 1. Although we embrace flexibility in formatting, clarity remains non-negotiable. Submissions must be easy to read and evaluate, with clear headings, logical structure, and legible figures.This balance between flexibility and clarity will make the submission process easier for authors without compromising the quality or integrity of our journal. For all papers,&lt;sup&gt;2&lt;/sup&gt; a&lt;em&gt;uthors may submit their&lt;/em&gt;&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Why We Are Making This Change&lt;/h2&gt;The current norms in academic publishing need reform. We need to tack ever more toward easing the needless burdens on authors and scientists. As people who often juggle many responsibilities, your time is already stretched thin. We do not want manuscript formatting to take time away from what matters: your patients, research, teaching, or personal life.What if all journals embraced common submission standards—a world where you spent your time crafting the best possible manuscript rather than&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Building the Future of Scientific Publishing&lt;/h2&gt;At &lt;em&gt;JACC&lt;/em&gt;, we view the publishing process as a partnership. Our YPYW initiative reflects our belief that authors, editors, consultants, reviewers, and readers should collaborate to ensure the publication of impactful, high-quality science. By focusing on rapid, thoughtful decisions and streamlining submissions, we align with the urgency of advancing cardiovascular scie","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"4 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amara Yad Image: The Mitral Valve, Aortic Root, and Aortomitral Continuity","authors":"Kalyanam Shivkumar","doi":"10.1016/j.jacc.2024.12.016","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.12.016","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Funding Support and Author Disclosures</h2>This work was supported by National Institutes of Health grants OT2OD023848 and P01 HL164311 to Dr Shivkumar and the UCLA Amara-Yad Project. Dr Shivkumar is a consultant to Nference and Anumana.</section></section>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"48 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Triglyceride Reduction and Cardiovascular Risk in ODYSSEY Outcomes Trial: Interpret With Caution","authors":"Chris J. Packard, Jan Borén, M. John Chapman","doi":"10.1016/j.jacc.2024.10.124","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.10.124","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"38 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}