Journal of Reproductive Immunology最新文献_第9页

Immune profiles in early pregnancy: A comparison of women with genetic abnormality-induced miscarriage and successful live birth 妊娠早期的免疫概况：遗传异常诱导流产和成功活产妇女的比较

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-26 DOI: 10.1016/j.jri.2025.104586

Margarita Ruseva , Dimitar Parvanov , Teodora Tihomirova , Stefka Nikolova , Lachezar Jelezarsky , Rumiana Ganeva , Maria Handzhiyska , Maria Serafimova , Maria Pancheva , Rada Staneva , Blaga Rukova , Savina Hadjidekova , Georgi Stamenov

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Micronutrient–Antioxidant Therapy, Male Fertility Improvement and ICSI Outcomes: Double-Blind, and Placebo-Controlled Clinical Trial 微量营养素-抗氧化治疗，男性生育能力改善和ICSI结果：双盲和安慰剂对照临床试验

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-26 DOI: 10.1016/j.jri.2025.104612

Marwa Lahimer , Habib BenAli , Hafida Khorsi-Cauet , Moncef BenKhalifa , Mounir Ajina

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MicroRNA-199a-5p and Autophagy related gene 5 in Behçet Disease: Possible Relation and Association with Disease Severity MicroRNA-199a-5p和自噬相关基因5在behaperet疾病中的作用：可能与疾病严重程度相关

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-26 DOI: 10.1016/j.jri.2025.104609

Mervat Eissa

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Complement and Collectins in pregnancy 妊娠期补体和集合

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-26 DOI: 10.1016/j.jri.2025.104616

Uday Kishore

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Membrane-bound mitochondrial DNA: a potential senescence signal in placenta tissue 膜结合线粒体DNA：胎盘组织中潜在的衰老信号

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-26 DOI: 10.1016/j.jri.2025.104560

Alin Mishel Hernández Bustos, Diana Maria Morales Prieto, Udo R. Markert, José Martín Murrieta Coxca

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Decidual macrophage efferocytosis of trophoblasts in full term human placenta 足月人胎盘中滋养细胞的蜕膜巨噬细胞efferocyte

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-26 DOI: 10.1016/j.jri.2025.104556

Kylie Belchamber , Jennifer Tamblyn

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Correlation between follicular fluid cytokines and follicular fluid hormones and role of follicular fluid hormones on the follicular dimensions in human physiological natural cycles 卵泡液细胞因子与卵泡液激素的相关性及卵泡液激素在人体生理自然周期中对卵泡尺寸的影响

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-26 DOI: 10.1016/j.jri.2025.104603

Letizia Lombardelli , Federica Logiodice , Rossella Vincenti , Raffaella Fabbri , Ornela Kullolli , Marco Pallecchi , Roberto Paradisi , Giovanna Danza , Maria Macciocca , Renato Seracchioli , Marie-Pierre Piccinni

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The roles of placental senescence, autophagy and senotherapeutics in the development and prevention of pre-eclampsia: A focus on ergothioneine 胎盘衰老、自噬和衰老治疗在先兆子痫发生和预防中的作用：麦角硫因的研究进展

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-18 DOI: 10.1016/j.jri.2025.104621

Douglas B. Kell , Loren Kell , Louise C. Kenny , Abi Merriel , J. Bernadette Moore , Etheresia Pretorius

{"title":"The roles of placental senescence, autophagy and senotherapeutics in the development and prevention of pre-eclampsia: A focus on ergothioneine","authors":"Douglas B. Kell , Loren Kell , Louise C. Kenny , Abi Merriel , J. Bernadette Moore , Etheresia Pretorius","doi":"10.1016/j.jri.2025.104621","DOIUrl":"10.1016/j.jri.2025.104621","url":null,"abstract":"<div><div>Cellular senescence is a well-established biological phenomenon in eukaryotes. It involves DNA damage, telomere shortening, a senescence-associated secretory phenotype (SASP), and the inability of cells to replicate. It is associated with ageing, and also with oxidative stress. Given the importance of oxidative stress in pre-eclampsia, there is considerable evidence, that we review, that senescence plays an important role in both normal placental development and in the development of both early- and late-term pre-eclampsia. Autophagy is capable of delaying or even reversing the development of senescence, and certain small molecules such as sulforaphane and spermidine can stimulate autophagy, including via the redox-sensitive transcription factor Nrf2. Ergothioneine is a thiohistidine antioxidant that is protective against a variety of cardiovascular and other diseases. Ergothioneine also interacts with Nrf2, and pre-eclampsia occurs far less frequently in individuals with higher plasma ergothioneine levels. Together, these elements provide a self-consistent, molecular and systems biology explanation for at least one mechanism by which ergothioneine may be protective against pre-eclampsia.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"171 ","pages":"Article 104621"},"PeriodicalIF":2.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental CCR5 polymorphisms in relation to fetal growth 胎盘CCR5多态性与胎儿生长的关系

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-07-16 DOI: 10.1016/j.jri.2025.104622

Li Qing Wang , Giulia F. Del Gobbo , Elizabeth Wong , Samantha L. Wilson , Mackenzie Campbell , Chaini Konwar , Maria Peñaherrera , Deborah Money , Hélène Côté , Wendy P. Robinson

{"title":"Placental CCR5 polymorphisms in relation to fetal growth","authors":"Li Qing Wang , Giulia F. Del Gobbo , Elizabeth Wong , Samantha L. Wilson , Mackenzie Campbell , Chaini Konwar , Maria Peñaherrera , Deborah Money , Hélène Côté , Wendy P. Robinson","doi":"10.1016/j.jri.2025.104622","DOIUrl":"10.1016/j.jri.2025.104622","url":null,"abstract":"<div><div>The placenta mediates fetal growth, and its development and function are influenced by immune interactions at the maternal-fetal interface. The cysteine-cysteine chemotactic cytokine receptor type 5 (<em>CCR5</em>) gene codes for a pro-inflammatory protein receptor expressed in the placenta on syncytiotrophoblasts and Hofbauer cells. Associations of the placental-fetal genotype at <em>CCR5</em> and birth outcomes have not been examined. Furthermore, influence of CCR5 polymorphisms on nearby DNA methylation in the placenta and in the context of infection is understudied. We assessed two functional polymorphisms in <em>CCR5</em>, a 32 base pair deletion (Δ32) in the open reading frame and an A/G promoter point mutation (rs1799987) in EPIC (n = 233) a cohort consisting of complicated and uncomplicated pregnancies ascertained in Vancouver BC and found that the variant alleles were associated with birth weight (p = 0.007 and p = 0.01 respectively). We validated the association of rs1799987 with birthweight (p = 0.003) in the published NICHD dataset of normative term births (n = 286). These variant associations were, however, not present in CARMA-Preg (n = 200) a cohort enriched for HIV-exposure. Interestingly, we found rs1799987 was associated with altered DNA methylation (DNAme) at multiple CpGs spanning over 275 kb, overlapping both the <em>CCR2</em> and <em>CCR5</em> genes. DNAme in this region was, however, not associated with birthweight. Further investigations are needed to validate the association of <em>CCR5</em> variants with fetal growth. Such studies must consider the population structure and demographics, as well as the large haplotype blocks spanning this region, which make it difficult to assign a causal relationship to specific variants.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"171 ","pages":"Article 104622"},"PeriodicalIF":2.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follicular fluid cytokine phenotypes reflect underlying etiologies for infertility 卵泡液细胞因子表型反映不孕症的潜在病因

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-06-24 DOI: 10.1016/j.jri.2025.104620

Jinxia Huang , Bin Liu , Yanjie Xiang , Yi Zhang , Lele Kuang , Di Xi , Bo Wang , Xiaowei Lu , Joanne Kwak-Kim , Wenjuan Wang

{"title":"Follicular fluid cytokine phenotypes reflect underlying etiologies for infertility","authors":"Jinxia Huang , Bin Liu , Yanjie Xiang , Yi Zhang , Lele Kuang , Di Xi , Bo Wang , Xiaowei Lu , Joanne Kwak-Kim , Wenjuan Wang","doi":"10.1016/j.jri.2025.104620","DOIUrl":"10.1016/j.jri.2025.104620","url":null,"abstract":"<div><div>To determine if the follicular fluid (FF) cytokine phenotype reflects underlying etiologies for infertility and oocyte/embryo quality. The study subjects comprised infertile women with diminished ovarian reserve (DOR, n = 42), tubal factor infertility (TFI, n = 72), and repeated implantation failures (RIF, n = 15). Controls were women with male factor infertility (MFI, n = 30). Tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), IL-4, IL-10, IL-17, and transforming growth factor beta1(TGF-β1) levels in the FF were measured by the enzyme-linked immunosorbent assay (ELISA). The results showed that TNF-α and TGF-β 1 levels in the DOR group were higher than in the MFI group (P = 0.028, P = 0.031, respectively). The IFN-γ/IL-4 and IFN-γ/IL-10 ratios were significantly lower in the TFI group. (P = 0.026, P = 0.016, respectively) than in the MFI group. TNF-α and IL-17 levels and TNF-α/IL-10 ratios in the RIF group were higher in the RIF group than in the MFI (P = 0.006, P = 0.002, P = 0.009, respectively). All six cytokine levels in the high-quality cleavage stage embryo group tend to be higher than those in the low-quality cleavage stage embryo group regardless of their underlying etiologies (P > 0.05). The FF cytokine phenotype may reflect the underlying immunopathology of infertile women undergoing ART cycles. DOR is associated with elevated FF TNF-α and TGF-β1, which may participate in the progression of DOR. FF of TFI has Th2 bias, while Th1 and Th17 bias was present in FF of RIF. Decrease FF cytokine levels may predict reduced oocyte/embryo quality.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"171 ","pages":"Article 104620"},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0