Elnaz Asadollahzadeh, F. Ghadiri, Zahra Ebadi, A. Naser Moghadasi
{"title":"The correlation of conventional and advanced MRI findings with cognitive function in multiple sclerosis: A systematic review and meta-analysis","authors":"Elnaz Asadollahzadeh, F. Ghadiri, Zahra Ebadi, A. Naser Moghadasi","doi":"10.34172/jrcm.2023.33409","DOIUrl":"https://doi.org/10.34172/jrcm.2023.33409","url":null,"abstract":"There are limited data on the possible association between conventional and advanced magnetic resonance imaging (MRI) findings and cognitive function in patients with multiple sclerosis (MS). Therefore, this systematic review and meta-analysis aimed to explore the correlation between MRI-derived metrics and cognitive tests in patients with MS. An electronic literature search of the PubMed, Web of Sciences, Embase, and Scopus databases was performed to identify related studies. The correlation coefficients of the MRI indices and cognitive tests were pooled. Thirteen studies were selected for inclusion of 824 patients diagnosed with MS. Most evaluated patients (60.44%) had relapsing-remitting MS (RRMS). The Paced Auditory Serial Addition Test (PASAT-3), Brief Visuospatial Memory Test (BVMT), and Symbol Digit Modalities Test (SDMT) were inversely correlated with the mean diffusivity (MD) of the brain with pooled correlation coefficient of -0.225, -0.361, and -0.438, respectively (P<0.0001). The SDMT test positively correlated with fractional anisotropy (FA) with a correlation coefficient of 0.351 (P<0.0001) and inversely correlated with T2 lesion volume with a correlation coefficient of -0.367 (P<0.0001). In the case of other tests, there was low number of studies with significant correlations being reported. We found significant correlations between some neuropsychological tests and MRI findings in patients with MS. Brain atrophy might disrupt the process of correct registration between anatomical and MRI diffusion scans. However, we did not have enough studies with exactly matched anatomical areas to evaluate correlations and we recommend that histological validation of diffusion tensor imaging (DTI) findings for brain atrophy is needed as a basis for picture processing procedures and correlation with cognition status.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139228312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ischemic stroke following COVID-19 vaccination","authors":"Nooshin Masoudian, Maryam Kakovan, Samaneh Ghorbani Shirkouhi, Fatemeh Ehsani, S. Andalib","doi":"10.34172/jrcm.2023.33321","DOIUrl":"https://doi.org/10.34172/jrcm.2023.33321","url":null,"abstract":"Following the coronavirus disease 2019 (COVID-19) vaccination, complications are expected. In this regard, coagulopathy after COVID-19 vaccination has been reported. Here, we report a rare case of ischemic stroke subsequent to receiving the Beijing Bio-Institute of Biological Products - Coronavirus (BBIBP-CorV) vaccine (Sinopharm). Ten days after receiving the first dose of the BBIBP-CorV vaccine, a 76-year-old woman showed right central hemifacial weakness, balance disorder, and right hemisensory involvement with normal muscle force. Although the magnetic resonance imaging assessment revealed an acute lacunar stroke in her left thalamus, laboratory findings were normal. Based on our report, ischemic stroke may be a post-complication of BBIBP- CorV vaccination. However, further studies are needed to confirm this finding.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139254247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir Hossein Jafari-Rouhi, Samad Shams Vahdati, Asghar Jafari-Rouhi, A. Khameneh, Leila Vahedi, Reza Azadi, N. Moharrami, Pooneh Navidi, Fatemeh Zeynalzadeh
{"title":"Association of end-tidal and venous carbon dioxide in intubated and ventilated children","authors":"Amir Hossein Jafari-Rouhi, Samad Shams Vahdati, Asghar Jafari-Rouhi, A. Khameneh, Leila Vahedi, Reza Azadi, N. Moharrami, Pooneh Navidi, Fatemeh Zeynalzadeh","doi":"10.34172/jrcm.2023.33335","DOIUrl":"https://doi.org/10.34172/jrcm.2023.33335","url":null,"abstract":"Introduction: The end-tidal CO2 pressure (PetCO2) monitoring which is a non-invasive method than PvCO2 (venous pressure of carbon dioxide), could determinate a graph depicting the carbon dioxide concentration in blood. The aim of this study was to investigate the correlation between PetCO2-PvCO2 in ventilated children. Methods: All children intubated in the PICU of Children hospital Tabriz, Iran from 2019 to 2020 using the census method were assessed in terms of initial diagnosis, age, sex, PetCO2, and PvCO2 during a prospective cross-sectional study. Associations between variables were calculated for total patients and patients in the subgroups. Descriptive statistics were used to describe the quantitative analysis of data and the Pearson correlation coefficient and Linear Regression Test were used for the evaluation of the relationship between variables and for assessing the predictive values of PvCO2 using SPSS.26. A P value<0.05 was considered statistically significant. Results: Out of 61 samples, 42 (68.9%) patients were males with a median age of 48 months. The mean of PetCO2 and PvCO2 were 20.3±8.5 and 43±12.3 mm Hg, respectively. The correlation of PetCO2-PvCO2 was significant in total patients (P value=0.003, r=0.379) and group 1 (P value=0.009, r=0.374). Furthermore, the results presented the predictive values of PvCO2 for PetCO2 while for one unit increase in the PvCO2 variable, PetCO2 could increase 0.372 units (P value=0.005, Slope b=0.24, Beta coefficient=0.372). Conclusion: In most intubated children, PetCO2 may estimate the ventilation and change concentrations of CO2. It is necessary that the sample size of future studies will become large due to the weak correlation.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139260537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ensar Turko, Ali Mahir Gunduz, Ali Fuat Gurbuz, F. Durmaz, Ilyas Dundar, Cemil Goya, Adem Yokuş
{"title":"Is there correlation between flow volume and Kt/V ratio in upper arm arteriovenous fistula in patients end stage renal failure?","authors":"Ensar Turko, Ali Mahir Gunduz, Ali Fuat Gurbuz, F. Durmaz, Ilyas Dundar, Cemil Goya, Adem Yokuş","doi":"10.34172/jrcm.2023.33343","DOIUrl":"https://doi.org/10.34172/jrcm.2023.33343","url":null,"abstract":"Introduction: Chronic kidney disease is irreversible and may result in end-stage renal failure (ESRF). The kidney replacement program is determined by calculating Kt/V ratios, one of the dialysis efficiency indicators in treatment planning in routine dialysis applications in ESRF patients. We aimed to investigate whether there is a correlation between flow rate and Kt/V ratio. Methods: All patients were evaluated by B-mode ultrasonography (US) and color doppler ultrasonography (CDUS). The anastomosis line diameter was measured in the B-mode US. The fistula flow rate was calculated in a spectral examination at the anatomical location where the fistulized flow was best obtained at the anastomosis level. Patients with a fistula flow rate above 300 mL/min in CDUS examinations were considered reasonable flow rates. The fistula flow rate in these patients was compared with the Kt/V ratios. Spearman’s rank correlation coefficient was calculated since the normal distribution condition was not met to determine the relationship between variables. Results: The results of this study showed a high level (r=0.72, P=0.001) of positive and statistically significant correlation between flow rate and Kt/V ratio in upper arm arteriovenous fistula in patients with end stage renal failure. Conclusion: We found a highly positive and statistically significant correlation between fistula flow rate and Kt/V ratio. Low Kt/V ratios have different causes. Low fistula flow should be considered first in low Kt/V values.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"27 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139262038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Batool Seifi, Mina Aghazadeh, Reza Naghdi Sadeh, J. Jalili, Abolhassan Shakeri Bavil Olyaei, Hamideh Hosseinpour Feizi, Soroush Mostafavi, M. Khalafi, Armin Zarrintan
{"title":"Psychological effects of recall after mammography: A cohort study based on the HADS questionnaire","authors":"Batool Seifi, Mina Aghazadeh, Reza Naghdi Sadeh, J. Jalili, Abolhassan Shakeri Bavil Olyaei, Hamideh Hosseinpour Feizi, Soroush Mostafavi, M. Khalafi, Armin Zarrintan","doi":"10.34172/jrcm.2023.31888","DOIUrl":"https://doi.org/10.34172/jrcm.2023.31888","url":null,"abstract":"Introduction: This study assessed anxiety and depression scores based on the Hospital Anxiety and Depression Scale (HADS) questionnaire, inpatients recalled after mammography. Methods: In this cohort study, women referred for mammography completed the HADS questionnaire. In 2019, 84 patients who required recall based on the results of their previous mammogram were selected and then completed the HADS questionnaire for the second stage. The HADS questionnaire was used to examine psychological problems. SPSS was used to analyze the collected data. Results: In this study, 86 women who were screened with mammography were evaluated. The mean age was 47.2±8.3 years. Based on the HADS questionnaire, the mean anxiety score before mammography was 10.2±4.8, and after the recall was 13.2±4.2, which was statistically significant (P<0.001). Also, the depression score in these patients before mammography was 10.7±3.8, and after the recall was 12.6±3.6 (P<0.001). Conclusion: Recalling patients after mammography can increase their anxiety and depression, which can decrease patients’ desire for follow-ups.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danial Esmaeilzadeh, Mohammad Shariati Rad, Mehrdad Esmaeilzadeh, B. Razavi, Amirhooshang Mohamadpoor, Hossein Hosseinzadeh
{"title":"Effect of minocycline in COVID-19 patients: A randomized clinical trial","authors":"Danial Esmaeilzadeh, Mohammad Shariati Rad, Mehrdad Esmaeilzadeh, B. Razavi, Amirhooshang Mohamadpoor, Hossein Hosseinzadeh","doi":"10.34172/jrcm.2023.33324","DOIUrl":"https://doi.org/10.34172/jrcm.2023.33324","url":null,"abstract":"Introduction: Minocycline a semi-synthetic tetracycline is a potential therapeutic option for COVID-19 because of its anti-inflammatory and immunomodulatory effects. Moreover, its antioxidant, antiviral, and antiapoptotic effects have been proven. In this study, the efficacy of minocycline in the therapy of COVID-19 patients has been evaluated. Methods: A randomized double-blind placebo-controlled clinical trial was performed in Mashhad, Iran. 40 outpatients were randomized to either the treatment with the minocycline group or the placebo group, in a 1:1 ratio with 20 patients in each group. The Iranian National COVID-19 Therapy Regimen at the time was used in both groups and patients in the treatment group also received oral minocycline 100 mg twice day for 14 days. Patients in both groups were followed on days 3, 7, and 14 after initiating therapy for clinical symptom improvement, improvement of lymphocytes, leukocytes, C-reactive protein (CRP) and SpO2. Results: A total of 40 patients with similar demographic and disease characteristics were enrolled. Results showed that the time interval until clinical symptoms improvement was significantly reduced in the minocycline group (6.85±0.79, day) compared to the placebo (10.95±1.18, day) group (P=0.006). Moreover, the time interval until leukocytes reaching normal limits was significantly reduced in the minocycline group (3.95±0.59, day) compared to the placebo (6.72±1.25, day) group (P=0.046). Conclusion: In this randomized double-blind placebo-controlled study, minocycline (100 mg, BID for 14 days) reduced the duration of clinical symptoms improvement as well as the duration of white blood cell (WBC) normalizing in outpatients of COVID-19 disease.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"86 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Mir-ershadi, M. Ahmadi, R. Rahbarghazi, Hossein Heiran, A. Delkhosh, Majid Khaksar, R. Keyhanmanesh
{"title":"Polarization of T-helper 2 to 1 phenotype has arisen in rat asthmatic pulmonary tissue after intra-tracheal administration of bone marrow-derived c-Kit+ cells","authors":"Fatemeh Mir-ershadi, M. Ahmadi, R. Rahbarghazi, Hossein Heiran, A. Delkhosh, Majid Khaksar, R. Keyhanmanesh","doi":"10.34172/jrcm.2023.32243","DOIUrl":"https://doi.org/10.34172/jrcm.2023.32243","url":null,"abstract":"Introduction: This study investigated the paracrine therapeutic effects of intra-tracheal administration of bone marrow-derived c-Kit+and c-Kit- cells on the T helper (Th)1/Th2 balance in ovalbumin-induced acute asthma in male rats. Methods: Forty male Wistar rats were randomly allocated into four experimental groups; healthy (group C) and sensitized (group S) rats received PBS (Phosphate-buffered saline); sensitized rats received PBS containing c-Kit- (group S+c-Kit- ) and c-Kit+cells (group S+c-Kit+). Total and percentages of differential leukocytes were calculated in bronchoalveolar Lavage. The lung cellular contents of interleukin (IL)-4, IL-10, and interferon gamma (IFN-γ) mRNAs were measured quantitatively. Moreover, the existence of excessive collagen deposition in pulmonary interstitial space was evaluated through Masson’s trichrome staining. Results: The results showed the successful homing of c-Kit+cells into the asthmatic niche. The significantly increased total number of leukocyte, eosinophil, neutrophil, and IL-4 mRNA levels, as well as decreased lymphocyte count, IL-10, IFN-γ mRNAs, and IL-4/IFN-γ ratio, were observed in asthmatic rats compared to C group (P<0.001). C-Kit+cells, but not c-Kit- cells, had the potential to participate in these changes (P<0.001 to P<0.05). The deposition of collagen fibers in the asthmatic pulmonary tissue decreased after administration of both c-Kit+and c-Kit-cells, which were more prominent in the S+c-Kit+group. Conclusions: The results of the current experiment highlighted the therapeutic capacity of c-Kit+cells in the alleviation of asthmatic changes at the cellular level.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"39 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Definition of child and adolescent psychiatry: A new insight into the importance of the discipline","authors":"Ayyoub Malek","doi":"10.34172/jrcm.2023.34528","DOIUrl":"https://doi.org/10.34172/jrcm.2023.34528","url":null,"abstract":"eviewing definitions regarding child and adolescent","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"1 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135541931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of practice with the simulated patient on the professionalism attitudes of medical students: An intervention study","authors":"Esra Çınar Tanrıverdi, Mustafa Bayraktar","doi":"10.34172/jrcm.2023.33433","DOIUrl":"https://doi.org/10.34172/jrcm.2023.33433","url":null,"abstract":"Introduction: Medical school education is effective in the professionalization development of students. In this study, it was aimed to evaluate the effectiveness of course training and to investigate the effect of interactions with simulated patients on the professional attitudes of medical students. Methods: The research is an intervention study designed in the pretest-posttest pattern. The sociodemographic questionnaire and Penn State College of Medicine (PSCOM) professionalism attitude scale were used as data collection tools. The scale was applied to the students three times: before the course (1), after the course (2) and after the simulated patient practice (3). Results: The mean age of the students was 21.40±2.07 years and 54.8% (n=148) were female. The PSCOM scale scores of the students were 154.11±10.91, 158.59±10.48, and 164.64±10.81 respectively for score 1, score 2 and score 3, and, there was a statistically significant increase in score (P<0.001). The scale dimension’s scores all increased after the course and simulated patient (SP) practice. The difference between scores 1, 2, and 3 is statistically significant. The score increased significantly for all dimensions after training and SP’ practices, and the difference between scores 1, 2, and 3 was found to be statistically significant (P<0.001 for all). The female students had significantly higher total scores of 1, 2, and 3 than the male students (P<0.001 for scores 1 and 2, P=0.005 for score 3). Conclusion: Training and simulated patient practices increase medical students’ professionalism scores. The highest score was determined after simulated patient applications.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"49 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134971570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Safa Dönmez, Erdal Tekin, Ahmet Burak Erdem, Alp Şener, Ahmet Coşkun
{"title":"Prospective, randomized single-blind, multicenter comparison of the analgesic efficacy of flurbiprofen/ thiocolchicoside and ibuprofen in myalgia complaints in SARS-CoV-2 patients","authors":"Safa Dönmez, Erdal Tekin, Ahmet Burak Erdem, Alp Şener, Ahmet Coşkun","doi":"10.34172/jrcm.2023.33431","DOIUrl":"https://doi.org/10.34172/jrcm.2023.33431","url":null,"abstract":"Introduction: Myalgia is a common symptom in patients with COVID-19. NSAIDs perform pain suppression mechanisms by suppressing prostaglandin synthesis through inhibition of cyclooxygenase enzyme (COX). Thiocolchicoside activates GABA and Glycine receptors at the spinal level and exerts a myorelaxant effect. The aim of this study is to compare the analgesic efficacy of two drugs, the active ingredients of which are ibuprofen and flurbiprofen/ thiocolchicoside. Method: The study was designed according to a multicenter, prospective, randomized, controlled clinical trial model. A power analysis was performed based on the study of Derosa et al. including patients with myalgia complaints(11). By accepting 80% power and 5% type-1 error, the number of patients to be included in each group was calculated as at least 68. We planned to include 100 patients in each group, taking into account data losses and patients who may drop out of the study during follow-up (n=200). Results: According to the results of the study, the difference between baseline and 2nd day NRS and the difference between baseline and 3rd day NRS were found to be statistically significantly higher in the group using ibuprofen 800 mg retard TB (P<0.05). Conclusion: In the treatment and follow-up of patients with COVID-19 and myalgia complaints, ibuprofen 800 mg retard tb can be preferred primarily because its effectiveness is superior and no side effects are observed.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"93 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135218863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}