Journal of Reproductive Immunology最新文献

{"title":"Results of introduction of anti-β2GPI/HLA-DR antibody (neoself antibody) testing at our clinic.","authors":"Motowo Nabeta, Mika Kawachi, Kodai Kawano, Kenzo Note, Mari Hasegawa, Kazuki Sakai, Ayumi Iki","doi":"10.1016/j.jri.2025.104492","DOIUrl":"10.1016/j.jri.2025.104492","url":null,"abstract":"","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"169 ","pages":"Article 104492"},"PeriodicalIF":2.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nobiletin on embryo development and uterine function","authors":"Yoko Kawamoto , Hina Suzuki , Karen Koshimizu , Ren Ozawa , Hanako Bai , Ryotaro Miura , Seizo Hamano , Komei Shirasuna","doi":"10.1016/j.jri.2025.104509","DOIUrl":"10.1016/j.jri.2025.104509","url":null,"abstract":"","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"169 ","pages":"Article 104509"},"PeriodicalIF":2.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular macrophages: Sculpting male fertility through immune regulation and tissue interactions","authors":"Keke Yang ,&nbsp;Jingdong Xue ,&nbsp;Chao Feng ,&nbsp;Wen Li","doi":"10.1016/j.jri.2025.104543","DOIUrl":"10.1016/j.jri.2025.104543","url":null,"abstract":"<div><div>Male infertility accounts for approximately 20–50 % of all infertility cases, with dysfunction in the testicular spermatogenic microenvironment identified as a pivotal factor contributing to this condition. Macrophages, which constitute 20–25 % of interstitial cells, are the most abundant immune cells in testicular tissue. These cells interact extensively with other testicular cell types to establish and maintain the spermatogenic microenvironment, playing critical roles in testicular development, spermatogenesis, and immune homeostasis. This review provides a comprehensive overview of the biological functions of macrophages within the testicular microenvironment and explores their interactions with other cell populations.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104543"},"PeriodicalIF":2.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous immunoglobulin versus placebo in recurrent pregnancy loss: A systematic review and meta-analysis of randomized trials","authors":"Louise Kofod ,&nbsp;Madicken Pedersen ,&nbsp;Mette Andersen ,&nbsp;Emilie Christensen ,&nbsp;Pernille Pedersen ,&nbsp;Hiva Alipour ,&nbsp;Pia Egerup ,&nbsp;Ole Bjarne Christiansen ,&nbsp;Ulrik Schiøler Kesmodel","doi":"10.1016/j.jri.2025.104541","DOIUrl":"10.1016/j.jri.2025.104541","url":null,"abstract":"<div><div>Recurrent pregnancy loss (RPL) affects 1–2 % of fertile couples, with immunological factors increasingly implicated in unexplained cases. Currently, no convincing treatment exists. Intravenous immunoglobulin (IVIg) has been explored as a potential treatment, but results have been inconsistent. This study evaluates whether IVIg affects live birth rates in women with RPL in subsequent pregnancies. We searched PubMed, Embase, and Cochrane libraries for relevant randomized controlled trials up to March 20, 2023, and contacted authors for individual patient data. Trials involving women with two or more consecutive pregnancy losses who received IVIg or placebo before or during the first trimester were included. Primary outcomes were live birth and clinical pregnancy rates, with secondary outcomes including pregnancy loss rate, side effects, adverse events, and perinatal outcomes. Risk of bias and certainty of evidence (GRADE) were evaluated. Ten studies involving 662 women were included. The intention-to-treat analysis showed no significant difference in live birth rates between IVIg and placebo groups (RR: 1.02, 95 % CI: 0.86–1.22, p = 0.78, GRADE: moderate). However, per-protocol analysis indicated an increased live birth rate with IVIg (RR: 1.23, 95 % CI: 1.00–1.50, GRADE: low). Live birth rates after IVIg improved with the number of previous losses, especially in patients with ≥ 6 losses (RR: 5.26 (1.58–17.53)). While IVIg therapy did not show a significant improvement in live birth rates overall, future research should focus on identifying specific patient subgroups, such as those with multiple prior losses, who may benefit most from this treatment.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104541"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the maternal microbiome on neonatal immune development","authors":"Eleni Dubé-Zinatelli ,&nbsp;Edwige Mayotte ,&nbsp;Luna Cappelletti ,&nbsp;Nafissa Ismail","doi":"10.1016/j.jri.2025.104542","DOIUrl":"10.1016/j.jri.2025.104542","url":null,"abstract":"<div><div>Historically, multigenerational health and disease transmission have primarily focused on genetic inheritance. However, the discovery that beneficial microorganisms known as commensal microbiota outnumber human genes tenfold has reshaped this perspective, highlighting their critical role in maintaining homeostasis and protecting against pathogens. Unlike the human genome, commensal microbiota is not genetically inherited but is acquired anew with each generation. with initial gut colonization playing a pivotal role in shaping an infant's immune system, neurodevelopment, and long-term health, all heavily influenced by maternal factors. In this review, we examine emerging research on maternal microbial influences on the fetus beginning in utero. We provide an updated overview of the current insights into the impact of the vaginal microbiome during parturition on offspring immunity and discuss the potential long-term health implications for infants born via cesarean section. We explore the advantages and limitations of techniques designed to mitigate these effects, such as vaginal seeding and emphasize that the development of the neonatal immune system is a dynamic process influenced by maternal factors beyond birth, including the transfer of microbiota through breast milk and skin contact. Finally, we present gaps in current research and propose future research directions to deepen our understanding of the impacts of the maternal microbiome on her child. Together, these insights demonstrate how maternal influence on offspring health and immunity extends beyond genetic factors, encompassing the transmission of microbiota, which, in turn, has profound long-term implications for health and disease resilience, offering a novel perspective on intergenerational health dynamics.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104542"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-matched analysis of endometrial immune profile between frozen embryo transfer success and recurrent implantation failure cases with predictive model","authors":"Lei Wang ,&nbsp;Mengxia Ji ,&nbsp;Xiaohua Fu ,&nbsp;Lifen Zhu ,&nbsp;Ting Duan ,&nbsp;Wanmao Ni","doi":"10.1016/j.jri.2025.104539","DOIUrl":"10.1016/j.jri.2025.104539","url":null,"abstract":"<div><div>Successful implantation during frozen embryo transfer (FET) is influenced by multiple factors. However, the role of endometrial immune cells in predicting FET outcomes remains unclear, particularly in an age-independent context. This study aimed to develop a prediction model based on endometrial immune cell characteristics to predict FET outcomes regardless of patient age. We analyzed 78 patients undergoing FET (2021–2023), categorized into successful FET and Recurrent Implantation Failure (RIF) groups. After age-matching via Propensity Score Matching, endometrial immune cell profiles were compared between groups. Key predictors identified through Elastic Net analysis were used to develop a CatBoost prediction model. Before age matching, significant differences between groups were observed in age, neutrophil, monocyte, lymphocyte, and CD56^hiCD16^-NK levels. After age matching, only lymphocyte and B cell levels remained significantly different. The model using lymphocytes, CD56^hiCD16⁺ NK cells, and B cells as predictors achieved ROC AUC scores of 0.88 (age-matched test set) and 0.84 (full dataset), with 0.80 accuracy. CD56^hiCD16⁺ NK cells showed strong positive correlation with RIF. This study reveals a novel association between CD56^hiCD16⁺ NK cells and recurrent implantation failure. The age-independent prediction model demonstrates the potential of immune cell profiling for predicting FET outcomes and may guide personalized reproductive medicine approaches.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104539"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD163 + M2-like monocytes increase in pregnant women with first-attempted frozen embryo transfer","authors":"Yao Ye ,&nbsp;Xiaowei Ji ,&nbsp;Pengcheng Xu ,&nbsp;Lin Peng ,&nbsp;Lin Wang ,&nbsp;Suying Liu ,&nbsp;Yunfeng Cheng ,&nbsp;Xi Dong","doi":"10.1016/j.jri.2025.104540","DOIUrl":"10.1016/j.jri.2025.104540","url":null,"abstract":"<div><div>Macrophages play a vital role in endometrial receptivity and embryo implantation. However, it remains unclear if macrophages in peripheral blood is associated with pregnancy outcomes of frozen embryo transfer during implantation window. 50 patients preparing for the first time of frozen embryo transfer (FET) and 17 patients with recurrent implantation failure (RIF) from December 2022 to March 2023 were included in our present study. The percentages of peripheral macrophages and other immune cells (B-cell, T-cell, NK cell) were evaluated by flow cytometry. The concentrations of cytokines were verified with an IMMULITE 1000 Immunoassay System. FET patients were categorized into pregnant and nonpregnant groups according to clinical outcomes, respectively. The proportion of peripheral CD68⁺CD163⁺ M2 macrophages was increased in pregnant women than in nonpregnant women among the first time of FET patients. CD4⁺ T helper cells were positively correlated with M2-like macrophages in these women. The pregnancy rate of women with higher peripheral CD163 + M2-like monocytes increased compared with women with lower peripheral CD163 + M2-like monocytes in an independent cohort according to the cutoff value of CD163 + M2-like monocytes in ROC curve. Our findings revealed that peripheral CD163⁺ M2 macrophages in implantation window were associated with pregnancy outcomes. This indicated that the importance of peripheral M2 macrophages at the implantation site for pregnancy success.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104540"},"PeriodicalIF":2.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between red cell distribution width and erectile dysfunction: A cross-sectional study using NHANES 2001–2004 data","authors":"Shuofeng Li ,&nbsp;Yang Xu ,&nbsp;Zhan Gao","doi":"10.1016/j.jri.2025.104536","DOIUrl":"10.1016/j.jri.2025.104536","url":null,"abstract":"<div><div>Red cell distribution width (RDW), a widely used and non-invasive biomarker of systemic inflammation, has been linked to various inflammatory conditions, including erectile dysfunction (ED). This study investigates the relationship between RDW and other inflammation-associated biomarkers with ED, using data from the National Health and Nutrition Examination Survey (NHANES) collected between 2001 and 2004. The analysis included 3988 participants, with 29.46 % classified as having ED. Biomarkers such as RDW, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), aggregate index of systemic inflammation (AISI), and C-reactive protein (CRP) were evaluated. Methods included multivariable logistic regression, subgroup analysis, generalized additive models (GAM), and smoothed curve fitting to explore associations. Receiver operating characteristic (ROC) curve analysis was used to assess diagnostic capabilities. Results showed significant positive associations between ED and RDW, MLR, NLR, and SIRI, with nonlinear relationships identified. RDW demonstrated the highest diagnostic accuracy for distinguishing ED (AUC = 0.66, 95 % CI: 0.65–0.68), outperforming other biomarkers. The study concludes that RDW is independently associated with ED, offering cost-effectiveness, non-invasiveness, and high diagnostic accuracy, making it a promising biomarker for ED assessment strategies.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104536"},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential therapeutic targets for ovarian hyperstimulation syndrome revealed by proteome-wide mendelian randomization and colocalization analysis","authors":"Bo Yao ,&nbsp;Shanshan Chen ,&nbsp;Xuanyi Chen ,&nbsp;Linlin Zou ,&nbsp;Tengyang Fan ,&nbsp;Xue Xiao","doi":"10.1016/j.jri.2025.104537","DOIUrl":"10.1016/j.jri.2025.104537","url":null,"abstract":"<div><div>Ovarian hyperstimulation syndrome (OHSS) is a severe complication associated with assisted reproductive technologies, characterized by metabolic, immune and vascular disorders. Understanding the molecular mechanisms underlying OHSS could reveal potential therapeutic targets and improve patient outcomes. In this study, We aimed to utilize proteome-wide Mendelian randomization (MR) and colocalization analysis to identify plasma proteins associated with OHSS and evaluate their potential as therapeutic targets through druggability assessment. We employed proteome-wide MR analysis summary data-based Mendelian randomization (SMR) analysis and phenome-wide association study (PheWAS) analysis to establish causal relationships between plasma proteins and OHSS. Colocalization analysis confirmed overlaps between proteins and genetic signals associated with OHSS. Pathway and network analyses were conducted to explore biological functions and protein interactions, while drug-target databases were queried for potential therapeutic interventions. Our results showed that 4 key proteins, including Suprabasin (SBSN), SLAMF4 (CD244), Enolase 3 (ENO3) and Thioredoxin domain-containing protein 12 (TXNDC12) were identified as significant contributors to OHSS. Pathway enrichment and interaction analyses further supported their involvement in metabolic, immune and structural pathways related to OHSS. Drug availability for colocalized proteins reveled potential drug targets for ENO3 (2-deoxy-D-glucose), CD244 (lenalidomide) and TXNDC12 (Auranofin), while no potential drug targets were identified for SBSN. Over all, our study identified15 plasma proteins, including SBSN, CD244, ENO3, and TXNDC12, as key contributors to the risk of OHSS through MR and colocalization analysis. These proteins were involved in metabolic regulation, immune response and antioxidant pathways, highlighting potential therapeutic targets and suggesting new directions for treatment strategies.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"169 ","pages":"Article 104537"},"PeriodicalIF":2.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological effects of GLP-1 analogs on female reproduction: Therapeutic perspectives for infertility and recurrent pregnancy loss","authors":"Ana Clara Muniz Tavares ,&nbsp;Maria Yzadora Moura Martins ,&nbsp;Giselle Ferreira de Souza ,&nbsp;Eduarda Maia Lima ,&nbsp;Camila Alves Rocha ,&nbsp;Larissa Cruz de Souza ,&nbsp;Júlia Machado Luz Simões ,&nbsp;Nicole Oliveira de Araújo ,&nbsp;Marcelo Borges Cavalcante","doi":"10.1016/j.jri.2025.104538","DOIUrl":"10.1016/j.jri.2025.104538","url":null,"abstract":"<div><div>This review evaluates the role of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in treating obesity-related infertility and recurrent pregnancy loss (RPL). Originally developed for managing type 2 diabetes mellitus (T2DM) and obesity, GLP-1RAs demonstrate potential in improving reproductive outcomes through their metabolic, vascular, and immunological effects. Obesity, a significant contributor to infertility and RPL, disrupts endocrine balance, promotes chronic inflammation, and impairs endometrial receptivity. GLP-1RAs alleviate these challenges by facilitating substantial weight loss, enhancing insulin sensitivity, and modulating immune responses. Research suggests that the immunological benefits of GLP-1RAs extend beyond their weight-loss effects. Key mechanisms associated with their impact on reproductive outcomes include macrophage polarization toward an anti-inflammatory phenotype, suppression of pro-inflammatory cytokine production, and restoration of maternal-fetal immune tolerance through increased regulatory T-cell activity. Emerging evidence highlights their role in enhancing vascularization and reducing oxidative stress at the maternal-fetal interface, critical processes for implantation and placental development. Despite these promising benefits, the use of GLP-1RAs during pregnancy remains contraindicated due to safety concerns. While they show promise in preconception protocols, further clinical trials are needed to establish their efficacy and safety in reproductive health. This review underscores the potential of GLP-1RAs as a multidimensional approach to managing infertility and RPL, particularly in obese women, and advocates for their integration into personalized therapeutic strategies to optimize reproductive outcomes.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"169 ","pages":"Article 104538"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}