Journal of the American Academy of Child and Adolescent Psychiatry最新文献

{"title":"The Inner World of the Child","authors":"Misty C. Richards MD, MS (Assistant Editor), Justin Schreiber DO, MPH (Assistant Editor)","doi":"10.1016/j.jaac.2025.04.013","DOIUrl":"10.1016/j.jaac.2025.04.013","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 8","pages":"Page 959"},"PeriodicalIF":9.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Adversity and Neonatal Brain Connectivity Relate to Emerging Executive Function at Age 2 Years.","authors":"Rachel E Lean,Jeanette K Kenley,Aidan R Latham,Tara A Smyser,Jeff Neil,Ashley N Nielsen,Chad M Sylvester,J Philip Miller,Joshua J Shimony,Joan Luby,Deanna M Barch,Barbara B Warner,Christopher D Smyser,Cynthia E Rogers","doi":"10.1016/j.jaac.2025.04.016","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.04.016","url":null,"abstract":"OBJECTIVEEarly life adversity alters the structure and function of higher-order brain networks that subserve executive function (EF). The extent that prenatal exposure to adversity and neonatal white matter (WM) microstructure and resting-state functional connectivity (rs-fc) underlie problems in emerging EF remains unclear.METHODThis prospective study includes 164 infants (45% female, 85% term-born) who were recruited prenatally and underwent neonatal diffusion and rs-fc MRI scans. Social Disadvantage and maternal Psychosocial Stress were assessed in the prenatal period. At age 2 years, children completed the Minnesota Executive Function Scale. Multivariable regression, moderation, and mediation analyses examined associations between prenatal adversity, neonatal WM microstructure and rs-fc, and emerging EF outcome.RESULTSPrenatal Social Disadvantage (PSD), but not maternal Psychosocial Stress, was associated with poorer emerging EF. After multiple comparison correction, higher mean diffusivity (MD) and lower fractional anisotropy (FA) in the corpus callosum, as well as higher MD in the inferior fronto-occipital fasciculus and corticospinal tract and lower FA in the uncinate, related to poorer emerging EF. In moderation analysis, associations between neonatal WM microstructure and emerging EF did not vary as a function of PSD. In mediation analyses, neonatal WM microstructure did not attenuate the association between PSD and emerging EF. Rs-fc findings did not pass multiple comparison correction.CONCLUSIONPSD was related to poorer emerging EF outcomes. Neonatal WM microstructure was also related to emerging EF, with similar associations for children with lower or higher PSD. Prenatal social welfare programs may support neonatal brain development and early neurodevelopmental outcomes.DIVERSITY & INCLUSIONWe worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnaires were prepared in an inclusive way.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"302 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Council Page","authors":"","doi":"10.1016/S0890-8567(25)00081-4","DOIUrl":"10.1016/S0890-8567(25)00081-4","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 5","pages":"Page A2"},"PeriodicalIF":9.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child and Youth Artwork","authors":"","doi":"10.1016/S0890-8567(25)00083-8","DOIUrl":"10.1016/S0890-8567(25)00083-8","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 5","pages":"Page A6"},"PeriodicalIF":9.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0890-8567(25)00080-2","DOIUrl":"10.1016/S0890-8567(25)00080-2","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 5","pages":"Page A1"},"PeriodicalIF":9.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis: Predictors of Adult Psychiatric Outcomes of Childhood Attention-Deficit/Hyperactivity Disorder.","authors":"Noa E van der Plas,Siri D S Noordermeer,Jaap Oosterlaan,Marjolein Luman","doi":"10.1016/j.jaac.2025.04.012","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.04.012","url":null,"abstract":"OBJECTIVEPsychiatric disorders are highly prevalent in adults with childhood-onset attention-deficit/hyperactivity disorder (ADHD). Currently, little is known about childhood predictors for these outcomes.METHODPubMed, PsychInfo, WoS, and EMBASE were searched until June 2024. Eligible studies investigated childhood predictors of persistent ADHD, substance use disorders (SUD), conduct disorder, antisocial personality disorder, major depressive disorder (MDD), and/or anxiety disorders in adults diagnosed with childhood ADHD (PROSPERO #CRD42022320887). Meta-analytic models were tested when N ≥3 for a predictor with similar effect measures, otherwise predictors were discussed narratively when N ≥2. Newcastle-Ottawa scale was used to assess study quality.RESULTSThe selected 36 studies included 119 predictors, with 10 predictors eligible for meta-analyses. History of stimulant treatment (OR = 1.88, 95% CI 1.28-2.75, p = .001) was associated with increased, and higher childhood IQ with decreased (OR = 0.99, 95% CI 0.98-1.00, p =.039), risk of ADHD persistence in adulthood. ADHD persistence was associated with increased risk of SUDs (OR = 2.12, 95% CI 1.53-3.17, p =.004) and MDD (OR = 3.19, 95% CI 1.71-5.95, p <.001). Narratively reviewed predictors of fair/good quality studies showed potential predictors for ADHD persistence (i.e., ADHD combined type, hyperactive/impulsive symptoms, anxiety disorders, externalizing problems, social dysfunctioning, and socioeconomic status).CONCLUSIONWe confirmed earlier reported childhood predictors (i.e., stimulant treatment history, ADHD persistence) and identified potential new predictors (i.e., childhood anxiety disorders, social problems, socioeconomic status) for psychiatric outcomes of ADHD. However, the available literature is hampered by methodological shortcomings. Future studies should focus on studying combined effects of potential predictors.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"83 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts.","authors":"Maia Choi,Holly E Poore,Sarah J Brislin,Peter B Barr,Fazil Aliev,Stephanie M Zellers,Gretchen R B Saunders,Jessica E Salvatore,Scott I Vrieze,K Paige Harden,Abraham A Palmer,Anu Raevuori,Antti Latvala,,Danielle M Dick","doi":"10.1016/j.jaac.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.04.010","url":null,"abstract":"OBJECTIVEUnderstanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from five large datasets to characterize behavioral manifestations of a genetic liability toward externalizing from ages 6 months- 26 years.METHODWe used polygenic scores (PGS) derived from a multivariate GWAS of Externalizing that identified hundreds of significantly associated genetic variants (EXTPGS) to estimate associations of genetic liability with relevant phenotypes within and across developmental periods, ranging from toddlerhood to early adulthood. We used data from five population- and family-based datasets spanning three countries.RESULTSThe EXTPGS was significantly associated with a breadth of externalizing phenotypes from toddlerhood to early adulthood. Higher EXTPGS was consistently associated with measures of impulsivity from early adolescence to early adulthood. Individuals with higher EXTPGS were more likely to experience conduct problems and symptoms of oppositional defiant and attention-deficit/hyperactivity disorders. Further, the EXTPGS was associated with higher levels of substance use and problems beginning in early adolescence through early adulthood, including alcohol and other illicit drug use. There was minimal evidence for sex interactions.CONCLUSIONA genetic liability toward externalizing is associated a wide array of behaviors and psychiatric/substance use outcomes beginning as early as childhood and through emerging adulthood. The early emergence and breadth of behaviors associated with a genetic liability toward externalizing could inform prevention and intervention.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"55 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Children's Mental Health Symptoms Impact Their Access to Unlocked Guns at Home?","authors":"Guangyu Tong,Josie Caves Sivaraman,Michele M Easter,Naomi N Duke,Megan L Ranney,Jeffrey W Swanson,William E Copeland","doi":"10.1016/j.jaac.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.04.011","url":null,"abstract":"OBJECTIVETo test whether changes in children's mental health symptoms predict changes in their access to unlocked guns at home.METHODThis study used data from a longitudinal cohort study of 1,420 youth and their parents in the Southeastern US. Parents were assessed annually up to eight times about their child's mental health (i.e., conduct, oppositional defiant, depression, and anxiety symptoms) between ages 9 to 16 (6,674 observations total). Parents were also asked whether there were guns in their home and whether they were locked. Generalized linear mixed-effect models were used to test associations between changes in symptoms and in-home gun access adjusted for sociodemographic variables. Children with or without access to unlocked guns at baseline were differentiated in analyses.RESULTSSixty-six percent of parents reported that their child had access to an unlocked gun at some point between ages 9-16. In homes in which children did not have gun access at baseline, changes in youth mental health symptoms did not increase or decrease the likelihood of child having access to unlocked guns subsequently. In homes in which children did have guns access at baseline, however, increases in some mental health symptoms (either oppositional defiant (OR= 0.43, CI=[0.35, 0.53], p<0.001), or depression symptom (OR=0.74, CI=[0.59, 0.92], p<0.008)) were associated with reduced gun access at the next timepoint. These associations were strongest for adolescents.CONCLUSIONIn an area where gun culture is strong, parents reported making safety-conscious adjustments to their children's gun access when their children displayed emotional or behavioral symptoms.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"83 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review: Antipsychotic Medication in Pregnancy and Neurodevelopmental Outcomes in Children.","authors":"Carly A Kaplan,Eline M P Poels,Marion I van den Heuvel,Hilmar H Bijma,Veerle Bergink,Anna-Sophie Rommel,Thalia Robakis","doi":"10.1016/j.jaac.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.04.008","url":null,"abstract":"OBJECTIVEAntipsychotic medications are widely prescribed, including during pregnancy, and pregnant individuals worry about the potential sequelae for the child. While antipsychotics do not seem to be teratogenic, the long-term neurodevelopmental impact of prenatal exposure remains unclear. A systematic review was conducted to determine if intrauterine antipsychotic exposure increases the risk of adverse neurodevelopmental outcomes.METHODA systematic search was performed in MEDLINE, Cochrane, Embase, and PsycINFO for studies published before September 7th, 2024. We included original studies assessing cognitive, motor, behavioral, social, and psychiatric outcomes in children prenatally exposed to antipsychotics, excluding case reports, reviews, pre-clinical studies, and studies without a control group. Quality and risk of bias were assessed using the Newcastle-Ottawa Scale (NOS).RESULTSOf 1349 studies identified, 56 underwent full-text screening, and 16 were included in the review. The number of exposed participants ranged from 11 to >15,000. In the eight studies assessing motor development, early motor delays were observed but did not persist into later childhood. Neurodevelopmental disorders were assessed in seven studies. Crude estimates showed greater risk in exposed children, but after adjusting for confounders, most studies found no significant risk. The mean NOS score was 7.1.CONCLUSIONTransient motor delays may be associated with antipsychotic use during pregnancy, although future studies adjusting for confounding factors should clarify this risk. After adjustment for confounders, the risk of neurodevelopmental disorders in school-age children does not seem to be increased. Studies with longer follow-up time are required to further investigate the risk of neurodevelopmental disorders.STUDY REGISTRATION INFORMATIONNeurodevelopmental Consequences of Antenatal Exposure to Antipsychotic Medication: A Systematic Review and Meta-Analysis; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024499352.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"74 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Progress Toward an Elaborated Externalizing Spectrum in Youth.","authors":"Irwin D Waldman","doi":"10.1016/j.jaac.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.04.009","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"35 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}