Journal of Stem Cells & Regenerative Medicine最新文献_第2页

INVESTIGATING THE EFFECT OF MESENCHYMAL STEM CELLS ON THE PROLIFERATION PHASE OF DUODENAL WOUND HEALING. 探讨间充质干细胞对十二指肠创面增殖期愈合的影响。

IF 1.6

Journal of Stem Cells & Regenerative Medicine Pub Date : 2025-12-22 eCollection Date: 2025-01-01 DOI: 10.46582/jsrm.2102008

Eko Setiawan, Dimas Irfan Nabih

{"title":"INVESTIGATING THE EFFECT OF MESENCHYMAL STEM CELLS ON THE PROLIFERATION PHASE OF DUODENAL WOUND HEALING.","authors":"Eko Setiawan, Dimas Irfan Nabih","doi":"10.46582/jsrm.2102008","DOIUrl":"10.46582/jsrm.2102008","url":null,"abstract":"Background: Duodenal perforation represents a critical gastrointestinal surgical emergency, often associated with high rates of morbidity and mortality. Mesenchymal stem cells (MSCs) have the potential to enhance wound healing by releasing various growth factors and antiinflammatory cytokines. This study aims to evaluate and analyze the impact of MSCs on the healing process of duodenal perforation wounds.Method: MSCs were extracted from the umbilical cords of rats and injected into the site of duodenal perforation at two different doses: 1.5 × 106 for Treatment Group 1 and 3 × 106 for Treatment Group 2. The control group consisted of rats with duodenal perforation that received local injections on normal saline. The levels of Transforming Growth Factor β (TGF-β) and Alpha Smooth Muscle Actin (α-SMA) were assessed via Western Blot analysis, while collagen and fibroblast presence were evaluated through histopathological examination. These examinations were conducted on days 3 and 7 post-treatment. Statistical analysis was performed using SPSS 25.0, with significance defined at p<0.05.Results: Significant increases in the expression of TGF-β, fibroblasts, collagen, and α-SMA were observed in the treatment groups compared to the control group on both day 3 and day 7.Conclusion: The administration of MSCs significantly enhances the proliferation phase of duodenal wound healing through the increased expression of fibroblasts, collagen, TGF-β, and α-SMA.","PeriodicalId":17155,"journal":{"name":"Journal of Stem Cells & Regenerative Medicine","volume":"21 2","pages":"37-48"},"PeriodicalIF":1.6,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12766067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ureter reconstruction using a biotube in a canine model: A pilot stud. 用生物管在犬模型中重建输尿管：一种试验种马。

IF 1.6

Journal of Stem Cells & Regenerative Medicine Pub Date : 2025-12-22 eCollection Date: 2025-01-01 DOI: 10.46582/jsrm.2102009

Noritaka Maeta, Rosuke Iwai, Yohei Mochizuki, Natsuki Akashi, Masahiro Miyabe, Akira Matsuda, Kenji Kutara, Keisuke Sugimoto, Takamasa Itoi, Yasuhide Nakayama

{"title":"Ureter reconstruction using a biotube in a canine model: A pilot stud.","authors":"Noritaka Maeta, Rosuke Iwai, Yohei Mochizuki, Natsuki Akashi, Masahiro Miyabe, Akira Matsuda, Kenji Kutara, Keisuke Sugimoto, Takamasa Itoi, Yasuhide Nakayama","doi":"10.46582/jsrm.2102009","DOIUrl":"10.46582/jsrm.2102009","url":null,"abstract":"Introduction: Ureteral injuries can lead to renal dysfunction, and conventional treatments such as ureteral stents and autologous tissue grafts have limitations. This study aimed to evaluate the biocompatibility of a \"biotube\" created using in-body tissue architecture (iBTA) technology for ureteral reconstruction in a canine model.Methods: Biotubes were implanted in dogs to replace a segment of the ureter. Ureteral stents were used to prevent obstruction. Autopsies were performed 2-3 months after implantation, and the implantation sites were examined histologically to assess tissue regeneration, vascularization, and potential inflammatory reactions.Results: Ureteral stenting effectively prevented obstruction and ensured adequate urinary flow during the observation period. All biotubes were significantly shortened after implantation. No signs of inflammation or foreign body reactions were recorded, indicating good biocompatibility. Although epithelial cell invasion was observed, muscle tissue migration and angiogenesis were limited.Conclusions: Biotubes demonstrate potential as temporary ureteral substitutes; however, improvements in epithelialization and muscle tissue migration are necessary for successful long-term ureteral regeneration. Further experimental studies are required to evaluate their clinical utility as scaffold materials for ureteral reconstruction.","PeriodicalId":17155,"journal":{"name":"Journal of Stem Cells & Regenerative Medicine","volume":"21 2","pages":"49-58"},"PeriodicalIF":1.6,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12766063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Commentary: Toward Off-the-Shelf Ureteral Substitutes Using iBTA "Biotubes". 编辑评论：使用iBTA“生物管”的现成输尿管替代品。

IF 1.3

Journal of Stem Cells & Regenerative Medicine Pub Date : 2025-12-22 eCollection Date: 2025-01-01 DOI: 10.46582/jsrm.2102006

Akio Horiguchi

引用次数: 0

Proteomic Comparison of Conditioned Media from Mesenchymal Stem Cells of Different Human Tissues: Implications for Therapy. 不同人体组织间充质干细胞条件培养基的蛋白质组学比较：对治疗的意义。

IF 1.6

Journal of Stem Cells & Regenerative Medicine Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.46582/jsrm.2101005

Atsushi Terunuma, Chun Kai Chiu, Tatsuya Sekine, Tsubasa Takane, Yoshihisa Sekine, Keisuke Ashiba, Hiroshi Terunuma

{"title":"Proteomic Comparison of Conditioned Media from Mesenchymal Stem Cells of Different Human Tissues: Implications for Therapy.","authors":"Atsushi Terunuma, Chun Kai Chiu, Tatsuya Sekine, Tsubasa Takane, Yoshihisa Sekine, Keisuke Ashiba, Hiroshi Terunuma","doi":"10.46582/jsrm.2101005","DOIUrl":"10.46582/jsrm.2101005","url":null,"abstract":"Objective: Mesenchymal stem cells (MSCs) suppress inflammation and promote tissue repair via paracrine factors. MSC-conditioned medium (MSC-CM), rich in these factors, shows promise as a cell-free therapy. This study explored the protein profiles of MSC-CMs from different human tissues (dental pulp, adipose tissue, umbilical cord, and placenta) to assess variations and therapeutic potential.Methods: MSCs were cultured from dental pulp, adipose tissue, umbilical cord, and placenta, and MSC-CMs were collected. Proteomic analysis using LC-MS/MS identified and quantified proteins, followed by bioinformatic analysis.Results: A total of 924 secreted proteins were identified in MSC-CMs from the four tissue sources. Extracellular matrix (ECM) signatures were prominent across all MSC-CMs. MSC-CM from adipose tissue had the highest levels of skin care-related proteins. Neuronal growth-related proteins were most abundant in umbilical cord and placental MSC-CMs, while wound healing proteins were prominent in dental pulp MSC-CM.Conclusions: MSC-CMs from different tissues exhibit distinct protein profiles, while sharing common ECM signatures. These findings suggest that MSC-CM could be used for specific applications such as neurodegenerative diseases and wound healing, depending on the tissue source. Further in vivo research is needed to explore their clinical relevance.","PeriodicalId":17155,"journal":{"name":"Journal of Stem Cells & Regenerative Medicine","volume":"21 1","pages":"25-30"},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unique Challenges in myocardial regeneration and the hidden potentials of resident cardiac macrophages. 心肌再生的独特挑战和常驻心脏巨噬细胞的隐藏潜力。

IF 1.3

Journal of Stem Cells & Regenerative Medicine Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.46582/jsrm.2101001

Samuel Jk Abraham

引用次数: 0

Comparative study the effect of human bone marrow mesenchymal stem cells and cardiomyocytes derived exosomes on improvement of Isoproterenol induced ischemic damaged cardiomyocytes. 人骨髓间充质干细胞与心肌细胞源性外泌体对异丙肾上腺素诱导的缺血性损伤心肌细胞改善作用的比较研究。

IF 1.6

Journal of Stem Cells & Regenerative Medicine Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.46582/jsrm.2101004

Saeideh Edalati, Pouyan Asadi, Mehdi Sheikh Arabi, Safoura Khajeniazi

{"title":"Comparative study the effect of human bone marrow mesenchymal stem cells and cardiomyocytes derived exosomes on improvement of Isoproterenol induced ischemic damaged cardiomyocytes.","authors":"Saeideh Edalati, Pouyan Asadi, Mehdi Sheikh Arabi, Safoura Khajeniazi","doi":"10.46582/jsrm.2101004","DOIUrl":"10.46582/jsrm.2101004","url":null,"abstract":"Background: Exosomes are small vesicles with intracellular origin which are released into the extracellular space. The properties of stem cell-derived exosomes are similar to their cellular origin and can be involved in repair the damaged tissues. This investigation aimed to evaluate the effect of exosomes derived from mesenchymal stem cells and cardiomyocytes on the repair of damaged cardiomyocyte in vitro.Methods: In this study, first damaged cells were created by Isopreternol treatment of mesenchymal-derived cardiomyocytes, then cells were affected by exosomes extracted from MSCs and MSC derived cardiomyocyes. Finally, mRNA levels of cardiac differentiation and damage markers were measured by Real Time PCR at the time intervals.Results: Our results showed the level of cardiac markers in damaged cardiomyocytes increased after treatment by cardiomyocytes derived exosomes compared to MSC derived exosomes. Reciprocally LDH a and b mRNA levels decrease in both conditions.Conclusion: our findings revealed the exosomes extracted from cardiomyocytes were more effective in the repair of injured cells compared to the exosomes derived MSCs.","PeriodicalId":17155,"journal":{"name":"Journal of Stem Cells & Regenerative Medicine","volume":"21 1","pages":"19-24"},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of the Immunomodulatory Functions of Dental Follicle Stem Cells and Their Apoptotic Vesicles. 牙滤泡干细胞及其凋亡囊泡免疫调节功能的比较分析。

IF 1.6

Journal of Stem Cells & Regenerative Medicine Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI: 10.46582/jsrm.2101003

Jie Chen, Tao Lin, Yue Yuan, Peilin Wu, Shishi Dai, Huan Xu, Jingyi Zhang, Jing Ma

{"title":"Comparative Analysis of the Immunomodulatory Functions of Dental Follicle Stem Cells and Their Apoptotic Vesicles.","authors":"Jie Chen, Tao Lin, Yue Yuan, Peilin Wu, Shishi Dai, Huan Xu, Jingyi Zhang, Jing Ma","doi":"10.46582/jsrm.2101003","DOIUrl":"10.46582/jsrm.2101003","url":null,"abstract":"The significant immunomodulatory capacity of mesenchymal stem cells (MSCs) is increasingly being recognized, making them valuable for the treatment of autoimmune disorders. MSCs influence immune cell behavior during therapy through intercellular communication mediated by extracellular vesicles (EVs). Moreover, MSC-derived apoptotic vesicles (apoEVs) can also exert immunomodulatory functions. This study compared the effects of dental follicle stem cells (DFSCs) and smaller apoptotic vesicles (apoSEVs) derived from DFSCs on the proliferation of peripheral blood mononuclear cells (PBMC), as well as their impact on T cell subpopulations and inflammatory factor expression. The results showed that apoSEVs derived from DFSCs significantly enhanced PBMC proliferation, inhibited Th1, Th17, and Treg cell populations, and reduced IFN-γ and TNF-α expression levels. These findings demonstrate that apoSEVsapoSEVs from DFSCs can effectively regulate immune responses in a manner similar to that of DFSCs themselves.","PeriodicalId":17155,"journal":{"name":"Journal of Stem Cells & Regenerative Medicine","volume":"21 1","pages":"11-18"},"PeriodicalIF":1.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of autologous stem cells in the treatment of ischaemic cardiomyopathy with heart failure after myocardial infarction. 自体干细胞在心肌梗死后缺血性心肌病合并心力衰竭治疗中的应用。

IF 1.6

Journal of Stem Cells & Regenerative Medicine Pub Date : 2025-01-28 eCollection Date: 2025-01-01 DOI: 10.46582/jsrm.2101002

Baglan Kemelbekov, Ainur Amanzholkyzy, Samat Saparbayev, Edgaras Stankevicius

{"title":"Application of autologous stem cells in the treatment of ischaemic cardiomyopathy with heart failure after myocardial infarction.","authors":"Baglan Kemelbekov, Ainur Amanzholkyzy, Samat Saparbayev, Edgaras Stankevicius","doi":"10.46582/jsrm.2101002","DOIUrl":"10.46582/jsrm.2101002","url":null,"abstract":"The proposed topic is important because it helps find a lot of problems that happen when cardiovascular diseases are passed on along with fibrosis and the link between stem cells and myocardial regeneration. This study aims to investigate the effectiveness of autologous stem cells in the treatment of post-infarction myocardial changes. Statistical, bibliographic, and bibliosemantic research methods and scientific literature for the last 6 years were used to achieve the purpose. Cardiovascular diseases hold the highest prevalence and mortality rates, second only to the number of accidents. Today, there are many methods in the fight against coronary heart disease. However, drug therapy is the least effective, and instrumental methods are too invasive and entail several complications and side effects. Therefore, conducting detailed research on the impact of stem cells on the myocardium affected by infarction presents a challenge. Stem cell transplantation, which includes autologous bone marrow stem cells, typically leads to noticeable and significant changes in cardiac hemodynamic parameters and rheological properties. The development of autologous bone marrow stem cells during the angiogenesis process substantiates such metamorphoses. In addition, factors such as vascular endothelial growth factor and the whole list of coagulogram indicators may influence these changes. The practical significance of the raised subject is using stem cell therapy as an alternative, less invasive method in the fight against postinfarction myocardial changes.","PeriodicalId":17155,"journal":{"name":"Journal of Stem Cells & Regenerative Medicine","volume":"21 1","pages":"3-10"},"PeriodicalIF":1.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical criteria for improvising the efficacy of transplanted cells; Significance of route of administration and microenvironment at the target site. 提高移植细胞疗效的关键标准；给药途径和靶点微环境的意义。

IF 1.1

Journal of Stem Cells & Regenerative Medicine Pub Date : 2024-12-31 eCollection Date: 2024-01-01 DOI: 10.46582/jsrm.2002004

引用次数: 0

I. IDC Key-note Lecture: Influence of gut microbiome in Duchenne muscular dystrophy. 一、IDC主题讲座：肠道微生物群对杜氏肌营养不良的影响。

IF 1.1

Journal of Stem Cells & Regenerative Medicine Pub Date : 2024-12-31 eCollection Date: 2024-01-01 DOI: 10.46582/jsrm.2002008

Fabio Arturo Iannotti

引用次数: 0