The association between vitamin D3 deficiency and acute kidney injury in COVID-19 patients

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2023-01-22 DOI:10.34172/jrip.2022.32126

M. Arabi, H. Samimagham, Azadeh Moradkhani, Fatemeh Khajavi Mayvan, Sara Binaei, Ali Salimi Asl, Mitra Kazemi Jahromi

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引用次数: 0

Abstract

Introduction: Vitamin D deficiency is a common clinical finding in the general population and hospitalized patients, including patients in the intensive care unit (ICU). Acute kidney injury (AKI) occurs in more than 50% in ICU admitted patients. Objectives: There are few studies regarding AKI in COVID-19 patients, therefore we investigated the relationship between vitamin D3 deficiency and the occurrence of AKI in COVID-19 patients. Patients and Methods: This cross-sectional study was conducted on 69 COVID-19 patients who were hospitalized in the ward for 12 months. Their serum vitamin D3 levels were measured in the first 24 hours of hospitalization in the ward. Patients were divided into three groups based on the serum levels of vitamin D3: >50 ng/mL as normal, 20-50 ng/mL as insufficient and <20 ng/mL as deficiency status. The patients were studied until the occurrence of acute renal injury or the occurrence of death. Results: Out of 69 hospitalized patients in the ward with COVID-19, there were 39 patients in group vitamin D3<20 ng/mL, 21 patients in group vitamin D3 of 20-50ng/mL and 9 patients in group of vitamin D3>50 ng/mL. The frequencies of AKI in groups of vitamin D3<20 ng/mL, 20-50 ng/mL, and >50 ng/mL were 46%, 28%, and 23%, respectively. A significant relationship was observed between AKI and our study groups (P=0.011). Furthermore, there was a significant association between our study groups and mortality (P=0.014), ICU admission (P=0.041) and hospital length of stay (P=0.017). In another division in patients with different levels of vitamin D3 in the presence or absence of AKI, there were significant associations between patients with vitamin D3<20 ng/mL and the presence of AKI and also with mortality (P=0.042), ICU admission (P=0.024) and additionally with hospital length of stay (P=0.027). Conclusion: Our study showed significant association between vitamin D deficiency and AKI in ICU-admitted COVID-19 patients. Moreover, there were relationships between vitamin D deficiency and mortality, ICU admission and hospital length of stay. These results suggest the correction of vitamin D deficiency may be beneficial to reduce AKI in patient with COVID-19.

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COVID-19患者维生素D3缺乏与急性肾损伤的关系

引言：维生素D缺乏症在普通人群和住院患者中很常见，包括重症监护室（ICU）的患者。急性肾损伤（AKI）发生在50%以上的ICU患者中。目的：关于新冠肺炎患者AKI的研究较少，因此我们研究了维生素D3缺乏与新冠肺炎患者AKI发生之间的关系。患者和方法：这项横断面研究对69名在病房住院12个月的新冠肺炎患者进行。在病房住院的前24小时测量他们的血清维生素D3水平。根据血清维生素D3水平将患者分为三组：正常时＞50 ng/mL，不足时为20-50 ng/mL和50 ng/mL。维生素D350ng/mL组的AKI发生率分别为46%、28%和23%。AKI和我们的研究组之间存在显著关系（P=0.011）。此外，我们的研究小组与死亡率（P=0.014）、ICU入院率（P=0.041）和住院时间（P=0.017）之间存在显著关联，维生素D3＜20ng/mL的患者与AKI的存在以及死亡率（P=0.042）、入住ICU（P=0.024）和住院时间（P=0.027）之间存在显著相关性。结论：我们的研究表明，入住ICU的新冠肺炎患者维生素D缺乏与AKI之间存在显著关联。此外，维生素D缺乏与死亡率、ICU入院率和住院时间之间存在关系。这些结果表明，纠正维生素D缺乏可能有利于减少新冠肺炎患者的AKI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.