Scholarly Research Exchange最新文献

Software failure probability quantification for system risk assessment 用于系统风险评估的软件故障概率量化

Scholarly Research Exchange Pub Date : 2009-11-03 DOI: 10.3814/2009/163456

Hyun Gook Kang, H. Eom, H. Son

引用次数: 1

Thermal Management of Wide-Beam Area X-Ray Sources 宽光束区域x射线源的热管理

Scholarly Research Exchange Pub Date : 2009-11-01 DOI: 10.3814/2009/608735

N. A. Bobolea, J. Doster, M. Bourham

引用次数: 0

Multiple Hypotheses LAO Testing for Many Independent Objects 多独立对象的多假设LAO检验

Scholarly Research Exchange Pub Date : 2009-09-17 DOI: 10.3814/2009/921574

E. Haroutunian, Parandzem M. Hakobyan

引用次数: 12

An Experimental Study of Thermal Fatigue on ASTM A 213 Grade T-23 Steel Tube ASTM a213级T-23钢管热疲劳试验研究

Scholarly Research Exchange Pub Date : 2009-08-31 DOI: 10.3814/2009/309529

G. R. Jinu, P. Sathiya, G. Ravichandran, A. Rathinam

{"title":"An Experimental Study of Thermal Fatigue on ASTM A 213 Grade T-23 Steel Tube","authors":"G. R. Jinu, P. Sathiya, G. Ravichandran, A. Rathinam","doi":"10.3814/2009/309529","DOIUrl":"https://doi.org/10.3814/2009/309529","url":null,"abstract":"Super heater tubes are subjected to alternate heating and cooling \u0000in power plants causes crack and eventually fail. This phenomenon \u0000is termed as thermal fatigue. In this paper, a laboratory \u0000simulation for reproducing thermal fatigue phenomenon is developed \u0000to determine the number of cycles of failure occurs in super \u0000heater tubes. Thermal fatigue tests are conducted in \u0000Non-Destructive Tested T23 base and SMAW welded tubes separately. \u0000The tubes are subjected to thermal cycles from 800∘C (accelerated temperature) to room temperature \u0000(28∘C). In this work 800∘C is selected in order to achieve the crack much \u0000earlier. The selected temperature is just below the Ac 1 temperature. The tubes are subjected to heat by \u0000Oxy-acetylene flame and subsequently quenched with water. The \u0000tests are carried out until open cracks are identified. Surface \u0000cracks are identified in the base and weld tubes after 120 and 80 \u0000cycles respectively. The tubes are then sectioned and subjected to \u0000optical microscopy. The causes of failures are thoroughly \u0000investigated using Scanning Electron Microscope (SEM). This study \u0000reveals that localised heating and cooling causes thermal fatigue \u0000which initiates cracks in the tubes.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128266634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-administration of Fluoxetine Alters the Steady State Pharmacokinetics of Fluconazole after Multiple Oral Administration in Dogs 氟西汀在狗体内多次口服后改变氟康唑的稳态药代动力学

Scholarly Research Exchange Pub Date : 2009-07-28 DOI: 10.3814/2009/834879

I. Zaghloul, Y. A. Asiri, L. Alnaim, B. Al-Hadiya

{"title":"Co-administration of Fluoxetine Alters the Steady State Pharmacokinetics of Fluconazole after Multiple Oral Administration in Dogs","authors":"I. Zaghloul, Y. A. Asiri, L. Alnaim, B. Al-Hadiya","doi":"10.3814/2009/834879","DOIUrl":"https://doi.org/10.3814/2009/834879","url":null,"abstract":"Objectives. Fluconazole is an antifungal agent which has become the mainstay treatment of opportunistic fungal infections in immuno-compromized patients. Fluoxetine is a selective serotonine reuptake inhibitor used in the treatment of psychiatric disorders. In the current study we investigated the effect of chronic administration of fluoxetine on the steady state pharmacokinetics parameters of fluconazole. Methods. The pharmacokinetics of Fluconazole, following 10 mg/kg single and multiple oral dosing for 10 days, was determined in dogs. Subsequently, the effect of 2 mg/kg fluoxetine given for 10 days, on the pharmacokinetics of Fluconazole was investigated. Results. The co-administration resulted in significant reduction of 40.1% and 35.6% in AUC 0- ∞ , and C max , respectively compared to fluconazole alone. \u0000 A significant \u0000alteration of V ss / F was also seen as it increased from 0.242 ± 0.04 to 0.654 ± 0.17 l/kg ( P .01 ). Accordingly, a significant reduction \u0000in K el from 0.048 ± 0.01 hr-1 to 0.031 ± 0.01 was detected ( P .01 ). \u0000Conclusion. fluoxetine reduced plasma concentration of fluconazole. The mechanism of the interaction is probably the inhibition of OATP or other transporters in the intestinal wall. This interaction may have significant clinical importance because reduction in fluconazole may lead to treatment failure of fungal infection.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129513803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Simulation of Weld Bead Geometry in GTA Welded Duplex Stainless Steel (DSS) 双相不锈钢(DSS) GTA焊接焊缝几何模拟

Scholarly Research Exchange Pub Date : 2009-07-22 DOI: 10.3814/2009/324572

P. Sathiya, G. R. Jinu, N. Singh

{"title":"Simulation of Weld Bead Geometry in GTA Welded Duplex Stainless Steel (DSS)","authors":"P. Sathiya, G. R. Jinu, N. Singh","doi":"10.3814/2009/324572","DOIUrl":"https://doi.org/10.3814/2009/324572","url":null,"abstract":"Temperature analysis of GTA welding of Duplex Stainless Steel material (2205) is simulated using ANSYS software by finite element technique taking in account the characteristics and advantage of GTAW than other sources. A travel heat source combined with body loads was designed by analyzing thermal physical parameters, latent heat of fusion of material. Modeling was carried out by using solid modeling and direct generation technique. A residual control method was taken for precise node selection, Simulation was done by varying the parameter of GTA, welding speed. The quasisteady state temperature field of GTA welding was simulated with the FEA software—ANSYS as well as tests. The objective of this work is to compare the experimentally obtained weld bead geometry of DSS material with simulated results from ANSYS software for various weld parameters. The higher the value of joining efficiency is, the less heat energy is spent on unnecessary heating-that is generating a heat affecting zone (HAZ) or distortion. Joining of two metals or alloys is important in every aspect of engineering which leads to welding in an effective manner and carrying out the analysis. The experimental analysis shows that the model is showing good agreement with the experimental results. Comparison of the experimental and simulated results shows the maximum deviation of 1.27% and 10% for calculating bead width and depth of penetration, respectively.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132825430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Searching genes encoding Leishmania antigens for diagnosis and protection 寻找利什曼原虫抗原编码基因用于诊断和保护

Scholarly Research Exchange Pub Date : 2009-06-11 DOI: 10.3814/2009/173039

M. Soto, L. Ram, M. Pineda, Victor M. Gonz, P. Entringer, I. Nascimento, A. P. Souza, L. Corvo, C. Alonso, P. Bonay, C. Brodskyn, A. Barral, M. Barral-Netto, S. Iborra

引用次数: 33

Different Dietary Levels of Protein to Lipid Ratio Affected Digestive Efficiency, Skeletal Growth, and Muscle Protein in Rainbow Trout Families 不同饲粮蛋白脂比水平影响虹鳟鱼家族的消化效率、骨骼生长和肌肉蛋白质

Scholarly Research Exchange Pub Date : 2009-06-07 DOI: 10.3814/2009/709529

K. Rungruangsak-Torrissen, L. Stien, Britt S. Daae, T. Vågseth, Grethe Thorsheim, D. Tobin, O. Ritola

{"title":"Different Dietary Levels of Protein to Lipid Ratio Affected Digestive Efficiency, Skeletal Growth, and Muscle Protein in Rainbow Trout Families","authors":"K. Rungruangsak-Torrissen, L. Stien, Britt S. Daae, T. Vågseth, Grethe Thorsheim, D. Tobin, O. Ritola","doi":"10.3814/2009/709529","DOIUrl":"https://doi.org/10.3814/2009/709529","url":null,"abstract":"Normal Protein (NP) and High Protein (HP) diets were provided to rainbow trout families from juvenile to maturity. Muscle protein concentration increased during growth and the protein to lipid (P/L) ratio was doubled at late stage with respect to the dietary P/L ratio. The HP-diet fish showed higher protein deposition in body and white muscle, and had lower condition factor due to protein deposition associated more with body length than body weight. Fish growth rates were decreased at maturation, and the HP-diet fish showed lower growth rate including the activity ratio of trypsin to chymotrypsin (T/C ratio) and feed efficiency. Trypsin and chymotrypsin specific activities were related to dietary protein levels, and the T/C ratio was related to intestinal weight and growth rate independent of the enzymes specific activity levels. The families with high growth capacity could double increase white muscle P/L ratio levels, compared to low and medium growth families, if they were fed on HP-diet. The digestive enzyme extracts from high growth families resulted in higher in vitro protein digestibility for all diets. The effect of dietary P/L ratio on digestion, skeletal growth (length) and the white muscle P/L ratio in fish with different growth capacities is illustrated.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122804282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Genes Involved in Human Ribosome Biogenesis are Transcriptionally Upregulated in Colorectal Cancer 参与人类核糖体生物发生的基因在结直肠癌中转录上调

Scholarly Research Exchange Pub Date : 2009-06-07 DOI: 10.3814/2009/657042

F. Mansilla, P. Lamy, T. Ørntoft, K. Birkenkamp-Demtröder

引用次数: 3

Atypical Hyperperfusion Encephalopathy in Post-Carotid Stenting 颈动脉支架置入术后非典型高灌注脑病

Scholarly Research Exchange Pub Date : 2009-06-02 DOI: 10.3814/2009/108498

N. Morelli, G. Cafforio, S. Gallerini, M. Puglioli, A. Chiti, F. Baldacci, G. Orlandi, L. Murri, D. Guidetti

{"title":"Atypical Hyperperfusion Encephalopathy in Post-Carotid Stenting","authors":"N. Morelli, G. Cafforio, S. Gallerini, M. Puglioli, A. Chiti, F. Baldacci, G. Orlandi, L. Murri, D. Guidetti","doi":"10.3814/2009/108498","DOIUrl":"https://doi.org/10.3814/2009/108498","url":null,"abstract":"Hyperperfusion encephalopathy (HPE) is a condition due to \u0000increased perfusion of the brain which is clinically characterized \u0000by headache, seizures, and other neurologic signs associated with \u0000increased (or not) systemic blood pressures and edema in the \u0000subcortical white matter (predominantly in the occipital lobe). \u0000Patients with critical carotid stenosis treated with \u0000endarterectomy or carotid artery stenting may develop a HPE \u0000syndrome of the ipsilateral hemisphere which closely resembles the \u0000unilateral HPE and that usually involves the vascular area \u0000subjected ipsilaterally to the carotid stenosis. We present here a \u0000case of a 62-year-old woman who developed atypical hyperperfusion \u0000syndrome after a carotid stenting for high-grade carotid artery \u0000stenosis. In our patient, the HPE involved bilaterally both \u0000hemispheres, even though the treatment of the carotid stenosis was \u0000unilaterally. Some authors have hypothesized that a high dose of \u0000contrast, in combination with an unidentified personal \u0000vulnerability, may result in the rupture of the blood-brain \u0000barrier, carrying the CA into the cerebral parenchyma (both \u0000hemispheres), leading to the encephalopathy. The course and \u0000prognosis of HPE in post-carotid stenting are excellent with \u0000conservative treatment and full recovery usually occurs within 24 \u0000to 48 hours.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130811637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0