Journal of Prosthetic Dentistry最新文献

{"title":"CAD-CAM complete digital dentures: An improved clinical and laboratory workflow.","authors":"Francesco Grande, Lorenzo Pavone, Fabrizio Molinelli, Federico Mussano, Murali Srinivasan, Santo Catapano","doi":"10.1016/j.prosdent.2024.11.016","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.11.016","url":null,"abstract":"<p><p>The purpose of this article was to present a novel clinical workflow for the fabrication of complete dentures using computer-aided design and computer-aided manufacturing (CAD-CAM) technology. The dental technique consists of 3 clinical steps and 2 laboratory phases that result in the production of 2 CAD-CAM milled complete denture bases with prefabricated teeth. The integration of analog and digital procedures and materials maximizes their benefits in the planning and fabrication of complete dentures, with the goal of improving clinical outcomes.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cementation technique and cement type on the amount of excess cement in implant-supported cement-retained crown restorations: An in vitro study.","authors":"Aybike Düzgün, Fatma Güneş, Mustafa Kocacıklı, Ömer Suat Yaluğ","doi":"10.1016/j.prosdent.2024.12.020","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.12.020","url":null,"abstract":"<p><strong>Statement of problem: </strong>Excess cement in implant-supported restorations can lead to peri-implant diseases, and its removal remains a clinical challenge. The optimum method of minimizing excess cement is unclear.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to compare 3 cementation techniques and 3 cement types and measure excess cement.</p><p><strong>Material and methods: </strong>A total of 63 metal crowns and universal straight abutments were divided into 3 groups according to cementation techniques: direct (DT), polytetrafluoroethylene tape (PTT), and extraoral replica (ERT). (n=21) In all groups, 3 different cement types were used: glass ionomer cement (Meron; Voco), polycarboxylate cement (Adhesor Carbofine; Pentron), and resin-modified glass ionomer cement (GC FujiCEM Evolve; GC Corp) (n=7). The cemented crown-abutment combination was examined under a ×10 magnification stereomicroscope, and the cement remaining on the surface was calculated by using a computer program (ImageJ and NIH Image Software; National Institutes of Health). The relationship between cementation techniques and cement type and residual cement was examined with a 2-way ANOVA test. A post hoc test was used for intragroup comparisons (α=.05).</p><p><strong>Results: </strong>Regardless of the cement type, the residual cement amount was found to be the lowest in the ERT group (P<.001). Regardless of the technique, the lowest residual cement was found in glass ionomer cement (1.55 ±1.05 mm², 95% CI: 1.07 to 2.02).</p><p><strong>Conclusions: </strong>The extraoral replica technique was the most effective in reducing excess cement, and cement type influenced its amount, with the highest residual cement amounts observed with resin-modified glass ionomer cement among all techniques.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual dentin thickness and biomechanical performance of post-and-core-restored mandibular premolars: A finite element analysis study.","authors":"Yi Sun, Ze-Feng Wang, Yue-Dan Xu, Ling Zhang","doi":"10.1016/j.prosdent.2024.11.014","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.11.014","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Statement of problem: &lt;/strong&gt;Endodontically treated teeth often require post-and-core restorations for structural support because of extensive hard tissue loss. Assessment of the effect of the residual dentin thickness on the biomechanical performance of these restorations is lacking.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The purpose of this study was to evaluate the residual dentin thickness in mandibular premolars after post-and-core restorations using cone beam computed tomography (CBCT) and to analyze the stress distribution with finite element analysis (FEA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;The CBCT data from 236 mandibular premolars having undergone post-and-core restorations were examined. An imaging software program (NNT; NewTom) was used to measure the buccolingual and mesiodistal root diameters in cross-sections 5 to 11 mm from the radiologic apex. The CBCT derived measurements were subsequently integrated into an FEA model. A 3-dimensional (3D) mandibular premolar model reflecting the residual dentin thickness was created with a computer-aided design software program (Hypermesh 9.0; Altair Engineering). A static force of 100 N was applied directly to the buccal cusp tip at 45, 60, 75, and 90 degrees to the long axis of the tooth, and the stress distribution of dentin was analyzed by using an FEA software program (ANSYS APDL 18.0; Ansys Inc).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;CBCT analysis showed that the buccolingual root diameter was wider than the mesiodistal diameter and that the residual dentin thickness of the buccal aspect was approximately 0.3 mm thinner compared with the lingual aspect along the root. The proportions of residual dentin thickness values in the buccolingual direction of the mandibular premolar teeth no less than 1 mm exceeded 96.2% at 5 to 11 mm from the apex. The proportions of residual dentin thickness values in the mesiodistal direction of the mandibular premolar teeth &gt;1 mm were 92.1% and 88.2% at 11 mm from the apex after post space preparation and decreased further to 70.8% and 58.9% at 5 mm from the apex. The von Mises stresses of the mandibular premolar model with residual dentin thickness were mainly localized to the cervical area (region C, cervix) and the post apex (region A, apex) in the buccolingual direction. Tensile and compressive stress were concentrated on regions C and A on the buccal and lingual sides, respectively. The actual residual dentin thickness model demonstrated higher maximum tensile stress compared with the 1-mm residual dentin thickness model under various loading conditions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;During the process of post space preparation in mandibular premolars, sufficient dentin thickness should be retained in the apical region. The tensile stresses of mandibular premolars after clinical post-and-core restoration were mainly concentrated in the cervical area and the post apex, and the maximum tensile stress value was higher than the ideal 1-mm r","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A technique to enhance the gingival esthetics of a prototype complete arch fixed implant-supported prototype prosthesis using a 3D printed gingival veneer.","authors":"Gregory Tao, Avinash S Bidra","doi":"10.1016/j.prosdent.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.12.007","url":null,"abstract":"<p><p>An important step in the workflow for a complete arch fixed implant-supported prosthesis is the fabrication of a prototype resin prosthesis to allow the patient to visualize the definitive treatment outcome and also to use as an interim prosthesis. Producing a prototype prosthesis with the natural appearance of the gingival color and contour has been challenging. Current methods include painted stains, manually applied pink composite resin or autopolymerizing acrylic resin, and multicolored resin blocks, but these are all relatively expensive, have less than optimal esthetics, and are labor-intensive and time-consuming. This technique article describes a digital workflow to design and fabricate a complete arch 3D printed gingival veneer that can be directly bonded onto a white prototype resin prosthesis to enhance gingival esthetics. Additional technical details related to the design and fabrication of the separate pink and white components and bonding and sealing them together are also provided.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of interproximal and occlusal contacts of single posterior implant-supported restorations fabricated using different CAD software programs: A clinical study.","authors":"Moamen Mohsen Sarhan, Nermeen Abd Elsalam Rady, Mohamed Moataz Khamis","doi":"10.1016/j.prosdent.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.11.009","url":null,"abstract":"<p><strong>Statement of problem: </strong>The accuracy of the interproximal and occlusal contacts of single posterior implant-supported restorations designed using computer-aided design (CAD) software programs remains uncertain.</p><p><strong>Purpose: </strong>The aim of this clinical study was to assess the interproximal and occlusal contacts of single posterior implant-supported restorations designed with 2 distinct dental CAD software programs.</p><p><strong>Material and methods: </strong>Forty single posterior implant-supported restorations were evaluated for interproximal and occlusal contacts. Restorations were designed with 2 CAD software programs (exocad and Dental System) by using the same digital scan and milled with the same milling machine and material. Two study groups were formed according to the CAD software program used (n=20). Dental floss, 12-µm shimstock, the OccluSense device, and the Medit occlusion analyzer app were used to evaluate the interproximal, static, and dynamic occlusal contacts. The Shapiro-Wilk normality test was used, and the Z-test was used to compare the results (α=.05).</p><p><strong>Results: </strong>The interproximal and static occlusal contacts were statistically more accurate when using the Dental System 3Shape software program than the exocad software program (P<.05). No statistically significant difference in the dynamic occlusal contact was found between the 2 studied groups (P=.147).</p><p><strong>Conclusions: </strong>The accuracy of interproximal and occlusal contacts of single posterior implant-supported restorations differed depending on the CAD software program used. The Dental System 3Shape software program demonstrated more accurate interproximal and static occlusal contacts than the exocad software program.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effectiveness of atorvastatin mouthwash on denture stomatitis: A randomized, double-blind controlled trial.","authors":"Iman Haghani, Majid Saeedi, Amirhossein Babaei, Zahra Yahyazadeh, Abolfazl Hosseinnataj, Mohammad Ebrahimi Saravi, Fatemeh Akbari, Anahita Lotfizadeh, Ehsan Rajabi Visroodi, Tahereh Molania","doi":"10.1016/j.prosdent.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.12.003","url":null,"abstract":"<p><strong>Statement of problem: </strong>Denture stomatitis (DS) is a common oral disorder in patients with complete maxillary dentures. Typical treatments such as nystatin or azoles lead to drug resistance after a long period. Several studies have shown the antifungal activity of statins against Candida albicans; however, studies on the antifungal effect of atorvastatin against DS are lacking.</p><p><strong>Purpose: </strong>The purpose of this randomized, double-blind controlled trial was to assess the effectiveness of atorvastatin mouthwash against DS.</p><p><strong>Material and methods: </strong>Twenty-two participants diagnosed with DS were randomly allocated into 2 groups: 11 in the intervention group (atorvastatin mouthwash) and 11 in the control group (nystatin). Participants were asked to use the mouthwash 3 times a day for 2 weeks. The length and width of the lesions were measured, and the number of colonies were counted on days 1 and 14. Data were analyzed with the Spearman correlation coefficient and the Mann-Whitney, Kruskal Wallis, and Wilcoxon tests (α=.05).</p><p><strong>Results: </strong>The number of colonies before and after using a mouthwash was significantly different in the control and intervention groups (P=.005 and P=.003, respectively). The number of colonies in the 2 groups were statistically similar on the first day (P=.809). However, a significant difference was observed between the groups on day 14 (P=.024). The number of colonies in the atorvastatin group decreased more than nystatin, indicating that atorvastatin was more effective. A significant difference among the groups was found in terms of Candida species detected after the intervention (P=.032).</p><p><strong>Conclusions: </strong>Atorvastatin was effective in reducing Candida species in participants with DS and can be used as an antifungal agent in treating DS.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A digital workflow for integrating diagnostic dentures into dynamic navigation-guided implant surgery.","authors":"Min Liu, Jun-Yu Shi, Yin-Xin Gu, Hong-Chang Lai","doi":"10.1016/j.prosdent.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.11.013","url":null,"abstract":"<p><p>The dual cone beam computed tomography (CBCT) method is the established way of planning prosthetically driven implant treatment for edentulous jaws. Although effective, it is time-consuming and complex for dynamic real-time navigation surgery procedures. This article presents a novel technique that describes a single CBCT scan registration method integrating diagnostic denture information into dynamic real-time navigation to streamline the implant planning process effectively.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wear resistance of 3D printed, milled, and prefabricated methacrylate-based resin materials: An in vitro study.","authors":"Passupang Veerapeindee, Pimduen Rungsiyakull, Wissanee Jia-Mahasap","doi":"10.1016/j.prosdent.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.12.006","url":null,"abstract":"<p><strong>Statement of problem: </strong>Three-dimensional (3D) printing and milling technologies have been increasingly used in prosthodontic practice for fabricating digital prostheses. Nevertheless, evidence relating to the wear resistance of denture teeth fabricated using these methods is lacking.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to compare the wear resistance exhibited by denture teeth fabricated using 3D printing and milling technologies with prefabricated denture teeth.</p><p><strong>Material and methods: </strong>Fifty specimens of resin denture teeth from 3 types of manufacturing processes were prepared and divided into 5 groups: 1 group of 3D printed denture teeth (NextDent C&B MFH), 2 groups of milled denture teeth (Ivotion Dent and VIPI Block), and 2 groups of prefabricated denture teeth (Major Dent and Cosmo HXL). Each group of specimens was occluded with a zirconia antagonist under a 49-N load with thermocycling conditions for 120 000 cycles. The antagonist was horizontally displaced back and forth at a 2-mm distance and a frequency of 1.6 Hz. The quantification of the volume loss and the maximal wear depth of the worn specimens were recorded, while the wear characteristics were assessed with a scanning electron microscope (SEM). Data were analyzed using the Kruskal-Wallis test followed by pairwise comparison tests (α=.05).</p><p><strong>Results: </strong>Significantly different wear depths and volume losses were found among groups (P<.05). The highest wear depth and volume loss were observed in the VIPI Block (0.513 ±0.147 mm and 3.094 ±0.790 mm³), followed by Cosmo HXL group (0.312 ±0.020 mm and 1.446 ±0.134 mm³), Major Dent (0.261 ±0.034 mm and 1.219 ±0.196 mm³), Ivotion Dent (0.253 ±0.021 mm and 1.082 ±0.089 mm³), and NextDent C&B MFH (0.208 ±0.059 mm and 0.843 ±0.372 mm³). Based on the analysis of the SEM images, distinct groups of specimens exhibited varying degrees of crack formation. Furthermore, their worn surfaces showed diverse characteristics in terms of wear patterns and roughness attributes.</p><p><strong>Conclusions: </strong>The manufacturing methods for fabricating 3D printed, milled, and prefabricated denture teeth exhibit comparable wear resistance, with 3D printed denture teeth demonstrating the highest level of wear resistance.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital trifunctional intraoral appliance for centric relation recording: A dental technique.","authors":"Chu-Chi Huang, Sang J Lee, German O Gallucci, Jason D Lee","doi":"10.1016/j.prosdent.2024.11.019","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.11.019","url":null,"abstract":"<p><p>A technique for fabricating a trifunctional intraoral appliance is described. This appliance streamlines the process of recording centric relation by combining the functions of an anterior deprogrammer, gothic arch tracer, and record base with occlusal rims into a single device. The use of digital tools in this technique offers greater convenience and efficiency compared with conventional methods.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of different surface treatments on PEEK-enamel bonds: Bonding durability and mechanism.","authors":"Yuchen Liu, Shizhu Bai, Hengyan Liu, Kangjie Li, Sheng Zhong, Meng Li, Li Chen, Min Tian, Lina Niu, Ming Fang","doi":"10.1016/j.prosdent.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.11.012","url":null,"abstract":"<p><strong>Statement of problem: </strong>Polyetheretherketone (PEEK) has been used in clinical dentistry because of its excellent physical and biological properties. However, achieving an effective and durable bond with enamel is challenging because of its chemical inertness and low surface energy, and data on the effects of different surface treatments on the durability of PEEK-enamel bonds are scarce.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to investigate airborne-particle abrasion, sulfuric acid etching, and the combined use of these treatments on the bonding durability of PEEK-enamel bonds and to gain a deeper understanding of their bonding mechanism.</p><p><strong>Material and methods: </strong>Sixty specimens were divided into 6 groups based on different surface treatments: untreated, sulfonation for 30 seconds, sulfonation for 60 seconds, airborne-particle abrasion, airborne-particle abrasion and sulfonation for 30 seconds, and sulfonation for 30 seconds and airborne-particle abrasion. Comprehensive evaluations were carried out on the surface morphology and physicochemical properties of the pretreated PEEK. After screening out the preferred surface treatment strategy of PEEK, the durability of PEEK-enamel bonds after thermal cycling (10 000 cycles at 5 to 55 °C) and the bonding mechanism were investigated by bond strength testing, cross-sectional topography, molecular dynamics,and Fourier transform infrared spectroscopy. Data were analyzed by 1-way analysis of variance, Weibull analysis, and the Fisher exact test (α=.05).</p><p><strong>Results: </strong>The shear bond strength of the 98% sulfuric acid etching group for either 30 seconds or 60 seconds was significantly higher than that of the other groups (P<.05). Intermolecular hydrogen bonding was found between PEEK and the methyl methacrylate- (MMA-) containing adhesive resin. Cross-sectional topography showed that the adhesive resin infiltrated into the pores of the sulfonated PEEK, thereby forming micromechanical locking at the bonded interface. The bond strength between the enamel and PEEK treated with 98% sulfuric acid for 60 seconds was found to be more reliable than that observed in the group treated with 98% sulfuric acid for 30 seconds after aging (P<.05).</p><p><strong>Conclusions: </strong>PEEK pretreated by 98% sulfuric acid etching for 60 seconds presented the best physicochemical properties. This was better than combined etching and airborne-particle abrasion or airborne-particle abrasion alone and showed durable PEEK-enamel bonds with the application of an MMA-containing adhesive.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}