吡啶[1,2-a]嘧啶合成的新方法

Scholarly Research Exchange Pub Date : 2008-09-16 DOI:10.3814/2008/434329

R. Toche, Bhausaheb K. Ghotekar, M. A. Kazi, Shivaraj P. Patil, M. Jachak

{"title":"吡啶[1,2-a]嘧啶合成的新方法","authors":"R. Toche, Bhausaheb K. Ghotekar, M. A. Kazi, Shivaraj P. Patil, M. Jachak","doi":"10.3814/2008/434329","DOIUrl":null,"url":null,"abstract":"A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α -acetyl- γ -butyrolactone, which upon cyclization using phosphorus \n oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2008-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines\",\"authors\":\"R. Toche, Bhausaheb K. Ghotekar, M. A. Kazi, Shivaraj P. Patil, M. Jachak\",\"doi\":\"10.3814/2008/434329\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α -acetyl- γ -butyrolactone, which upon cyclization using phosphorus \\n oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.\",\"PeriodicalId\":169134,\"journal\":{\"name\":\"Scholarly Research Exchange\",\"volume\":\"4 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scholarly Research Exchange\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3814/2008/434329\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scholarly Research Exchange","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3814/2008/434329","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 6

摘要

以二氢呋喃酮为中间体，成功地合成了以氯乙基为顽固性侧链的吡啶[1,2- A]嘧啶。以2-氨基吡啶与α -乙酰基- γ -丁内酯缩合为原料合成了二氢呋喃酮中间体，经氯化磷或乙醇在乙氧基钠中环化后得到了吡啶[1,2-a]，产率高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines

A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α -acetyl- γ -butyrolactone, which upon cyclization using phosphorus oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Scholarly Research Exchange

自引率

0.00%

发文量