Journal of Reports in Pharmaceutical Sciences最新文献_第8页

Enhancing cognitive performance with rejuvenation of brain antioxidant markers and acetylcholinesterase activity by ethanolic extract of Cucurbita pepo L. seeds in scopolamine-induced model of dementia in rats 东莨菪碱致痴呆模型大鼠脑抗氧化标志物和乙酰胆碱酯酶活性恢复，增强认知能力

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.4103/jrptps.jrptps_22_21

Jaspreet Kaur, Parminder Nain, Sunil Kumar, M. Bhatia

引用次数: 0

Tin (IV) oxide (SnO2) nanoparticles inhibit the viability of cervical cancer HeLa cells through induction of apoptosis 氧化锡(SnO2)纳米颗粒通过诱导凋亡抑制宫颈癌HeLa细胞的活力

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.4103/jrptps.jrptps_109_20

E. Eftekhar, Parisa Bazsefidpar, Shabnaz Koochakkhani, Behnaz Rahnama Inchehsablagh, Elahe Aliasgari

引用次数: 0

Effects of Aegle marmelos (L.) methanolic leaf extracts on biochemical parameters in diabetic rats 蜜瓜醇叶提取物对糖尿病大鼠生化指标的影响

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2021-01-01 DOI: 10.4103/jrptps.jrptps_12_20

Padmavathi Pamulapati, R. Birudu, Sathish Kumar Manoharan

引用次数: 1

Apoptotic effects of ginger extract (Zingiber officinale) on esophageal cancer cells ESO26: An in vitro study 姜提取物对食管癌症细胞ESO26凋亡作用的体外研究

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_98_19

Abbas Abbasi, A. Azizi, Seidmostafa Nachvak, E. Alizadeh, R. Abbsavaran, E. Mirtaheri, Mehdi Moradinazar, M. Rahimi

{"title":"Apoptotic effects of ginger extract (Zingiber officinale) on esophageal cancer cells ESO26: An in vitro study","authors":"Abbas Abbasi, A. Azizi, Seidmostafa Nachvak, E. Alizadeh, R. Abbsavaran, E. Mirtaheri, Mehdi Moradinazar, M. Rahimi","doi":"10.4103/jrptps.JRPTPS_98_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_98_19","url":null,"abstract":"Aim: Ginger is a natural dietary rhizome with antioxidant, anti-inflammatory, and anticarcinogenic properties. It has many medical beneficial properties such as anti-proliferation and antiapoptotic effects on cancerous esophageal cells. Materials and Methods: Esophageal cancer cells ESO26 were cultured in the presence and absence of ginger extract at various concentrations for 12, 18, and 24h. Then, the viability was determined by 3-(4,5-dimethylthiazol)-2,5-diphenyl tetrazolium bromide (MTT) assay. Western blot analysis of caspase-3 was performed to detect apoptosis. p21, Bax, and Bcl-2 gene expression was measured using quantitative polymerase chain reaction (PCR). Data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey test. Results: The ginger extract increased the cleavage of caspase-3 in cells (P < 0.05). Results of real-time PCR have shown that ginger decreased the expression of Bcl-2 and increased Bax and p21 gene expression (P < 0.05). Conclusions: Results showed that the process of cell proliferation has been stopped. Also, this study indicated that ginger might exert a chemopreventive effect on esophageal cancer through the suppression of proliferation and the growth of tumor cells as well as the induction of apoptosis.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49489997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant capacity and HPLC determination of phenolic in different organs of Calligonum polygonoides subspecies comosum 细花亚种细花不同器官中酚类物质抗氧化能力及HPLC测定

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_23_19

Hayam S Ahmed, A. Moawad, A. Owis, S. AbouZid

{"title":"Antioxidant capacity and HPLC determination of phenolic in different organs of Calligonum polygonoides subspecies comosum","authors":"Hayam S Ahmed, A. Moawad, A. Owis, S. AbouZid","doi":"10.4103/jrptps.JRPTPS_23_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_23_19","url":null,"abstract":"Background: Calligonum polygonoides subsp. comosum is a perennial desert plant. Most of the previous chemical investigation of this plant was performed on the whole herb but there were no data about quantification of active constituent in different organs of C. polygonoides. Materials and Methods: in vitro antioxidant activity, total phenolic, and total flavonoid contents of the different organs were determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH), Folin–Ciocalteu, and aluminum chloride (AlCl3) methods, respectively. Quantitative analysis of the phenolic compounds was determined in the different organs of the plant using high-performance liquid chromatography (HPLC). Results: Both bark and leaves showed the highest radical scavenging activity with the values of 450.30 and 398.10 μg/g ascorbic acid equivalent, respectively. The total phenolic content of the samples was in the range of 27.9–281.5 μg/g gallic acid equivalent and total flavonoid content of the samples was in the range of 53.9–257.4 μg/g rutin equivalent where the leaves and bark showed the highest contents. HPLC analysis showed that flavonol glycosides content was higher in all organs compared to the aglycones. Flowers and fruits were the richest organs in flavonols, whereas leaves, stems, and bark were the richest in taxifolin and catechin. Conclusion: Depending on the obtained results C. polygonoides is an excellent source of natural antioxidants.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42609303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Deciphering the in vitro antioxidant potential and mineral analysis of Fagopyrum species from Kashmir and Ladakh regions 克什米尔和拉达克地区金合欢属植物的体外抗氧化潜力和矿物分析

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_70_19

F. Dar, Tanveer Bilal Pirzadah, I. Tahir, R. Rehman

{"title":"Deciphering the in vitro antioxidant potential and mineral analysis of Fagopyrum species from Kashmir and Ladakh regions","authors":"F. Dar, Tanveer Bilal Pirzadah, I. Tahir, R. Rehman","doi":"10.4103/jrptps.JRPTPS_70_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_70_19","url":null,"abstract":"Context: The Kashmir and Ladakh Himalayan regions are having a rich diversity of buckwheat germplasm, which is an excellent source of nutrition and functional food. The objective of this study was based on comparative in vitro flavonoid, antioxidant, and mineral analyses of Fagopyrum species grown in these regions. Materials and Methods: To achieve this goal, leaf samples from the four buckwheat species were subjected to antioxidant analysis. Besides, the mineral analysis of the groat samples of different buckwheat species was carried out by atomic absorption spectroscopy (AAS). Results: Results indicated that the methanolic extract shows higher total phenolic content (TPC) and total flavonoid content (TFC) in the samples of Fagopyrum sagittatum followed by Fagopyrum tataricum, Fagopyrum kashmirianum, and Fagopyrum esculentum. Total reducing power (TRP), ferric reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide anion radical (SOR), and hydrogen peroxide (H2O2) radical scavenging assays indicated excellent results from the leaf extracts of F. sagittatum. The results suggested that the crude methanolic extract of buckwheat species had effective reducing power, radical scavenging activity, and metal-chelating ability compared to other standard antioxidants. AAS analysis revealed that calcium content was higher in F. sagittatum (21,600 ppm), whereas the iron and zinc contents were higher in F. kashmirianum (1,122.5 ppm) and F. sagittatum (166.75 ppm), respectively. Conclusion: Our study suggested that methanolic extracts of Fagopyrum species could act as a potent source of natural antioxidants to the pharmaceutical and food industry. In addition, the study also revealed that the rich elemental profiles of buckwheat species specify their therapeutic value and thus could be used as a potential biofortification crop.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41750604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hollow fiber-based liquid-phase microextraction and HPLC-UV determination of lovastatin in biological fluids 中空纤维液相微萃取- HPLC-UV法测定生物体液中的洛伐他汀

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_71_19

F. Bayat, Atefeh Hajiagha Bozorgi

{"title":"Hollow fiber-based liquid-phase microextraction and HPLC-UV determination of lovastatin in biological fluids","authors":"F. Bayat, Atefeh Hajiagha Bozorgi","doi":"10.4103/jrptps.JRPTPS_71_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_71_19","url":null,"abstract":"In this study, a hollow fiber liquid-phase microextraction (HF-LPME) method coupled with high-performance liquid chromatography (HPLC) was successfully developed for the determination of trace levels of lovastatin in urine and plasma samples. Lovastatin was extracted from 15 mL of the acidic sample solution with a pH of 2 into an organic extracting solvent (n-octanol) impregnated in the pores of a hollow fiber and then back extracted into an acidified aqueous solution in the lumen of the hollow fiber. After extraction, 10 µL of the acceptor phase was injected into HPLC system. To obtain high extraction efficiency, the parameters affecting the HF-LPME, including pH of the sample and extractant phases, type of organic phase, ionic strength, stirring rate, extraction time, and temperature, were studied and optimized. Under the optimized conditions (solvent 1-octanol, pH = 2, 45 min stirring at 45°C with 750rpm), the relative recovery percentage was 85.2–97, which shows the capability of the method to analyze the analyte concentration. This technique provided preconcentration factor 199, 185, and 170 for water, urine, and plasma, respectively. Good precisions values (with relative standard division ≤ 10.5%) were obtained. The results indicated that the HF-LPME method has an excellent cleanup capacity and a high preconcentration factor and could serve as a simple and sensitive method for monitoring the drug in biological samples.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47993107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the development of the nanostructured lipid carriers for the topical fungal infections 局部真菌感染纳米结构脂质载体的研究进展

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_99_19

Amandeep, S. Bhatt, Manish Kumar, S. Devi, P. Upadhyay, V. Saini, Amit Mittal, N. Mehan, Anupam Saini

{"title":"Recent advances in the development of the nanostructured lipid carriers for the topical fungal infections","authors":"Amandeep, S. Bhatt, Manish Kumar, S. Devi, P. Upadhyay, V. Saini, Amit Mittal, N. Mehan, Anupam Saini","doi":"10.4103/jrptps.JRPTPS_99_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_99_19","url":null,"abstract":"Topical fungal infections are one of the often faced diseases worldwide. The first choice for the treatment of fungal infection is topical therapy due to its advantages such as decreasing the risk of systemic side effects and targeting the drug at the site of fungal infection. The treatment of the fungal infection depends on the penetration of the drug molecules through the outermost layer of the skin (stratum corneum) at an effective concentration. The disadvantages of topical treatment are its lack of drug adherence at the site of application and bigger particle size of drug molecules. Nanostructured lipid carriers are the advanced form of lipid nanoparticles and carry the nano range of the drug molecules, which helps to achieve localized and slow release. The topical route is generally preferred due to the possible side effects of oral medication. Advances in the field of formulation may soon render outdated conventional products such as creams, ointments, and gels. Several carrier systems loaded with antifungal drugs have shown promising results in the treatment of skin fungal infections.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47908599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Repeated administration of fluvoxamine worsens gentamicin-induced nephrotoxicity in rats 反复给药氟伏沙明加重庆大霉素引起的大鼠肾毒性

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_57_19

Afshin Ramian, I. Javadi, H. Sadeghi, H. Sadeghi, E. Panahi kokhdan, A. Doustimotlagh, R. Abbasi, S. Alizadeh, Hamed Nikbakht

{"title":"Repeated administration of fluvoxamine worsens gentamicin-induced nephrotoxicity in rats","authors":"Afshin Ramian, I. Javadi, H. Sadeghi, H. Sadeghi, E. Panahi kokhdan, A. Doustimotlagh, R. Abbasi, S. Alizadeh, Hamed Nikbakht","doi":"10.4103/jrptps.JRPTPS_57_19","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_57_19","url":null,"abstract":"Background: Depression is one of the most prevalent and life-threatening forms of mental disorders in chronic kidney disease. Antidepressant agents such as fluvoxamine are broadly prescribed in this situation. This study investigated the effects of fluvoxamine on gentamicin (GEN)-induced nephrotoxicity in rats. Materials and Methods: Twenty-four male Wistar rats were randomly divided into four groups (n = 6) including (1) control group, (2) GEN group, (3) GEN + fluvoxamine (25 mg/kg) group, and (4) GEN + fluvoxamine (50 mg/kg) group. Fluvoxamine was orally given to animals 45 min before GEN was injected (100 mg/kg, intraperitoneally [i.p.]). Blood urea nitrogen (BUN), creatinine (Cr), sodium (Na+), potassium (K+), and malondialdehyde (MDA) levels in serum were measured. Moreover, the glucose (Glu) and protein (Pro) levels in urine and the ratio of kidney to body weight (g/100g body weight) were determined. Histopathological alterations in kidney were evaluated. Results: GEN significantly increased the Cr and BUN serum levels as well as urine Glu and Pro concentrations (P ≤ 0.001). Fluvoxamine exacerbated the elevation in the indicated parameters. GEN also significantly increased the serum MDA levels. Fluvoxamine had no effect on the elevated serum levels of MDA. GEN did not show any effect on the K+ and Na+ serum concentrations. Increased kidney-to-body weight ratio due to GEN nephrotoxicity was further exacerbated by 25 mg/kg of fluvoxamine (P ≤ 0.001). Pathologic findings also confirm the biochemical results. Conclusion: The data suggest that fluvoxamine worsens the nephrotoxicity of GEN. However, further clinical and animal investigations are required to elucidate the mechanism of this interaction.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44293981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and evaluation of thiadiazole-based antileishmanial agents 噻二唑类抗利什曼原虫药物的合成与评价

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Journal of Reports in Pharmaceutical Sciences Pub Date : 2020-07-01 DOI: 10.4103/jrptps.JRPTPS_3_20

F. Hassanzadeh, E. Jafari, M. Saeedi, S. Saberi

{"title":"Synthesis and evaluation of thiadiazole-based antileishmanial agents","authors":"F. Hassanzadeh, E. Jafari, M. Saeedi, S. Saberi","doi":"10.4103/jrptps.JRPTPS_3_20","DOIUrl":"https://doi.org/10.4103/jrptps.JRPTPS_3_20","url":null,"abstract":"Background and Objectives: The 1, 3, 4-thiadiazole scaffold is one of the principal structural components, in a variety of drug categories such as antimicrobial, anti-inflammatory, antineoplastic, and antileishmanial agents. Considering the reported antileishmanial effects of thiadiazole derivatives and the importance of this disease, some of the thiadiazole derivatives with modifications at sulfur atom or amine group attached to the 2-position were synthesized and evaluated for antileishmanial activity. Materials and Methods: Derivatives of 1,3,4-thiadiazole including 2-substituted-thio-1,3,4-thiadiazoles bearing (5-(4-nitrobenzylideneamino) or 5-amino (II, IV, V) and one derivative of 2-substituted-amino-1,3,4-thiadiazole bearing (5- (4-nitrophenyl) (VII) were synthesized and evaluated for their in vitro antileishmanial activity against promastigote and amastigote forms of the Leishmania major. Results: The most active compound was found to be compound II after 24-h incubation against promastigotes and amastigotes with the half maximal inhibitory concentration (IC50) values of 44.4 µM and 64.7 µM, respectively. Conclusion: All of the synthesized compounds showed good antileishmanial activity against both forms of L. major after 48 and 72h incubation.","PeriodicalId":16966,"journal":{"name":"Journal of Reports in Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49664362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1