Journal of the American Animal Hospital Association最新文献

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Tibial Plateau and Stifle Joint Invasion with a Subcutaneous Mast Cell Tumor. 皮下肥大细胞瘤侵袭胫骨平台和膝关节。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-09-01 DOI: 10.5326/JAAHA-MS-7278
Monique Triglia, Hollie Horton, Melanie Dobromylskyj, Amy Jo Ferreira, William Peter Robinson
{"title":"Tibial Plateau and Stifle Joint Invasion with a Subcutaneous Mast Cell Tumor.","authors":"Monique Triglia,&nbsp;Hollie Horton,&nbsp;Melanie Dobromylskyj,&nbsp;Amy Jo Ferreira,&nbsp;William Peter Robinson","doi":"10.5326/JAAHA-MS-7278","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7278","url":null,"abstract":"<p><p>A 4 yr old female neutered Labrador retriever was referred with a history of left hind-limb lameness and an acute, nonpainful, subcutaneous mass on the medial aspect of the left stifle. Stifle radiographs and fine needle aspirates of the soft tissue mass performed by the referring veterinarian confirmed the presence of predominantly highly granulated mast cells, consistent with a mast cell tumor. Computed tomography demonstrated a soft tissue mass centered on the left medial stifle, with associated joint effusion and polyostotic lytic lesions on the tibial plateau and distal patella. Ultrasound-guided aspirates of the liver, spleen, and popliteal lymph nodes were obtained to rule out further metastatic spread. Cytology of the joint fluid demonstrated a low number of well-differentiated mast cells. Surgical and oncological interventions were discussed, and full hind-limb amputation was elected. Histopathological analysis of the submitted tissues after amputation diagnosed a subcutaneous mast cell tumor with neoplastic cell infiltrate extending into sections of joint capsule and synovial membrane. Infiltration to the tibia and distal patella were suspected following the presence of mast cell clusters in both osteolytic lesions. No evidence of metastasis was identified in the popliteal lymph node. Postoperative monitoring of iliac lymph node size using ultrasound did not identify evidence of metastasis 12 mo postoperatively.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 5","pages":"234-240"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10649870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suspected Fluoroquinolone-Induced Exacerbation of Myasthenia Gravis in Dogs. 疑似氟喹诺酮所致犬重症肌无力加重。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-09-01 DOI: 10.5326/JAAHA-MS-7353
Karen Marina Hernandez Guzman, Kenneth Harkin
{"title":"Suspected Fluoroquinolone-Induced Exacerbation of Myasthenia Gravis in Dogs.","authors":"Karen Marina Hernandez Guzman,&nbsp;Kenneth Harkin","doi":"10.5326/JAAHA-MS-7353","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7353","url":null,"abstract":"<p><p>Acquired myasthenia gravis (MG) in dogs can present with focal or generalized weakness and is diagnosed by the presence of circulating antibodies to the acetylcholine receptor. Megaesophagus is the most common focal form of MG. Although exacerbation of MG has been associated with the use of fluoroquinolones in humans, it has not been previously described in dogs. The medical records of 46 dogs diagnosed with MG based on acetylcholine receptor antibody testing from 1997 to 2021 were retrospectively evaluated to identify any dogs who demonstrated exacerbation of MG after the administration of a fluoroquinolone. Exacerbation of MG, from focal to generalized, occurred in a median of 4.5 days after initiation of fluoroquinolone therapy in six dogs. In addition, one dog with generalized MG and megaesophagus developed pyridostigmine resistance subsequent to fluoroquinolone therapy. Marked improvement in generalized weakness was reported 36 hr after discontinuation of fluoroquinolone therapy alone in one dog and in combination with pyridostigmine in two dogs. Fluoroquinolone therapy was never stopped in three dogs who were euthanized because of severe weakness and one dog who died of respiratory arrest.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 5","pages":"249-254"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tolerability of Otic Solutions Containing Different Enrofloxacin Concentrations in Dogs with Healthy Ears. 含不同恩诺沙星浓度耳液对健康耳犬的耐受性。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-09-01 DOI: 10.5326/JAAHA-MS-7363
Jennifer Clegg, Clarissa Souza, Bailey Brame
{"title":"Tolerability of Otic Solutions Containing Different Enrofloxacin Concentrations in Dogs with Healthy Ears.","authors":"Jennifer Clegg,&nbsp;Clarissa Souza,&nbsp;Bailey Brame","doi":"10.5326/JAAHA-MS-7363","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7363","url":null,"abstract":"<p><p>Otitis externa (OE) is a common disease in dogs, and topical medications are the preferred treatment. Compounded solutions of enrofloxacin are commonly used in practice to treat bacterial OE; however, the tolerability of different concentrations of this antibiotic in the ear canals of dogs has not been evaluated. The objective of this study is to determine if a higher concentration of enrofloxacin applied to the external ear canal is clinically tolerated in dogs with healthy ears. Sixteen client-owned dogs with bilateral healthy ears and no previous history of OE were enrolled. Injectable enrofloxacin 2.27% diluted with sterile sodium chloride in 1:1 (11.35 mg/mL) and 2:1 (15 mg/mL) ratios were applied into the dogs' right and left ears, respectively, q 12 hr for 14 days. Based on video otoscopic examination, clinical score for canine OE (OTIS3) results before application were ≤1 for all dogs. During the study and at the conclusion, all scores remained ≤2, which is considered normal. No cytologic inflammatory cells were seen in any of the dogs' ears throughout the study. Different concentrations of enrofloxacin solution applied topically were well tolerated by dogs with healthy ears and can be considered for the treatment of dogs with bacterial OE.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 5","pages":"214-218"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10649866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Hyperglycemia and Canine Serum Pancreatic Lipase Immunoreactivity Concentration in Diabetic Dogs. 糖尿病犬高血糖与血清胰脂肪酶免疫反应浓度的关系。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-09-01 DOI: 10.5326/JAAHA-MS-7365
Joonseok Kim, Yeon Chae, Dohee Lee, Yoonhoi Koo, Sijin Cha, Taesik Yun, Mhan-Pyo Yang, Byeong-Teck Kang, Hakhyun Kim
{"title":"Association between Hyperglycemia and Canine Serum Pancreatic Lipase Immunoreactivity Concentration in Diabetic Dogs.","authors":"Joonseok Kim,&nbsp;Yeon Chae,&nbsp;Dohee Lee,&nbsp;Yoonhoi Koo,&nbsp;Sijin Cha,&nbsp;Taesik Yun,&nbsp;Mhan-Pyo Yang,&nbsp;Byeong-Teck Kang,&nbsp;Hakhyun Kim","doi":"10.5326/JAAHA-MS-7365","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7365","url":null,"abstract":"<p><p>It has been reported that hypertriglyceridemia can partially mediate between diabetes mellitus (DM) and pancreatitis in dogs, implying that another mediator, such as chronic hyperglycemia, might exist. Therefore, this study aimed to evaluate the relationship between hyperglycemia and serum canine pancreatic lipase immunoreactivity (cPLI) concentration in diabetic dogs. This retrospective cohort study included 26 client-owned diabetic dogs, divided according to their serum fructosamine levels (<500 μmol/L = well-controlled DM group; ≥500 μmol/L = untreated or poorly controlled DM group). Five of the 26 DM dogs (19.2%) had serum cPLI concentrations consistent with pancreatitis, among which two showed ultrasonographic evidence of pancreatitis without clinical signs. The serum cPLI concentrations (median [interquartile range]) were significantly higher in the untreated or poorly controlled group (520 μg/L [179.76-1000 μg/L]) than in the well-controlled group (77 μg/L [32.22-244.6 μg/L], P = 0.0147). The serum fructosamine concentration was positively correlated with the serum cPLI concentration (r = 0.4816; P = 0.0127). Multivariate analysis revealed serum triglyceride and fructosamine concentrations were associated with the serum cPLI concentration. In conclusion, this study suggests that chronic hyperglycemia may induce pancreatic inflammation in diabetic dogs; however, the clinical significance of increased cPLI concentration is unknown.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 5","pages":"241-248"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10649868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver Lipoma in a Dog: Case Report and Literature Review. 犬肝脂肪瘤一例报告及文献复习。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-07-01 DOI: 10.5326/JAAHA-MS-7330
Miranda de la Vega, Mitch Robbins, Mark Howes, Miranda Vieson
{"title":"Liver Lipoma in a Dog: Case Report and Literature Review.","authors":"Miranda de la Vega,&nbsp;Mitch Robbins,&nbsp;Mark Howes,&nbsp;Miranda Vieson","doi":"10.5326/JAAHA-MS-7330","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7330","url":null,"abstract":"<p><p>Lipoma of the liver has not been reported in dogs. An 8 yr old spayed female Great Dane was referred for diagnostic workup of abdominal distention. Computed tomography showed fat-attenuating masses with negative attenuation values (variable between -60 to -40 Hounsfield units) and minimal contrast uptake within the left cranial abdomen. Left lateral and right medial liver lobectomies were performed to remove two liver masses. Histopathology showed large lipomas arising from within the hepatic parenchyma. Immunohistochemistry for smooth muscle actin was negative, consistent with true lipomas. The dog was euthanized 8 mo later because of causes likely unrelated to the liver lipoma. This is the first case report of lipoma in the liver of a dog. The purpose of this case report and brief literature review is to provide evidence that surgical excision of fat-attenuating masses within the liver that are consistent with lipoma using immunohistochemistry can be curative.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 4","pages":"188-192"},"PeriodicalIF":1.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
High-Grade, Stage 2 Mast Cell Tumors: Outcome in Dogs With Local and Systemic Therapy. 高级别2期肥大细胞瘤:局部和全身治疗犬的预后
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-07-01 DOI: 10.5326/JAAHA-MS-7319
Rhonda Burge, Kevin D Woolard, Jennifer L Willcox, Robert B Rebhun, Jenna H Burton, Sami Al-Nadaf, Katherine A Skorupski
{"title":"High-Grade, Stage 2 Mast Cell Tumors: Outcome in Dogs With Local and Systemic Therapy.","authors":"Rhonda Burge,&nbsp;Kevin D Woolard,&nbsp;Jennifer L Willcox,&nbsp;Robert B Rebhun,&nbsp;Jenna H Burton,&nbsp;Sami Al-Nadaf,&nbsp;Katherine A Skorupski","doi":"10.5326/JAAHA-MS-7319","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7319","url":null,"abstract":"<p><p>Canine mast cell tumors (MCTs) have highly variable clinical behavior, and predicting outcomes in individual dogs remains challenging. Many studies combine dogs with varying tumor grades, clinical stage, or treatments, confounding those results. The purpose of this retrospective study was to determine outcome and prognostic factors in a specific subset of dogs with high-grade, stage 2, cutaneous MCTs treated with adequate local control via surgery with or without radiation therapy and adjuvant cytotoxic chemotherapy. Seventeen dogs met the inclusion criteria, and the median survival time was 259 days. Development of local recurrence, tumor location, and presence of ulceration were all associated with shorter survival times. Tumor size, mitotic count, chemotherapy protocol, lymph node classification, and radiation therapy were not significantly associated with outcome. In this study, a specific population of dogs characterized by high-grade MCTs with local lymph node metastasis who received aggressive local and systemic therapy had a median survival of about 8.5 mo. Dogs with ulcerated tumors, recurrent tumors, or tumors located on the head had a worse outcome despite aggressive therapy. These results may serve as a basis of comparison for future research exploring alternative treatment combinations in this specific population of dogs.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 4","pages":"167-176"},"PeriodicalIF":1.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9817327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of Leptomeningeal Carcinomatosis by Cerebrospinal Fluid in a Dog with a Negative MRI. 犬MRI阴性脑脊液检测脑膜轻脑癌。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-07-01 DOI: 10.5326/JAAHA-MS-7338
Tania Al Kafaji, Carlo Cantile, Fabio Tocco, Antonella Gallucci
{"title":"Detection of Leptomeningeal Carcinomatosis by Cerebrospinal Fluid in a Dog with a Negative MRI.","authors":"Tania Al Kafaji,&nbsp;Carlo Cantile,&nbsp;Fabio Tocco,&nbsp;Antonella Gallucci","doi":"10.5326/JAAHA-MS-7338","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7338","url":null,"abstract":"<p><p>An 11 yr old female French bulldog was presented for acute onset of seizures and a 2 wk history of disorientation. On physical examination, a nodular mass at the fourth mammary gland level was observed. Neurological evaluation showed obtundation and compulsive behavior. Brain MRI study did not reveal any abnormalities. Cerebrospinal fluid (CSF) collected from the cerebellomedullary cistern showed a marked increase of total nucleated cell count (400 cells/μL). Cytological evaluation identified the presence of a monomorphic round cell population characterized by large cell bodies, a single eccentrical located nucleus with high nuclear:cytoplasmatic ratio, and marked atypia with anisocytosis, anisokaryosis, and multiple nucleoli. Leptomeningeal carcinomatosis (LC) was suspected. The dog was euthanatized for worsening of clinical signs. Post-mortem examination identified an anaplastic mammary carcinoma in the nodular mammary mass. Infiltration by neoplastic cells exhibiting the same morphological features was detected along leptomeninges of the telencephalon and cerebellum associated with cortical and subcortical parenchymal micrometastases. To our knowledge, this is the first case of LC in a dog detected by CSF evaluation but without any MRI abnormalities. This finding emphasizes the usefulness of CSF cytology in patients with suspected LC even in the absence of any MRI identifiable lesions.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 4","pages":"184-187"},"PeriodicalIF":1.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9817325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subtotal Pericardiectomy and Epicardiectomy for Treatment of Septic Pericarditis and Constrictive Epicarditis in a Dog. 犬脓毒性心包炎和缩窄性心外膜炎的次全心包膜切除术和心外膜切除术治疗。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-07-01 DOI: 10.5326/JAAHA-MS-7350
Andrea Nichole Mastorakis, Barbro Filliquist
{"title":"Subtotal Pericardiectomy and Epicardiectomy for Treatment of Septic Pericarditis and Constrictive Epicarditis in a Dog.","authors":"Andrea Nichole Mastorakis,&nbsp;Barbro Filliquist","doi":"10.5326/JAAHA-MS-7350","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7350","url":null,"abstract":"<p><p>A 1 yr old, 1.7 kg, spayed female Chihuahua was presented for respiratory distress and an enlarged cardiac silhouette as seen on thoracic radiographs. Echocardiogram revealed pericardial effusion and cardiac tamponade. Computed tomography revealed marked pleural and pericardial effusion, thickening of the pericardium caudally, and a mass along the mediastinum. Pericardial fluid obtained via pericardiocentesis showed suppurative inflammation with mixed anaerobic bacteria isolated on culture. Subtotal pericardiectomy and partial lung lobectomy was performed to treat septic pericarditis. Postoperative echocardiogram showed increased right-sided pressures consistent with constrictive epicarditis, and 10 days after surgery, the dog was re-presented for right-sided heart failure. An epicardectomy was performed. A definitive source of infection was not identified, although a penetrating foreign body (e.g., grass awn) was suspected. The dog recovered and 10 yr follow up revealed no evidence of constrictive pathology on echocardiogram. This case report demonstrates the successful treatment of septic pericarditis and constrictive epicarditis via subtotal pericardiectomy and epicardiectomy.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 4","pages":"198-202"},"PeriodicalIF":1.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9817321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluoroscopy-Guided Surgical Removal of a Microchip from the Spinal Canal of Two Cats. 透视引导下从两只猫的椎管中取出微芯片的手术。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-07-01 DOI: 10.5326/JAAHA-MS-7356
Justin Mergl, Laura Nutt, Augusto Pareja
{"title":"Fluoroscopy-Guided Surgical Removal of a Microchip from the Spinal Canal of Two Cats.","authors":"Justin Mergl,&nbsp;Laura Nutt,&nbsp;Augusto Pareja","doi":"10.5326/JAAHA-MS-7356","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7356","url":null,"abstract":"<p><p>Two cats were presented with acute left-sided paresis after implantation of a microchip at the referring veterinary clinic. Neurological examinations were consistent with left-sided lesions between spinal cord segments C1 and C5. Orthogonal radiographs of the cervical spine showed a microchip dorsoventrally oriented, partially embedded in the cervical vertebral canal. Fluoroscopy was used to localize and retrieve the foreign body from the cervical spinal cord in each case. Improvement in clinical condition and return to ambulation was observed in both cats within 48 hr of surgical removal of the implant. No significant perioperative adverse events were noted during the surgical retrieval of the microchip. Two previously reported cases of intraspinal canal microchip placement had been treated surgically by hemilaminectomy. This approach carries a risk of complications, including hemorrhage from the venous sinus, iatrogenic damage to the spinal cord, and improper identification of the surgical site, requires advanced surgical training, and typically has an extended surgical time. The use of fluoroscopy to assist intraoperative localization of a spinal canal foreign body may lessen the requirement for more invasive surgical procedures.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 4","pages":"193-197"},"PeriodicalIF":1.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Therapeutic Use of Antifibrinolytics in Cats. 猫抗纤溶药物治疗应用的评价。
IF 1.3 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2023-07-01 DOI: 10.5326/JAAHA-MS-7349
Lotta Wahldén, Giacomo Stanzani, Simone Cutler, Dominic Barfield, Katrina C Manson, Helen E Wilson, Emily K Thomas
{"title":"Evaluation of Therapeutic Use of Antifibrinolytics in Cats.","authors":"Lotta Wahldén,&nbsp;Giacomo Stanzani,&nbsp;Simone Cutler,&nbsp;Dominic Barfield,&nbsp;Katrina C Manson,&nbsp;Helen E Wilson,&nbsp;Emily K Thomas","doi":"10.5326/JAAHA-MS-7349","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7349","url":null,"abstract":"<p><p>Limited data are available regarding the use of the antifibrinolytic drugs tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) in cats. This study aimed to evaluate the indications for the use of TXA and EACA in cats and to describe dosing regimens used, occurrence of adverse events, and patient outcomes. This was a retrospective multicenter study. Medical databases were searched for feline patients billed for TXA or EACA between 2015 and 2021. Thirty-five cats met the inclusion criteria; 86% received TXA and 14% received EACA. The most common indication was nontraumatic hemorrhage (54%), followed by traumatic hemorrhage (17%) and elective surgery (11%). The median dose was 10 mg/kg for TXA and 50 mg/kg for EACA. Overall, 52% of cats survived to discharge. Potential adverse events were noted in 7/35 (20%) patients. Of these, 29% survived to discharge. No standardized dosing regimen was identified; rather, dose, dosing interval, and duration of administration varied markedly between patients. Administration was potentially associated with severe adverse events, although the retrospective design makes it difficult to establish a causal association with antifibrinolytic use. This study provides a base for future prospective studies by giving an insight into the use of antifibrinolytic drugs in cats.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"59 4","pages":"177-183"},"PeriodicalIF":1.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9817320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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