Journal of Reports in Pharmaceutical Sciences最新文献_第9页

Synthesis and comparison of anti-Leishmania major activity of antimony and iron complexes of 3-hydroxypyran-4-one and 3-hydroxypyridine-4-one as bi-dentate ligands 双齿配体3-羟基吡喃-4-酮和3-羟基吡啶-4-酮锑铁配合物抗利什曼原虫主要活性的合成及比较

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_64_18

Zeynab Zarrabi, L. Saghaie, A. Fassihi, N. Pestechian, S. Saberi

{"title":"Synthesis and comparison of anti-Leishmania major activity of antimony and iron complexes of 3-hydroxypyran-4-one and 3-hydroxypyridine-4-one as bi-dentate ligands","authors":"Zeynab Zarrabi, L. Saghaie, A. Fassihi, N. Pestechian, S. Saberi","doi":"10.4103/jrptps.JRPTPS_64_18","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_64_18","url":null,"abstract":"Background: Leishmaniasis infection threatens millions of people in under developing and developing countries. Treatment of this neglected disease is very complicated. Subjects and Methods: A novel series of antimony (V) complexes using bidentate ligands of hydroxypyranones and hydroxypyridinones have been designed and synthesized. For the synthesis of the complexes, SbCl5 in water was added to the solution of each ligand at 60°C and the pH of mixture was adjusted to 8 using aqueous NaOH. After 24 h stirring, extraction of produced compound into acetone gave the desired complex. The structure of complexes was achieved by using FTIR, 1HNMR, and electron spin ionization mass spectroscopic techniques. All compounds were evaluated for in vitro anti amastogote form of Leishmania major. Results and Conclusion: The most potent antimony complexes against amastigotes were 5b (after 48 and 72 h) and 5a (after 72 h) with IC50 values of 24.4, 16.3, and 30.1 µg/mL, respectively. Furthermore, antimony and iron complexes were used together for in vitro anti amastigote form of L. major activity. These compounds were toxic for macrophages and destroyed them.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43434269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Contribution of community pharmacy in treating tuberculosis: A pharmacy centric study from Belagavi district 社区药房对结核病治疗的贡献:一项来自Belagavi地区的以药房为中心的研究

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_69_19

U. Rangaswamy, M. Ganachari

{"title":"Contribution of community pharmacy in treating tuberculosis: A pharmacy centric study from Belagavi district","authors":"U. Rangaswamy, M. Ganachari","doi":"10.4103/jrptps.JRPTPS_69_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_69_19","url":null,"abstract":"Introduction: Tuberculosis (TB) is an important global health problem, which is aimed to be eradicated by 2025 from India. Community pharmacists play a significant role in treating and eradication of TB. This study aimed to understand the contribution of community pharmacy and their potential role in RNTCP (Revised National TB Control Programme) functioning. Materials and Methods: The study was conducted at Belagavi, Karnataka, India on 312 community pharmacies. A structured interview form was used to assess several factors such as education, knowledge, anti-TB drug dispensing patterns, willingness to be trained, and become a DOTS (Directly Observed Treatment Short course) provider. Results: On an overall scale, we found that the majority of licensed community pharmacy was managed by D. Pharm holders with a limited knowledge of TB. It was also noted that there was a lack of willingness to be rigorously trained for updating their knowledge, although they were interested in being trained for being recognized as a DOTS center. Conclusion: There is a strong need for strengthening community pharmacy services in tune with RNTCP to achieve better efficiency in treating and eradication of TB.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43230218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic, antimicrobial activities, and phytochemical investigation of three peach cultivars and acerola leaves 三个桃品种和针叶的细胞毒性、抗菌活性和植物化学研究

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.jrptps_88_19

S. El-hawary, O. Mousa, R. El-Fitiany, Rania A El Gedaily

{"title":"Cytotoxic, antimicrobial activities, and phytochemical investigation of three peach cultivars and acerola leaves","authors":"S. El-hawary, O. Mousa, R. El-Fitiany, Rania A El Gedaily","doi":"10.4103/jrptps.jrptps_88_19","DOIUrl":"https://doi.org/10.4103/jrptps.jrptps_88_19","url":null,"abstract":"Background: Phytoconstituents of Prunus persica Linn. (Peach) and Malpighia glabra Linn. (Acerola) leaves were not thoroughly studied, although they are commonly incorporated in the food industry. Aim: Our aim is to explore metabolites and vitamins in three peach cultivars leaves; Desert red, Florida prince, Swelling and acerola. Material and Methods: Analysis was done using GC/MS (gas chromatography–mass spectrometry), HPLC (high-performance liquid chromatography), and spectrophotometry. Cytotoxicity was performed using MTT assay. Results: Total phenolic and flavonoid content varied from 79.54 to 121.51 μg gallic acid equivalent/mg dry weight and 31.05 to 39.77 μg quercetin equivalent/mg dry weight, respectively. Twenty-four flavonoids were identified; hesperidin was the major flavonoid in peach cultivars (3863.4 mg/100 g in Desert red, 2971 mg/100 g in Swelling, and 2624 mg/100g in Florida prince). Glucuronic acid (33.04%) and vitamin C (34 mg/100 g) were major in acerola. Thirty-four metabolites including supraene and sitosterol as well as 24 fatty-acid esters including linoleic and oleic acids were detected in the unsaponifiable and saponifiable matter, respectively. Antimicrobial activity against bacterial and fungal strains was screened in comparison with ampicillin and amphotericin B. All tested extracts significantly decreased cell viability against breast (MCF-7) and colon cell lines (HCT-116). M. glabra showed no significant difference from standard doxorubicin (0.1 μg/mL) which may suggest a strong anticancer activity against colon cell line. Conclusion: This study may highlight the magnitude of the leaves of these plants as rich sources of important metabolites and vitamin C.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44694765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cocrystallization: An innovative route toward better medication 共结晶:通往更好药物治疗的创新途径

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_103_19

Braham Dutt, M. Choudhary, Vikaas Budhwar

{"title":"Cocrystallization: An innovative route toward better medication","authors":"Braham Dutt, M. Choudhary, Vikaas Budhwar","doi":"10.4103/jrptps.JRPTPS_103_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_103_19","url":null,"abstract":"Nowadays, poor solubility, lower bioavailability, and hindered physical, chemical, and biopharmaceutical properties of active pharmaceutical ingredients (APIs) become a very important matter of discussion for pharmaceutical scientists. It is a challenging task for pharmaceutical researchers and industry to develop a suitable formulation with improved physicochemical properties. The process of cocrystallization is long known; however, in the recent times, this approach has gained enormous importance in pharmaceuticals as a relatively new method for enhancement of solubility, bioavailability, stability, thermal properties, permeability, tablet ability, and other related physicochemical properties. Cocrystals are multicomponent systems in which two components, an API and a coformer, were present in stoichiometric ratio and bonded together with non-covalent interactions in the crystal lattice. Cocrystallization offers better optimization of not only physicochemical properties but also therapeutic response and pharmacological properties of APIs. The design of a cocrystallization experiment is based on robustness, hydrogen bonding rules, and potential intermolecular interactions. Various theoretical and experimental approaches increase the chances for selection of a suitable coformer, the most challenging step during the design of cocrystal formation. The present review covers classification of cocrystals, drug selection criteria for cocrystals, chemistry involved in cocrystal formation, methods of preparation, their characterizations, and various applications in pharmaceutical and biomedical fields.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41789962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Combinational treatments for breast cancer 癌症的联合治疗

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_89_19

O. Tavallaei, Marzieh Marzbany, M. Rasekhian

{"title":"Combinational treatments for breast cancer","authors":"O. Tavallaei, Marzieh Marzbany, M. Rasekhian","doi":"10.4103/jrptps.JRPTPS_89_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_89_19","url":null,"abstract":"Heterogenicity is an indispensable element of breast cancer, which manifests itself on clinical, histopathological, and molecular levels. This heterogenicity could be a determinant factor of disease progression and drug resistance in the patients. Common therapies for metastatic breast cancer include surgery, radiotherapy, chemotherapy, and immunotherapy. On the introduction of biologic medicine, target therapy, and gene therapy, a potential has been reached to lower the rate of morbidity and mortality and also to improve the quality of life among patients with breast cancer. Although these treatments have been frequently proved by yielding promising results, a very few number of them have found their way into clinic settings due to progressive nature of these tumors, diversity of cancer populations and their microenvironments, genetic instability, and heterogenicity of breast cancers. As only minor advancements have been made in the case of recurrent metastatic breast cancer, handling this condition is now considered a medical necessity. According to genetic instability and heterogenicity of breast tumors, it is implausible to assume a single-targeted therapy could help treating most solid tumors. So, this review aimed to put together studies focused on combinational treatments targeting growth inhibition and apoptosis induction in breast cancer cells and comparing the results with monotherapies.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42039242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The role of duloxetine in changing the process of tolerance to morphine analgesic effects in male rats 度洛西汀在改变雄性大鼠吗啡镇痛耐受过程中的作用

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_87_19

A. Parvizpur, K. Fekri, L. Fekri, P. Ghadimi, M. Charkhpour

{"title":"The role of duloxetine in changing the process of tolerance to morphine analgesic effects in male rats","authors":"A. Parvizpur, K. Fekri, L. Fekri, P. Ghadimi, M. Charkhpour","doi":"10.4103/jrptps.JRPTPS_87_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_87_19","url":null,"abstract":"Introduction: Among various neurological systems involved in the development of morphine tolerance, serotonergic and adrenergic systems are very significant. In this study, we used duloxetine to further investigate the association between serotonergic and noradrenergic systems and the occurrence of opioid tolerance. Materials and Methods: Six groups of male Wistar rats were studied including saline, morphine, morphine + duloxetine (15, 30, and 60 mg.kg–1.day–1), and duloxetine-treated groups. Base latency time (BL) was determined using hot plate test (50 ± 0.5ºC). The latency times were reported as MPE% (maximum possible effect) and AUC (area under the curve) was calculated for each MPE%-Time curve (to evaluate global analgesic effect). Results: Morphine-treated group showed tolerance on the 9th day. As the same way, the groups treated with morphine and duloxetine (15, 30, 60 mg/kg) showed tolerance on the 13th, 17th, and 23rd days, respectively. Duloxetine-treated group was tolerated on the 11th day. There was a significant difference between the mean AUC in morphine + duloxetine (60 mg/kg-1/day–1) and morphine-treated groups. Conclusion: Previous studies revealed that chronic administration of morphine would reduce serotonin release in the central nervous system (CNS). This study showed the effective role of duloxetine and the serotonergic system in postponing the tolerance to analgesic effects of morphine.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42880086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fosfomycin protects intestinal cells from nuclear changes suggestive of deoxynivalenol-induced apoptosis 磷霉素保护肠道细胞免受脱氧雪腐镰刀菌烯醇诱导的细胞凋亡的核变化的影响

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_124_19

D. P. Pérez Gaudio, J. Mozo, G. Martínez, M. F. Fernández Paggi, J. Decundo, A. Romanelli, S. Diéguez, A. Soraci

{"title":"Fosfomycin protects intestinal cells from nuclear changes suggestive of deoxynivalenol-induced apoptosis","authors":"D. P. Pérez Gaudio, J. Mozo, G. Martínez, M. F. Fernández Paggi, J. Decundo, A. Romanelli, S. Diéguez, A. Soraci","doi":"10.4103/jrptps.JRPTPS_124_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_124_19","url":null,"abstract":"Background: Fosfomycin (FOS) is a broad-spectrum antibiotic that inhibits cell wall synthesis. It has bactericidal activity against both gram-positive and gram-negative bacteria. FOS also promotes phagocytosis, has immunomodulatory effects, and protects against the toxicity caused by other drugs. On the contrary, deoxynivalenol (DON) causes cytotoxicity on tissues of rapid growth and fast turnover. Objectives: The aim of this study was to determine the percentage of nuclear changes indicative of DON-induced apoptosis on intestinal cell cultures (Caco-2) and to evaluate the protective effect of FOS on mycotoxin-exposed cells. Materials and Methods: Cell cultures were treated as follows: (1) DON: 2.8 µg/mL, (2) calcium FOS: 580 µg/mL, (3) DON 2.8 µg/mL + calcium FOS 580 µg/mL, and (4) negative control. Nuclear morphology was evaluated in fixed cells stained with 4′,6-diamino-2-phenylindol and then visualized under an immunofluorescence microscope. Results: Percentages of cells with nuclear changes were significantly higher in cells treated with DON (31.53% ± 4.17%) compared to those incubated with the antibiotic in conjunction with the mycotoxin (5.63% ± 4.23%). On the contrary, there were no significant differences between cells incubated with DON + FOS and cells incubated only with the antibiotic (1.10% ± 1.55%) when compared to the negative control (3.50% ± 0.09%). Conclusion: The results from this study showed that DON induces nuclear changes suggestive of apoptosis in intestinal cells and that FOS can protect cells from DNA damage. Further studies are needed to determine whether DON induces apoptosis only on cells of epithelial origin and to understand the implications of FOS protective effect under in vivo conditions.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47411448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of cytotoxic and apoptotic effects of DT386–BR2: A promising anticancer fusion protein 一种有前景的抗癌融合蛋白DT386–BR2的细胞毒性和凋亡作用评估

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-01-01 DOI: 10.4103/jrptps.JRPTPS_15_19

F. Shafiee, M. Rabbani, A. Jahanian-Najafabadi

{"title":"Evaluation of cytotoxic and apoptotic effects of DT386–BR2: A promising anticancer fusion protein","authors":"F. Shafiee, M. Rabbani, A. Jahanian-Najafabadi","doi":"10.4103/jrptps.JRPTPS_15_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_15_19","url":null,"abstract":"Purpose: In the previous studies, we designed an anticancer immunotoxin containing the catalytic and translocation domains of diphtheria toxin fused to BR2, a buforin II-derived antimicrobial peptide as a cancer-specific cell penetrating peptide, in order to target various cancer cells. The aim of this study was to evaluate the in vitro cytotoxicity of DT386–BR2 against K-562 cells as the most famous cell line for leukemia. Materials and Methods: MTT and flow-cytometry assays were used for determining the cytotoxic effects and cell death mechanism of DT386–BR2, respectively, against K-562 cell line. The recombinant DT386 and synthetic BR2 were used as the negative control in cytotoxicity assay. Results: The results of this study showed a significant reduction in survival of K-562 cells caused by DT386–BR2 as compared with BR2 and DT386 fragments. On the contrary, the flow-cytometry results showed apoptosis induction by DT386–BR2 after 12h in a dose- and time-dependent manner. Conclusion: DT386–BR2 fusion protein can be used for further preclinical studies for determining its pharmacokinetic/pharmacodynamic profiles and evaluating its anticancer efficacy in suitable animal models.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41356610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A review on analytical methods of antigout agents 抗痛风药物分析方法综述

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-01-01 DOI: 10.4103/jrptps.JRPTPS_32_19

R. Kachave, P. Mandlik, S. Wakchaure

引用次数: 1

Antibacterial effect of combination of cinnamon essential oil and thymol, carvacrol, eugenol, or geraniol 肉桂精油与百里酚、香芹酚、丁香酚或香叶醇组合的抗菌效果

IF 0.6

Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-01-01 DOI: 10.4103/jrptps.JRPTPS_25_19

Y. El Atki, I. Aouam, A. Taroq, Fatima El Kamari, M. Timinouni, B. Lyoussi, A. Abdellaoui

{"title":"Antibacterial effect of combination of cinnamon essential oil and thymol, carvacrol, eugenol, or geraniol","authors":"Y. El Atki, I. Aouam, A. Taroq, Fatima El Kamari, M. Timinouni, B. Lyoussi, A. Abdellaoui","doi":"10.4103/jrptps.JRPTPS_25_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_25_19","url":null,"abstract":"Bacterial resistance to classic antibiotics is an alarming rate to put this into control with the use of natural products of plant derivatives. The objective of this study was to determine the phytochemical of cinnamon essential oil (EO) and to evaluate its antibacterial activity alone and in combination with some main components of EOs such as thymol, carvacrol, eugenol, or geraniol against three bacterial strains (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa). The phytochemical analysis of cinnamon EO was evaluated using gas chromatography-flame ionization detector and gas chromatography-mass spectrometer analysis. The antibacterial activity of tested compounds was determined by agar disk diffusion and minimum inhibitory concentration (MIC) assays. The checkerboard method was used to quantify the efficacy of cinnamon EO in combination with those compounds. The results showed that the major compound in the cinnamon EO was trans-cinnamaldehyde (91.01%). Cinnamon oil was the highest antibacterial activity with MIC of 0.005, 0.005, and 0.02 mg/mL against E. coli, S. aureus, and P. aeruginosa, respectively. Synergistic activity was shown only against S. aureus by the combination of cinnamon EO and thymol. The additive effect was found against E. coli when cinnamon EO was combined with thymol or carvacrol, and against S. aureus when cinnamon EO was combined with carvacrol. However, the combination of EO and thymol or carvacrol showed an indifference action against P. aeruginosa. The combination of cinnamon EO with thymol or carvacrol can be used as an alternative therapeutic agent for medical application and as a natural preservative.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43280821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4