含有卡的细胞凋亡相关斑点样蛋白

Chinese bulletin of Life sciences Pub Date : 1900-01-01 DOI:10.32388/8xysif

S. Long

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引用次数: 7

摘要

含有CARD的凋亡相关斑点样蛋白(ASC)是一种具有两部分结构域结构的接头蛋白，它具有n端pyrin结构域(PYD)和c端caspase募集结构域(CARD)。近年来的研究表明，ASC通过其蛋白-蛋白相互作用域PYD和CARD在炎症、肿瘤发生、细胞凋亡和NF-κ b调控等多种信号通路中发挥重要作用。

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Apoptosis-Associated Speck-Like Protein Containing A CARD

Apoptosis-associated speck-like protein containing a CARD(ASC) is an adaptor protein that has a bipartite domain structure,an N-terminal pyrin domain(PYD) and a C-terminal caspase recruitment domain(CARD).Recent researches demonstrate that ASC plays an important role in many signal pathways by it′s protein– protein interaction domains PYD and CARD,such as inflammations,tumor occurrences,apoptosis and the regulation of NF-κB.

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Chinese bulletin of Life sciences

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