Journal of reconstructive microsurgery最新文献

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Angiosome-Guided Perfusion Decellularization of Fasciocutaneous Flaps. 血管造影剂引导的筋膜瓣灌注脱细胞术
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-27 DOI: 10.1055/a-2404-2608
Liya Yang, Xueshan Bai, Yuanbo Liu, Shanshan Li, Zixiang Chen, Tinglu Han, Shenyang Jin, Tingjun Xie, Danying Wang, Shuai Yue, Miao Wang, Shan Zhu, Mengqing Zang
{"title":"Angiosome-Guided Perfusion Decellularization of Fasciocutaneous Flaps.","authors":"Liya Yang, Xueshan Bai, Yuanbo Liu, Shanshan Li, Zixiang Chen, Tinglu Han, Shenyang Jin, Tingjun Xie, Danying Wang, Shuai Yue, Miao Wang, Shan Zhu, Mengqing Zang","doi":"10.1055/a-2404-2608","DOIUrl":"https://doi.org/10.1055/a-2404-2608","url":null,"abstract":"<p><p>Background Tissue engineering based on whole-organ perfusion decellularization has successfully generated small-animal organs, including the heart and limbs. Herein, we aimed to use angiosome-guided perfusion decellularization to generate an acellular fasciocutaneous flap matrix with an intact vascular network. Method Abdominal flaps of rats were harvested, and the vascular pedicle (iliac artery and vein) was dissected and injected with methylene blue to identify the angiosome region and determine the flap dimension for harvesting. To decellularize flaps, the iliac artery was perfused sequentially with 1% sodium dodecyl sulfate, deionized water, and 1% Triton-X100. Gross morphology, histology, and DNA quantity of flaps were then obtained. Flaps were also subjected to glycosaminoglycan and hydroxyproline content assays, as well as computer tomography angiography. Results Histological assessment indicated that cellular content was completely removed in all flap layers following 10-h perfusion in sodium dodecyl sulfate. DNA quantification confirmed 81% DNA removal. Based on biochemical assays, decellularized flaps had hydroxyproline content comparable with that of native flaps, although significantly fewer glycosaminoglycans (p = 0.0019). Histology and computed tomography angiography illustrated the integrity and perfusability of the vascular system. Conclusion The proposed angiosome-guided perfusion decellularization protocol could effectively remove cellular content from rat fasciocutaneous flaps and preserve the integrity of innate vascular networks.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevating Lower Extremity Reconstruction: An Algorithmic Approach to Free Flap Re-Elevation. 抬高下肢重建:游离皮瓣再抬高的算法方法。
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-27 DOI: 10.1055/a-2404-2759
Jessica Nye, David Mitchell, Michael Talanker, David Hopkins, Ellen Wang, Chioma G Obinero, Jose Barrera, Matthew R Greives, Yuewei Wu-Fienberg, Mohin A Bhadkamkar
{"title":"Elevating Lower Extremity Reconstruction: An Algorithmic Approach to Free Flap Re-Elevation.","authors":"Jessica Nye, David Mitchell, Michael Talanker, David Hopkins, Ellen Wang, Chioma G Obinero, Jose Barrera, Matthew R Greives, Yuewei Wu-Fienberg, Mohin A Bhadkamkar","doi":"10.1055/a-2404-2759","DOIUrl":"https://doi.org/10.1055/a-2404-2759","url":null,"abstract":"<p><strong>Background: </strong>Free flap (FF) reconstruction is frequently required for soft tissue coverage after significant orthopedic trauma of the lower extremity (LE). While usually the final step in limb salvage, re-elevation of the previously inset FF may be necessary to restore a functional limb. In this study, we present our algorithm for LE FF re-elevation and review our experience to identify factors associated with successful limb salvage and return to ambulation.</p><p><strong>Methods: </strong>A retrospective, single-institution review was conducted of adult patients with LE wounds who required FF reconstruction from 2016-2021. From this cohort, patients that required re-elevation of their LE FF were identified. Successful FF re-elevation was defined by limb salvage and return to ambulation.</p><p><strong>Results: </strong>During the study period, 412 patients with LE wounds required flap reconstruction. Of these patients, 205 (49.8%) underwent free tissue transfer, and 39 (9.5%) met our inclusion criteria. From this cohort, 34 had successful FF re-elevations, while 1 was non-weight bearing and 4 elected for amputation due to chronic complications unrelated to their FF. Univariate analysis revealed the total number of FF re-elevations (p < 0.001), the frequency of re-elevation indicated for orthopedic access (p < 0.001), and infections necessitating return to the operating room (p = 0.001) were each negatively associated with limb salvage and return to ambulation.</p><p><strong>Conclusion: </strong>The described algorithm highlights the preoperative planning and meticulous flap preservation necessary for the successful coverage of critical structures following FF re-elevation. Our data demonstrates that LE FFs can be safely re-elevated for hardware access or flap revision. In these complex cases of LE trauma, management by a multidisciplinary team is essential for successful limb salvage.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Resident and Attending Surgeon Training Level on Free Tissue Transfer Ischemia Time and Complications. 住院医师和主治外科医生的培训水平对游离组织转移缺血时间和并发症的影响
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-27 DOI: 10.1055/a-2404-7899
Brooke Elizabeth Porter, Thalia Anderson, Angela Ash, Sarah Elizabeth Langsdon, Leanna Zelle, Thomas Willson
{"title":"Impact of Resident and Attending Surgeon Training Level on Free Tissue Transfer Ischemia Time and Complications.","authors":"Brooke Elizabeth Porter, Thalia Anderson, Angela Ash, Sarah Elizabeth Langsdon, Leanna Zelle, Thomas Willson","doi":"10.1055/a-2404-7899","DOIUrl":"https://doi.org/10.1055/a-2404-7899","url":null,"abstract":"<p><strong>Background: </strong>Microsurgical free tissue transfer has become an essential method for reconstruction of complex surgical defects, making the level of training an important factor to consider. There is little published regarding the impact of training level on microsurgical outcomes. This study investigates microsurgical free tissue transfer ischemia time and post-operative complications based on resident and attending surgeon experience level.</p><p><strong>Methods: </strong>A retrospective review of all free flaps at a single institution from 1/1/2013 to 12/31/2021 was performed. Linear regression was performed analyzing ischemia time of 497 free flaps and attending surgeon experience defined by years in practice and resident level defined as post graduate year (PGY). Logistic regression model was used to analyze complications based on attending experience and resident level.</p><p><strong>Results: </strong>The average resident PGY was 3.5 +/- 0.8; the average attending has been practicing 6.4 +/- 5.1 years. There was no statistically significant difference in ischemia time or complication rates based on resident PGY or attending surgeon experience level.</p><p><strong>Conclusion: </strong>Lower PGY residents were not found to increase ischemia time or increase complication rates. Lower attending surgeon year was not found to increase ischemia time or increase complication rates compared to surgeons who had been practicing for longer. Microsurgical free tissue transfer is considered a safe procedure in residency training and trainee involvement should be encouraged to improve resident education and enhance technical skills.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transabdominal Robotic Harvest of Bilateral DIEP Pedicles in Breast Reconstruction: Technique and Interdisciplinary Approach. 经腹机器人采集双侧 DIEP椎弓根用于乳房重建:技术和跨学科方法。
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-27 DOI: 10.1055/s-0044-1788930
Daniel Murariu, Brian Chen, Elizabeth Bailey, William Nelson, Richard Fortunato, Stanislav Nosik, Andrea Moreira
{"title":"Transabdominal Robotic Harvest of Bilateral DIEP Pedicles in Breast Reconstruction: Technique and Interdisciplinary Approach.","authors":"Daniel Murariu, Brian Chen, Elizabeth Bailey, William Nelson, Richard Fortunato, Stanislav Nosik, Andrea Moreira","doi":"10.1055/s-0044-1788930","DOIUrl":"https://doi.org/10.1055/s-0044-1788930","url":null,"abstract":"<p><strong>Background: </strong> The deep inferior epigastric artery perforator (DIEP) flap is the gold standard for autologous breast reconstruction. However, the conventional procedure's anterior sheath division, from perforating vessels to the pedicle origin, risks weakening the abdominal wall's primary strength layer. Employing the da Vinci Xi Surgical System with indocyanine green dye and near-infrared fluorescence imaging, we refined a robotic technique for bilateral DIEP flap harvest. This approach enhances safety during vessel dissection, utilizing smaller fascial incisions. This study will present this technique in detail to microsurgeons interested in robotic DIEP flaps.</p><p><strong>Methods: </strong> In a retrospective cohort study spanning July 2021 to September 2022, female patients undergoing robotic bilateral DIEP flap reconstruction were analyzed. Following suprafascial flap dissection, the surgical robot was docked to target the pelvis, identifying and exposing deep inferior epigastric vessels intracorporeally. Mobilization and division occurred at their bases, with retrieval through a minimal anterior fascial incision, minimizing disruption to the abdominal wall and its motor innervation.</p><p><strong>Results: </strong> The study comprised 23 patients (46 flaps), with a mean fascial length of 4.1 cm and mean pedicle length of 12.82 cm. Mesh usage was absent. Robotic time averaged 139 minutes, overall case length was 739 minutes, and the average length of stay was 3.9 days. Notably, no pedicle or intra-abdominal injuries were reported.</p><p><strong>Conclusion: </strong> This technique ensures safe and efficient pedicle dissection in robotic DIEP flap harvests. Given the limited number of plastic surgeons adept in minimally invasive abdominal surgeries, we recommend collaborative efforts, with general surgeons initially assisting microsurgeons in adopting the robotic approach. This strategy facilitates a smooth transition until plastic surgeons attain confidence and competence in independent robotic dissection.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embracing Robotics in Microsurgery: Robotic-Assisted Deep Inferior Epigastric Perforator (DIEP) Flap Breast Reconstruction. 将机器人技术应用于显微外科:机器人辅助深下上腹部穿孔器(DIEP)皮瓣乳房重建术。
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-27 DOI: 10.1055/a-2404-2445
Joshua Choe, Christopher Aiello, Jina Yom, Raquel A Minasian, Gainosuke Sugiyama, Mark L Smith, Jesse Selber, Neil Tanna
{"title":"Embracing Robotics in Microsurgery: Robotic-Assisted Deep Inferior Epigastric Perforator (DIEP) Flap Breast Reconstruction.","authors":"Joshua Choe, Christopher Aiello, Jina Yom, Raquel A Minasian, Gainosuke Sugiyama, Mark L Smith, Jesse Selber, Neil Tanna","doi":"10.1055/a-2404-2445","DOIUrl":"https://doi.org/10.1055/a-2404-2445","url":null,"abstract":"<p><p>The integration of robotic-assisted surgery (RAS) has transformed various surgical disciplines, including more recently plastic surgery. While RAS has gained acceptance in multiple specialties, its integration in plastic surgery has been gradual, challenging traditional open methods. Robotic-assisted deep inferior epigastric perforator (DIEP) flap breast reconstruction is a technique aimed to overcome drawbacks associated with the traditional open DIEP flap approach. These limitations include a relatively large fascial incision length, potentially increasing rates of postoperative pain, abdominal bulge, hernia rates, and core weakening. The robotic-assisted DIEP flap technique emerges as an innovative and advantageous approach in fascial-sparing abdominal based autologous breast reconstruction. While acknowledging certain challenges such as increased operative time, ongoing refinements are expected to further improve the overall surgical experience, optimize results, and solidify the role of robotics in advancing reconstructive microsurgical procedures in plastic surgery. Herein, the authors provide an overview of robotic surgery in the context of plastic surgery and its role in the DIEP flap harvest for breast reconstruction.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computer-aided design and manufacturing to facilitate microvascular free tissue transfer in extremity, pelvic, and spinal reconstructions. 计算机辅助设计和制造,促进四肢、骨盆和脊柱重建中的微血管游离组织转移。
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-27 DOI: 10.1055/a-2404-7819
Alec D Simoni, Justin E Bird, Patrick Lin, Laurence D Rhines, Alexander F Mericli
{"title":"Computer-aided design and manufacturing to facilitate microvascular free tissue transfer in extremity, pelvic, and spinal reconstructions.","authors":"Alec D Simoni, Justin E Bird, Patrick Lin, Laurence D Rhines, Alexander F Mericli","doi":"10.1055/a-2404-7819","DOIUrl":"https://doi.org/10.1055/a-2404-7819","url":null,"abstract":"<p><strong>Background: </strong>Numerous surgical fields have embraced computer-aided design and computer-aided manufacturing (CAD/CAM), including plastic and reconstructive surgery. However, most of the literature and clinical use pertains to reconstruction of the head and neck. Herein we provide a case series and systematic review of the literature, documenting the use of CAD/CAM in facilitating complex microvascular free tissue transfer for reconstructions involving the extremities, pelvis, and spine (EPS).</p><p><strong>Methods: </strong>This study consisted of two components: a case series and a systematic review of the literature. For the case series, the senior author's cases that included CAD/CAM to assist microvascular free tissue transfer reconstructions of the EPS were included. For the systematic review, all PubMed, SCOPUS, and Google Scholar-indexed studies describing the use of CAD/CAM to facilitate free tissue transfer in the EPS were identified and included using PRSMA-guidelines.</p><p><strong>Results: </strong>The case series identified ten patients who received CAD/CAM assisted microvascular reconstruction. Our systematic review identified 15 articles, representing 124 patients and 133 CAD/CAM assisted free tissue transfers. Most authors believed that CAD/CAM facilitated a more efficient operation by shifting much of the intraoperative planning to the preoperative phase, ultimately translating to a shorter and more accurate surgery with improved function and cosmesis.</p><p><strong>Conclusions: </strong>CAD/CAM can be used to facilitate microvascular reconstruction of the extremities, pelvis, and spine. Our cases series and systematic review suggests that CAD/CAM for EPS surgery may improve outcomes.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Less Is More: The Role of Mesh in Microsurgical Breast Reconstruction with Abdominal Flaps. 少即是多:网片在腹部皮瓣显微外科乳房重建中的作用。
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-21 DOI: 10.1055/s-0044-1788929
Farrah C Liu, Daniel Najafali, Dung Nguyen, Arash Momeni
{"title":"Less Is More: The Role of Mesh in Microsurgical Breast Reconstruction with Abdominal Flaps.","authors":"Farrah C Liu, Daniel Najafali, Dung Nguyen, Arash Momeni","doi":"10.1055/s-0044-1788929","DOIUrl":"https://doi.org/10.1055/s-0044-1788929","url":null,"abstract":"<p><strong>Background: </strong> The use of mesh to reinforce the abdominal wall after abdominal flap harvest has been reported to decrease the risk of bulging and herniation. However, the impact of the plane of mesh placement in relation to the anterior rectus sheath (vs. no mesh) on postoperative abdominal complications remains unclear.</p><p><strong>Methods: </strong> We retrospectively analyzed the length of stay and clinical outcomes in 158 female patients who underwent breast reconstruction with 250 free abdominal flaps. Group 1 consisted of patients who underwent polypropylene sublay-onlay (\"sandwich\") mesh placement (<i>N</i> = 70) versus polypropylene sublay-only mesh (group 2; <i>N</i> = 54) versus primary fascial repair without mesh (group 3; <i>N</i> = 34).</p><p><strong>Results: </strong> Patient demographics and comorbidities were comparable between study groups, except for rates of neoadjuvant chemotherapy (group 1: 53% vs. group 2: 33% vs. group 3: 24% [<i>p</i> < 0.01]), postoperative follow-up in months (group 1: 21.5; group 2: 11.5; group 3: 7.6 [<i>p</i> < 0.01]), and length of stay in days (group 1: 4.9 vs. group 2: 4.4 vs. group 3: 3.3 [<i>p</i> < 0.01]). No differences were observed in breast flap and donor-site complications between study groups. Patients in group 3 required significantly lower oral morphine equivalent units postoperatively compared with those in groups 1 and 2 (group 1:185.5 vs. group 2: 79.7 vs. group 3: 71.6 [<i>p</i> < 0.01]).</p><p><strong>Conclusion: </strong> Abdominal donor-site closure without mesh was associated with a shorter length of stay and less narcotic intake without an increase in donor-site complications. These findings should be considered when deciding to place mesh for donor-site closure after abdominal flap harvest.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scar Decompression in Managing Breast Cancer-Related Lymphedema: Is it Needed? 治疗乳腺癌相关淋巴水肿的疤痕减压术:需要吗?
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-12 DOI: 10.1055/a-2371-4748
Emily R Finkelstein, Dylan Treger, Aziz Shittu, Kyle Y Xu, Juan Mella-Catinchi
{"title":"Scar Decompression in Managing Breast Cancer-Related Lymphedema: Is it Needed?","authors":"Emily R Finkelstein, Dylan Treger, Aziz Shittu, Kyle Y Xu, Juan Mella-Catinchi","doi":"10.1055/a-2371-4748","DOIUrl":"10.1055/a-2371-4748","url":null,"abstract":"<p><strong>Background: </strong> Mastectomy, axillary lymph node dissection, and irradiation for breast cancer commonly result in perivascular and axillary scarring. This scarring is thought to cause functional venous stenosis that leads to downstream venous hypertension in the affected extremity. Standard surgical practice is to decompress perivascular scarring at the time of physiologic lymphedema surgery in patients with breast cancer-related lymphedema (BCRL). However, it is unknown whether this scar release influences surgical outcomes. The purpose of this study was to evaluate the prevalence of functional venous stenosis in patients with BCRL and determine whether scar decompression is a necessary step in physiologic lymphedema surgery.</p><p><strong>Methods: </strong> The authors conducted a retrospective review of 64 patients with unilateral BCRL that presented to our lymphedema center between January 2020 and October 2022. Radiologist reports of venous duplex ultrasound for the bilateral upper extremities identified any disturbances in venous flow or indications of venous stenosis.</p><p><strong>Results: </strong> Of the 64 patients with BCRL, 78% (<i>n</i> = 50) had prior axillary lymph node dissection. Forty-seven (73%) patients completed ultrasound imaging, of which, one patient (2%) had venous stenosis in the affected lymphedematous extremity identified on duplex ultrasound that may have suggested functional scarring. Vascularized lymph node transfer (VLNT) without scar decompression was performed in six patients (9%). Average preoperative Lymphedema Life Impact Scale and Lymphedema Index scores were 35 and 19 units, with a mean decrease of 23 (67%) and 6 (30%) units postoperatively.</p><p><strong>Conclusion: </strong> Most patients with BCRL did not have identifiable functional venous stenosis on duplex ultrasound, apart from one patient with suspected postthrombotic changes. All six patients that received VLNT without scar decompression had a successful outcome with decreased measures of lymphedema postoperatively. Scar decompression may therefore be unnecessary in physiologic lymphedema surgery, reducing operative times and avoiding risk of injury to neurovascular structures of the axilla.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Porcine VCA Model Using an External Iliac Vessel-Based Vertical Rectus Abdominus Myocutaneous Flap. 利用基于髂外血管的腹直肌肌皮瓣开发猪 VCA 模型。
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-06 DOI: 10.1055/s-0044-1788812
Caitlin M Blades, Mark A Greyson, Zari P Dumanian, Jason W Yu, Yong Wang, Bing Li, Zhaohui Wang, Kia M Washington, Christene A Huang, Nalu Navarro-Alvarez, David W Mathes
{"title":"Development of a Porcine VCA Model Using an External Iliac Vessel-Based Vertical Rectus Abdominus Myocutaneous Flap.","authors":"Caitlin M Blades, Mark A Greyson, Zari P Dumanian, Jason W Yu, Yong Wang, Bing Li, Zhaohui Wang, Kia M Washington, Christene A Huang, Nalu Navarro-Alvarez, David W Mathes","doi":"10.1055/s-0044-1788812","DOIUrl":"https://doi.org/10.1055/s-0044-1788812","url":null,"abstract":"<p><strong>Background: </strong> Vascularized composite allotransplantation (VCA) involves transplanting a functional and anatomically complete tissue graft, such as a hand or face, from a deceased donor to a recipient. Although clinical VCA has resulted in successful outcomes, high rates of acute rejection and increased requirements for immunosuppression have led to significant long-term complications. Of note, immunosuppressed graft recipients are predisposed to infections, organ dysfunction, and malignancies. The long-term success of VCA grafts requires the discovery and implementation of unique approaches that avoid these complications altogether. Here, we describe our surgical technique and initial experience with a reproducible heterotopic porcine VCA model for the preclinical assessment of approaches to improve graft outcomes.</p><p><strong>Methods: </strong> Six heterotopic porcine allogeneic vertical rectus abdominis myocutaneous flap transplants were performed using Sinclair donors and Yucatan recipients. Immunosuppressive therapy was not used. Each flap was based on the left external iliac vessel system. Animals were followed postoperatively for surgery-related complications.</p><p><strong>Results: </strong> The six pigs underwent successful VCA and were euthanized at the end of the study. Each flap demonstrated complete survival following vessel anastomosis. For the allogeneic recipients, on average, minimal erythema and healthy flap color were observed from postoperative days 1 to 4. There were no surgery-related animal deaths or complications.</p><p><strong>Conclusion: </strong> We have developed a reproducible, technically feasible heterotopic porcine VCA model based on the left external iliac vessel system. Our results demonstrate this model's potential to improve VCA graft outcomes by exploring tolerance induction and rejection biomarker discovery in preclinical studies.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Era in Perforator Flap Surgery for Breast Reconstruction: A Comparative Study of Robotic versus Standard Harvest of Bilateral Deep Inferior Epigastric Artery Perforator Flaps. 用于乳房重建的打孔器皮瓣手术的新时代:双侧深腹下动脉穿孔瓣机器人与标准采集的比较研究。
IF 2.2 3区 医学
Journal of reconstructive microsurgery Pub Date : 2024-08-05 DOI: 10.1055/s-0044-1788642
Andrea Moreira, Elizabeth A Bailey, Brian Chen, William Nelson, Jenna Li, Richard Fortunato, Stanislav Nosik, Daniel Murariu
{"title":"A New Era in Perforator Flap Surgery for Breast Reconstruction: A Comparative Study of Robotic versus Standard Harvest of Bilateral Deep Inferior Epigastric Artery Perforator Flaps.","authors":"Andrea Moreira, Elizabeth A Bailey, Brian Chen, William Nelson, Jenna Li, Richard Fortunato, Stanislav Nosik, Daniel Murariu","doi":"10.1055/s-0044-1788642","DOIUrl":"https://doi.org/10.1055/s-0044-1788642","url":null,"abstract":"<p><strong>Background: </strong> Traditional deep inferior epigastric artery perforator (DIEP) flap harvest splits the anterior sheath, weakening the abdominal wall and predisposing patients to bulge or hernia. Abdominal wall morbidity may be decreased using minimally invasive techniques. We refined a transabdominal approach to the robotic harvest of bilateral DIEP flaps.</p><p><strong>Methods: </strong> A retrospective medical record study involving all patients who underwent bilateral or bipedicled robotic DIEP (rDIEP) or standard DIEP (sDIEP) flap harvest between July 2021 and September 2022. Outcomes included abdominal wall morbidity, total operative time, length of stay (LOS), and complications.</p><p><strong>Results: </strong> Forty-seven patients were included (48 sDIEP flaps, 46 rDIEP flaps) with no significant difference in patient characteristics. Fascial incision length in the rDIEP group was shorter (4.1 vs. 11.7 cm, <i>p</i> < 0.001). Mesh reinforcement of the abdominal wall was used in 13/24 sDIEP and none in rDIEP patients (<i>p</i> < 0.001). Operative time was longer in the rDIEP cohort (739 vs. 630 minutes, <i>p</i> = 0.013), although subanalysis showed no difference in the second half of the cohort. The average robotic dissection time was 135 minutes, which decreased significantly with the surgeon's experience. There were no intraoperative complications from using the robot. LOS was shorter with rDIEP but not statistically significant (3.9 vs. 4.3 days, <i>p</i> = 0.157).</p><p><strong>Conclusion: </strong> This study represents the most extensive cohort analysis of bilateral rDIEP flap harvest, offering a comprehensive comparison to traditional sDIEP. The initial results underscore the viability of robotic techniques for flap harvesting, highlighting potential advantages including reduced fascial incision length and decreased abdominal disruption. Furthermore, using robotics may obviate the necessity for fascial reinforcement with mesh.</p>","PeriodicalId":16949,"journal":{"name":"Journal of reconstructive microsurgery","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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