Scholarly Research Exchange最新文献_第6页

Aromatic Herbal Products Analysis by Laser-Induced Breakdown Spectroscopy 芳香草药产品的激光诱导击穿光谱分析

Scholarly Research Exchange Pub Date : 2008-10-19 DOI: 10.3814/2008/152607

J. Anzano, Beatriz Bonilla, Beatriz Montull-Ibor, Justiniano Casas

引用次数: 3

Putting Yukawa-Like Modified Gravity (MOG) on the Test in the Solar System 在太阳系中进行汤川修正重力(MOG)的试验

Scholarly Research Exchange Pub Date : 2008-09-21 DOI: 10.3814/2008/238385

L. Iorio

引用次数: 20

New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines 吡啶[1,2-a]嘧啶合成的新方法

Scholarly Research Exchange Pub Date : 2008-09-16 DOI: 10.3814/2008/434329

R. Toche, Bhausaheb K. Ghotekar, M. A. Kazi, Shivaraj P. Patil, M. Jachak

引用次数: 6

HomoSAR: An Integrated Approach Using Homology Modeling and Quantitative Structure-Activity Relationship for Activity Prediction of Peptides HomoSAR:利用同源性建模和定量构效关系预测多肽活性的综合方法

Scholarly Research Exchange Pub Date : 2008-09-14 DOI: 10.3814/2008/360572

Raghuvir R. S. Pissurlenkar, E. Coutinho

{"title":"HomoSAR: An Integrated Approach Using Homology Modeling and Quantitative Structure-Activity Relationship for Activity Prediction of Peptides","authors":"Raghuvir R. S. Pissurlenkar, E. Coutinho","doi":"10.3814/2008/360572","DOIUrl":"https://doi.org/10.3814/2008/360572","url":null,"abstract":"3D-QSAR of peptides is a daunting task. The difficulty in peptide QSAR arises due to the sheer number of conformational degrees of freedom for peptides that makes alignment in a 3D grid an overwhelming task. In this paper, we propose a method of QSAR where the alignment of peptides is shifted from 3D space to 1D space, making the alignment of peptides a very simple proposition. The method called HomoSAR, is based on an integrated approach that uses the principles of homology modeling in conjunction with the QSAR formalism to predict and design new peptide sequences. The peptides to be studied are subjected to a multiple sequence alignment which is followed by scoring every position in the peptide sequence against a reference peptide in the alignment, through calculation of similarity indices. The similarity indices obtained for each position (amino acid residue) in the peptide form the “descriptor” values (independent variables) which are then correlated to the biological activity of the peptide by G/PLS techniques. As an application, the methodology has been illustrated for the dataset of nonamer peptides that bind to the Class I major histocompatibility complex (MHC) molecule HLA- A ∗ 0201 as this dataset has been extensively studied. The models generated have statistically significant correlation coefficients and predictive r 2 . The cross validated coefficients ( q 2 ) are in an acceptable range. The HomoSAR approach identifies amino acids and properties that are preferred or detrimental at every position in the peptide sequence. The approach is simple to use and is able to extract all information contained in the dataset to explain the underlying structure activity relationships. The approach is applicable to peptide sequences which are not all of uniform length.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"29 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129713608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Drug-Drug Interaction between Pravastatin and Gliclazide in Animal Models 普伐他汀与格列齐特在动物模型中的相互作用

Scholarly Research Exchange Pub Date : 2008-09-03 DOI: 10.3814/2008/620489

S. Satyanarayana, M. Chandrasekhar, O. Gouda, K. E. Kumar

{"title":"Drug-Drug Interaction between Pravastatin and Gliclazide in Animal Models","authors":"S. Satyanarayana, M. Chandrasekhar, O. Gouda, K. E. Kumar","doi":"10.3814/2008/620489","DOIUrl":"https://doi.org/10.3814/2008/620489","url":null,"abstract":"The present study is planned to evaluate the safety of gliclazide (antidiabetic) therapy in the presence of pravastatin (antihyperlipidemic) in rats and rabbits. Studies in normal and alloxan-induced diabetic rats were conducted with oral doses of gliclazide, pravastatin, and their combination. Similarly, studies in normal rabbits were conducted with oral doses of gliclazide, pravastatin, and their combination with adequate washout periods in between the treatments. Blood samples were collected from rats and rabbits at different time intervals and were analyzed for blood serum gliclazide levels. Gliclazide produced hypoglycaemic/antihyperglycaemic activity in normal and diabetic rats with peak activity after 2 hours and 8 hours and hypoglycaemic activity in normal rabbits with peak activity after 3 hours. Pravastatin alone produced minor reduction in blood glucose levels in normal rats/diabetic rats/normal rabbits. Pravastatin increased the hypoglycaemic effect of gliclazide in normal rats/diabetic rats/normal rabbits when administered together. The serum insulin levels were increased with pravastatin treatment in rabbits. The serum gliclazide levels and pharmacokinetic parameters of gliclazide were altered significantly in presence of pravastatin in rabbits. The interaction observed appears to be pharmacokinetic interaction at metabolic and excretion levels.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128345345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Pancreatic Cancer Suppression by Natural Polyphenols 天然多酚抑制胰腺癌

Scholarly Research Exchange Pub Date : 2008-08-26 DOI: 10.3814/2008/540872

Guoliang Cui, Yuebo Zhang, Cindy Liu, Sheri Skinner, Ying Qin

引用次数: 4

Energy and Deformation during Explosive Compaction of ZrB2-SiC Ultrahigh Temperature Ceramics ZrB2-SiC超高温陶瓷爆炸压实过程中的能量与变形

Scholarly Research Exchange Pub Date : 2008-08-11 DOI: 10.3814/2008/754838

Jinping Li, S. Meng, Jiecai Han, Baolin Wang

{"title":"Energy and Deformation during Explosive Compaction of ZrB2-SiC Ultrahigh Temperature Ceramics","authors":"Jinping Li, S. Meng, Jiecai Han, Baolin Wang","doi":"10.3814/2008/754838","DOIUrl":"https://doi.org/10.3814/2008/754838","url":null,"abstract":"To introduce a new technique and to choose the process parameters, ZrB2-SiC ultrahigh temperature ceramics (UHTCs) were prepared by mixing and explosive compaction. The explosive kinds or explosive mass was variable so as to change the explosive impact energy. We have studied the relationships of the explosive impact energy, the tube deformation energy, the powder compaction energy and the ratio of the explosive mass to the tube mass (R), the relationships of the tube deformation energy, the tube equivalent strain and the mass ratio R, and the relationships of the densities of the ZrB2 composites and the powder compact energy. The results show that the densities of the ZrB2 composites reach 93.37% of theory density. For any kind of explosive, the reduction of the outer diameter and the equivalent strain of the steel tubes raises gradually with the rise of the mass ratio R. Generally speaking, the higher the explosion speed of the explosive is, the larger the deformation degree and the equivalent strain of the steel tubes are. The explosive impact energy can be divided into two parts: the tube deformation energy and the powder compact energy; with the rise of the mass ratio R, the tube deformation energy hardly changes, while the explosive impact energy and powder compact energy increase synchronously, and the densities of the ZrB2 composites also increase gradually. The density of the ZrB2 composites produced by different explosives orders from big to small as RDX, Ammonium Nitrate, TNT, and Urea Nitrate.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"352 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113989623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Otter Surveys of the North West Scottish Islands 西北苏格兰群岛水獭调查

Scholarly Research Exchange Pub Date : 2008-08-10 DOI: 10.3814/2008/735403

P. Yoxon

引用次数: 1

Comparison of Methodologies to Estimate Intake Dose for Exposure to Soil Contaminants 估算土壤污染物摄入剂量的方法比较

Scholarly Research Exchange Pub Date : 2008-07-21 DOI: 10.3814/2008/341202

A. Olsen, N. Persaud

{"title":"Comparison of Methodologies to Estimate Intake Dose for Exposure to Soil Contaminants","authors":"A. Olsen, N. Persaud","doi":"10.3814/2008/341202","DOIUrl":"https://doi.org/10.3814/2008/341202","url":null,"abstract":"It has been suggested that probabilistic approaches would provide more \u0000 realistic estimates for human intake dose from exposure to soil contaminants than the commonly-used \u0000 standard deterministic method. The objective of this study was to compare intake dose estimated by \u0000 these methods for noncarcinogens and carcinogens in soil from 21 contaminated sites in \u0000 Pennsylvania, USA. Intake doses by the principal human exposure routes for these contaminants were \u0000 estimated by the standard deterministic method using fixed input parameter values, and by two emergent probabilistic methods. The probabilistic methods were based (a) on distribution functions for \u0000 all input parameters, or (b) on some combination of these functions and fixed parameter \u0000 values. Intake doses were then taken as the 90th, 95th, or 99.9th percentile of the generated cumulative output distribution and compared with the commonly-used deterministic estimates over all contaminant/site combinations. For all exposure routes, the 90th and 95th percentile intake dose estimates were not markedly different from the deterministic values or from each other. The opposite \u0000 was generally the case for the 99.9th percentile estimates. These results did not indicate clear and definitive advantages in using probabilistic methods over the deterministic method for estimating human intake dose from exposure to soil contaminants.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114461912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel and Efficient Synthesis of Intermediates for the Preparation of Fexofenadine 一种新型高效合成非索非那定中间体的方法

Scholarly Research Exchange Pub Date : 2008-07-14 DOI: 10.3814/2008/137091

Jiangang Mao, Haining Gu, Pengfei Zhang

引用次数: 0