Journal of Research in Pharmacy Practice最新文献

{"title":"Evaluating the Role of Machine Learning and Artificial Intelligence in Oncology Drug Repurposing Efforts.","authors":"Adam Mann","doi":"10.4103/jrpp.jrpp_50_25","DOIUrl":"10.4103/jrpp.jrpp_50_25","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate how machine learning (ML) contributes to drug repurposing efforts in oncology, considering the pharmaceutical industry's mounting R and D inefficiencies and economic pressures. Through qualitative interviews with experts across artificial intelligence, oncology, and pharmaceutical development, this paper explores the real-world applications of ML in this field, the challenges to its implementation, and its future potential to streamline drug discovery.</p><p><strong>Methods: </strong>This study employed the \"research onion\" framework (Saunders <i>et</i> <i>al</i>., 2016), adopting an interpretivist philosophy and inductive approach to explore stakeholder perspectives on integrating ML into oncological drug repurposing. A multimethod strategy combined a narrative literature review with 13 semi-structured interviews, selected through purposive and snowball sampling. Data were thematically analyzed using Braun and Clarke's six-step framework, supported by NVivo. Research trustworthiness was ensured via Lincoln and Guba's criteria, and ethical approval was granted by Imperial College London.</p><p><strong>Findings: </strong>Three major thematic domains emerged: The technological, regulatory, and business landscapes. Technological challenges included poor data quality, limited accessibility to real-world datasets, and the need for robust infrastructure to support predictive modeling. Regulatory barriers are centered on ethical concerns in data governance and the difficulty of securing exclusivity and market protection for repurposed drugs. From a business perspective, profitability concerns, generic competition, and fragmented data ownership underscored the need for more collaborative and economically sustainable models.</p><p><strong>Conclusion: </strong>ML offers potential for oncological drug repurposing, but realizing its benefits requires addressing key technological, regulatory, and economic challenges.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 4","pages":"152-168"},"PeriodicalIF":0.7,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12685000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Synergistic Effect of Colistin with Levofloxacin and Meropenem against Multidrug-resistant <i>Acinetobacter baumannii</i>.","authors":"Fatemeh Shafiee, Rasool Soltani, Mahnaz Momenzadeh","doi":"10.4103/jrpp.jrpp_60_25","DOIUrl":"10.4103/jrpp.jrpp_60_25","url":null,"abstract":"<p><strong>Objective: </strong>Many antibiotics currently in use show limited effectiveness against <i>Acinetobacter baumannii</i> due to its high resistance. The current investigation set out to assess the synergistic effect of colistin in combination with levofloxacin and meropenem to provide an appropriate antibiotic regimen for infections caused by multidrug-resistant <i>A. baumannii</i> (MDR-AB).</p><p><strong>Methods: </strong>Utilizing the broth microdilution approach, the minimum inhibitory concentration (MIC) of levofloxacin, colistin, and meropenem versus isolates of MDR-AB obtained from hospitalized individuals with nosocomial infections caused by this pathogen was ascertained. The checkerboard approach was also used to determine the antibiotics' simultaneous effects on the pathogen.</p><p><strong>Findings: </strong>Twenty isolates underwent testing. Every isolate was meropenem-resistant. Conversely, all 20 isolates showed sensitivity to colistin, with a MIC range of 0.031-2 µg/mL. The synergy test revealed that no instances of antagonistic interactions existed between meropenem and colistin in 60% of isolates, indicating partial synergy (additive impact). However, only 40% of isolates demonstrated partial synergism with no instances of antagonistic behavior when colistin and levofloxacin were administered together.</p><p><strong>Conclusion: </strong>Levofloxacin and meropenem exhibit respectable synergistic effects when combined with colistin; as a result, these combinations may be clinically assessed for MDR-AB infections.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 4","pages":"169-172"},"PeriodicalIF":0.7,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12684997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Self-medication with Glucocorticoids during the COVID-19 Pandemic and Their Clinical Consequences in Rheumatoid Arthritis Patients: A Before-and-after Study.","authors":"Adriana-Alejandra Moctezuma-Ocampo, Daniel-Xavier Xibillé-Friedmann, José-Iván Martínez-Rivera, Diana-Lizbeth Gómez-Galicia, José-Luis Montiel-Hernández","doi":"10.4103/jrpp.jrpp_30_25","DOIUrl":"10.4103/jrpp.jrpp_30_25","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to evaluate factors associated with glucocorticoid (GC) self-medication during the COVID-19 pandemic and to describe its clinical consequences.</p><p><strong>Methods: </strong>Self-medication practices and disease activity were assessed in rheumatoid arthritis patients before and after the hospital closure due to the COVID-19 pandemic through telephone survey and clinical record review. GC toxicity was evaluated using a modified Glucocorticoid Toxicity Index (GTI). Comparisons were performed using statistical tests as appropriate.</p><p><strong>Findings: </strong>Following the hospital's reopening, 51% of patients had modified their GC dose (\"changers\"), while 49% maintained the same dose (\"nonchangers\"). Lower adherence to methotrexate (MTX) was significantly associated with self-medication (<i>P</i> < 0.001). Self-medication correlated with increased C-reactive protein levels and pain perception but did not alter clinical activity score. The GTI revealed more infections and neurological effects in the changer group.</p><p><strong>Conclusion: </strong>MTX nonadherence was the primary determinant of GC self-medication during the hospital closure. Although transient, this behavior was associated with increased inflammatory markers, pain perception, and adverse events.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 3","pages":"120-125"},"PeriodicalIF":0.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Therapeutic Efficacy of Bamboo Salt Mouthwash Compared to Benzydamine Hydrochloride Mouthwash for Recurrent Aphthous Ulceration: A Double-blind Randomized Clinical Trial.","authors":"Zahra Saberi, Rasool Soltani, Zahra Vatankhah, Mehdi Saffaran Khouzani","doi":"10.4103/jrpp.jrpp_38_25","DOIUrl":"10.4103/jrpp.jrpp_38_25","url":null,"abstract":"<p><strong>Objective: </strong>There is no evidence regarding the efficacy of bamboo salt in the treatment of recurrent aphthous ulceration. The objective of the present study was to investigate the effect of bamboo salt mouthwash in comparison to benzydamine hydrochloride in the treatment of recurrent aphthous ulceration.</p><p><strong>Methods: </strong>This randomized double-blind clinical trial was performed on 40 patients diagnosed with minor recurrent aphthous ulceration. Patients were randomized to use bamboo salt or benzydamine mouthwashes for 5 days. Patients in both groups were instructed to use 30 mL of mouthwash every 8 h for 30 s each day. Study outcomes, comprising ulcer size, pain, healing time, and patients' satisfaction, were recorded by investigators.</p><p><strong>Findings: </strong>The adjusted between-group analyses showed that the mean ulcer size reduction was significantly greater in the bamboo salt group than the benzydamine hydrochloride group (mean difference: -1.40 ± 0.53; <i>P</i> = 0.01) on day 3. In addition, a marginally significant difference was observed between the two groups in terms of ulcer size reduction on day 5 (<i>P</i> = 0.07) and pain score reduction on day 3 (<i>P</i> = 0.06). There was a significant difference between the two groups in the mean duration of ulcer healing, both in the crude and adjusted analyses (<i>P</i> < 0.05). Patients' satisfaction was significantly higher in the bamboo salt group than in the benzydamine hydrochloride group (<i>P</i> = 0.03).</p><p><strong>Conclusion: </strong>The present study demonstrated that the mouthwash of bamboo salt may be considered an effective option in the management of recurrent aphthous ulceration. However, further studies are needed to confirm our findings.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 3","pages":"112-119"},"PeriodicalIF":0.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Artificial Intelligence on the Future of Clinical Pharmacy and Hospital Settings.","authors":"Hadi Hamishehkar, Mehrdad Shahidi","doi":"10.4103/jrpp.jrpp_51_25","DOIUrl":"10.4103/jrpp.jrpp_51_25","url":null,"abstract":"<p><p>This review aimed to comprehensively evaluate the impact of artificial intelligence (AI) on the future of clinical pharmacy practice and hospital settings. To achieve this, a thorough literature search was conducted across major databases, including PubMed, Scopus, Web of Science, Embase, and Google Scholar, covering studies published up to July 2025. Relevant keywords - such as \"artificial intelligence,\" \"machine learning,\" \"clinical pharmacy,\" \"hospital pharmacy,\" \"medication management,\" and \"decision support systems\" - were used to identify studies assessing the applications, challenges, and outcomes of AI in these contexts. All eligible articles were narratively analyzed. The findings indicated that AI has a significant role in optimizing pharmaceutical inventory management, reducing medication errors, enhancing the accuracy and safety of drug dispensing, and streamlining drug distribution processes in hospital environments. Advancements in machine learning algorithms and clinical decision support systems not only assist pharmacists in selecting optimal therapeutic regimens and detecting drug-drug interactions but also facilitate the delivery of personalized patient care and prediction of medication needs. In addition, AI integration was shown to improve workflow efficiency, reduce administrative workload, and enhance both pharmacist training and job satisfaction. In conclusion, the integration of AI into clinical pharmacy and hospital settings emerges as a transformative factor, promising to elevate the quality of pharmaceutical care, improve patient outcomes, and shape a more dynamic and efficient future for the pharmacy profession.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 3","pages":"87-97"},"PeriodicalIF":0.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Patient Perspectives and Willingness to Use Mobile Health Applications for Diabetes Medication Adherence: A Descriptive and Cross-Sectional Study.","authors":"Sultan M Alshahrani, Ahmed Khaled Shukri","doi":"10.4103/jrpp.jrpp_43_25","DOIUrl":"10.4103/jrpp.jrpp_43_25","url":null,"abstract":"<p><strong>Objective: </strong>Mobile health (mHealth) applications are widely acknowledged as beneficial interventions for enhancing medication adherence in patients with chronic conditions, including type 2 diabetes mellitus (T2DM). Despite the extensive smartphone prevalence in Saudi Arabia, the practical utilization of mHealth applications for diabetes self-management remains constrained. This study aimed to investigate the attitudes, willingness, and obstacles regarding the use of mHealth applications for medication adherence among patients with type 2 diabetes mellitus in Saudi Arabia.</p><p><strong>Methods: </strong>A cross-sectional study was performed with 489 adult patients with type 2 diabetes mellitus across healthcare facilities and digital platforms in Saudi Arabia. The questionnaire had five domains: demographics, technological utilization, attitudes, willingness, and perceived obstacles. Descriptive analyses were conducted with SPSS.</p><p><strong>Findings: </strong>The majority of participants had a favorable disposition toward mHealth tools. The majority concurred that applications may facilitate adherence and favored interfaces in Arabic. Whereas 71.0% indicated a readiness to utilize mHealth, barely 37.0% were actively employing such applications. Principal obstacles encompassed forgetfulness, feelings of being overwhelmed, adverse effects, financial constraints, and restricted digital accessibility. Cultural and behavioral factors, including the utilization of herbal treatments and religious considerations, also impacted app usage.</p><p><strong>Conclusion: </strong>mHealth possesses significant potential to enhance medication adherence among Saudi patients with type 2 diabetes mellitus. However, successful implementation relies on overcoming behavioral, cultural, and infrastructural obstacles. These findings underscore the necessity for customized, Arabic-compatible digital health solutions that match with the objectives of Saudi Vision 2030.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 3","pages":"105-111"},"PeriodicalIF":0.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Markup to Value: Global Implications of Iran's Cost-plus Pharmaceutical Pricing for Emerging Markets.","authors":"Hadi Hayat","doi":"10.4103/jrpp.jrpp_34_25","DOIUrl":"10.4103/jrpp.jrpp_34_25","url":null,"abstract":"<p><strong>Objective: </strong>In many emerging economies, simple cost-plus markups push medicine prices far above reference benchmarks, undermining affordability and access. Iran exemplifies this problem, with a public sector median price ratio (MPR) of 6.70 - nearly seven times the reference price - and an out-of-pocket (OOP) burden exceeding 50%. This study aims to benchmark Iran's cost-plus pricing framework against international alternatives, quantify the independent effects of cost-plus dominance and inflation on relative prices, and model policy scenarios to reduce household spending.</p><p><strong>Methods: </strong>We compared eleven countries (high-income: Germany, France, UK; upper-middle-income: South Korea, China, Brazil, Turkey, South Africa, Thailand; lower-middle-income: Iran, India) using WHO/HAI surveys (2023) to derive public/private MPRs, OOP percentages, and availability metrics. An ordinary-least-squares regression of ln (MPR) on cost-plus dominance (binary), log GDP per capita, and consumer-price-index (CPI) inflation quantified key drivers. Scenario modeling for Iran estimated OOP impacts under (i) a 30% CPI-adjusted cap (MPR = 4.69) and (ii) an health-technology assessment (HTA)-linked value-based regime (MPR = 2.00).</p><p><strong>Findings: </strong>Iran's cost-plus system predicts a 178% higher MPR (β = 1.02; <i>P</i> < 0.001); each 1% inflation adds 2% to ln (MPR) (β = 0.02; <i>P</i> < 0.001). Under a CPI cap, OOP falls from 52% to 35%; HTA-based pricing could halve OOP to 20%.</p><p><strong>Conclusion: </strong>Static cost-plus pricing perpetuates catastrophic patient costs. Phased reforms - beginning with CPI-indexed ceilings and advancing to HTA-driven value pricing - can transform unaffordable systems into sustainable, equitable models for emerging markets.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 3","pages":"98-104"},"PeriodicalIF":0.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Assessment of Individuals with Opioid Use Disorder under Methadone Treatment.","authors":"Hoda Barkhordari, Mohammad Masoumi, Mansour Moazenzadeh, Hamidreza Esmaili, Hamidreza Rashidinejad","doi":"10.4103/jrpp.jrpp_15_25","DOIUrl":"10.4103/jrpp.jrpp_15_25","url":null,"abstract":"<p><strong>Objective: </strong>Methadone treatment is effective for managing opioid use disorder (OUD) but raises concerns about its impact on cardiac function. This study aimed to assess the prevalence of cardiac dysfunction among individuals under methadone treatment.</p><p><strong>Methods: </strong>This cross-sectional study involved 200 OUD patients admitted to addiction treatment centers of Kerman, Iran, who were at least 1 year under methadone maintenance therapy. Participants were enrolled using a convenience sampling method. Exclusion criteria included concurrent alcohol or nonopioid drug abuse, underlying diseases affecting cardiac function (diabetes, hypertension, and chronic renal failure), hepatic diseases, or use of drugs affecting methadone metabolism. Data on methadone dose, treatment duration, and cardiac parameters assessed through echocardiography and electrocardiography were collected.</p><p><strong>Findings: </strong>A total of 200 OUD patients aged 46.34 ± 13.93 years (72% male) were included. The average duration of methadone use was 2.17 ± 1.34 years, and the average dose was 52.10 ± 27.46 mg/day. 38% of subjects had QT prolongation, while echocardiographic assessment revealed various cardiac abnormalities: 17.5% with systolic dysfunction, 12.5% with abnormal left ventricular end-diastolic diameter, 66.5% with diastolic dysfunction, and 15.5% with increased systolic pulmonary artery pressure. Significant correlations were observed between methadone dose and duration with all measured cardiac parameters.</p><p><strong>Conclusion: </strong>This study demonstrated an association between methadone treatment characteristics (higher dose and longer duration) and cardiac dysfunction. These findings suggest dose- and time-dependent cardiotoxic effects of methadone. Clinicians should implement cardiac monitoring, dose minimization, and risk-reduction strategies for patients on long-term methadone therapy.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 2","pages":"59-65"},"PeriodicalIF":0.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft Skills, Strong Results: The Impact on Medical Representatives in the Saudi Pharmaceutical Sector.","authors":"Mutaz Qashlan, Khaled Halawany, Majid Ali, Olfat Ahmad, Zeyad Halawani","doi":"10.4103/jrpp.jrpp_25_25","DOIUrl":"10.4103/jrpp.jrpp_25_25","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the impact of soft skills on the performance of medical representatives (MRs), aimed to identify key competencies deemed essential for success, and explored effective training methods to develop these skills.</p><p><strong>Methods: </strong>A cross-sectional survey was designed to gather insights from leaders across various departments in Saudi pharmaceutical companies, including sales, marketing, medical affairs, and human resources (HR). Using purposive non-probability sampling, the survey was distributed to 80 potential participants through email and LinkedIn. Data were analyzed using descriptive statistics and thematic analysis of open-ended responses.</p><p><strong>Findings: </strong>Fifty-five leaders responded (69% response rate), representing diverse departments and geographic locations. Communication skills and emotional intelligence were ranked as the most critical soft skills (mean ratings: 4.8 ± 0.4 and 4.7 ± 0.5 out of 5, respectively), followed by negotiation (4.6 ± 0.6), problem-solving (4.5 ± 0.5), and time management (4.4 ± 0.6). The majority (96.4% [<i>n</i> = 53]) of respondents agreed that MRs with strong soft skills perform better, particularly in client interaction (mean impact: 4.9 ± 0.3) and relationship building (4.8 ± 0.4). Managerial performance reviews (74.1%, <i>n</i> = 40) and sales growth (70.4%, <i>n</i> = 38) were identified as the primary metrics for evaluating soft skills. Communication workshops (83.6%, <i>n</i> = 46) and role-playing sessions (72.7%, <i>n</i> = 40) were deemed the most effective training methods. However, challenges such as time constraints (50.9%, <i>n</i> = 28), lack of employee interest (43.6%, <i>n</i> = 24), and resistance to change (41.8%, <i>n</i> = 23) were identified as significant barriers to skill development.</p><p><strong>Conclusion: </strong>This study underscores the pivotal role of soft skills in enhancing employee performance and driving business success in Saudi Arabia's pharmaceutical industry. It highlights the need for structured training programs during onboarding and continuous development to equip MRs with essential soft skills. The findings offer actionable insights for leaders and HR professionals, paving the way for further research in this domain.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 2","pages":"66-75"},"PeriodicalIF":0.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the Risk Factors of Medication Errors in a Tertiary Hospital in Iran.","authors":"Saeed Mohammad Soleymani, Mahdi Mirheydari Peykani, Sara Salarian, Alireza Manafi Rasi, Alireza Heidarian, Hadi Esmaily","doi":"10.4103/jrpp.jrpp_44_25","DOIUrl":"10.4103/jrpp.jrpp_44_25","url":null,"abstract":"<p><strong>Objective: </strong>The services of pharmacists in the hospital go beyond the distribution of medicine, and today, it means the role of pharmacists in the optimal use of medicines by patients and improving their health outcomes. The purpose of this research is to monitor pharmaceutical services in the inpatient departments of Imam Hossein Hospital using a standardized authoring tool.</p><p><strong>Methods: </strong>In this research, two questionnaires were compiled and validated, and different departments of Imam Hossein Hospital in Tehran, which is the largest tertiary hospital in Iran, were monitored in terms of pharmaceutical services. Correct answers below 50% were classified as \"Inappropriate,\" between 50% and 70% as \"Relatively Appropriate\" and above 70% as \"Appropriate.\"</p><p><strong>Findings: </strong>The findings indicate that the highest risk points included absence of drug combination at the beginning of the patient's hospitalization in all departments, absence of drug calculation tables in 90%, absence of control protocol for the abuse of narcotic drugs and their prescription in 90%, absence of quick preparation guide and how to use injectable medicines in 80%, absence of stock list in 75%, and the absence of a control protocol for controlled medicines in 60% of inpatient departments.</p><p><strong>Conclusion: </strong>The study conducted is the first comprehensive study of monitoring pharmaceutical services in hospital wards. The unique features of this study, such as the breadth, comprehensiveness and selection of the largest medical, educational and therapeutic center, and the largest tertiary hospital in Iran, can be generalized to all hospitals and benefit from it.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"14 2","pages":"76-85"},"PeriodicalIF":0.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}