Scholarly Research Exchange最新文献_第2页

Hodgkin's Disease with Atypical Clinical Presentation, Associated with Ataxia-Telangiectasia 何杰金氏病临床表现不典型，伴共济失调-毛细血管扩张

Scholarly Research Exchange Pub Date : 2009-06-02 DOI: 10.3814/2009/974576

M. Spasova, I. Ivanov, J. Grudeva-Popova, A. Stoyanova, H. Dimitrov, I. N. Moumdjiev

{"title":"Hodgkin's Disease with Atypical Clinical Presentation, Associated with Ataxia-Telangiectasia","authors":"M. Spasova, I. Ivanov, J. Grudeva-Popova, A. Stoyanova, H. Dimitrov, I. N. Moumdjiev","doi":"10.3814/2009/974576","DOIUrl":"https://doi.org/10.3814/2009/974576","url":null,"abstract":"The authors report a 4-year-old male with Hodgkin's disease with atypical clinical presentation, laboratory data and imaging studies as well as an increased radiosensitivity. These were the first symptoms which raised the suspicion of ataxia-telangiectasia. The lymphoma presented as a solid tumor mass in the right upper posterior mediastinum without peripheral lymphadenopathy. The alpha-fetoprotein was significantly increased and the diagnosis of a germ-cell tumor or neuroblastoma was suspected. After partial resection of the tumor the histology indicated Hodgkin's disease-mixed cellularity. The boy received chemotherapy according to DAL HD-95 protocol without any unusual toxicity. Low-dose radiation therapy of the upper and middle mediastinum was followed by early radiation-induced esophagitis and appearance of a large pericardial effusion one year later. Ataxia and bulbar and skin telangiectasias at the radiation site appeared in the next years. He suffered recurrent pulmonary infections and succumbed to severe pneumonia with respiratory failure and pulmonary hypertension five years after the diagnosis of malignant lymphoma without evidence of recurrence of Hodgkin's disease.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125233021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histologic Effects of Bilateral Adrenalectomy under the Light Microscopy on Rat Mandibular Condyle 光镜下双侧肾上腺切除术对大鼠下颌髁的组织学影响

Scholarly Research Exchange Pub Date : 2009-05-28 DOI: 10.3814/2009/478468

S. Z. Ulku, A. Zengingul, A. Ketani

{"title":"Histologic Effects of Bilateral Adrenalectomy under the Light Microscopy on Rat Mandibular Condyle","authors":"S. Z. Ulku, A. Zengingul, A. Ketani","doi":"10.3814/2009/478468","DOIUrl":"https://doi.org/10.3814/2009/478468","url":null,"abstract":"The aim of this study was to compare the histologic findings from \u0000the condyles of rats with the general system findings. 30 \u0000Sprague-Dawley adult rats were used. The rats were sacrified and \u0000their condyles and femurs were examined histologically. The rats’ \u0000weight were observed weekly, their femoral height and weight, \u0000femoral mineral elements, and their daily food and water consumes \u0000were recorded. The results were analysed statistically by using \u0000SPSS (10.0). During the histologic examination of femur, the osteogenesis and calcification of the femur layers of the male/female rats in the experimental group were found to be lower than those of the ones in the control group. In addition to that, during the histological examination of condyle the level of thickness of condyle layers, the number of cellular elements, the osteogenesis and calcification seemed to be decreased for the male/female rats in the experimental group than for those in the control group. The decrease was found to be more significant for the female rats than the male rats in experimental group and it is thought that this is related to the gonad hormones. These findings emphasize that a reduction of sex hormone levels, induced by adrenalectomy, significantly influences condylar histogenesis.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114626797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic Intradural Extramedullary Arachnoid Cyst and Associated Syringomyelia 特发性硬膜内髓外蛛网膜囊肿及相关脊髓空洞

Scholarly Research Exchange Pub Date : 2009-05-26 DOI: 10.3814/2009/452627

L. Moschettoni, D. Lisciani, G. Cacciotti, M. Fraioli

引用次数: 0

Differential Toxicological Interaction among Arsenic, Cadmium, Lead, and Mercury on MCF 7 Cell Line 砷、镉、铅和汞在mcf7细胞系上的不同毒理学相互作用

Scholarly Research Exchange Pub Date : 2009-05-05 DOI: 10.3814/2009/789636

C. Klutse, K. Mack, K. Squibb, A. Ishaque

{"title":"Differential Toxicological Interaction among Arsenic, Cadmium, Lead, and Mercury on MCF 7 Cell Line","authors":"C. Klutse, K. Mack, K. Squibb, A. Ishaque","doi":"10.3814/2009/789636","DOIUrl":"https://doi.org/10.3814/2009/789636","url":null,"abstract":"Evaluation of joint toxic action of metal ion mixtures is one of the priority research areas due to the simultaneous occurrence of metals in the environment and the health risk they posed to humans and the environment as a mixture. Individual and composite mixture acute toxicities of arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb), which are among the top eight toxic chemicals, were characterized at varying concentrations. MCF 7 cell lines were exposed to individual and composite mixtures containing the four metal ions in the proportion of their EPA's MCL for 24 hours, and the concentration-response data were generated spectrofluorometrically. Acute toxicities were estimated based on the uptake of fluorescence diacetate dye. Toxicological interactions among the four metals were profiled, based on computed interactive index. Results demonstrated that the toxicity of each of the metal ions was enhanced in the composite mixture, and the metals demonstrated differential interactions in a concentration dependent manner. Lead, the least toxic among the four metals, showed the highest enhancement (23-to 64-fold) in toxicity when in the mixture. Interaction among the four metals was largely additive although there was slight departures form additivity at the two extremes of the concentration range.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131366204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Preclinical Assays for Identifying Cancer Chemopreventive Phytochemicals 鉴别癌症化学预防植物化学物质的临床前试验

Scholarly Research Exchange Pub Date : 2009-04-28 DOI: 10.3814/2009/475963

T. Oyama, Y. Yasui, S. Sugie, Takuji Tanaka

引用次数: 9

Extraosseous Cemento-Ossifying Fibroma of the Cheek 面颊骨外骨水泥骨化纤维瘤

Scholarly Research Exchange Pub Date : 2009-04-22 DOI: 10.3814/2009/493190

G. Longobardi, I. Pagano, U. Sisalli, Maurizio Foresti, V. Poddi

{"title":"Extraosseous Cemento-Ossifying Fibroma of the Cheek","authors":"G. Longobardi, I. Pagano, U. Sisalli, Maurizio Foresti, V. Poddi","doi":"10.3814/2009/493190","DOIUrl":"https://doi.org/10.3814/2009/493190","url":null,"abstract":"Background. Cemento-ossifying fibroma (COF) is a relatively rare tumor of the maxillary bones, classified among the fibro-osseous lesions Feller et al. (2004). The lesion that develops appears within the bone, although in some cases, it involves the soft tissues Kaufmann et al. (1999), Jung et al. (1999). In literature there is not report of COF in the thickness of the cheek. Methods. A 24-year-old Caucasian woman presented a hard mass of 1.5 cm in the thickness of the right cheek; no signs of damaged tissues were present. Radiographically all the mass appeared radiopaque as bone, and well demarcated with an evident capsule, without invasing the adjacent structures. The lesion was resected en bloc. Result. Pathological examination of the excised mass revealed an encapsulated cemento-ossifying fibroma that did not invade the adjacent tissues. The case was resolved with no complicance and with restitutio ad integrum. Conclusion. Typically, the unusual characterisitcs of a pathology get difficult as for its diagnosis and therapy. This is a case report of a rare cemento-ossifying fibroma of the cheek. Clinical and instrumental examinations exclude a malignant pathology and lead to an appropriate conservative surgical therapy. Only the histological examination confirmed the clinical diagnosis of extraosseous COF.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123068962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Syringocystadenocarcinoma Papilliferum In Situ: Case Report with Immunohistochemical Observations 原位乳头状囊腺癌:1例伴免疫组织化学观察

Scholarly Research Exchange Pub Date : 2009-04-05 DOI: 10.3814/2009/176837

C. Lindboe, H. Brekke, Irina Schønhardt, Unn Houge

引用次数: 0

Severe Invasive Group A Streptococcal Disease with Rhabdomyolysis but without Evidence of Shock or Local Myositis 严重侵袭性A组链球菌病伴横纹肌溶解，但无休克或局部肌炎证据

Scholarly Research Exchange Pub Date : 2009-04-05 DOI: 10.3814/2009/786451

Arthur Okere, D. Schwartz, P. Tierno, P. Schlievert, R. Hamadeh

引用次数: 0

Vasoactive Intestinal Peptide Tumor 血管活性肠肽肿瘤

Scholarly Research Exchange Pub Date : 2009-04-05 DOI: 10.3814/2009/938325

Naveed M. Natanzi, M. Amini, D. Yamini, S. Nielsen, R. Ram

{"title":"Vasoactive Intestinal Peptide Tumor","authors":"Naveed M. Natanzi, M. Amini, D. Yamini, S. Nielsen, R. Ram","doi":"10.3814/2009/938325","DOIUrl":"https://doi.org/10.3814/2009/938325","url":null,"abstract":"Background and aim. Vasoactive intestinal peptide tumor is a rare neuroendocrine neoplasm which causes voluminous watery diarrhea via hypersecretion of electrolytes and water from the intestinal mucosa through a vasoactive intestinal peptide-mediated, cyclic AMP-dependent mechanism. The acid base imbalance generated by the loss of water and electrolytes leads to severe dehydration and potential renal failure, which can ultimately result in death if left untreated. This paper aims to review the clinical, histological, radiological, and diagnostic features of this disease as well as the therapeutic modalities in treating this condition. \u0000Methods. A review of literature was performed using MEDLINE, Pubmed, and Cochrane databases in collection of data using MeSH terms including vasoactive intestinal peptide, VIPoma, and WDHA. \u0000Results and conclusion. Vasoactive intestinal peptide tumor is a rare neoplasm associated with significant morbidity and mortality through secretion of water and electrolytes in the gastrointestinal tract. The nonspecific clinical presentation of this neoplasm can pose diagnostic challenges, as these tumors can be easily misdiagnosed as other conditions, ranging from laxative overdose to the presence of a carcinoid secreting tumor. Nevertheless, a number of imaging and laboratory studies can facilitate the correct evaluation and diagnosis of VIPoma. Following proper diagnosis, VIPomas are treated by either medical or surgical modalities depending on the existence and extent of metastasis.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121899864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Bilateral Leg Compartment Syndrome Complicating Prolonged Spine Surgery in the Kneeling Position 跪姿长时间脊柱手术并发双侧腿室综合征

Scholarly Research Exchange Pub Date : 2009-04-05 DOI: 10.3814/2009/535178

R. Ballesteros, F. J. García-Lázaro, J. Moreno, Marta Chacón, Olivia Málaga, M. Lee

引用次数: 5