Journal of Orthopaedic Science最新文献

{"title":"Outcomes and complications after treatment for anteromedial facet fracture of the coronoid process: A systematic review","authors":"Du-Han Kim,&nbsp;Beom-Soo Kim,&nbsp;Ji-Hoon Kim,&nbsp;Chul-Hyun Cho","doi":"10.1016/j.jos.2023.11.002","DOIUrl":"10.1016/j.jos.2023.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Fracture of the anteromedial facet (AMF) of the coronoid process is associated with varus posteromedial rotatory instability (VPMRI). However, there is still controversy regarding the optimal treatment for AMF fracture. The purpose of this study is to report on a systematic review of the outcomes and complications after treatment for AMF fracture.</div></div><div><h3>Methods</h3><div>This study was conducted using electronic databases, PubMed, EMBASE and Scopus. Studies reporting outcome scores and complications were included. Studies that did not utilize O'Driscoll classification for AMF fractures were excluded. Through conduct of a thorough review of included studies, definite VPMRI were identified and cases involving other injury mechanisms were excluded.</div></div><div><h3>Results</h3><div><span>Fifteen articles reporting on 246 patients were included. According to O'Driscoll classification, 6.2% of cases were anteromedial subtype I, 73.7% were subtype II, and 20.1% were subtype III. Two-hundred sixteen patients (87.8%) were treated surgically and 30 patients (12.2%) were treated conservatively. Lateral collateral ligament<span><span> (LCL) injuries were 76.2% (157/206) and medial collateral ligament injuries were 16.9% (33/195). Among 216 cases who underwent surgical treatment, depending on the fragment size, displacement, and instability, coronoid fixation was performed in 189 cases and LCL repair alone was performed in 27 cases. The mean final </span>Mayo Elbow Performance Score was 92.1 and the Broberg &amp; Morrey score was 89.5. The overall complication and </span></span>reoperation rates were 17.7% (41/232) and 12.9% (26/202).</div></div><div><h3>Conclusions</h3><div>Both surgical and conservative treatment for AMF fractures resulted in satisfactory final clinical outcomes. However, high complication and reoperation rates were observed.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1489-1495"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72209758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital skin defect management: Hand and wrist volar flap solutions","authors":"Takuya Tsumura ,&nbsp;Taiichi Matsumoto ,&nbsp;Toshihide Imanaka ,&nbsp;Hiromu Ito","doi":"10.1016/j.jos.2023.11.009","DOIUrl":"10.1016/j.jos.2023.11.009","url":null,"abstract":"<div><h3>Background</h3><div>Selecting the optimal flap for managing digit skin defects is challenging, particularly for inexperienced surgeons, given the numerous reconstructive options and insufficient evidence supporting one flap type's superiority over another. This retrospective study introduces four efficacious hand flaps to address volar skin defects and transverse and oblique cuts, examines the optimal flap advancement distance, and discusses effective management.</div></div><div><h3>Methods</h3><div><span>Patients with digit skin defects who underwent flap surgery between 2009 and 2022 were included. Fifty-four patients treated with oblique triangular, volar VY advancement (unilateral and bilateral pedicled volar VY advancement flaps for fingers and thumbs, respectively), reverse homodigital island, and </span>radial artery superficial palmar branch flaps were included. We evaluated the flap advancement distance, flap length, range of motion, complications, and Semmes–Weinstein monofilament test and Disabilities of the Arm, Shoulder, and Hand questionnaire results.</div></div><div><h3>Results</h3><div><span>The median flap advancement distances for triangular oblique (19 patients), unilateral (11 patients), and bilateral pedicled (5 patients) volar VY advancement flaps were 1.3, 1.8, and 2.0 cm, respectively. The flap lengths for the reverse digital island (8 patients) and radial artery superficial palmar branch (11 patients) flaps were 2.4 and 5.0 cm, respectively. Five, three, and one cases of proximal interphalangeal flexion contractures of ≥ -20° were observed in the VY advancement, reverse digital island, and radial artery superficial palmar branch flaps, respectively. One unilateral VY advancement flap case caused severe numbness and </span>neuroma. All complication cases featured &gt;15 and &gt; 20 mm defect lengths on the fingers and thumb, respectively.</div></div><div><h3>Conclusions</h3><div>To minimize sensory disruption and contractures, we recommend oblique triangular and unilateral pedicle volar VY advancement flaps for finger skin defects up to 12 mm and defects sized 12–15 mm, respectively. Advancement flaps are unsuitable for &gt;15 and &gt; 20–25 mm defects on the fingers and thumb, respectively.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1395-1400"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the microstructural and mechanical qualities of semitendinosus tendon grafts between skeletally immature and mature patients in anterior cruciate ligament reconstruction","authors":"Kazuki Asai ,&nbsp;Junsuke Nakase ,&nbsp;Toru Kuzumaki ,&nbsp;Tatsuya Ishikawa ,&nbsp;Noriyuki Ozaki ,&nbsp;Hiroyuki Tsuchiya","doi":"10.1016/j.jos.2023.11.004","DOIUrl":"10.1016/j.jos.2023.11.004","url":null,"abstract":"<div><h3>Background</h3><div><span>This study aimed to investigate the microstructural and mechanical properties of semitendinosus tendon graft tissues during </span>anterior cruciate ligament reconstruction and the clinical outcomes in skeletally immature and mature patients.</div></div><div><h3>Methods</h3><div>Twenty-two patients who underwent primary anterior cruciate ligament reconstruction<span><span><span> using a hamstring tendon graft were analyzed and divided into skeletally immature (n = 7) and mature groups (n = 15) based on magnetic resonance imaging findings of the </span>epiphyseal plate<span> of the distal femur. Tissue samples were collected from the mid-portion of the semitendinosus tendon. The </span></span>collagen fibril diameter, maximum stress, and strain at maximum stress point in the semitendinosus tendon tissues were calculated for comparison of the microstructural and mechanical properties between the two groups. Postoperative outcomes were also assessed between the two groups.</span></div></div><div><h3>Results</h3><div>The mean and 60th and 80th percentiles of fibril diameters in the skeletally immature group were significantly smaller than those in the mature group (65.9 ± 13.0, 73.5 ± 19.3, and 91.3 ± 27.4 nm in the skeletally immature group; and 90.3 ± 14.7, 94.0 ± 18.4, and 125.3 ± 19.9 nm in the skeletally immature group; p = 0.001, 0.024, and 0.004, respectively). Additionally, the strain at maximum stress was higher in the skeletally immature group (237.2 ± 102.4% vs. 121.5 ± 51.9%, p = 0.024). However, there was no difference in maximum stress between the skeletally immature and mature groups (19.9 ± 14.3 MPa vs. 24.5 ± 23.4 MPa, p = 0.578). Strain was negatively correlated with the mean fibril diameter and the 60th and 80th percentiles of fibril diameters, whereas stress was positively correlated with the mean fibril diameter. The skeletally immature group had a higher pivot shift test-positive rate than the mature group at the last follow-up (p = 0.023).</div></div><div><h3>Conclusion</h3><div>Semitendinosus tendon graft tissues differed microstructurally and mechanically between skeletally immature and mature patients.</div></div><div><h3>Level of evidence</h3><div>Level Ⅳ</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1430-1437"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138176442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip joint stress distribution changes depending on three-dimensional pelvic orientation: Finite-element analysis","authors":"Yumiko Ojima ,&nbsp;Yusuke Matsuura ,&nbsp;Sei Yano ,&nbsp;Seiji Ohtori","doi":"10.1016/j.jos.2023.11.015","DOIUrl":"10.1016/j.jos.2023.11.015","url":null,"abstract":"<div><h3>Background</h3><div>Pelvis experiences changes in its orientation due to the alignment of the hip joint and spine, and its orientation might affect both joints. Pelvic tilt on the sagittal plane has been widely discussed; however, the pelvis is oriented also on the coronal and horizontal planes. This study aimed to examine how stress distribution on intact hip joint changes under the three-dimensional pelvic orientation.</div></div><div><h3>Methods</h3><div>Computed tomography<span> data of five patients with unilateral pelvic girdle<span> were analyzed. Thirteen models were evaluated by the MECHANICAL FINDER: neutral position at 0°; 10° and 20° anterior and posterior pelvic tilt; 10° and 20° pelvic hike and drop; 10° and 20° pelvic forward and backward rotation. Stress assessment was performed in four parts of the acetabulum: anterosuperior, posterosuperior, posteroinferior, and central parts.</span></span></div></div><div><h3>Results</h3><div>Compared with the neutral position, the mean value of the equivalent stress and maximum principal stress in the anterosuperior part significantly increased by 1.51 times and 1.57 times at 20° posterior tilt, respectively. The maximum principal stress in the anterosuperior part significantly increased by 1.44 times at 20° hike. A significant increase of 1.45 times was found in the maximum principal stress in the anterosuperior part at 20° forward rotation.</div></div><div><h3>Conclusions</h3><div>Local stress accumulated in the anterosuperior acetabulum at the posterior pelvic tilt, pelvic hike, and pelvic forward rotation, which might lead to hip overload. The effect of posterior pelvic tilt appears to be greater for the hip joint than at the pelvic hike or forward rotation.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1462-1468"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior gluteal artery injury in pelvic ring injury and acetabular fracture: Single center observational study","authors":"Hoon Kwon ,&nbsp;Jae Hoon Jang ,&nbsp;Nam Hoon Moon ,&nbsp;Seung Joon Rhee ,&nbsp;Dong Yeon Ryu ,&nbsp;Tae Young Ahn","doi":"10.1016/j.jos.2023.10.007","DOIUrl":"10.1016/j.jos.2023.10.007","url":null,"abstract":"<div><h3>Background</h3><div><span><span><span><span>Intrapelvic hemorrhage following pelvic fractures, including pelvic ring and </span>acetabular fractures, originates from the </span>venous system and the fracture. </span>Arterial injury often causes significant bleeding and </span>hemodynamic instability. The superior gluteal artery (SGA) is a frequently injured artery in patients with pelvic fractures. This study investigated the incidence and pattern of SGA injuries associated with pelvic fractures.</div></div><div><h3>Methods</h3><div><span>We retrospectively reviewed the medical records<span> of patients with pelvic fractures who visited our institution between January 2016 and April 2022. Patients who underwent angiography for suspected arterial injury and </span></span>SGA embolization were identified. Furthermore, the demographics and patterns of pelvic fractures were evaluated.</div></div><div><h3>Results</h3><div>In total, 2042 patients with pelvic fractures visited our trauma emergency department<span> and 498 patients (24.4%) underwent embolization for arterial injuries. Of these, 30 patients (1.5% of the total and 6.0% of the patients who underwent procedures) received embolization therapy of the main trunk of the SGA. The mean age of patients was 51.2 (23–85 years), and the injury mechanisms were all high-energy injuries. There were 19 pelvic ring injuries, eight acetabular fractures, and three combined injuries. Acetabular fractures involved mostly both columns. The three combined injuries were lateral compression involving both columns, vertical shear involving both columns, and lateral compression with T-type fractures. Twelve (40.0%) occurred through the sciatic notch of different patterns.</span></div></div><div><h3>Conclusions</h3><div>SGA injury occurred in 1.5% of all pelvic fractures and was identified in 6% of patients receiving embolization. SGA injury occurs through various injury mechanisms and fracture patterns, even in the absence of a fracture in the sciatic notch. However, no conclusions could be drawn in this study on the association between SGA injuries, injury mechanisms, and fracture patterns. Since the prediction of SGA injury by fracture pattern is limited, angiography should be performed regardless of fracture pattern when an injury is suspected.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1483-1488"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The survey of bone allograft transplantation in a Japanese regional bone bank","authors":"Takamune Asamoto ,&nbsp;Yusuke Osawa ,&nbsp;Yasuhiko Takegami ,&nbsp;Genta Takemoto ,&nbsp;Daigo Komatsu ,&nbsp;Taisuke Seki ,&nbsp;Shiro Imagama","doi":"10.1016/j.jos.2023.11.001","DOIUrl":"10.1016/j.jos.2023.11.001","url":null,"abstract":"<div><h3>Background</h3><div>In reconstructive surgery<span><span> for large bone defects, the demand for </span>bone allografts<span> has increased over the years; however, it is unclear how the supply and demand in Japanese regional bone banks have evolved over time. This study investigated the 15-year supply and demand of bone allografts stored in a regional bone bank, along with assessing the screening process's effectiveness.</span></span></div></div><div><h3>Methods</h3><div>The target period was 15 years from April 2005 to March 2020. The period was subdivided into three 5-year periods: first, second, and third. The study items included the number of bone allografts donated, the number of bone allografts used, donor and user facilities, surgical methods using bone allografts, and the number of bone allografts discarded. We used the Cochran-Armitage test for statistical analysis.</div></div><div><h3>Results</h3><div>A total of 1852 bone allografts were donated to the bone bank, and a total of 1721 were used. A total of 677 bone allografts grafts were provided in the first period, 738 in the second period, and 525 in the third period, indicating a decreasing trend. The average number of allografts per surgery was 2.8 in the first, 3.1 in the second, and 1.7 in the third, showing a decreasing trend. Concerning the percentage of each surgery using bone allografts, spine fusion<span> decreased in the third period but not significantly, whereas primary hip arthroplasty increased significantly in the third period. The total number of discarded bone allografts was 4.8% of the total number of donated bone allografts, largely because of a lack of screening tests.</span></div></div><div><h3>Conclusion</h3><div>Although the number of allogeneic bone surgeries has been increasing over time, the number of allogeneic bone donations has shown a decreasing trend, and there is a need to develop a system that can provide surgeons with sufficient bone allografts.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1528-1533"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89718748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral ulnar collateral ligament reconstruction enhancing secondary stabilizers in chronic PLRI of the elbow provides good to excellent clinical results with no recurrent instability","authors":"Nikolay Dimitrov,&nbsp;Tsvetan Tsenkov","doi":"10.1016/j.jos.2023.11.013","DOIUrl":"10.1016/j.jos.2023.11.013","url":null,"abstract":"<div><h3>Purpose</h3><div>The adopted treatment for chronic elbow PLRI is lateral ulnar collateral ligament reconstruction. However, the most frequently reported complication after primary reconstruction is recurrent instability – up to 25 %. It was thus hypothesized that enhancing the secondary stabilizers will provide successful results with a lower rate of recurrent instability in comparison to techniques with primary reconstruction only. This study aimed to demonstrate a novel surgical technique involving secondary stabilizers.</div></div><div><h3>Methods</h3><div>In this retrospective study of 29 cases with chronic PLRI the mean duration of symptoms was 39.6 ± 4.9 months. The mean age was 47.9 years with mainly male patients. The surgeries were performed by one senior surgeon at a single institution. The Mayo Elbow Performance Score (MEPS) and the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH) were recorded.</div></div><div><h3>Results</h3><div>The mean follow-up was 36.8 ± 7.7 months. The MEPS score improved significantly from 59.8 ± 13.1 to 84.7 ± 7.6 (p &lt; 0.001). 23/29 patients (79.2 %) had converted to good and excellent results (MEPS &gt;75 points). The DASH score improved from 40.8 ± 4.6 to 20.9 ± 7.2 (p &lt; 0.001). The total complication rate was 10.3 % (N = 3). No recurrent instability was recorded in comparison to 12.2 % for primary reconstruction only, as reported in the literature (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Enhancing the secondary stabilizers by utilizing an adjacently located autograft provided good and excellent results with no recurrent instability. This novel surgical procedure is easy to reproduce and provides a safe and reliable alternative in cases of chronic PLRI when compared to techniques with primary reconstruction only.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1401-1405"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wrong-level spine surgery: A multicenter retrospective study","authors":"Ryohei Saito ,&nbsp;Shunsuke Fujibayashi ,&nbsp;Takayoshi Shimizu ,&nbsp;Koichi Murata ,&nbsp;Bungo Otsuki ,&nbsp;Eijiro Onishi ,&nbsp;Shuichi Matsuda ,&nbsp;Tadashi Yasuda","doi":"10.1016/j.jos.2023.11.005","DOIUrl":"10.1016/j.jos.2023.11.005","url":null,"abstract":"<div><h3>Background</h3><div>Wrong-level spine surgery is a rare but serious complication of spinal surgery that increases patient harm and legal risks. Although such surgeries have been reported by many spine surgeons, they have not been adequately investigated. Therefore, this study aimed to examine the causes and preventive measures for wrong-level spine surgeries.</div></div><div><h3>Methods</h3><div>This study analyzed cases of wrong-level spine surgeries from 10 medical centers. Factors such as age, sex, body mass index, preoperative diagnosis, surgical details, surgeon’s experience, anatomical variations, responses, and causes of the wrong-level spine surgeries were studied. The methods used by the surgeons to confirm the surgical level were also surveyed using a questionnaire for each surgical procedure and site.</div></div><div><h3>Results</h3><div>Eighteen cases (13 men and 5 women; mean age, 61.2 years; mean body mass index, 24.5 kg/m²<span>) of wrong-level spine surgeries were evaluated in the study. Two cases involved emergency surgeries, three involved newly introduced procedures, and five showed anatomical variations. Wrong-level spine surgeries occurred more frequently in patients who underwent posterior thoracic surgery<span> than in those who underwent other techniques (p &lt; 0.01). Twenty-two spinal surgeons described the methods used to confirm the levels preoperatively and intraoperatively. In posterior thoracic laminectomies<span>, half of the surgeons used preoperative markers to confirm the surgical level and did not perform intraoperative fluoroscopy. In posterior thoracic fusion, all surgeons confirmed the level using fluoroscopy preoperatively and intraoperatively.</span></span></span></div></div><div><h3>Conclusions</h3><div><span>Wrong-level spine surgeries occurred more frequently in posterior thoracic surgeries. The thoracic spine<span> lacks the anatomical characteristics observed in the cervical and lumbar spine. The large drop in the </span></span>spinous process<span> can make it challenging for surgeons to determine the positional relationship between the spinous process and the vertebral body. Moreover, unfamiliarity with the technique and anatomical variations were also risk factors for wrong-level spine surgeries.</span></div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1359-1363"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating miRNA-122 is associated with knee osteoarthritis progression: A 6-year longitudinal cohort study in the Yakumo study","authors":"Hiroto Funahashi ,&nbsp;Yasuhiko Takegami ,&nbsp;Yusuke Osawa ,&nbsp;Hiroaki Nakashima ,&nbsp;Shinya Ishizuka ,&nbsp;Ryosuke Fujii ,&nbsp;Hiroya Yamada ,&nbsp;Koji Suzuki ,&nbsp;Yukiharu Hasegawa ,&nbsp;Shiro Imagama","doi":"10.1016/j.jos.2023.10.004","DOIUrl":"10.1016/j.jos.2023.10.004","url":null,"abstract":"<div><h3>Objective</h3><div><span><span>The association between knee osteoarthritis (OA) and </span>miRNAs<span> has been widely reported. However, the utility of miRNAs<span> as predictors of knee osteoarthritis (KOA) progression in longitudinal studies has not been reported. We aimed to identify </span></span></span>circulating miRNAs (c-miRNAs) associated with KOA progression in the general population and to examine their potential use as predictors of KOA progression.</div></div><div><h3>Methods</h3><div><span>In 2012 and 2018, 66 participants (128 knees) took part in a resident health check-up in the Yakumo study. If the KL classification progressed two or more levels, the patient was classified as having progressive OA<span>. Quantitative real-time polymerase chain reaction was used to screen 21 c-miRNAs. The expression levels of those c-miRNAs were compared between the progressive OA group and non-progressive OA group using student-t-test. Logistic analysis was performed in c-miRNAs less than p &lt; 0.10 in </span></span>univariate analysis.</div></div><div><h3>Results</h3><div><span>The progressive OA group consisted of 78 knees. The results of the comparison between the progressive OA group and the non-progressive OA group showed that six c-miRNAs as follows; let7d (p = 0.030), c-miRNA-122 (p &lt; 0.001), 150 (p = 0.070), 199 (p = 0.078), 21 (p = 0.016) and 320 (p = 0.093) were extracted as factors related to the progression of knee OA. In addition, </span>logistic regression analysis identified c-miRNA-122 as an independent factor involved in the progression of knee osteoarthritis (odds ratio: 1.510, 95% confidence interval: 1.060–2.140, p = 0.023). The ROC curve showed by c-miRNA-122 for the progression of OA risk had an area under the curve of 0.702 (95% CI: 0.609–0.795). The threshold of c-miRNA-122 was −4.609.</div></div><div><h3>Conclusion</h3><div>The expression level of c-miRNA-122 was associated with the risk of KOA progression in community dwelling Japanese people.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1411-1416"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of back pain in patients with adolescent idiopathic scoliosis: Considerations in candidates for corrective surgery","authors":"Yuta Kusabe ,&nbsp;Toru Hirano ,&nbsp;Ren Kikuchi ,&nbsp;Masayuki Ohashi ,&nbsp;Hideki Tashi ,&nbsp;Yohei Shibuya ,&nbsp;Tatsuo Makino ,&nbsp;Kazuhiro Hasegawa ,&nbsp;Naohito Tanabe ,&nbsp;Kei Watanabe","doi":"10.1016/j.jos.2023.11.014","DOIUrl":"10.1016/j.jos.2023.11.014","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have demonstrated that the point prevalence of back pain<span><span> ranges from 12 % to 33 % and that the lifetime prevalence of back pain ranges from 28 % to 51 % in adolescents. However, few studies on back pain in patients with </span>Adolescent idiopathic scoliosis (AIS) have been conducted, and these studies had significant limitations, including a lack of comparative controls and detailed information about scoliotic deformity or pain location. This study aimed to determine whether adolescents with AIS experience back pain in specific regions.</span></div></div><div><h3>Methods</h3><div><span>This retrospective case-control study included 189 female adolescents with AIS who underwent corrective fusion from 2008 to 2020. Questionnaires on back pain and health-related quality of life (HRQOL) using the </span>Scoliosis Research Society Outcomes Instrument-22 (SRS-22) were conducted preoperatively. The control group included 2909 general female adolescents.</div></div><div><h3>Results</h3><div>The mean Cobb angles in the main thoracic and thoracolumbar/lumbar curves were 51.4 ± 15.3° and 40.4 ± 12.9°. Back pain characteristics included higher point prevalence (25.9 %) and lifetime prevalence (64.6 %) compared to healthy controls. Adolescents with back pain showed lower scores in the pain and mental health domains of the SRS-22. Adolescents with major thoracic AIS showed more back pain in the upper and middle right back compared to adolescents with major thoracolumbar/lumbar AIS.</div></div><div><h3>Conclusion</h3><div>The point and lifetime prevalence of back pain were definitely higher in patients with AIS, which affected their HRQOL. There was a relationship between pain around the right scapula and the right major thoracic curve with a rib hump deformity.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1364-1369"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}