Apoptosis-Associated Speck-Like Protein Containing A CARD

Abstract

Apoptosis-associated speck-like protein containing a CARD(ASC) is an adaptor protein that has a bipartite domain structure,an N-terminal pyrin domain(PYD) and a C-terminal caspase recruitment domain(CARD).Recent researches demonstrate that ASC plays an important role in many signal pathways by it′s protein– protein interaction domains PYD and CARD,such as inflammations,tumor occurrences,apoptosis and the regulation of NF-κB.