Journal of the American College of Cardiology最新文献

{"title":"Intraindividual Variability in Serial Lipoprotein(a) Concentrations Among Placebo-Treated Patients in the OCEAN(a)-DOSE Trial","authors":"Prakriti Gaba, Robert S. Rosenson, J. Antonio G. López, Gerald F. Watts, Thorsten M. Leucker, Julia F. Kuder, KyungAh Im, Helina Kassahun, Huei Wang, You Wu, Jingying Wang, E. Magnus Ohman, Marc S. Sabatine, Michelle L. O’Donoghue","doi":"10.1016/j.jacc.2024.10.081","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.10.081","url":null,"abstract":"Lipoprotein(a) [Lp(a)] is a presumed risk factor for atherosclerotic cardiovascular disease (ASCVD), and its levels are primarily genetically determined (∼70%-90%).<span><span>¹</span></span>^,<span><span>²</span></span> As such, many guidelines and consensus groups recommend measuring Lp(a) levels only once in a person’s lifetime for risk stratification.<span><span>³</span></span>^,<span><span>⁴</span></span> However, data assessing the intraindividual variability of Lp(a) levels over time are limited.<span><span>5</span></span>, <span><span>6</span></span>, <span><span>7</span></span>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"98 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finerenone, Obesity, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: Prespecified Analysis of FINEARTS-HF","authors":"Jawad H. Butt, Alasdair D. Henderson, Pardeep S. Jhund, Brian L. Claggett, Akshay S. Desai, James Lay-Flurrie, Prabhakar Viswanathan, Andrea Lage, Markus F. Scheerer, Carolyn S.P. Lam, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Johann Bauersachs, Cândida Fonseca, Mikhail N. Kosiborod, Gerard C.M. Linssen, Mark C. Petrie, Morten Schou, Subodh Verma, John J.V. McMurray","doi":"10.1016/j.jacc.2024.10.111","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.10.111","url":null,"abstract":"&lt;h3&gt;Background&lt;/h3&gt;Obesity is associated with excessive adipocyte-derived aldosterone secretion, independent of the classical renin-angiotensin-aldosterone cascade, and mineralocorticoid receptor antagonists may be more effective in patients with heart failure (HF) and obesity.&lt;h3&gt;Objectives&lt;/h3&gt;This study sought to examine the effects of the nonsteroidal mineralocorticoid receptor antagonist finerenone compared with placebo, according to body mass index (BMI) in FINEARTS-HF (FINerenone trial to investigate Efficacy and sAfety superioR to placebo in paTientS with Heart Failure).&lt;h3&gt;Methods&lt;/h3&gt;A total of 6,001 patients with HF with NYHA functional class II, III, and IV, a left ventricular ejection fraction of ≥40%, evidence of structural heart disease, and elevated natriuretic peptide levels were randomized to finerenone or placebo. BMI (kg/m&lt;sup&gt;2&lt;/sup&gt;) was examined using World Health Organization categories, namely, underweight/normal weight (&lt;25.0 kg/m&lt;sup&gt;2&lt;/sup&gt;; n = 1,306); overweight (25.0-29.9 kg/m&lt;sup&gt;2&lt;/sup&gt;; n = 1,990); obesity class I (30.0-34.9 kg/m&lt;sup&gt;2&lt;/sup&gt;; n = 1,546); obesity class II (35.0-39.9 kg/m&lt;sup&gt;2&lt;/sup&gt;; n = 751); and obesity class III (≥40 kg/m&lt;sup&gt;2&lt;/sup&gt;; n = 395). The primary outcome was cardiovascular death and total worsening HF events.&lt;h3&gt;Results&lt;/h3&gt;Data on baseline BMI were available for 5,988 patients (median: 29.2 kg/m&lt;sup&gt;2&lt;/sup&gt;; Q1-Q3: 25.5-33.6 kg/m&lt;sup&gt;2&lt;/sup&gt;). Compared with patients who were underweight/normal weight, those with obesity class II or III had a higher risk of the primary outcome (underweight/normal weight, reference; overweight, unadjusted rate ratio: 0.96 [95% CI: 0.81-1.15]; obesity class I: 1.04 [95% CI: 0.86-1.26]; obesity class II-III: 1.26 [95% CI: 1.03-1.54]). The effect of finerenone on the primary outcome did not vary by baseline BMI (underweight/normal weight, rate ratio: 0.80 [95% CI: 0.62-1.04]; overweight: 0.91 [95% CI: 0.72-1.15]; obesity class I: 0.92 [95% CI: 0.72-1.19]; obesity class II-III: 0.67 [95% CI: 0.50-0.89]; &lt;em&gt;P&lt;/em&gt;&lt;sub&gt;interaction&lt;/sub&gt; = 0.32). However, when BMI was examined as a continuous variable, the beneficial effect of finerenone seemed to be greater in those with a higher BMI (&lt;em&gt;P&lt;/em&gt;&lt;sub&gt;interaction&lt;/sub&gt; = 0.005). A similar pattern was observed for total worsening HF events. Consistent effects across baseline BMI were observed for cardiovascular and all-cause death and improvement in the Kansas City Cardiomyopathy Questionnaire scores.&lt;h3&gt;Conclusions&lt;/h3&gt;In patients with HF with mildly reduced/preserved ejection fraction, the beneficial effects of finerenone on clinical events and symptoms were consistent, irrespective of BMI at baseline, possibly with a greater effect on the primary outcome in patients with higher BMI. (FINEARTS-HF [FINerenone trial to investigate Efficacy and sAfety superioR to placebo in paTientS with Heart Failure]; &lt;span&gt;&lt;span&gt;NCT04435626&lt;/span&gt;&lt;svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"23 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 ACC Expert Consensus Decision Pathway on Strategies and Criteria for the Diagnosis and Management of Myocarditis: A Report of the American College of Cardiology Solution Set Oversight Committee","authors":"Mark H. Drazner, Biykem Bozkurt, Leslie T. Cooper, Niti R. Aggarwal, Cristina Basso, Nicole M. Bhave, Alida L.P. Caforio, Vanessa M. Ferreira, Bettina Heidecker, Amy R. Kontorovich, Pilar Martín, Gregory A. Roth, Jennifer E. Van Eyk","doi":"10.1016/j.jacc.2024.10.080","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.10.080","url":null,"abstract":"&lt;h2&gt;Section snippets&lt;/h2&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Solution Set Oversight Committee&lt;/h2&gt;Nicole M. Bhave, MD, FACC, &lt;em&gt;Chair&lt;/em&gt;Niti R. Aggarwal, MD, FACCKatie Bates, ARNP, DNPJohn P. Erwin &lt;span&gt;iii&lt;/span&gt;, MD, FACCMartha Gulati, MD, MS, FACCDharam J. Kumbhani, MD, SM, FACCGurusher S. Panjrath, MBBS, FACCBarbara Wiggins, PharmD, FACCMegan Coylewright, MD, MPH, FACC, &lt;em&gt;Ex Officio&lt;/em&gt;&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Table of Contents&lt;/h2&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;&lt;/span&gt;&lt;span&gt;Top 10 Key Takeaway Points&lt;!-- --&gt; &lt;!-- --&gt;3&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;1.&lt;/span&gt;&lt;span&gt;Introduction&lt;!-- --&gt; &lt;!-- --&gt;4&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;2.&lt;/span&gt;&lt;span&gt;Assumptions and Proposed Definitions&lt;!-- --&gt; &lt;!-- --&gt;4&lt;ul&gt;&lt;li&gt;&lt;span&gt;2.1.&lt;/span&gt;&lt;span&gt;General Clinical Assumptions&lt;!-- --&gt; &lt;!-- --&gt;4&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;2.2.&lt;/span&gt;&lt;span&gt;Definitions&lt;!-- --&gt; &lt;!-- --&gt;5&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;3.&lt;/span&gt;&lt;span&gt;Pathway Summary Graphic&lt;!-- --&gt; &lt;!-- --&gt;5&lt;ul&gt;&lt;li&gt;&lt;span&gt;&lt;/span&gt;&lt;span&gt;Figure 1. The Evaluation and Management of Clinically Suspected Myocarditis Described as a 5-Step Care Pathway&lt;!-- --&gt; &lt;!-- --&gt;6&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;4.&lt;/span&gt;&lt;span&gt;Description, Rationale, and Implication of Pathway&lt;!-- --&gt; &lt;!-- --&gt;7&lt;ul&gt;&lt;li&gt;&lt;span&gt;4.1.&lt;/span&gt;&lt;span&gt;Diagnosis of Myocarditis&lt;!-- --&gt; &lt;!-- --&gt;7&lt;ul&gt;&lt;li&gt;&lt;span&gt;4.1.1.&lt;/span&gt;&lt;span&gt;Clinical Symptoms&lt;!-- --&gt; &lt;!-- --&gt;7&lt;ul&gt;&lt;li&gt;&lt;span&gt;&lt;/span&gt;&lt;span&gt;Figure 2. Three Classic Presentations of Myocarditis&lt;!-- --&gt; &lt;!-- --&gt;8&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;4.2.&lt;/span&gt;&lt;span&gt;Diagnostic Testing&lt;!-- --&gt; &lt;!-- --&gt;7&lt;ul&gt;&lt;li&gt;&lt;span&gt;4.2.1.&lt;/span&gt;&lt;span&gt;Electrocardiogram&lt;!-- --&gt; &lt;!-- --&gt;7&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;4.2.2.&lt;/span&gt;&lt;span&gt;Echo and Strain Echocardiography&lt;!-- --&gt; &lt;!-- --&gt;7&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;4.2.3.&lt;/span&gt;&lt;span&gt;Circulating Cardiac Troponin&lt;!-- --&gt; &lt;!-- --&gt;7&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;4.2.4.&lt;/span&gt;&lt;span&gt;&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Top 10 Key Takeaway Points&lt;/h2&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;1.&lt;/span&gt;&lt;span&gt;Clinicians need to be aware of the 3 classic presentations of myocarditis: chest pain, heart failure (HF)/shock, and/or symptoms related to arrhythmia (eg, presyncope or syncope). In a young person, the history of an antecedent viral infection, or other risk factors that define stage A at-risk for myocarditis, followed by any of these cardiovascular symptoms should raise the suspicion of this diagnosis.&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;2.&lt;/span&gt;&lt;span&gt;High-sensitivity cardiac troponin (hs-cTn) is a common diagnostic test in patients with&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;General Clinical Assumptions&lt;/h2&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;1.&lt;/span&gt;&lt;span&gt;The principal focus of this ECDP is on adults with acute myocarditis. For information on myocarditis in the pediatric population, the reader is referred to the “2021 AHA Scientific Statement on Diagnosis and Management of Myocarditis in Children.”&lt;sup&gt;1&lt;/sup&gt; This ECDP does not address conditions with chronic inflammatory infiltrates of the myocardium, as","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"19 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-Related Heart Failure With Preserved Ejection Fraction: Weighing the Benefit of Finerenone","authors":"Amanda R. Vest, Andrew J. Sauer","doi":"10.1016/j.jacc.2024.11.033","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.11.033","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Funding Support and Author Disclosures</h2>Dr Vest has received research grant funding from the National Heart, Lung, and Blood Institute (grant R01HL167113) and the National Center for Advancing Translational Sciences (grant RC2TR004377). Dr Sauer has received salary support for research activities from Saint Luke’s Mid America Heart Institute, a nonprofit academic research organization affiliated with the University of Missouri-Kansas City, that receives or has received funding from Bayer, CSL Vifor, Pfizer, Rivus, AstraZeneca,</section></section>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"240 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalizability of the Mass General Brigham Lp(a) Registry Study","authors":"Kazuo Komamura, Hiroshi Miyake, Koichi Kobayashi, Mitsunori Iwase","doi":"10.1016/j.jacc.2024.08.085","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.08.085","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"85 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Respiratory Infections Fuel Cardiovascular Disease","authors":"Florien S. van Royen, Roderick P. Venekamp, Patricia C.J.L. Bruijning-Verhagen, Frans H. Rutten","doi":"10.1016/j.jacc.2024.10.079","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.10.079","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Funding Support and Author Disclosures</h2>The authors have reported that they have no relationships relevant to the contents of this paper to disclose.</section></section>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"140 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audio Summary","authors":"","doi":"10.1016/s0735-1097(24)10433-0","DOIUrl":"https://doi.org/10.1016/s0735-1097(24)10433-0","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"34 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Health Interventions: Addressing Developmental Differences and Focusing on Creative Thinking in Children","authors":"Hanjun Ma, Jiangmi Mo, Zonglong He, Qunqiang Luo","doi":"10.1016/j.jacc.2024.08.086","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.08.086","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"90 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Outcome in Patients With Tricuspid Regurgitation: Look At the Kidneys and the Liver!","authors":"Marco Metra, Marianna Adamo, Javed Butler","doi":"10.1016/j.jacc.2024.09.1238","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.09.1238","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Funding Support and Author Disclosures</h2>Dr Metra has received consulting fees from Abbott Structural Heart, AstraZeneca, Bayer, Boehringer Ingelheim, Cytokinetics, Edwards Lifesciences, and Novo Nordisk. Dr Adamo has received consultant/speaker honoraria from Abbott Vascular and Edwards Lifesciences. Dr Butlar is a consultant for Abbott, American Regent, Amgen, Applied Therapeutic, AskBio, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Boston Scientific, Bristol Myers Squibb, Cardiac Dimension, Cardiocell, Cardior, CSL Bearing,</section></section>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"20 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPLY: Generalizability of the Mass General Brigham Lp(a) Registry Study","authors":"Adam N. Berman, David W. Biery, Brittany N. Weber, Deepak L. Bhatt","doi":"10.1016/j.jacc.2024.09.1239","DOIUrl":"https://doi.org/10.1016/j.jacc.2024.09.1239","url":null,"abstract":"No Abstract","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"37 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}