Journal of Raman Spectroscopy最新文献

{"title":"Serum Raman Spectroscopy Explorations in Canine Cancers: A Pilot Study","authors":"Panchali Saha,&nbsp;Debosmita Goswami,&nbsp;Arti Hole,&nbsp;Kiran Bendale,&nbsp;Pradip Chaudhari,&nbsp;C. Murali Krishna","doi":"10.1002/jrs.6760","DOIUrl":"https://doi.org/10.1002/jrs.6760","url":null,"abstract":"<div>\u0000 \u0000 <p>The examination of canine cancers has garnered substantial attention in recent years. This is primarily because of the parallel between dogs and humans in the development of spontaneous cancers without the need for experimental induction, unlike in laboratory rodents. Numerous studies have explored the utility of canine subjects in the advancement of our understanding of cancers, recognizing their potential as valuable natural models. A particularly noteworthy diagnostic tool in this context is serum Raman spectroscopy (RS), a method known for its minimally invasive, label-free, rapid, and objective nature, with a wide range of applications that extends to various diseases, including cancer. In this study, serum RS was explored for canine cancers, potentially offering a novel approach to the field of veterinary oncology. This investigation included 12 healthy dogs (C) and 38 companion dogs afflicted with an array of malignancies (T), including 18 carcinomas, 9 sarcomas, 3 head and neck tumors, 2 mast cell tumors, and 1 venereal granuloma. Serum was separated from the blood samples collected and subjected to RS, followed by spectral preprocessing and multivariate analyses. Multivariate curve resolution-alternating least squares revealed alterations in nucleic acids, lipids, and proteins among the groups. Principal component-based linear discriminant analysis (PC-LDA) results demonstrated correct identification of 73% of the C and 87% of the T samples. The outcomes of this study highlight the efficacy of serum RS in the detection of canine cancers. Comprehensive large-scale studies involving diverse cancer types are imperative to validate findings.</p>\u0000 </div>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 4","pages":"301-306"},"PeriodicalIF":2.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Exosome SERS Assay Based on TiN-Ag@Ag Sol Composite Substrate and Its Application in the Diagnosis of Gastric Cancer","authors":"Huan Wang,&nbsp;Zhengang Wu,&nbsp;Yingna Wei,&nbsp;Ying Chen,&nbsp;Xiao jie An,&nbsp;Jingwu Li,&nbsp;Zhiwu Wang,&nbsp;Yankun Liu,&nbsp;Hengyong Wei","doi":"10.1002/jrs.6767","DOIUrl":"https://doi.org/10.1002/jrs.6767","url":null,"abstract":"<div>\u0000 \u0000 <p>Gastric cancer (GC) is a highly lethal malignancy, seriously threatening people's physical health. Accurate screening of gastric cancer could improve the survival rate of patients. Therefore, exploring noninvasive and efficient cancer screening methods for gastric cancer is of great significance. In the past few years, exosomes have received much attention for their potential in disease diagnosis and treatment. Here, the aim of this study was to explore the detection of serum exosomes via surface-enhanced Raman spectroscopy (SERS) technique based on TiN-Ag@Ag sol composite substrate, and its potential application in gastric cancer diagnosis is evaluated. Exosomes were extracted from the serum of 31 GC patients and 31 healthy controls (HC) using an exosome kit. This study used various machine learning algorithms such as principal component analysis linear discriminant analysis (PCA-LDA), partial least squares discriminant analysis (PLS-DA), support vector machine (SVM), and k-nearest neighbor (KNN) algorithm to analyze SERS spectra, in order to distinguish between HC and GC. The results show that the k-nearest neighbor algorithm performs the best in HC and GC classification. These results indicate that the combination of SERS and machine learning methods provides a new technological approach for gastric cancer screening. This study offers a new proposal for the universal applicability of analysis and identification with SERS of serum exosomes samples in clinical diagnosis.</p>\u0000 </div>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 4","pages":"307-315"},"PeriodicalIF":2.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoiding Overestimation and the ‘Black Box’ Problem in Biofluids Multivariate Analysis by Raman Spectroscopy: Interpretation and Transparency With the SP-LIME Algorithm","authors":"Lyudmila A. Bratchenko,&nbsp;Ivan A. Bratchenko","doi":"10.1002/jrs.6764","DOIUrl":"https://doi.org/10.1002/jrs.6764","url":null,"abstract":"<div>\u0000 \u0000 <p>Raman spectroscopy, in combination with multivariate analysis, is a powerful analytical tool for solving regression and classification problems in various fields—from materials science to clinical practice. However, in practical applications, experimental studies and the implementation of Raman spectroscopy present numerous challenges, including multicollinearity in spectral data and the ‘black box’ problem of complex analytical models. To avoid these problems, the proposed classification and regression models require proper interpretation. This study makes use of a comparative analysis of explanation methods based on the SP-LIME (local interpretable model-agnostic explanations with submodular pick) algorithm of a bilinear model (projection onto latent structures [PLS]) and a nonlinear model (one-dimensional convolutional neural network [CNN]). The models to be interpreted are trained to solve the regression task of the blood serum Raman characteristics and the urea levels. Effective SP-LIME evaluation of the blood Raman spectra revealed that in urea analysis for both PLS and CNN models, the important band is at 1003 cm⁻¹. This approach is based on the value of the root mean square error estimation only when a single Raman band is analyzed. The aim of this paper is to develop an approach to explain the operation of the analytical models and provides the way to reveal the exact Raman bands with the biggest impact on the model performance.</p>\u0000 </div>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 4","pages":"353-364"},"PeriodicalIF":2.4,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-Site Raman and XRF Study of Complex Metal Patinas and Cloisonné Enamels From 19th-Century Christofle Masterpieces: Technological Study of the Decoration Techniques","authors":"Julie Schröter,&nbsp;Philippe Colomban,&nbsp;Michel Bouchard,&nbsp;Ludovic Bellot-Gurlet,&nbsp;Audrey Gay-Mazuel","doi":"10.1002/jrs.6761","DOIUrl":"https://doi.org/10.1002/jrs.6761","url":null,"abstract":"<p>A major effort in technological development was conducted during the 19th century. The polychrome surfaces of the metal parts of a corner cabinet, a torch vase, an “elephant” vase, and a candelabra pair designed by Emile Reiber between 1874 and 1878 for the Christofle &amp; Cie Company were investigated on site by means of noninvasive Raman, FTIR, and X-ray fluorescence spectroscopy after examination under white light at different magnifications and under UV illumination. Despite the low thickness of the patinas (a few tens of microns) different (electro)chemically formed phases were identified in these layers (Cu₂O, Ag₂S, CuS or Cu₂S, and sulfates). Residues of organic conservation products are identified by FTIR reflectance. The results are compared with the information available in the patents filed by the company as well as other written sources from that period. The pigments and opacifiers (Naples yellows, lead arsenates, fluorite, spinels, cassiterite, and chromates), and the vitreous matrices of the cloisonné enamels of the objects above are identified and testify to the deliberate combination of European and Asian enameling techniques.</p>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 3","pages":"243-261"},"PeriodicalIF":2.4,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jrs.6761","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Assessment of Tablet Quality Based on Raman Spectroscopy Analysis: Investigating the Effect of Storage Conditions on the Degradation of Active Pharmaceutical Ingredient (API) of Acetaminophen Tablet","authors":"M. Keshavarz Mohammadian,&nbsp;S. H. Tavassoli,&nbsp;S. Karimi","doi":"10.1002/jrs.6757","DOIUrl":"https://doi.org/10.1002/jrs.6757","url":null,"abstract":"<div>\u0000 \u0000 <p>The effectiveness and safety of drugs may be compromised by the degradation of APIs during preparation processes or after they have been released to market. This study has investigated the degradation of 500-mg Acetaminophen tablet (C₈H₉NO₂) when stored under unfavorable conditions such as increased temperature and high levels of humidity. To quantify the amount of API, the Raman intensity variations of characteristic peaks of API and polyvinylpyrrolidone (PVP) (C₆H₉NO) are explored. By considering various sources of error in all experiments, the reliability of the extracted data set from Raman spectrums and the quality of results obtained using the utilized technique for predicting API is investigated at standard room temperature. The results demonstrate an acceptable precision in the range of pharmacopeia monograph. Then, the effect of temperature and humidity variations on the amount of API is investigated based on the related Raman spectra. The results show that the API's quantity starts to decrease after about 60 min at the temperature of 45°C ± 2°C and the relative humidity (RH) of 75% ± 2%. According to our results, when tablets are kept under the unfavorable conditions, the degradation pattern of API follows a logarithmic trend.</p>\u0000 </div>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 3","pages":"278-285"},"PeriodicalIF":2.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Identification of Candida auris by Raman Spectroscopy Combined With Deep Learning","authors":"S. Kiran Koya,&nbsp;Michelle A. Brusatori,&nbsp;Sally Yurgelevic,&nbsp;Changhe Huang,&nbsp;Jake DeMeulemeester,&nbsp;Danielle Percefull,&nbsp;Hossein Salimnia,&nbsp;Gregory W. Auner","doi":"10.1002/jrs.6763","DOIUrl":"https://doi.org/10.1002/jrs.6763","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Candida</i> auris is a multidrug-resistant yeast that can lead to outbreaks in healthcare facilities, even with strict infection prevention and control measures. <i>Candida auris</i> detection is challenging using standard laboratory methods. Advancements in identification methods, such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and polymerase chain reaction, have improved detection, though these methodologies can be costly and impractical in resource-limited settings. This study presents a practical, portable, and reagentless platform known as Counter-Propagating Gaussian Beam Raman Spectroscopy (CPGB-RS), integrated with deep learning spectral analysis for the rapid and accurate identification of <i>C. auris</i>. This method has shown a sensitivity of 96% and a specificity of 99% in differentiating <i>C. auris</i> from other highly prevalent pathogenic species, such as <i>Candida albicans</i>, <i>Candida glabrata</i>, and <i>Candida tropicalis</i>. The differentiation between species is based on unique variations in their Raman spectra, influenced by differences in cell wall composition (including β-glucan, chitin, and mannoprotein), cell membrane components (like ergosterol), and cellular energy states (mitochondrial cytochromes b and c). This platform allows for automated molecular screening, generating diagnostic results within 2 min, making it highly practical for clinical applications. Furthermore, this technology has the potential to evaluate the effectiveness of antifungal agents, which could significantly improve patient outcomes.</p>\u0000 </div>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 3","pages":"218-227"},"PeriodicalIF":2.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Material Profiling of Mesopotamian Cylinder Seals by Raman Spectroscopy","authors":"Stylianos Aspiotis,&nbsp;Albert Dietz,&nbsp;Zsombor Földi,&nbsp;Frank Hildebrandt,&nbsp;Jochen Schlüter,&nbsp;Boriana Mihailova","doi":"10.1002/jrs.6765","DOIUrl":"https://doi.org/10.1002/jrs.6765","url":null,"abstract":"<p>Raman spectroscopy has been used to non-invasively analyse 30 Mesopotamian cylinder seals dated from the end of the fourth to the last half of the first millennium <span>bce</span>, kept in the collection of Museum für Kunst und Gewerbe (Hamburg, Germany). Besides the identification of the mineral constituents of the seals, the chemical compositions of the corresponding minerals were quantitatively determined from the Raman spectra. Using previously established relationships between the crystal chemistry and Raman-peak positions widths and/or relative intensities for various mineral groups, we demonstrate that (i) the Mg content in calcite-based seals as well as the Mg, Fe²⁺ and Ca contents in pyroxene present in one silicate seal can be determined with a relative error of 2%; (ii) the ^MMg and ^M(Fe + Mn)²⁺ contents in talc-based seals as well as the ^MMg and ^MFe²⁺ contents in antigorite-based seals can be quantified with a relative error of 5%; and (iii) in the case of chlorite-based cylinder seals the content of ^MMg, ^MFe²⁺, ^MAl, ^TSi and ^TAl could be estimated with relative errors of 15%–20%. We show that a classical gemological description of cylinder seals is insufficient, particularly when the most abundant mineral phases are oxides, iron sulfides and phyllosilicates, such as talc, antigorite and chlorite-group minerals. We demonstrate that combining classical art historical studies with archaeological evidence and detailed material profiles can advance provenance studies, reveal trade roots, unravel forgeries and distinguish replaced parts.</p>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 3","pages":"228-242"},"PeriodicalIF":2.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jrs.6765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental and Theoretical Evidence of Weak Spin–Lattice Coupling in the Double Perovskite Sr2YRuO6","authors":"Hsiang-Lin Liu,&nbsp;Bommareddy Poojitha,&nbsp;Yi-Lin Lin,&nbsp;Hsiao-Wen Chen,&nbsp;Chao-Hung Du,&nbsp;Ting-Hua Lu,&nbsp;Supratik Mukherjee,&nbsp;A. C. Garcia-Castro,&nbsp;Ganapathy Vaitheeswaran","doi":"10.1002/jrs.6758","DOIUrl":"https://doi.org/10.1002/jrs.6758","url":null,"abstract":"<div>\u0000 \u0000 <p>Sr₂YRuO₆ is a material that provides an ideal platform for studying magnetic frustration in three-dimensional geometries. Herein, we combine Raman spectroscopy and density functional theory calculations to establish connections between the lattice dynamics and magnetic states in Sr₂YRuO₆ single crystals. The x-ray diffraction profiles reveal that Sr₂YRuO₆ possesses an ordered double-perovskite structure with distorted monoclinic symmetry. Three magnetic phase transitions are observed and linked to the presence of weak ferromagnetism at 135 K and short- and long-range antiferromagnetic orderings at 32 and 26 K. The oxygen-octahedron antistretching and stretching modes, observed at 570 and 766 cm⁻¹, exhibit anomalies near the magnetic phase transition temperatures, indicating an intriguing interplay between the lattice and spin degrees of freedom. Their spin–phonon coupling constants of 0.7 cm⁻¹ reflect the weak spin–lattice interactions in Sr₂YRuO₆.</p>\u0000 </div>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 3","pages":"286-296"},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conformation Dependence of Phenylalanine Characteristic Raman Markers","authors":"Belén Hernández,&nbsp;Yves-Marie Coïc,&nbsp;Sergei G. Kruglik,&nbsp;Santiago Sanchez-Cortes,&nbsp;Mahmoud Ghomi","doi":"10.1002/jrs.6759","DOIUrl":"https://doi.org/10.1002/jrs.6759","url":null,"abstract":"<div>\u0000 \u0000 <p>Conformational dependence of six characteristic phenylalanine (Phe) Raman markers (F_i, i = 1, …, 6) was assessed through a multiconformational approach. Herein, aqueous solution off-resonance Raman spectra of the cationic species of the tripeptide Gly-Phe-Gly, with amine/amide backbone terminal groups, accompanied by the density functional theory calculations, using three different hybrid functionals (B3LYP, wB97XD and M062X), were presented. A set of 15 initial conformers, having five types of backbone secondary structures (β-strand, polyproline-II, helical, classic and inverse γ-turn) and three plausible side chain orientations, were submitted to geometry optimization. The optimized conformers permitted analysing the effect of non-bonded interactions, such as intramolecular hydrogen bonds, as well those occurring through space between aromatic side chain and adjacent peptide bonds. It has been shown that M062X was the only functional capable of maintaining the stability of all conformers, especially those having an inverse γ-turn backbone. In all calculations, extended chains (β-like) and classic γ-turn structures were shown to form the lowest and the highest energy conformers, respectively. Helical and pP-II structures belong to intermediate energy conformers. Raman spectrum was calculated by the thermal (Boltzmann) average of those spectra arising from the whole optimized conformers. An increasing global improvement of the spectral shape is to be noticed in going from the data obtained B3LYP to ωB97XD and M062X. Furthermore, explicit hydration of conformers improves the quality of the calculated spectrum by means of M062X. Wavenumber dispersion of the characteristic Raman markers revealed that F₅ (~1004 cm⁻¹) has the lowest dispersion (≤ 1 cm⁻¹), remaining unaffected by explicit hydration. In contrast, F₃ (~1207 cm⁻¹) shows the largest shift (≤ 6 cm⁻¹), whereas a moderate one (≤ 3 cm⁻¹) was predicted for F₁ (~1605 cm⁻¹), F₂ (~1586 cm⁻¹) and F₄ (~1035 cm⁻¹). Explicit versus implicit hydration seems to affect the wavenumber dispersion of F₆ (~622 cm⁻¹). It can be concluded that the conformational sensitivity of the Phe characteristic markers basically arises from the nature of their vibrational motions.</p>\u0000 </div>","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"56 3","pages":"262-277"},"PeriodicalIF":2.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of Raman Spectroscopy in Art and Archaeology","authors":"Anastasia Rousaki,&nbsp;Juan Manuel Madariaga","doi":"10.1002/jrs.6756","DOIUrl":"https://doi.org/10.1002/jrs.6756","url":null,"abstract":"&lt;p&gt;Raman spectroscopy is considered as one of the most valued and important techniques in the art and archaeology analysis field. Its increasing importance when the technique is applied on cultural heritage objects is reflected on the number of &lt;i&gt;peer reviewed&lt;/i&gt; papers published each year on a variety of journals regarding cultural heritage science, analytical chemistry and (vibrational) spectroscopy, among others. Moreover, the importance of the application Raman spectroscopy on works of art and archaeology together with its improvements and breakthroughs is underlined on dedicated international scientific conferences (and sessions) such as the International Conference on the Application of Raman Spectroscopy in Art and Archaeology (RAA).&lt;/p&gt;&lt;p&gt;The RAA conferences is a great gathering of scientists working on Raman spectroscopy and its instrumental developments and an excellent opportunity to be informed on the latest advances of the technique on Cultural Heritage studies. The first edition of the RAA conference was realized in London in 2001 [&lt;span&gt;1&lt;/span&gt;], followed by Ghent (2003) [&lt;span&gt;2&lt;/span&gt;] and then Paris (2005) [&lt;span&gt;3&lt;/span&gt;], Modena (2007) [&lt;span&gt;4&lt;/span&gt;], Bilbao (2009) [&lt;span&gt;5&lt;/span&gt;], Parma (2011) [&lt;span&gt;6&lt;/span&gt;], Ljubljana (2013) [&lt;span&gt;7&lt;/span&gt;], Wroclaw (2015) [&lt;span&gt;8&lt;/span&gt;], Évora (2017) [&lt;span&gt;9&lt;/span&gt;] and Potsdam (2019) [&lt;span&gt;10&lt;/span&gt;]. The 11&lt;sup&gt;th&lt;/sup&gt; edition of the RAA conference (RAA2023, 6 to 9 September 2023) was hosted by the National Gallery-Alexandros Soutsos Museum, located in Athens, Greece in collaboration with Ghent University, Ghent, Belgium. For the first time, the RAA2023 conference included a &lt;i&gt;two-day&lt;/i&gt; Raman spectroscopy training school (4 to 5 September 2023) on selected topics addressed to students and early career researchers.&lt;/p&gt;&lt;p&gt;As the previous editions, the scientific programme was focused on characterization of materials associated with cultural heritage research (natural and synthetic inorganic and organic materials including biological materials), degradation processes, conservation related themes and challenges, surface enhanced Raman spectroscopy (SERS), chemometrics, Raman spectroscopy related topics in paleontology, paleoenvironment and archaeology, the development and progresses of Raman techniques and the application, advantages and challenges of new Raman instrumentation. The aforementioned topics can be connected either to laboratory or in situ analysis, or both while Raman spectroscopy should act as a core technique in studies that include other analytical techniques. During the RAA2023, these type of studies were organized in 3 keynote and 1 plenary lectures, 30 oral presentations, 4 sponsor oral presentations and 37 poster presentations. The RAA2023 conference garnered 100 registries from 21 countries. There were 332 authors and co-authors in the studies of the conference's scientific programme.&lt;/p&gt;&lt;p&gt;This special issue includes 14 selected manuscripts reflecting th","PeriodicalId":16926,"journal":{"name":"Journal of Raman Spectroscopy","volume":"55 12","pages":"1218-1223"},"PeriodicalIF":2.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jrs.6756","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}