Journal of the American Animal Hospital Association最新文献_第9页

Luteinizing Hormone Receptor Expression in Neoplastic Mast Cells Is Increased in Spayed and Neutered Dogs. 绝育犬肿瘤肥大细胞促黄体生成素受体表达增加

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-11-01 DOI: 10.5326/JAAHA-MS-7150

Michelle Anne Kutzler, Valerio Moccia, Khawla Zwida, Christiane Verena Löhr

{"title":"Luteinizing Hormone Receptor Expression in Neoplastic Mast Cells Is Increased in Spayed and Neutered Dogs.","authors":"Michelle Anne Kutzler, Valerio Moccia, Khawla Zwida, Christiane Verena Löhr","doi":"10.5326/JAAHA-MS-7150","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7150","url":null,"abstract":"Luteinizing hormone receptors (LHRs) are expressed in canine lymphoma and hemangiosarcoma. We hypothesized that LHR would be expressed in canine mast cell tumors (MCTs) and that more neoplastic mast cells would express LHR in gonadectomized dogs compared with intact dogs. Eleven archived formalin-fixed paraffin-embedded cutaneous MCT tissue sections were processed using routine immunohistochemistry. For both the KIT protein and LHR, the percentage of positive cells for each staining pattern (I-III) was calculated. A Student's t test was used to compare the total percentage of positive cells expressing LHR and KIT in intact and gonadectomized dogs. A one-way analysis of variance was used to compare the percentage of cells within each staining pattern for LHR and KIT in intact and gonadectomized dogs. All MCT expressed LHR. MCT from gonadectomized dogs had a significantly higher percentage of LHR-positive mast cells (84.2 ± 8.7%) compared with MCTs from intact dogs (64.3 ± 4.2%). This is the first study to demonstrate the expression of LHR in canine MCTs and to report that LHR expression is increased in neoplastic mast cells from gonadectomized dogs compared with intact dogs. Future studies are planned to evaluate the functionality of the LHR in canine neoplastic mast cells.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"58 6","pages":"271-276"},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40437049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acquired Systolic Dysfunction and Subsequent Congestive Heart Failure Following Treatment of Hypoadrenocorticism in Two Dogs. 低肾上腺皮质激素治疗后获得性收缩功能障碍和随后的充血性心力衰竭。

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-11-01 DOI: 10.5326/JAAHA-MS-7223

Lindsey Jett, Shaina Mooshian, Erin Anderson

{"title":"Acquired Systolic Dysfunction and Subsequent Congestive Heart Failure Following Treatment of Hypoadrenocorticism in Two Dogs.","authors":"Lindsey Jett, Shaina Mooshian, Erin Anderson","doi":"10.5326/JAAHA-MS-7223","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7223","url":null,"abstract":"Acquired cardiomyopathies have been described in human patients with hypoadrenocorticism. Several mechanisms have been described to explain the cardiac effects of primary adrenal insufficiency, but, clinically, these manifestations may be underappreciated in dogs. In humans, there is an infrequently described, reversible dilated cardiomyopathy in patients with hypoadrenocorticism. Two dogs were presented to a single referral center for evaluation of weakness or collapse and were subsequently diagnosed with hypoadrenocorticism after a full diagnostic workup. Following the diagnosis of hypoadrenocorticism and administration of glucocorticoids and desoxycorticosterone pivalate, both dogs developed left-sided congestive heart failure and had systolic dysfunction diagnosed by echocardiogram. Both dogs were euthanized; one because of recurrent congestive heart failure and another because of a concern for poor long-term prognosis and decreased quality of life. The purpose of this case report is to document multiple cases of hypoadrenocorticism-associated systolic dysfunction and subsequent cardiogenic pulmonary edema in dogs.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"58 6","pages":"297-302"},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40437048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resolution of Signs of Epiglottic Retroversion Following Medical Management of Hyperadrenocorticism in a Dog. 犬肾上腺皮质亢进医学治疗后会厌后倾体征的解决。

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-11-01 DOI: 10.5326/JAAHA-MS-7225

Shota Wada, Kensuke Nakamura

{"title":"Resolution of Signs of Epiglottic Retroversion Following Medical Management of Hyperadrenocorticism in a Dog.","authors":"Shota Wada, Kensuke Nakamura","doi":"10.5326/JAAHA-MS-7225","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7225","url":null,"abstract":"A 6 yr old spayed female Chihuahua was referred for a 10 mo history of chronic respiratory compromise. Decreased serum thyroxine and thyroid-stimulating hormone concentrations had been confirmed at a primary clinic, but no treatment was initiated. Serum biochemistries revealed elevated alkaline phosphatase and cholesterol concentrations. An adrenocorticotropic hormone-stimulating test revealed elevated preserum and postserum cortisol concentrations. Fluoroscopy revealed marked epiglottic retroversion (ER) during inhalation. Enlarged bilateral adrenal glands were found on abdominal ultrasonography. Based on these findings, ER and hyperadrenocorticism (HAC) were diagnosed and surgical correction of the ER was planned. Trilostane administration was initiated before surgery to reduce the risk of thrombosis due to HAC. Seven days after the initiation of trilostane therapy, clinical signs of chronic respiratory compromise were resolved. The patient had remained clinically stable without recurrence of respiratory compromise for at least 15 mo at the time of this case report. This case suggests that HAC could contribute to the development of clinical signs of ER, which could potentially be successfully controlled by medical treatment of HAC.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"58 6","pages":"288-291"},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40446808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal Leech Therapy in Veterinary Medicine: A Retrospective Study. 兽药水蛭治疗:回顾性研究。

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-11-01 DOI: 10.5326/JAAHA-MS-7146

Celine S Kermanian, Nicole J Buote, Philip J Bergman

{"title":"Medicinal Leech Therapy in Veterinary Medicine: A Retrospective Study.","authors":"Celine S Kermanian, Nicole J Buote, Philip J Bergman","doi":"10.5326/JAAHA-MS-7146","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7146","url":null,"abstract":"The objective of this study was to report the clinical indications, outcomes, and complications associated with medicinal leech therapy (MLT) in dogs and cats. Medical records (2012-2016) of client-owned dogs (n = 9) and cats (n = 3) treated with MLT at one institution were retrospectively reviewed. Retrieved data included the signalment, indications, physical examination findings, laboratory results, methods of leeching, outcomes, and complications associated with MLT. Following MLT sessions, nine patients (75%) visibly showed clear improvement of the affected tissue. One patient (8%) was euthanized before complete healing owing to pulmonary parenchymal disease. Improvement or appearance of tissue following MLT was not recorded in two patients (17%). Results suggest that MLT may be a safe and effective treatment modality for venous congestion and necrosis in compromised skin flaps and wounds with success in resolving 75% of the lesions in this study. This study is suggestive of the value of MLT when more conventional treatment methods fail in dogs and cats. A data collection form was created for veterinarians to use with the goal of obtaining standardized, objective MLT data for future studies.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"58 6","pages":"303-308"},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40446806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Responses to Nasal Stimulation Under Ethmoidal-Maxillary Nerve Block and Lidocaine Gel in Anesthetized Beagles. 麻醉比格犬在筛颌神经阻滞和利多卡因凝胶下对鼻刺激的心血管反应。

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-11-01 DOI: 10.5326/JAAHA-MS-7183

Hyunseok Kim, Won-Gyun Son, Min Jang, Dalhae Kim, Donghwi Shin, Jiyoung Kim, Inhyung Lee

{"title":"Cardiovascular Responses to Nasal Stimulation Under Ethmoidal-Maxillary Nerve Block and Lidocaine Gel in Anesthetized Beagles.","authors":"Hyunseok Kim, Won-Gyun Son, Min Jang, Dalhae Kim, Donghwi Shin, Jiyoung Kim, Inhyung Lee","doi":"10.5326/JAAHA-MS-7183","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7183","url":null,"abstract":"This study aimed to compare the effect of ethmoidal-maxillary nerve block (EMBLOCK) and topical application of 2% lidocaine gel (LGEL) on cardiovascular variables (heart rate and arterial blood pressure) during mechanical stimulation of the nasal cavity. The working hypothesis was that both techniques (EMBLOCK and LGEL) similarly blunt the cardiovascular responses to the stimulation. Six beagles were anesthetized using alfaxalone and isoflurane on three occasions with each treatment (EMBLOCK, LGEL, and control) in random order. The nasal cavity from the nose tip to the medial canthus was stimulated with a standard-tip cotton swab, and cardiovascular variables were recorded before and after stimulation. The maximum increases in heart rate and blood pressure were significantly smaller in EMBLOCK and LGEL than in the control. There was no significant difference between EMBLOCK and LGEL. Therefore, although further clinical studies are required, EMBLOCK and LGEL can be used because both EMBLOCK and LGEL attenuated the cardiovascular response to mechanical stimulation of the nasal cavity in dogs.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"58 6","pages":"265-270"},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40446807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic Rectovesicular Fistula in a Dog. 犬外伤性直肠囊瘘一例。

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-11-01 DOI: 10.5326/JAAHA-MS-7191

Candance Tam, Vanna Dickerson, Jessica Vallone, Kelley Thieman Mankin

引用次数: 0

Combined Hypofractionated Radiotherapy and Chemotherapy Versus Hypofractionated Radiotherapy Alone for Cats with Localized Sinonasal Lymphoma. 低分割放化疗联合放疗与单独低分割放疗治疗局限性鼻窦淋巴瘤的比较。

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-09-01 DOI: 10.5326/JAAHA-MS-7267

Sho Goto, Ryota Iwasaki, Hiroki Sakai, Takashi Mori

{"title":"Combined Hypofractionated Radiotherapy and Chemotherapy Versus Hypofractionated Radiotherapy Alone for Cats with Localized Sinonasal Lymphoma.","authors":"Sho Goto, Ryota Iwasaki, Hiroki Sakai, Takashi Mori","doi":"10.5326/JAAHA-MS-7267","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7267","url":null,"abstract":"Despite considering hypofractionated radiotherapy (HRT) a useful treatment option for feline localized sinonasal lymphoma (stage I), the benefits of additional chemotherapy remain controversial. This retrospective cohort study evaluated the efficacy of the early initiation of chemotherapy in combination with HRT (HRTC) to prolong the progression-free survival (PFS) and overall survival (OS) in cats with localized sinonasal lymphoma compared with HRT alone. While 24 eligible cats received HRT alone (HRT group), 18 received HRTC (HRTC group). The total median administered dose was 35 Gy, with one fraction per week, for a median of five fractions. In the HRTC group, the chemotherapy protocol was cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP)-based and cyclophosphamide, vincristine, and prednisolone (COP)-based in 14 (78%) and 4 cats (22%), respectively. Cats in the HRTC group had significantly longer PFS (677 versus 104 days; P = .04) and OS (983 versus 263 days; P = .04) than those in the HRT group. Considering the poor outcome in the HRT group despite the cats having received rescue chemotherapy for progressive disease, the early initiation of additional chemotherapy along with HRT may be recommended for feline localized sinonasal lymphoma.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"58 5","pages":"254-261"},"PeriodicalIF":1.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40337909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Irreversible Electroporation Balloon Therapy for Palliative Treatment of Obstructive Urethral Transitional Cell Carcinoma in Dogs. 不可逆电穿孔球囊治疗犬梗阻性尿道移行细胞癌。

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-09-01 DOI: 10.5326/JAAHA-MS-7160

Emmanuelle Marie Butty, Bruce Forsyth, Mary Anna Labato

{"title":"Irreversible Electroporation Balloon Therapy for Palliative Treatment of Obstructive Urethral Transitional Cell Carcinoma in Dogs.","authors":"Emmanuelle Marie Butty, Bruce Forsyth, Mary Anna Labato","doi":"10.5326/JAAHA-MS-7160","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7160","url":null,"abstract":"Progression of transitional cell carcinoma (TCC) in dogs often leads to urinary obstruction. This observational pilot study aimed to evaluate the safety and efficacy of irreversible electroporation (IRE) balloon therapy for the palliative treatment of TCC with partial urethral obstruction. Three client-owned dogs diagnosed with TCC causing partial urethral obstruction were enrolled. After ultrasonographic and cystoscopic examination, IRE pulse protocols were delivered through a balloon catheter device inflated within the urethral lumen. After the procedure, the patients were kept overnight for monitoring and a recheck was planned 28 days later. No complication was observed during the procedure and postprocedural monitoring. After 28 days, one dog had a complete normalization of the urine stream, one dog had stable stranguria, and one dog was presented with a urethral obstruction secondary to progression of the TCC. On recheck ultrasound, one dog had a 38% diminution of the urethral mass diameter whereas the other two dogs had a mass stable in size. IRE balloon therapy seems to be a feasible and apparently safe minimally invasive novel therapy for the palliative treatment of TCC causing urethral obstruction. Further studies are needed to better characterize the safety, efficacy, and outcome of this therapy.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"58 5","pages":"231-239"},"PeriodicalIF":1.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40337911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteremia and Late-Term Abortion Secondary to Salmonellosis in a Dog. 犬沙门氏菌病继发的菌血症和晚期流产。

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-09-01 DOI: 10.5326/JAAHA-MS-7237

Ashley Allen-Durrance, Kaitlyn M Mazzaccari, Cory L Woliver

引用次数: 1

Evaluation for Postoperative Infections Following Cutaneous Punch Biopsies in Dogs and Cats: 154 Cases (2013-2018). 狗和猫皮肤穿刺活检术后感染的评估:154例(2013-2018)

IF 1.3 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2022-09-01 DOI: 10.5326/JAAHA-MS-7249

Jason B Pieper, Shahla Doroud, William E Sander

{"title":"Evaluation for Postoperative Infections Following Cutaneous Punch Biopsies in Dogs and Cats: 154 Cases (2013-2018).","authors":"Jason B Pieper, Shahla Doroud, William E Sander","doi":"10.5326/JAAHA-MS-7249","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7249","url":null,"abstract":"Antimicrobial stewardship is becoming more important every day with increasing bacterial resistance and limitations on antibiotics. Prophylactic antibiotics are not necessary with all procedures, which has been shown previously with a variety of human and veterinary surgeries. Medical records were retrospectively evaluated for cases who had a cutaneous punch biopsy performed between 2013 and 2018 including the following information: species, signalment, concurrent diseases, concurrent medications, location of biopsy, histopathologic diagnosis, and bacterial infections postoperatively. The prevalence of secondary infections, due to punch biopsies in all animals, was 1.9% and further divided into 2.3% (3/128) of dogs and 0% (0/26) of cats. It was determined that the relative risk of developing complications from punch biopsy was 0.06 (0.01-0.93) when diagnosing a dermatologic disease versus a cutaneous mass (neoplastic and nonneoplastic), which was statistically significant. The risk increased 2.16 (0.16-59.91) times if the biopsy site was the trunk, which includes the neck, thorax, and abdomen. These results indicate that in veterinary medicine, postoperative complications are uncommon with cutaneous punch biopsies. The administration of prophylactic antibiotics in dogs and cats is unnecessary when performing a punch biopsy when there is no infection present at the time of biopsy.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"58 5","pages":"249-253"},"PeriodicalIF":1.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40337908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0