Journal of the American Animal Hospital Association最新文献

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Long-Term Survival of Primary Intracranial Histiocytic Sarcoma Through Surgical Resection and Low-Dose CCNU. 手术切除和低剂量CCNU治疗原发性颅内组织细胞肉瘤的远期生存率。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2025-01-01 DOI: 10.5326/JAAHA-MS-7458
Kyosuke Hidari, Yuya Nakamoto, James K Chambers, Kazuyuki Uchida, Isao Mori, Miwa Nakamoto
{"title":"Long-Term Survival of Primary Intracranial Histiocytic Sarcoma Through Surgical Resection and Low-Dose CCNU.","authors":"Kyosuke Hidari, Yuya Nakamoto, James K Chambers, Kazuyuki Uchida, Isao Mori, Miwa Nakamoto","doi":"10.5326/JAAHA-MS-7458","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7458","url":null,"abstract":"<p><p>A 5 yr old chihuahua presented to our clinic with a complaint of decreased activity and focal seizures. Based on the findings of MRI and computed tomography, a primary brain tumor originating from the right frontal lobe region was suspected. Surgical resection was performed, and a diagnosis of histiocytic sarcoma was made via histopathological examination and immunohistochemical staining. Low-dose 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (45 mg/m2 every 4-5 wk) was started postoperatively, and no apparent recurrence was found on two MRI scans until the patient's death on day 359. We hypothesized that long-term survival might be achieved in dogs with solitary histiocytic sarcoma of the central nervous system with no metastatic lesions at diagnosis by combining local treatment with CCNU. We also suggested that CCNU may effectively suppress the recurrence of histiocytic sarcoma, even at low doses.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"61 1","pages":"15-20"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment Outcomes of Canine Orbital Meningiomas in Seven Cases. 犬眼眶脑膜瘤7例治疗结果分析。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2025-01-01 DOI: 10.5326/JAAHA-MS-7434
Akihiro Uno, Ryota Iwasaki, Takashi Mori
{"title":"Treatment Outcomes of Canine Orbital Meningiomas in Seven Cases.","authors":"Akihiro Uno, Ryota Iwasaki, Takashi Mori","doi":"10.5326/JAAHA-MS-7434","DOIUrl":"https://doi.org/10.5326/JAAHA-MS-7434","url":null,"abstract":"<p><p>Although intracranial and spinal cord meningioma prognoses have been reported, few studies have evaluated the outcomes and prognoses of orbital and optic nerve meningiomas in dogs. We aimed to evaluate the outcomes of canine orbital meningiomas. The seven dogs included were cytologically or histopathologically diagnosed with meningiomas. Four underwent first-line surgery; three received postoperative radiation therapy. The remaining three underwent first-line radiation therapy; however, 372 days after radiation therapy, one dog underwent surgery as the lesion progressed in size. Five dogs underwent surgical resection, had incomplete resections, and died during the observation period, with a median survival time of 943 days (range 668-1083 days). The two surviving dogs were followed up for 119 and 1083 days. Local recurrence was detected in three of the five dogs at 478, 660, and 814 days. The median progression-free survival was 569 days (range 262-814 days). Although keratoconjunctivitis (grade 2) was observed in one dog that underwent eye-sparing radiation therapy, no serious side effects were observed in the other dogs. Our results suggest that surgery and radiation therapy may play an important role in the treatment of orbital meningiomas and may offer longer survival than that of brain or spinal cord meningiomas.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"61 1","pages":"1-6"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2022 AAHA Canine Vaccination Guidelines (2024 Update). 2022 年 AAHA 犬类疫苗接种指南(2024 年更新)。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7468
John Ellis, Elizabeth Marziani, Chumkee Aziz, Catherine M Brown, Leah A Cohn, Christopher Lea, George E Moore, Neha Taneja
{"title":"2022 AAHA Canine Vaccination Guidelines (2024 Update).","authors":"John Ellis, Elizabeth Marziani, Chumkee Aziz, Catherine M Brown, Leah A Cohn, Christopher Lea, George E Moore, Neha Taneja","doi":"10.5326/JAAHA-MS-7468","DOIUrl":"10.5326/JAAHA-MS-7468","url":null,"abstract":"<p><p>Vaccination is a cornerstone of canine preventive healthcare and one of the most cost-effective ways of maintaining a dog's health, longevity, and quality of life. Canine vaccination also serves a public health function by forming a barrier against several zoonotic diseases affecting dogs and humans. Canine vaccines are broadly categorized as containing core and noncore immunizing antigens, with administration recommendations based on assessment of individual patient risk factors. The guidelines include a comprehensive table listing canine core and noncore vaccines and a recommended vaccination and revaccination schedule for each vaccine. The guidelines explain the relevance of different vaccine formulations, including those containing modified-live virus, inactivated, and recombinant immunizing agents. Factors that potentially affect vaccine efficacy are addressed, including the patient's prevaccination immune status and vaccine duration of immunity. Because animal shelters are one of the most challenging environments for prevention and control of infectious diseases, the guidelines also provide recommendations for vaccination of dogs presented at or housed in animal shelters, including the appropriate response to an infectious disease outbreak in the shelter setting. The guidelines explain how practitioners can interpret a patient's serological status, including maternally derived antibody titers, as indicators of immune status and suitability for vaccination. Other topics covered include factors associated with postvaccination adverse events, vaccine storage and handling to preserve product efficacy, interpreting product labeling to ensure proper vaccine use, and using client education and healthcare team training to raise awareness of the importance of vaccinations.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"60 6","pages":"1-19"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 AAHA Community Care Guidelines for Small Animal Practice. 2024 AAHA《小动物医院社区护理指南》。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7464
Mike Greenberg, Donita McCants, Elizabeth Alvarez, Elizabeth Berliner, Michael Blackwell, Emily McCobb, Tierra Price, Jyothi Robertson, Melina Stambolis
{"title":"2024 AAHA Community Care Guidelines for Small Animal Practice.","authors":"Mike Greenberg, Donita McCants, Elizabeth Alvarez, Elizabeth Berliner, Michael Blackwell, Emily McCobb, Tierra Price, Jyothi Robertson, Melina Stambolis","doi":"10.5326/JAAHA-MS-7464","DOIUrl":"10.5326/JAAHA-MS-7464","url":null,"abstract":"<p><p>Community care is a creative way of thinking about health care that mobilizes resources within a community and consists of four core principles: recognition of the urgency of access-to-care for the veterinary profession, collaboration within community networks, family-centered health care, and redefining the gold standard of care. The AAHA Community Care Guidelines for Small Animal Practice offer strategies to help busy veterinary practitioners increase access to care within their practice and community by optimizing collaborative networks. While these guidelines do not claim to provide exhaustive solutions to access-to-care issues, they propose a starting point from which private practices can explore and implement workable solutions for their community and their practice. Broadening the scope of care to reach all people with pets requires multimodal, collaborative, and creative solutions both within and outside of the veterinary profession. These solutions can begin with greater communication and collaboration between private veterinary practices and nonprofit veterinary practices, with the goal of keeping pets in their homes with their loving families as much as reasonably possible.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"60 6","pages":"227-246"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Outcome of a Chihuahua With Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion. 一只患有抗利尿激素分泌不当特发性综合征的吉娃娃的长期治疗结果
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7453
Darcy B Adin, Ilana Levinzon, Autumn N Harris
{"title":"Long-term Outcome of a Chihuahua With Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion.","authors":"Darcy B Adin, Ilana Levinzon, Autumn N Harris","doi":"10.5326/JAAHA-MS-7453","DOIUrl":"10.5326/JAAHA-MS-7453","url":null,"abstract":"<p><p>An approximately 3 yr old female Chihuahua was presented for evaluation of polyuria and polydipsia noted by the owner after adoption. Serum biochemistry and urinalysis revealed hyponatremia, hypochloremia, hypo-osmolality, and normal fractional excretion of sodium. Serum antidiuretic hormone concentration was 5.54 pg/mL and serum copeptin concentration was 135.40 pg/mL. The antidiuretic hormone value was above the reported range for healthy dogs and was considered inappropriate in light of serum osmolality. Idiopathic syndrome of inappropriate antidiuretic hormone secretion was considered the most likely diagnosis after excluding other potential causes, such as diuretic use, renal disease, adrenal disease, and thyroid dysfunction. The dog remains clinically well 2 yr after diagnosis without specific treatment other than minimal dietary salt supplementation. This case is unique because of the absence of systemic or neurologic signs, good long-term outcome without treatment, and use of novel diagnostic testing.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"60 6","pages":"265-269"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Management of Incompletely Resected Transitional Cell Carcinoma with Sorafenib Tosylate in a Dog. 用索拉非尼-对甲苯磺酸盐成功治疗一只未完全切除的输尿管细胞癌。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7463
Dongheon Shin, Chaerin Kim, Yeon Chae, Taesik Yun, Byeong-Teck Kang, Kyung-Mee Park, Hakhyun Kim
{"title":"Successful Management of Incompletely Resected Transitional Cell Carcinoma with Sorafenib Tosylate in a Dog.","authors":"Dongheon Shin, Chaerin Kim, Yeon Chae, Taesik Yun, Byeong-Teck Kang, Kyung-Mee Park, Hakhyun Kim","doi":"10.5326/JAAHA-MS-7463","DOIUrl":"10.5326/JAAHA-MS-7463","url":null,"abstract":"<p><p>Most urinary bladder (UB) tumors are malignant, and transitional cell carcinoma (TCC) is the most common neoplasm affecting the UB in dogs. Sorafenib may be a potential therapeutic agent for canine TCC. A 12 yr old spayed female Maltese dog weighing 3.6 kg and with a history of hematuria was referred for a suspected UB tumor. Abdominal ultrasonography revealed a UB mass attached to the cranioventral wall. The remaining abdominal examinations, including that of the lymph nodes, were unremarkable. Ultrasound-guided traumatic catheterization of the UB mass was performed, and the cytological evaluation of the UB mass indicated TCC. Excision was performed by partial cystectomy, and histopathology confirmed TCC, although the tumor had infiltrated the surgical margins. A chemosensitivity assay was conducted using tissue from the excised tumor. Sorafenib tosylate, a tyrosine kinase inhibitor, showed the greatest effect in the chemosensitivity assay. Therefore, adjuvant chemotherapy with sorafenib tosylate and piroxicam was administered postoperatively. The dog lived without any clinical signs, including hematuria or tumor relapse, for more than 2 yr after the surgery. This is the first report of successful long-term management of TCC with sorafenib tosylate in a dog.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"60 6","pages":"275-279"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Nonsocial Environmental Fear in a Service Dog Using Fluoxetine and Behavior Modification. 使用氟西汀和行为矫正治疗服务犬的非社交环境恐惧。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7455
Michael Zafar Khan, Sara Lynn Bennett
{"title":"Treatment of Nonsocial Environmental Fear in a Service Dog Using Fluoxetine and Behavior Modification.","authors":"Michael Zafar Khan, Sara Lynn Bennett","doi":"10.5326/JAAHA-MS-7455","DOIUrl":"10.5326/JAAHA-MS-7455","url":null,"abstract":"<p><p>Training and maintaining a service dog requires extensive time and financial resources. The emotional bond between service dogs and their handlers poses unique challenges when dogs develop behavioral issues. We present a case of an otherwise healthy adult service dog exhibiting acute environmental fears, hindering her job performance. The dog's fear responses escalated in various settings, including school and home environments. Diagnostic evaluation ruled out medical pathology, leading to a diagnosis of nonsocial environmental fear and generalized anxiety. A multimodal treatment approach involving environmental management, antidepressant medication (fluoxetine), and behavior modification was implemented. Desensitization and counterconditioning protocols targeted specific triggers, such as shiny floors and elevators. Eight weeks after treatment initiation, the dog showed improvement, enabling a modified behavior treatment plan to be implemented as she gradually returned to work with reduced fear responses. Follow-up revealed sustained progress with additional dosage adjustment of fluoxetine.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"60 6","pages":"270-274"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urine Contamination Prevalence Using a Midstream Collection Device Compared with Clean Voided Collections in Dogs. 使用中游收集装置和清洁排尿收集装置收集犬尿液的污染率比较。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7415
Meghan Hoel, Faye A Hartmann, Michael R Lasarev, Michael W Wood
{"title":"Urine Contamination Prevalence Using a Midstream Collection Device Compared with Clean Voided Collections in Dogs.","authors":"Meghan Hoel, Faye A Hartmann, Michael R Lasarev, Michael W Wood","doi":"10.5326/JAAHA-MS-7415","DOIUrl":"10.5326/JAAHA-MS-7415","url":null,"abstract":"<p><p>Collecting clean-caught voided urine samples is minimally invasive, but contamination occurs when urine passes through the nonsterile urethra and external genitalia. Discarding the initial urine stream may reduce these contaminants. This study hypothesized that using a midstream urine collection device would decrease bacterial and cellular contamination as compared with cleanly caught voided urine. This descriptive cross-sectional study collected urine from dogs using standard clean-caught (SCC), midstream collection device (MCD), and cystocentesis (CYS) techniques. Urinalysis and aerobic urine culture characteristics were recorded with each characteristic's prevalence described using percentages and 95% confidence intervals for each mode of collection. Positive urine culture prevalence did not differ between SCC and MCD (adjusted P value = .099); however, CYS had a lower prevalence compared with SCC and MCD (adjusted P values of <.001 [CYS versus SCC] and 0.009 [CYS versus MCD]). For other variables, there was no difference in prevalence when comparing SCC with MCD. There was no identified advantage to collecting urine using an MCD as compared with the SCC technique. Either option is a suitable alternative when CYS is not practical; however, clinicians need to interpret results cautiously because bacterial contamination is more common as compared with CYS.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"60 6","pages":"247-251"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcome, Complications, and Follow-Up in Dogs Treated with Pancarpal Arthrodesis Stabilized with Orthogonal Plates. 使用正交钢板稳定腕关节的狗的疗效、并发症和随访。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2024-11-01 DOI: 10.5326/JAAHA-MS-7421
Alba Rial García, Charlie Brincin, Andrew Craig
{"title":"Outcome, Complications, and Follow-Up in Dogs Treated with Pancarpal Arthrodesis Stabilized with Orthogonal Plates.","authors":"Alba Rial García, Charlie Brincin, Andrew Craig","doi":"10.5326/JAAHA-MS-7421","DOIUrl":"10.5326/JAAHA-MS-7421","url":null,"abstract":"<p><p>Pancarpal arthrodesis was performed in 21 dogs, using orthogonal (cranial/dorsal and medial) plates without postoperative rigid external coaptation. Short-term and long-term outcomes, arthrodesis progression, and complications were assessed using a retrospective review of case records and radiographs. Three of 21 (14.2%) dogs required a revision surgery: 2 had total implant explantation and 1 had a screw removed. Other complications were managed successfully medically. One of 21 (4.8%) dogs had confirmed deep surgical site infection requiring implant removal, and 4 of 21 (19%) had suspected (not confirmed on microbiology) superficial surgical site infections that resolved with medical management. Long-term outcomes were assessed via owner questionnaire (Canine Brief Pain Inventory) and were available for nine dogs at a mean of 26.78 mo after surgery. The mean score for the first part (assessment of pain) was 7.83/40, which is classified as no pain to mild pain. The mean score for the second part (assessment of function) was 12.67/60, which is classified as very good. The last part (overall impression) was defined as excellent in four dogs (44.44%), very good in one dog (11.11%), and good in the other four dogs (44.44%). This retrospective study documents a suitable technique for pancarpal arthrodesis in dogs with carpal injuries.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"60 6","pages":"252-264"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resolution of Canine Acute Bilirubin Encephalopathy and Immune-Mediated Hemolytic Anemia Following Four Plasmapheresis Treatments. 犬急性胆红素脑病和免疫性溶血性贫血经四次血浆置换治疗后缓解。
IF 1.5 4区 农林科学
Journal of the American Animal Hospital Association Pub Date : 2024-09-01 DOI: 10.5326/JAAHA-MS-7430
Nolan V Chalifoux, Brett Montague, Curtis Rheingold, Rachel Clarkin-Breslin, Erica L Reineke
{"title":"Resolution of Canine Acute Bilirubin Encephalopathy and Immune-Mediated Hemolytic Anemia Following Four Plasmapheresis Treatments.","authors":"Nolan V Chalifoux, Brett Montague, Curtis Rheingold, Rachel Clarkin-Breslin, Erica L Reineke","doi":"10.5326/JAAHA-MS-7430","DOIUrl":"10.5326/JAAHA-MS-7430","url":null,"abstract":"<p><p>An 8 mo old spayed female mixed-breed dog was presented for pale mucous membranes. The dog was diagnosed with intravascular immune-mediated hemolytic anemia (IMHA) and was started on medical management including corticosteroids, thromboprophylaxis, a packed red blood cell transfusion, and IV immunoglobulin. The dog developed severe hyperbilirubinemia (total bilirubin 48.1 mg/dL) and was referred for centrifugal plasmapheresis. Before treatment, the dog was stuporous to comatose, had intermittent opisthotonos, forelimb extension, and an absent menace consistent with acute bilirubin encephalopathy (ABE). The dog underwent a previously reported protocol of three therapeutic plasma exchange (TPE) treatments 24 hr apart. Moderate improvement was noted in her neurological status, although autoagglutination and hemolysis persisted, and the protocol was deemed inadequate. A fourth TPE treatment was performed on day 6. The following morning, the dog was autoagglutination negative. Her neurological status gradually improved, and she was discharged from the hospital on day 12. The dog remains neurologically normal and continues to do well at home on monotherapy with mycophenolate. Continued plasmapheresis treatments should be offered as a treatment option for severe cases of IMHA in the face of persistent disease, because TPE is able to provide ongoing support and stabilization, particularly in the face of ABE.</p>","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"60 5","pages":"207-213"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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