{"title":"Genetic evidence for the causal effects of malocclusion and dental attrition on temporomandibular disorders: A multivariable Mendelian randomization study.","authors":"Sasidharan Sivakumar, Sivan Sathish, Balakrishnan Ramalingam, Ashok K Sundramoorthy, Gowardhan Sivakumar","doi":"10.1016/j.prosdent.2026.09.019","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.09.019","url":null,"abstract":"<p><strong>Statement of problem: </strong>The causal role of occlusal factors, particularly malocclusion and dental attrition, in temporomandibular disorders (TMDs) remains unclear because of inconsistent observational evidence and confounding influences, limiting definitive conclusions regarding their independent etiological contributions.</p><p><strong>Purpose: </strong>The purpose of this study was to investigate the independent causal effects of malocclusion and dental attrition on TMDs using multivariable Mendelian randomization (MVMR).</p><p><strong>Material and methods: </strong>A 2-sample MR framework used genome-wide association study (GWAS) summary data from European cohorts. Pairwise Mendelian randomization (MR) analyses and linkage disequilibrium score regression (LDSC) estimated genetic correlations. MVMR then assessed independent causal effects, accounting for shared genetic architecture, utilizing the inverse variance weighted (IVW) method as the primary estimator. Instrument strength was verified via conditional F-statistics. Sensitivity analyses evaluated instrument heterogeneity (Cochran Q) and directional horizontal pleiotropy (MR-Egger intercepts).</p><p><strong>Results: </strong>Genetic liability to malocclusion demonstrated a strong association with TMD risk (IVW β=1.059, P<.001), remaining robust in MVMR (β=1.013, P≤.001). Conversely, dental attrition showed no causal effect (MVMR β=-.018, P=.078). LDSC revealed moderate genetic correlation (rg=.580). Sensitivity diagnostics confirmed the absence of heterogeneity and pleiotropy (P>.05).</p><p><strong>Conclusions: </strong>Genetic liability to malocclusion was found to be an independent risk factor for TMDs, whereas attrition was found to be a secondary marker of occlusal instability, lacking an independent direct effect.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bozhi Li, Chuishang Kong, Gang Nan, Lizhi Ren, Wei Liu, Qianqian Wang, Dan Wang, Fang Pang, XueJun Ge
{"title":"Nanoparticle jetting 3D printing of zirconia: Optimized intaglio microstructures for achieving superior bonding performance and fracture resistance in fixed prosthodontics.","authors":"Bozhi Li, Chuishang Kong, Gang Nan, Lizhi Ren, Wei Liu, Qianqian Wang, Dan Wang, Fang Pang, XueJun Ge","doi":"10.1016/j.prosdent.2026.09.024","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.09.024","url":null,"abstract":"<p><strong>Statement of problem: </strong>Ultrathin 3-dimensionally (3D) printed zirconia restorations require optimized intaglio microstructures to balance bonding performance and fracture resistance; however, systematic data regarding surface morphology and depth for nanoparticle jetting (NPJ)-fabricated zirconia are lacking.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to investigate the effects of surface-microstructural morphology and depth on the shear bond strength (SBS) and fracture load of NPJ 3D printed zirconia restorations and to optimize the surface-topography design for clinical use.</p><p><strong>Material and methods: </strong>Zirconia specimens with 4 surface textures (circular, triangular, concentric circular, and undercut circular) and 4 depths (40, 60, 80, and 100 μm) were fabricated by NPJ additive manufacturing and conventional milling. Ultrathin zirconia complete crowns (0.5 mm thick) were prepared. The SBS and fracture load were tested with a universal material testing machine. The debonding modes and interfacial elemental composition were analysed by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). One-way analysis of variance (ANOVA) coupled with the Tukey HSD test was adopted for intergroup comparisons (α=.05).</p><p><strong>Results: </strong>The bonding performance and mechanical strength of nontextured NPJ-printed zirconia were similar to those of milled zirconia (P=.984). The surface microstructures significantly increased the bond strength, with the circular and undercut circular textures performing the best. The bond strength increased with depth and plateaued at 80 to 100 μm. For the 0.5-mm crowns, the fracture load decreased significantly with increasing depth (P<.001). The 60-μm circular microstructure balanced favorable SBS and mechanical stability, and all the groups satisfied clinical mechanical criteria under the International Organization for Standardization (ISO) 6872 graded standards.</p><p><strong>Conclusions: </strong>NPJ technology enables precise control of the zirconia surface topography to increase bonding. For ultrathin prostheses, the 60-μm circular microstructure represented the optimal design that provided high bond strength and sufficient fracture resistance for clinical application.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eirini Zampara, Eleana Kontonasaki, Edmara T P Bergamo, Ronaldo Hirata, Caroline Vieira Maluf, Savvas Koltsakidis, Dimitrios Tzetzis, Marly Vale, Estevam A Bonfante, Leila Jahangiri, Lukasz Witek
{"title":"Fatigue reliability and failure modes of metal-ceramic, monolithic zirconia, and lithium disilicate implant-supported crowns cemented to titanium bases: A step-stress accelerated life testing study.","authors":"Eirini Zampara, Eleana Kontonasaki, Edmara T P Bergamo, Ronaldo Hirata, Caroline Vieira Maluf, Savvas Koltsakidis, Dimitrios Tzetzis, Marly Vale, Estevam A Bonfante, Leila Jahangiri, Lukasz Witek","doi":"10.1016/j.prosdent.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.09.007","url":null,"abstract":"<p><strong>Statement of problem: </strong>The fatigue behavior under clinically relevant loading conditions of implant-supported screw-retained crowns cemented to titanium bases fabricated from different restorative materials remains insufficiently understood.</p><p><strong>Purpose: </strong>The purpose of this study was to evaluate the failure modes, fatigue reliability, and survival probabilities of metal-ceramic (MC), monolithic zirconia (3Y-TZP), and lithium disilicate (LD) single premolar implant-supported screw-retained crowns cemented to titanium bases using step-stress accelerated life testing (SSALT).</p><p><strong>Material and methods: </strong>Sixty crowns were bonded to titanium bases (UNP RH 4 mm, GH 2 mm; Adin Dental Implant Systems Ltd), connected to internal hexagon implants (4.2-mm platform diameter, 10-mm length; Touareg S, Adin Dental Implant Systems Ltd), embedded in acrylic resin blocks, and subjected to single-load-to-failure testing (n=6) to determine stress profiles for SSALT (n=54). Use-level probability Weibull curves were calculated to estimate reliability for a mission of 100 000 cycles at 200 and 300 N. Failed specimens underwent polarized light stereomicroscopy and scanning electron microscopy (SEM) for fractographic analysis.</p><p><strong>Results: </strong>All specimens failed during SSALT loading profiles. Beta (β) values derived from use-level probability Weibull curves were greater than 1 for all groups, indicating fatigue-driven failure behavior. 3Y-TZP crowns demonstrated the highest fatigue reliability, with survival probabilities up to 98% at tested load levels (200 and 300 N). LD showed intermediate performance (93% at 200 N and 88% at 300 N), whereas MC crowns showed the lowest survival probabilities (86% at 200 N and 82% at 300 N). At 200 N, no statistically significant differences were observed among groups. At 300 N, 3Y-TZP crowns showed significantly higher survival probability than MC crowns (P=.038), while LD showed intermediate values and was not significantly different from either group. Fractographic analysis revealed material-specific fracture origins and crack propagation patterns.</p><p><strong>Conclusions: </strong>All crown types demonstrated high survival probabilities. 3Y-TZP crowns showed higher fatigue reliability than MC crowns, while LD crowns demonstrated intermediate performance.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor regarding \"Three-dimensionally printed, noninvasive restorations in the treatment of localized tooth wear using the Dahl approach: A preliminary clinical trial\".","authors":"Syeda Maryam Rehman, Javeria Kashaf Zain","doi":"10.1016/j.prosdent.2026.09.021","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.09.021","url":null,"abstract":"","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor regarding, \"An analog-digital hybrid approach to constructing immediate dentures with optimized border extensions\".","authors":"Suraj Lawande, Manish Jadhav, Madhav V N V","doi":"10.1016/j.prosdent.2026.07.038","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.07.038","url":null,"abstract":"","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarthak Singh Tomar, Manu Rathee, Mathiyazhagan Stalin, Senthilvelpalani Balavignesh
{"title":"Digital technique for fabricating complete dentures with detachable 3D printed cheek plumper prostheses using integrated attachments.","authors":"Sarthak Singh Tomar, Manu Rathee, Mathiyazhagan Stalin, Senthilvelpalani Balavignesh","doi":"10.1016/j.prosdent.2026.09.016","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.09.016","url":null,"abstract":"<p><p>Cheek plumper prostheses have been used to restore facial fullness in completely edentulous individuals with sunken cheeks. Conventional methods of fabricating detachable cheek plumper prostheses often rely on prefabricated attachments or manual laboratory procedures, which may increase prosthesis bulk and limit reproducibility. This dental technique describes a combined conventional-digital workflow for fabricating complete dentures with detachable 3-dimensionally (3D) printed cheek plumper prostheses using integrated attachment components. A silicone ring-retained matrix and an antirotational feature were incorporated to improve retention and stability. This approach facilitates controlled prosthesis design and the predictable fabrication of detachable components.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
André-Joubin Derakhshani, Ingrid Peroz, Robert Nicic, Zhen Mao, Florian Beuer, Simon Peroz, Elisabeth Prause
{"title":"Response to Letter to the Editor on the manuscript \"Three-dimensionally printed, noninvasive restorations in the treatment of localized tooth wear using the Dahl approach: A preliminary clinical trial\".","authors":"André-Joubin Derakhshani, Ingrid Peroz, Robert Nicic, Zhen Mao, Florian Beuer, Simon Peroz, Elisabeth Prause","doi":"10.1016/j.prosdent.2026.09.020","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.09.020","url":null,"abstract":"","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uriel Paulo Coelho Silva, Eduarda Stefanny Reis da Cunha, Maria Eduarda Casadei Motta Bellini, Liliana Vicente Melo de Lucas Rezende, Lucas Fernando Tabata, Cristine Miron Stefani, Fernanda Cristina Pimentel Garcia
{"title":"Repair strategies for lithium disilicate ceramics: A scoping review.","authors":"Uriel Paulo Coelho Silva, Eduarda Stefanny Reis da Cunha, Maria Eduarda Casadei Motta Bellini, Liliana Vicente Melo de Lucas Rezende, Lucas Fernando Tabata, Cristine Miron Stefani, Fernanda Cristina Pimentel Garcia","doi":"10.1016/j.prosdent.2026.09.018","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.09.018","url":null,"abstract":"<p><strong>Statement of problem: </strong>Repair techniques for lithium disilicate ceramics vary widely, and their effects on immediate and aged bond strength have not been fully established.</p><p><strong>Purpose: </strong>The purpose of this scoping review was to map evidence on surface treatment protocols and repair materials used for lithium disilicate ceramics and their influence on repair bond strength.</p><p><strong>Material and methods: </strong>This scoping review followed Joanna Briggs Institute methodology and was registered in Open Science Framework. Searches were performed in major electronic databases and nonpeer-reviewed literature up to January 2025. In vitro studies evaluating surface treatments and repair materials for lithium disilicate ceramics were included.</p><p><strong>Results: </strong>Twenty-seven in vitro studies were included. Mechanical pretreatments mainly involved hydrofluoric acid etching, aluminum oxide airborne-particle abrasion, phosphoric acid etching, and laser irradiation. Chemical conditioning commonly included silane application with adhesive systems, followed by composite resin repair.</p><p><strong>Conclusions: </strong>The findings highlighted that combined mechanical and chemical pretreatment strategies are essential to optimize repair bond strength, although aging consistently reduces adhesion durability.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Circular comparison of finish lines obtained from digital scans and conventional impressions: A clinical study.","authors":"Heng Chen, Shaza Bishti, Sven Reich","doi":"10.1016/j.prosdent.2026.07.037","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.07.037","url":null,"abstract":"<p><strong>Statement of problem: </strong>Clinical studies that have investigated whether intraoral scanners (IOSs) are equivalent or even superior to conventional impressions in capturing subgingival finish lines are sparse.</p><p><strong>Purpose: </strong>The purpose of this clinical study was to compare circumferentially the course of subgingival chamfer preparations captured by both digital scans (DIGI) and conventional impressions (CONI) using CONI as reference.</p><p><strong>Material and methods: </strong>Sixteen patients with a total of 50 teeth requiring crown preparations were included. For each die, a conventional polyether double-mix impression was made for the CONI workflow, and an intraoral scan was obtained for the DIGI setup. The CONI definitive casts were digitized, and the finish lines of the dies were defined for both workflows. The corresponding CONI and DIGI dies were registered. The deviations of the finish lines were analyzed circumferentially using an inspection software program with CONI as the reference. Positive (apical) and negative (coronal) deviations were calculated. Descriptive statistics were computed, normality was assessed using the Shapiro-Wilk test, and differences among tooth regions were analyzed using a linear mixed-effects model (α=.05).</p><p><strong>Results: </strong>On average, 9% of the DIGI finish lines were apical relative to the CONI margins, with a mean ±standard deviation of 68 ±54 µm. In contrast, 91% of the DIGI finish lines were located coronally, with a mean ±standard deviation of 245 ±108 µm. There were no statistically differences among tooth regions (P>.05).</p><p><strong>Conclusions: </strong>The results of this study suggest that digital scans may not capture subgingival preparation margins with the same accuracy as conventional methods.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhen Mao, Elisabeth Prause, Robert Nicic, Tadas Korzinskas, Till Edward Bechtold, Florian Beuer, André-Joubin Derakhshani
{"title":"Enhancing color and comfort: A preliminary clinical study on the Dahl approach using 3D printed noninvasive restorations.","authors":"Zhen Mao, Elisabeth Prause, Robert Nicic, Tadas Korzinskas, Till Edward Bechtold, Florian Beuer, André-Joubin Derakhshani","doi":"10.1016/j.prosdent.2026.08.028","DOIUrl":"https://doi.org/10.1016/j.prosdent.2026.08.028","url":null,"abstract":"<p><strong>Statement of problem: </strong>Clinical evidence regarding the long-term (up to 24 months) color stability of 3-dimensional printed (3D), noninvasive restorations is scarce, particularly when used to implement the Dahl concept. Whether these restorations meet esthetic requirements over time and how potential discoloration affects patient-reported outcomes remains unclear.</p><p><strong>Purpose: </strong>The purpose of this clinical pilot study was to provide initial clinical evidence on the performance of 3D printed, noninvasive restorations used for the implementation of the Dahl concept, with a particular focus on their long-term color stability and their impact on patient-reported oral health-related quality of life.</p><p><strong>Material and methods: </strong>Five participants with localized tooth wear were included in the study, each treated with 3D printed, noninvasive restorations fabricated from a computer-aided design and computer-aided manufacturing (CAD-CAM) ceramic-filled hybrid composite material. Color change measurements were performed using a spectrophotometer to record L* (lightness), a* (red-green), and b* (blue-yellow) values at 6, 12, and 24 months. Patient-related quality of life was evaluated using the Oral Health Impact Profile (OHIP) questionnaire.</p><p><strong>Results: </strong>Four participants with 24 restorations were documented. All restorations remained clinically in complete function over the 24-month follow-up. Spectrophotometric analysis revealed progressive color changes over time, with mean ΔE values exceeding commonly accepted perceptibility (ΔE=3.7) and acceptability (ΔE=5.5) thresholds at 12 months (5.84 ±2.59) and 24 months (11.27 ±5.85). Despite the observed discoloration, patient-reported oral health-related quality of life improved after treatment and remained stable throughout the observation period, with high ratings for function, comfort, and esthetics.</p><p><strong>Conclusions: </strong>Although 3D printed, noninvasive restorations improved patient-related oral health quality of life, their unfavorable long-term color stability limits their use to long-term interim restorations as advocated by the Dahl concept.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}