组织工程对严重破碎指尖的简约重建。

IF 1.1 Q4 CELL & TISSUE ENGINEERING
Srinjoy Saha
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引用次数: 0

摘要

治疗指尖损伤的目标是最大限度地提高手指长度、触觉、牙髓填充物和指尖外观,同时尽量减少感染和截肢等并发症。目前,断指、二次愈合和皮瓣手术被广泛用于粉碎指尖损伤,但它们有自己的一系列问题和局限性。我们提出了一种组织工程方法,通过将富含血小板的纤维蛋白注射与合成可生物降解的临时基质堆叠层相结合来治疗严重挤压的指尖。这种新疗法在成功再生新软组织的同时,最大限度地减少了重建。在堆积的可生物降解基质内的软组织再生在保持其骨骼长度的同时,获得了新重建的指尖足够的体积、感觉、功能和活动性。值得注意的是,再生的指尖让病人恢复了作为一个繁忙的软件工程师的正常工作。因此,极简的指尖重建不仅可以防止残疾,而且可以作为大型重建手术的可行选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tissue-engineered Minimalistic Reconstruction of a Severely Crushed Fingertip.

The goals of treatment for fingertip injuries are maximising digital length, tactile sensation, pulp padding, and fingertip appearance while minimising complications like infection and amputation. Currently, terminalisation, healing by secondary intention, and flap surgeries are widely used for crushing fingertip injuries, but they have their own set of issues and limitations. We present a tissue-engineered method by combining platelet-rich fibrin injections with stacked-up layers of synthetic biodegradable temporising matrix to treat a severely crushed fingertip. This novel therapy minimised reconstructions while successfully regenerating new soft-tissues. Soft-tissue regeneration within the stacked-up biodegradable matrix achieved adequate volume, sensation, function, and mobility of the newly reconstructed fingertip while maintaining its skeletal length. Notably, the regenerated fingertip allowed the patient to resume work normally as a busy software engineer. Thus, minimalistic fingertip reconstruction not only prevented a disability, but also served as a viable alternative to major reconstructive surgeries.

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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
5
审稿时长
14 weeks
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