Journal of the American Animal Hospital Association最新文献_第2页

Ilunocitinib-Induced Pancytopenia in an Australian Shepherd Dog with the MDR1 Mutation. 伊卢西替尼诱导的MDR1突变澳大利亚牧羊犬全血细胞减少症。

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-05-01 DOI: 10.5326/JAAHA-MS-7552

Katrina L Mealey, Mary McFillen, Alisa Hutchison

{"title":"Ilunocitinib-Induced Pancytopenia in an Australian Shepherd Dog with the MDR1 Mutation.","authors":"Katrina L Mealey, Mary McFillen, Alisa Hutchison","doi":"10.5326/JAAHA-MS-7552","DOIUrl":"10.5326/JAAHA-MS-7552","url":null,"abstract":"A 5 yr old female spayed Australian shepherd dog with a prior diagnosis of atopy presented for increased pruritus despite immunotherapy. The dog had a history of seizures well controlled by levetiracetam and was genotyped as MDR1 mutant/normal. Ilunocitinib, indicated for controlling pruritus in dogs, was considered. Because the label indicates ilunocitinib can cause cytopenias, a complete blood count (CBC) was performed before initiating treatment. Neutrophils, platelets, and red blood cell numbers were all within reference ranges, so treatment with ilunocitinib was initiated. At a 1 mo follow-up appointment, the dog was bright, alert, and responsive with an improved Pruritus Visual Analog Scale score. A CBC indicated pancytopenia. Ilunocitinib was discontinued and a CBC was repeated after 7 days, indicating resolution of neutropenia and thrombocytopenia, but persisting anemia. One month after discontinuing ilunocitinib, all cytopenias had resolved. Because of the dog's MDR1 genotype, the status of ilunocitinib as a canine P-glycoprotein substrate was assessed. Ilunocitinib was identified as a canine P-glycoprotein substrate. Blunted P-glycoprotein-mediated biliary excretion of ilunocitinib likely resulted in accumulation and a relative overdose. Enhanced penetration of ilunocitinib into hematopoietic stem cells lacking P-glycoprotein expression may have also contributed to dysregulated hematopoiesis. Ilunocitinib should be used cautiously in dogs with P-glycoprotein deficiency.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"62 3","pages":"127-130"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Complications of Minoxidil Toxicosis in Two Dogs. 两只狗米诺地尔中毒的心血管并发症。

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-05-01 DOI: 10.5326/JAAHA-MS-7538

Allison D O'Donnell, Curtis G Rheingold, Jon Stack, Kristen Hutchinson

{"title":"Cardiovascular Complications of Minoxidil Toxicosis in Two Dogs.","authors":"Allison D O'Donnell, Curtis G Rheingold, Jon Stack, Kristen Hutchinson","doi":"10.5326/JAAHA-MS-7538","DOIUrl":"10.5326/JAAHA-MS-7538","url":null,"abstract":"A 3 yr old female spayed golden retriever and a 9 mo old female spayed mixed-breed dog were evaluated at separate veterinary hospitals for ingestion of oral minoxidil tablets at dosages of 1.1 and 1.52 mg/kg, respectively. Decontamination was initiated in both dogs. Both dogs were hospitalized and developed sinus tachycardia. Both dogs developed hypotension, with one requiring vasopressor therapy. Both dogs were treated with antiarrhythmic medications and one dog received IV injectable lipid emulsion therapy. Markedly elevated serum cardiac troponin I (TnI) values were reported in both dogs during hospitalization, indicating myocardial damage. Both dogs had resolution of clinical signs by the second day of hospitalization and were discharged. A TnI measurement was obtained in one dog weeks after discharge and was within normal limits, whereas the other showed significant improvement in TnI levels during hospitalization. Minoxidil has long been recognized as a cardiovascular toxin in dogs and cats. Existing reports of minoxidil toxicosis in pets involve the topical formulation of the drug. To the authors' knowledge, this is the first report of toxicity involving the oral formulation of minoxidil and the first reported instance of minoxidil-related acute myocardial injury with clinical resolution and marked reduction in TnI levels.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"62 3","pages":"131-135"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood Pressure and Adrenocortical Hormone Profiles in 84 Ill Dogs with Normal Post-ACTH Cortisol Concentrations. 84只acth后皮质醇浓度正常的病犬的血压和肾上腺皮质激素谱

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-05-01 DOI: 10.5326/JAAHA-MS-7451

Robert L J Runde, Sharon A Center, Ronald Lyman, John F Randolph

{"title":"Blood Pressure and Adrenocortical Hormone Profiles in 84 Ill Dogs with Normal Post-ACTH Cortisol Concentrations.","authors":"Robert L J Runde, Sharon A Center, Ronald Lyman, John F Randolph","doi":"10.5326/JAAHA-MS-7451","DOIUrl":"10.5326/JAAHA-MS-7451","url":null,"abstract":"Relationship between systolic blood pressure (SBP) and adrenocortical hormones in 10 normotensive (NT) control dogs and 84 ill dogs with clinical features of hypercortisolism but normal post-adrenocorticotropic hormone (ACTH) cortisol was studied. Doppler blood pressure classified dogs as NT (<140 mm Hg), prehypertensive (PHT; 140-159 mm Hg), or hypertensive (HT; ≥160 mm Hg). Serum cortisol, progesterone, 17-hydroxyprogesterone, androstenedione, and aldosterone were measured before and 1-hr after intramuscular (IM) ACTH (250 μg/dog). Ill dogs (40 NT, 29 PHT, and 15 HT) were significantly (P ≤ .04) older, smaller, and received higher ACTH dose/kg versus controls. ACTH dose/kg was not significantly associated with post-ACTH hormone concentrations. Compared to controls, baseline hormones were significantly (P ≤ .05) higher in ill dogs, except progesterone and 17-hydroxyprogesterone in HT and aldosterone in PHT dogs; significantly higher post-ACTH 17-hydroxyprogesterone and androstenedione (P ≤ .01) in NT and PHT dogs, and aldosterone (P = .03) in HT dogs occurred. No significant differences in baseline or post-ACTH hormones existed between SBP groups. Only 3/10 controls had all hormones within reference limits. Findings suggest risk for PHT and HT in ill dogs with increased noncortisol adrenocortical hormones, and show inexplicably increased adrenocortical sex hormones in NT healthy dogs.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"62 3","pages":"94-103"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Growing Tension Between Clinical Expertise and Corporate Consolidation in Veterinary Medicine. 兽医临床专业知识与企业整合之间日益紧张的关系。

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-05-01 DOI: 10.5326/JAAHA-MS-7524

Joe Hill

引用次数: 0

Treatment Outcomes and Tolerability of Postoperative Radiotherapy in 10 Dogs with Spinal Meningiomas. 10只脊髓脑膜瘤犬术后放疗疗效及耐受性分析。

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-05-01 DOI: 10.5326/JAAHA-MS-7498

Akihiro Uno, Ryota Iwasaki, Takashi Mori

{"title":"Treatment Outcomes and Tolerability of Postoperative Radiotherapy in 10 Dogs with Spinal Meningiomas.","authors":"Akihiro Uno, Ryota Iwasaki, Takashi Mori","doi":"10.5326/JAAHA-MS-7498","DOIUrl":"10.5326/JAAHA-MS-7498","url":null,"abstract":"Canine meningioma is the most common intradural extramedullary and primary spinal cord tumor. Previous studies suggest that postoperative radiation therapy can be effective for spinal meningiomas. Information on radiation-induced complications and prognosis remains limited. This case series evaluated treatment outcomes of surgical and radiation therapy in dogs with spinal meningiomas. Ten dogs were included. All underwent surgery, and histopathological examination confirmed meningioma. Among the four cases where surgical margins were assessed, three had incomplete resections. Postoperative radiation therapy was administered as an adjuvant treatment in nine dogs. One dog that did not receive postoperative radiation underwent radiation upon recurrence, observed at 99 days postsurgery. The radiation protocol consisted of fractionated irradiation (32-55 Gy/12-21 fractions) delivered five times per week. During the observation period, nine of 10 dogs died, with a median survival time of 568 days (range: 165-1823 days). Local recurrence occurred in six dogs at 95, 99, 153, 367, 433, and 1086 days postoperatively, confirmed by magnetic resonance imaging. Among 10 dogs receiving radiation, one experienced worsening limb paralysis on day 1679, suspected as a radiation-induced complication. No clinically evident acute or late radiation-induced side effects were noted in the medical records of the remaining cases.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"62 3","pages":"108-114"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2026 AAHA Diabetes Management Guidelines for Cats. 2026 AAHA猫糖尿病管理指南。

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-05-01 DOI: 10.5326/JAAHA-MS-7572

Andrew Bugbee, Renee Rucinsky, Elizabeth Alvarez, Audrey Cook, Patty Lathan, Cassie Panning

引用次数: 0

Free-Form Bilateral Multiplanar External Skeletal Fixation for Pes Varus Correction in a Miniature Dachshund. 自由形式双侧多平面骨外固定治疗迷你腊肠内翻畸形。

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-03-01 DOI: 10.5326/JAAHA-MS-7506

Shuya Kihara, Takeshi Aikawa, Yuta Miyazaki, Hiromi Muyama

{"title":"Free-Form Bilateral Multiplanar External Skeletal Fixation for Pes Varus Correction in a Miniature Dachshund.","authors":"Shuya Kihara, Takeshi Aikawa, Yuta Miyazaki, Hiromi Muyama","doi":"10.5326/JAAHA-MS-7506","DOIUrl":"10.5326/JAAHA-MS-7506","url":null,"abstract":"This report describes the surgical correction of a pes varus deformity in a 13 mo old miniature dachshund using free-form bilateral multiplanar external skeletal fixation (ESF). The dog exhibited lameness in the right pelvic limb, with a varus deformity of the distal tibia and grade 2 lateral patellar luxation. Radiographic and computed tomography imaging confirmed the presence of varus in the distal diaphyseal portion of the right tibia, without procurvatum or internal torsion. Medial opening wedge osteotomy and free-form bilateral multiplanar ESF successfully corrected the deformity. Dynamization was performed by removing the lateral column 3 mo after surgery, followed by the removal of all transfixation pins and the medial column under sedation 4 mo after surgery. The dog remained free of clinical signs at the last follow-up 24 mo after surgery, although residual pin tract holes were evident on radiographs. Free-form bilateral multiplanar ESF is an alternative rigid fixation method for pes varus correction, allowing technically simple relative to plate fixation, three-dimensional precise adjustments, and staged dynamization.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"62 2","pages":"54-60"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Medical Management of Severe Macroglossia Associated With Lingual Abscess in a Dog. 犬重度舌大缺失伴舌脓肿的成功医学治疗

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-03-01 DOI: 10.5326/JAAHA-MS-7531

Dohee Lee, Sorin Choi, Jisoo Ahn, Youngjae Lee, Jong-Won Lee, Sangmoon Lee, Hyeon-Ho Kim, Hakhyun Kim

引用次数: 0

The Current State of Evidence-Based Medicine in Veterinary Practice: A Commentary. 循证医学在兽医实践中的现状：评论。

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-03-01 DOI: 10.5326/JAAHA-MS-7523

Joann Lindenmayer

引用次数: 0

AAHA Oncology Guidelines for Dogs and Cats. 美国癌症协会猫狗肿瘤指南。

IF 1.1 4区农林科学

Journal of the American Animal Hospital Association Pub Date : 2026-01-01 DOI: 10.5326/JAAHA-MS-7549

Jaci Christensen, Kim Johnson, Sue Ettinger, Laura Garrett, Ira Gordon, Shadi Ireifej, Ashley Love, Michelle Wisecup

{"title":"AAHA Oncology Guidelines for Dogs and Cats.","authors":"Jaci Christensen, Kim Johnson, Sue Ettinger, Laura Garrett, Ira Gordon, Shadi Ireifej, Ashley Love, Michelle Wisecup","doi":"10.5326/JAAHA-MS-7549","DOIUrl":"10.5326/JAAHA-MS-7549","url":null,"abstract":"Primary care veterinarians may diagnose, stage, and treat many canine and feline cancers while providing comprehensive patient health care in their practices. Collaboration between general practitioners and veterinary oncologists can optimize patient care and enhance client engagement, and referral is often necessary, especially in complex cases. These guidelines cover key fundamentals of, and new developments in, cancer diagnosis, staging, and treatment in dogs and cats, including patient supportive care and follow-up assessments. Therapy is based on identifying the tumor type, grade, and stage by using cytologic or histologic evaluation or both, combined with staging diagnostic testing such as imaging and lymph node sampling. Therapy is most often multimodal and may include chemotherapy, immunotherapy, radiation therapy, and surgery, along with nutritional support and pain management. Methods to protect patient, team, and client safety as related to handling cytotoxic chemotherapeutics are emphasized. In addition, strengthening the training, education, and responsibilities of veterinary technicians is encouraged to promote team engagement and practice efficiency, which is highly beneficial when managing complex cancer cases. These guidelines also highlight how to achieve successful collaboration between all members of primary care and referral practice teams, cover tools that can aid in referral to or consultation with veterinary oncologists, and describe communication skills that enhance client understanding and compliance.","PeriodicalId":17185,"journal":{"name":"Journal of the American Animal Hospital Association","volume":"62 1","pages":"1-37"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0