{"title":"Molecular mechanisms on embryonic stem cell pluripotency","authors":"G. Han, Hongtao Wang, J. Hao","doi":"10.5772/54365","DOIUrl":"https://doi.org/10.5772/54365","url":null,"abstract":"Derived from early embryo, embryonic stem (ES) cells have potential to self renew indefinitely and develop to any type of cells in human body (pluripotency). Several extrinsic signals such as LIF, BMPs and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the \"pluri- potent genes.\" In combination with intrinsic transcription factors such as FoxD3, Nanog, Oct4 , these factors form a regulatory network to support or limit each other's expression level, which maintain the properties of ES cells.","PeriodicalId":170351,"journal":{"name":"Chinese bulletin of Life sciences","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123150437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Embryonic Stem Cells","authors":"Crystal L. Sengstaken, E. Schulze, Qi-Long Ying","doi":"10.1002/9780470199138.CH1","DOIUrl":"https://doi.org/10.1002/9780470199138.CH1","url":null,"abstract":"Embryonic stem(ES) cells are able to self-renew and differentiate into all kinds of human cells.Due to their unique properties,ES cells are used in diverse fields of biological research,particular in developmental biology.Meanwhile,their potential medical application become a research hot-spot worldwidly.Since pre-implantation eggs are sources to generate ES cells,the use of embryonic stem cells is therefore controversial.This review will outline characterization of ES cells,regulation of self-renewal,and the applications of the cell in treating diseases,as well as ethical issues related to human ES cells research.","PeriodicalId":170351,"journal":{"name":"Chinese bulletin of Life sciences","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121705903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Apoptosis-Associated Speck-Like Protein Containing A CARD","authors":"S. Long","doi":"10.32388/8xysif","DOIUrl":"https://doi.org/10.32388/8xysif","url":null,"abstract":"Apoptosis-associated speck-like protein containing a CARD(ASC) is an adaptor protein that has a bipartite domain structure,an N-terminal pyrin domain(PYD) and a C-terminal caspase recruitment domain(CARD).Recent researches demonstrate that ASC plays an important role in many signal pathways by it′s protein– protein interaction domains PYD and CARD,such as inflammations,tumor occurrences,apoptosis and the regulation of NF-κB.","PeriodicalId":170351,"journal":{"name":"Chinese bulletin of Life sciences","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116457530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulation of Mitochondrial Function by MicroRNA","authors":"M. Tomasetti, Lan-Feng Dong, J. Neuzil","doi":"10.1007/978-94-017-8984-4_3","DOIUrl":"https://doi.org/10.1007/978-94-017-8984-4_3","url":null,"abstract":"","PeriodicalId":170351,"journal":{"name":"Chinese bulletin of Life sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134192960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unfolded protein response","authors":"Mao Ze","doi":"10.1007/978-1-4614-1533-6_101304","DOIUrl":"https://doi.org/10.1007/978-1-4614-1533-6_101304","url":null,"abstract":"","PeriodicalId":170351,"journal":{"name":"Chinese bulletin of Life sciences","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121949711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"C-type lectins","authors":"X. Jian","doi":"10.1007/978-3-540-47648-1_1407","DOIUrl":"https://doi.org/10.1007/978-3-540-47648-1_1407","url":null,"abstract":"","PeriodicalId":170351,"journal":{"name":"Chinese bulletin of Life sciences","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128222108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progress in Parkinson's disease","authors":"Zhang Li","doi":"10.1002/j.2326-1951.1969.tb02572.x","DOIUrl":"https://doi.org/10.1002/j.2326-1951.1969.tb02572.x","url":null,"abstract":"Parkinson's disease(PD) is a progressive neurodegenerative disorder, characterized by degeneration of dopamine-containing neurons located in substantia nigra. Up to now, the specific etiology and pathogenesis of PD are unknown. There has not yet a specific, sensitive predictive and early diagnostic system, and treatment is basically symptomatic. The incidence of PD is rising with the increase of aging population, and bringing great challenge to society and economy. So our country and government pay more and more attention to PD research. The Ministry of Science and Technology of China has approved two 973 projects, the Research of Pathogenesis andTreatment Strategy on Neurodegenerative Disease and the Research of Pathogenesis and Treatment Strategies on PD. The review mainly focuses on the etiology, pathogenesis, early diagnostic system and treatment strategies of PD. All the results will contribute to the progress of our country's PD research.","PeriodicalId":170351,"journal":{"name":"Chinese bulletin of Life sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129849402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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