Journal of Renal Injury Prevention最新文献

{"title":"Paraquat poisoning; an experience from a tertiary care center in India","authors":"Nisha Jose, Indhumathi Elayaperumal, Devia Arumugam, Jayakumar Matcha","doi":"10.34172/jrip.2023.32045","DOIUrl":"https://doi.org/10.34172/jrip.2023.32045","url":null,"abstract":"Introduction: Paraquat poisoning is a commonly used toxin within the Indian sub-continent. Despite several advances in medical care, mortality in cases of paraquat poisoning continues to be high with controversies in the ideal management. Objectives: The aim of this study was to throw light on the clinical course of these patients in the current setting and evaluate some of the novel therapeutic options such as hemoperfusion in the setting of paraquat poisoning. Patients and Methods: This study is a retrospective observational study examining all adult patients with paraquat poisoning over the last five years from a tertiary care centre in Southern India. Demographic characteristics, clinical and laboratory profile, treatment options, and outcome were analysed from online hospital records. Results: Of 13 patients, all patients, except one, had ingested paraquat deliberately. Acute kidney injury (AKI) occurred in all patients (100%). Dialysis was required in 7 patients (54%) with AKI. Lung injury was seen in 63.5% of patients (n=8) and most patients i.e. 92.3% (12 patients) had multi-organ dysfunction syndrome (MODS). Hemoperfusion was provided to 30.8% of patients without much benefit in terms of duration of hospitalisation or time to death. Hemodialysis and continuous renal replacement therapy (CRRT) were offered for conventional indications. Dialysis was found to have significant bearing on time to death. Conclusion: Paraquat is a highly lethal herbicide with few effective therapeutic options. The majority of patients develop multi-organ dysfunction and succumb to death owing to circulatory collapse. Dialysis may be able to delay mortality in paraquat poisoning.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of steroids in severe infection-related glomerulonephritis","authors":"Varadharajan Jayaprakash, Mathew Gerry George, Santhanam Jennie","doi":"10.34172/jrip.2023.32213","DOIUrl":"https://doi.org/10.34172/jrip.2023.32213","url":null,"abstract":"<jats:p>\u0000 </jats:p>","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of cinacalcet on hypercalcemia in kidney transplant patients with hyperparathyroidism: systematic review and meta-analysis","authors":"Hanie Fooladi, Fatemeh Vashahi Torfi, Ali Khodaparast, Sara Abbasian, N. Alivand, Mohamad Khaledi, Soleyman Alivand, Farshad Gharebakhshi, Moein Shakerian","doi":"10.34172/jrip.2023.32207","DOIUrl":"https://doi.org/10.34172/jrip.2023.32207","url":null,"abstract":"Introduction: Following renal transplantation, patients with end-stage renal disease develop parathyroid dysfunction and electrolyte abnormalities, including calcium and phosphate levels. However, cinacalcet is one of the most used medications for hypercalcemia. Therefore, the present systematic review and meta-analysis aimed to investigate the effect of cinacalcet administration on hypercalcemia in patients with renal transplantation. Materials and Methods: The online databases of Cochrane, Web of Science, Scopus, and PubMed were searched until April 2023 using validated keywords. Moreover, PRISMA was used for qualitatively evaluating the studies since the study protocol was registered on the PROSPERO website. In addition, data analysis was conducted using Stata version 14, and the significance level was set at 0.05. Results: The present meta-analysis included 26 studies (24 cohort studies and two randomized clinical trials) investigating 602 patients with renal transplantation and hyperparathyroidism. According to our findings, cinacalcet reduced the serum calcium (MD: -2.24, 95% CI: -2.82, -1.67), parathormone (SMD: -0.85, 95% CI: -1.15, -0.54), and alkaline phosphatase levels (SMD: -0.45, 95% CI: -0.91, -0.01). Moreover, 30-60 mg of cinacalcet per day effectively treated hypercalcemia (SMD: -2.77, 95% CI: -3.57, -1.98), while other doses were not significantly effective. Furthermore, the effect of cinacalcet was investigated in patients using the medication for less than six months (SMD: -2.55, 95% CI: -4.25, -0.86), 12-18 months (SMD: -2.60, 95% CI: -3.53, -1.67), and more than 24 months (SMD: -1.71, 95% CI: -2.54, -0.88). Finally, the effect of cinacalcet was the highest in the patients who were 60-64 years old compared to other age groups (SMD: -3.59, 95% CI: -5.14, -2.04). Conclusion: Cinacalcet could improve hypercalcemia and hyperparathyroidism in patients with renal transplantation. Moreover, the effect of cinacalcet had a direct and positive relationship with the patient’s age. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (ID: CRD42023428620) and Research Registry (UIN: reviewregistry1667) website.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48065343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colovesical fistula in a 11-year-old girl with ambiguous genitalia and recurrent urinary tract infection; a brief report","authors":"Paniz Pourpashang, Seyed Mohammad Taghi Hosseini Tabatabaei, Arefeh Zahmatkesh, Mina Vatanpour","doi":"10.34172/jrip.2023.32206","DOIUrl":"https://doi.org/10.34172/jrip.2023.32206","url":null,"abstract":"VACTERL (V-Vertebral, A-Anorectal, C-Cardiac, TE-Tracheoesophageal, R-Renal, L-Limb) is an acronym for multiple organ dysfunction, which often occurs together. These prospects may affect patients with other abnormalities, such as urogenital abnormalities. Here we present a case of VACTERL syndrome with ambiguous genitalia who was referred and hospitalized due to recurrent urinary tract infection (UTI) and urosepsis. A colovesical fistula was discovered in the following examinations, which could explain this complication.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41538299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glomerulotubular function in transfusion-dependent thalassemia children: a prospective cohort study","authors":"H. Puspitasari, L. Rahmartani, Diashati Ramadhani Mardiasmo, P. Wahidiyat, E. L. Hidayati","doi":"10.34172/jrip.2023.32184","DOIUrl":"https://doi.org/10.34172/jrip.2023.32184","url":null,"abstract":"Introduction: Thalassemia is the most common hemoglobinopathy in Indonesia. Chronic anemia, iron overload, and treatment with iron chelating agents are factors that contribute to kidney dysfunction in children with transfusion-dependent thalassemia (TDT). Urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine albumin-creatinine ratio (uACR) are markers of glomerular and tubular damage. Objectives: To analyze the glomerulotubular function in TDT children. Patients and Methods: This prospective cohort study recruited 40 TDT children aged ≤18 years old from thalassemia transfusion outpatient clinic, Dr. Cipto Mangunkusumo general hospital, Jakarta, Indonesia between February and June 2021. Disease history, treatment, and anthropometry were obtained during enrollment (T0). Blood and urine samples were taken at enrollment (T0) and at 1 (T1), 2 (T2), and 3 (T3) month follow-up appointments. Data analyzed were iron chelating agent, ferritin, hemoglobin, estimated glomerular filtration rate (eGFR ), uNGAL, uACR levels. Results: We observed kidney hyperfiltration in more than 30% of the participants. Transfusion volume was the most dominant factor for eGFR (β=-0.974, P=0.022) and uNGAL (β=0.872, P=0.015). A low-proportion of albuminuria was found with duration of disease as the predominant factor (β=-0.946, P=0.000). Deferiprone (DFP) and deferasirox (DFX) showed comparable association with all kidney biomarkers. Conclusion: The findings of this study indicate glomerular hyperfiltration in TDT children as the main early sign of glomerulotubular function impairment. In addition, a small proportion of proteinuria was also found in our study. Thus, both biomarkers should be part of long term kidney follow up in TDT children.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45153568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pioglitazone on proteinuria and cardiovascular events in patients with diabetic nephropathy","authors":"S. M. Hejazian, S. Zununi Vahed, Nooshin Khadem Haghighi, Bahram Niknafs, F. Farnood","doi":"10.34172/jrip.2023.32186","DOIUrl":"https://doi.org/10.34172/jrip.2023.32186","url":null,"abstract":"Introduction: Slowing the progression of diabetes to DN has established a great deal of interest in recent years. Objectives: Considering the enormous costs of managing patients with diabetes and the lack of similar studies on the Iranian population, the present study aimed at investigating the effect of pioglitazone on the progression of DN and the prevalence of cardiovascular events. Patients and Methods: The present prospective study was undertaken on 55 patients with type 2 diabetes who were divided into two groups. The group 1 patients received 30 mg of pioglitazone daily in addition to other blood sugar-controlling drugs. Patients in the group 2 recieved other anti-diabetic medications. During a six-month follow-up period, proteinuria and the occurrence of cardiovascular events were assessed. Results: The 24-hour urinary proteinuria decreased within the group 1 and these intragroup differences were significant (P<0.001) during six months of follow-up compared to month two. There was no significant difference in the ratio of cardiovascular events in the group 1 compared to the group 2. Conclusion: Adding 30 mg of pioglitazone to other blood sugar-lowering medications could lower proteinuria in individuals with type 2 diabetes; however, it had no impact on the risk of cardiovascular events.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42885515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma neutrophil gelatinase-associated lipocalin role as a developing biomarker of acute renal failure following coronary artery bypass surgery","authors":"Aiyoub Pezeshgi, Hamid Musavi Zenouz, Abdolreza Esmaeilzadeh, Negin Parsamanesh, Koorosh Kamali, Sattar Jafari","doi":"10.34172/jrip.2023.32202","DOIUrl":"https://doi.org/10.34172/jrip.2023.32202","url":null,"abstract":"Introduction: Acute kidney injury (AKI) following coronary artery bypass graft (CABG) procure is related with elevated morbidity and mortality, early diagnosis of which is important for effective management of these patients. Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted glycoprotein in response to inflammation. Objectives: The current study aimed to evaluate the role of serum NGAL in predicting AKI in a group of Iranian patients undergoing CABG. Patients and Methods: This study was a cross-sectional prospective study conducted on 79 patients undergoing CABG from Mousavi hospital, Zanjan, Iran. The blood samples for serum creatinine and plasma NGAL levels were collected before anesthesia induction and at 12th, 24th and 48th hour’s post-operative. The plasma NGAL level was measured using enzyme-linked immunosorbent assay method. The incidence of AKI was known by the risk-injury-failure-loss-end-stage renal disease (RIFLE) criteria. Results: In 23 cases (29%) AKI development was detected. In a 24-hour follow-up, the mean serum creatinine values did not change in patients while the mean plasma NGAL level was elevated within 12 hours post-operatively (207.2±180.8 ng/mL and 119.26±103.5 ng/mL in the AKI and non-AKI groups, respectively). The plasma NGAL level measured after CABG (with the cut-off point equal to 126.4 ng/mL) showed a sensitivity of 77% and a specificity of 81% for the prediction of AKI. In AKI group, no patient had grade 3 AKI and neither required dialysis. Conclusion: These data indicated that the plasma NGAL levels could be potentially utilized for early diagnosis of AKI in patients undergoing CABG.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136082702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac surgery of aortic valve and ascending aorta (Bentall procedure) in a patient with Fabry disease without enzyme replacement therapy: an overview of aortic and aortic valve surgical tips","authors":"M. Hekmat, H. Ghaderi, Mandana Hekmat, Zahra Ansari Aval, Amirhesam Alirezaei, S. Mirjafari, R. Tirdad","doi":"10.34172/jrip.2023.32162","DOIUrl":"https://doi.org/10.34172/jrip.2023.32162","url":null,"abstract":"Introduction: Fabry disease (FD) is a rare disease in which cardiovascular events are one of its manifestations. Aortic and mitral valve involvement are among its manifestations, but due to the concern of suture failure without enzyme replacement therapy (ERT), the desire for its surgery has been very low, and its reported cases have been few. After the introduction of ERT, cardiovascular surgery for such patients has been gradually reported from different places, but due to the high cost of ERT, it is not practically available to patients in the third world and the backward countries. Reports of the experiences of patients with FD who underwent cardiac surgery without ERT can help improve cardiac surgery in these patients. Case Report: A 34-year-old man diagnosed with FD due to chronic renal failure and underwent dialysis 3 times a week for 1.5 years became a candidate for kidney transplant. In pre-transplant examinations, dilatation of aortic root and aortic valve insufficiency were diagnosed, and the patient’s kidney transplant surgery was postponed until after cardiac surgery. The patient underwent cardiac surgery, aortic valve replacement, and ascending aortic replacement, as well as re-implantation of both right and left coronary buttons on the ascending aorta (Bentall procedure). The post-surgery period passed without any special event. The patient’s dialysis continued; after 4 months, he underwent kidney transplant surgery, and the one-year follow-up period also was good. Conclusion: Although there is very little evidence of cardiovascular surgery in patients with FD without ERT, and surgeons have always been worried about suture failure and complications of cardiac surgery, due to the high cost of ERT, this treatment is not available to everyone. The introduced patient underwent cardiac surgery by Bentall procedure without receiving ERT and was discharged without any special complications. By reporting and collecting similar cases, guidance may be provided for patients with FD for whom ERT is not available.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44318942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview on the diagnostic role of electron microscopy for kidney diseases, study of 2006 native kidney biopsies in Iran","authors":"S. Owji, Farshad Dehghani, S. Torabinezhad, Seyed Hossein Owji, H. Raeisi Shahraki, A. Karami","doi":"10.34172/jrip.2023.32152","DOIUrl":"https://doi.org/10.34172/jrip.2023.32152","url":null,"abstract":"Introduction: Kidney diseases affect millions of people worldwide. Over several decades, electron microscopy has been an integral part of the kidney biopsy study repertoire. Objectives: In this study, we assessed the role of electron microscopy in the diagnosis of kidney diseases. Patients and Methods: This was a retrospective cross-sectional study conducted at a referral center over a 16-year period (2001-2016). The electron microscopy (EM), light microscopy (LM), and immunofluorescence (IF) profiles of the patients were assessed. The final diagnosis was based on EM, and the primary LM results were compared to those of EM in order to assess the contribution rate of EM to the final diagnosis. The role of EM was categorized as essential, helpful, or non-contributory. Results: A total of 2006 kidney biopsies were performed. Male subjects accounted for 44.3%, and adults for 74.1% of the cases. The most common diagnosis was lupus nephritis (LN) (20.7%), followed by focal segmental glomerulosclerosis (FSGS) (15.7%) and membranous glomerulonephritis (MGN) (14.5%). EM was the most contributory in hereditary nephritis and minimal change disease (MCD). Overall, EM was essential in 25.2%, helpful in 17.4%, and non-contributory in 57.4% of all 2006 cases. Conclusion: The common kidney disorders in this geographic area of Iran are LN, FSGS, and MGN. In about half of the patients, EM study played an important role in the more accurate diagnosis of kidney diseases and prevented misdiagnosis. This role has been found to be more prominent in inherited diseases. We recommend EM as a useful and indispensable tool for routine pathologic study of biopsies when possible.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43435727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predicting factors of acute kidney injury due to methanol intoxication; a systematic review","authors":"Mohammad Hesam Gharaeikhezri, Farinaz Fattahi, Pegah Karami, Arash Izadpanah Ghahremani, Bareza Rezaei, Hooman Rafiei, Hamidreza Khodabandeh, Aisan Ghasemi Oskui, Farshad Gharebakhshi, Mohammad Reza Rezaei","doi":"10.34172/jrip.2023.32195","DOIUrl":"https://doi.org/10.34172/jrip.2023.32195","url":null,"abstract":"Introduction: Methanol intoxication and subsequence acute kidney injury (AKI) can be dangerous and deadly in case of a missed or delayed diagnosis; therefore, identifying its prevalence and predictor factors is necessary. Objectives: This study was conducted to identify the prevalence and predictor factors of AKI in methyl alcohol-intoxicated patients. Methods and Materials: The search strategy was conducted with the standard keyword in the international database, including Web of Science, Scopus, PubMed /Medline, Embase, Cochrane, WorldCat, Dimension, OpenGrey, EBSCO, DOAJ, CINAHL, and Google scholar search engines. Studies that reported the prevalence of AKI due to methanol poisoning were included in this review study. Results: Results demonstrated that six studies from five countries, with a sample size of 816 methanol intoxication patients, were included in this study. Mean AKI prevalence in all reviewed studies was 28.18%; Gender male, hypertension, older age, anemia, alcohol addiction, metabolic acidosis, high blood osmolality, high Formate concentration, alcohol overdose, sepsis, rhabdomyolysis, acute pancreatitis, and volume depletion were the reported AKI predictors in the reviewed studies. Conclusion: Identifying the AKI prevalence and its predictor factors in patients with methanol intoxication can help in their quick diagnosis, timely treatment, and reduce the subsequent complications.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47705854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}