Potential biomarkers of chronic kidney disease progression among kidney-derived proteins; a review

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2023-01-22 DOI:10.34172/jrip.2023.32040

S. P. Kademani, Prabhudas Nelaturi, Vishnu Bhat, Sathya Sagar, R. Sambandam

引用次数: 0

Abstract

The incidence and mortality rate of kidney disease and its progression to end-stage disease have predominantly increased worldwide. Other morbid conditions, such as diabetes and hypertension, are major risk factors for kidney disease. Detection of kidney disease is difficult due to its heterogeneity and complex pathophysiology. Kidney injury and advanced stages of the disease are currently assessed by traditional biomarkers such as serum creatinine, albuminuria, proteinuria and estimated glomerular filtration rate. Numerous biomarkers derived from the kidney involved in endothelial dysfunction, inflammatory processes and tubular cell damage are potential targets for disease progression management. The review summarized potential biomarkers of chronic kidney disease (CKD) to improve patient care in various clinical practices with an increased focus on loss of kidney function.

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肾脏衍生蛋白中慢性肾脏疾病进展的潜在生物标志物；评论

肾脏疾病的发病率和死亡率及其向终末期疾病的进展在世界范围内显著增加。其他疾病，如糖尿病和高血压，是肾脏疾病的主要危险因素。肾脏疾病由于其异质性和复杂的病理生理学而难以检测。肾损伤和疾病的晚期目前通过传统的生物标志物进行评估，如血清肌酐、蛋白尿、蛋白尿和估计的肾小球滤过率。来自肾脏的许多涉及内皮功能障碍、炎症过程和肾小管细胞损伤的生物标志物是疾病进展管理的潜在靶点。该综述总结了慢性肾脏疾病（CKD）的潜在生物标志物，以改善各种临床实践中的患者护理，并更加关注肾功能的丧失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.