Journal of Prosthetic Dentistry最新文献

{"title":"A digital workflow for recording implant positions and jaw relation for implant-supported complete arch prostheses.","authors":"Min Liu, Xiao-Jiao Fu, Bei-Lei Liu, Hong-Chang Lai, Jun-Yu Shi","doi":"10.1016/j.prosdent.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.10.002","url":null,"abstract":"<p><p>Conventional impression and jaw relation recording techniques for complete arch implant-supported fixed dental prostheses are complicated, but intraoral scanning offers alternatives to conventional procedures. This article presents a novel digital workflow for recording the relative positions of implants and jaw relation for complete arch implant-supported fixed dental prostheses.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthodontic rehabilitation of a patient after mucormycosis using a digitally fabricated hollow complete denture with 3D printed intramucosal inserts.","authors":"Sarthak Singh Tomar, Manu Rathee, Kritika Diwan, Aarti Sulekh","doi":"10.1016/j.prosdent.2024.09.022","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.022","url":null,"abstract":"<p><p>Denture retention in edentulous patients following resection for mucormycosis or carcinoma is challenging because of the lack of bony support. Traditional dentures are often unsatisfactory, and implants require complex bone grafting. This clinical report presents a novel approach using 3-dimensionally (3D) printed intramucosal inserts and a digitally fabricated hollow denture. The process involved conventional impressions, digital designing, and 3D printing of both the hollow denture and the custom intramucosal inserts based on mucosal thickness. This approach led to improved retention, functionality, and esthetics, offering a minimally invasive alternative with fewer complications to traditional dentures and implants.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unconventional digital dentures: Overcoming software challenges and integrating digital workflows into conventional techniques.","authors":"Sarthak Singh Tomar, Manu Rathee, Kritika Diwan, Balavignesh Senthilvelpalani","doi":"10.1016/j.prosdent.2024.09.026","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.026","url":null,"abstract":"<p><p>Digital workflows have revolutionized denture fabrication, offering greater customization and rapid production. This clinical report describes 2 treatment approaches using digital techniques to address prosthetic challenges. The first patient had a large maxillary defect after mucormycosis surgery, necessitating a combination of digital and conventional methods for obturator fabrication because of computer-aided design software program limitations. For the second patient, digital workflows were combined with the conventional neutral zone technique to improve denture stability and retention, effectively addressing the challenge of severely resorbed arches. These treatment approaches demonstrate the potential of digital workflows in prosthodontics and highlight the need for further technological advancements.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.","authors":"David R Cagna, Terence E Donovan, James R McKee, James E Metz, Riccardo Marzola, Kevin G Murphy, Matthias Troeltzsch","doi":"10.1016/j.prosdent.2024.10.014","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.10.014","url":null,"abstract":"<p><p>The Scientific Investigation Committee of the American Academy of Restorative Dentistry offers this review of select 2023 dental literature to briefly touch on several topics of interest to modern restorative dentistry. Each committee member brings discipline-specific expertize in their subject areas that include (in order of appearance here): prosthodontics; periodontics, alveolar bone, and peri-implant tissues; dental materials and therapeutics; occlusion and temporomandibular disorders; sleep-related breathing disorders; oral medicine, oral and maxillofacial surgery, and oral radiology; and dental caries and cariology. The authors have focused their efforts on presenting information likely to influence the daily dental treatment decisions of the reader with an emphasis on current innovations, new materials and processes, emerging technology, and future trends in dentistry. With the overwhelming volume of literature published daily in dentistry and related disciplines, this review cannot be comprehensive. Instead, its purpose is to inform and update interested readers and provide valuable resource material for those willing to subsequently pursue greater detail on their own. Our intent remains to assist colleagues in navigating the tremendous volume of newly minted information produced annually. Finally, we hope readers find this work helpful in providing evidence-based care to patients seeking healthier and happier lives. (J Prosthet Dent 2024;132:■■■-■■■).</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically coupled tooth arrangement for an implant-supported fixed complete denture: A dental technique.","authors":"Omar Moustafa, Jacqueline Chow, Damian J Lee","doi":"10.1016/j.prosdent.2024.09.025","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.025","url":null,"abstract":"<p><p>Magnets have been used to help position dental components, including magnetic mounting plates for articulators and magnetic attachments for implant surgical guides. A magnetically coupled tooth arrangement technique used the fixed reference point of integrated implants to determine maxillomandibular relations and the tooth arrangement, thus improving the efficiency of the clinical appointment. The magnetic framework was screwed into the implants only once for the duration of a clinical appointment. The base was used to complete the tooth arrangement and determine the maxillomandibular jaw relationship.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of polishing protocols on microhardness and surface roughness of occlusal device materials fabricated using microwave-polymerized acrylic or 3D printed resins.","authors":"Thiago Carvalho de Sousa, Alexia Guimarães Ramos, Fernanda Cristina Pimentel Garcia, Rodrigo Antonio de Medeiros","doi":"10.1016/j.prosdent.2024.10.010","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.10.010","url":null,"abstract":"<p><strong>Statement of problem: </strong>With advancements in digital technologies, the digital workflow has revolutionized the fabrication of occlusal devices through additive methods using 3-dimensional (3D) printing. However, an established protocol for polishing 3D printed occlusal devices is lacking, despite this step being crucial for minimizing surface porosity, material fatigue and preventing bacterial plaque accumulation, thereby contributing to device longevity.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to evaluate the impact of polishing systems on the surface roughness and Vickers microhardness of heat-polymerizing acrylic resin and 3D printing resins used for occlusal devices.</p><p><strong>Material and methods: </strong>One hundred and twenty microwaved-polymerized acrylic resin and 3D printed resin specimens (40×40×3 mm) were divided into 12 groups (n=10) based on the type of resin and polishing protocol (Sealant, DhPro, Dhpro + Sealant, Trihawk, Trihawk + Sealant, and control). Surface roughness (Ra) and Vickers microhardness were tested. Additionally, 1 specimen per group underwent scanning electron microscopy before and after thermocycling (5000 cycles, 5 ºC and 55 ºC). Data analysis involved a 2-way ANOVA, 2-way repeated measured ANOVA, and Tukey's multiple comparison test (α=.05).</p><p><strong>Results: </strong>The Trihawk polishing protocol yielded significantly higher microhardness and lower surface roughness values for both resins. After thermocycling, the acrylic resin maintained its surface roughness for the Trihawk, Trihawk + Sealant, and unpolished groups, but all groups showed decreased microhardness. The 3D printing resin exhibited increased surface roughness and reduced microhardness after thermocycling across all groups.</p><p><strong>Conclusions: </strong>The polishing protocol affects the surface microhardness and roughness of 3D printing resins and microwave acrylic resins for occlusal devices. Polishing using the Trihawk polishing protocol demonstrated significantly smoother and harder surfaces for both resins tested.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of speed sintering on the mechanical and optical properties of multilayered zirconia.","authors":"Omar Mohamed, Hyeongil Kim, Steven Makowka, Ahmed AlMozayen, Kedith Sawangsri, Rui Li","doi":"10.1016/j.prosdent.2024.09.030","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.030","url":null,"abstract":"<p><strong>Statement of problem: </strong>Speed sintering techniques have been introduced to shorten the sintering time of zirconia ceramics, yet their impact on multilayered zirconia properties remains understudied.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to assess the effect of speed sintering on the optical properties and the mechanical flexural strength of multilayered zirconia materials.</p><p><strong>Material and methods: </strong>A total of 360 disks (Ø14 ±2 mm ×1.2 ±0.02 mm) were fabricated by following the International Organization for Standardization (ISO) 6872:2015 standard using 2 types of Vita A2 shade multilayered zirconia materials: IPS e.max ZirCAD Prime (ZP) and IPS e.max ZirCAD Prime Esthetic (ZPE). Each material comprised translucent (Tr), gradient l (Gr), and dentin (De) layers, with 60 disks per layer. Half were sintered using a standard sintering protocol and half using a speed sintering protocol. Biaxial flexural strength was accessed using a universal testing machine equipped with the Blue Hill Universal software program by following the ISO 6872:2015 standard, with 20 disks per subgroup. The spectrophotometric analysis of optical properties (contrast ratio [CR], translucency parameter [TP], and total transmittance [Tt%]) was performed using a dual-beam spectrophotometer (Ultrascan VIS) in accordance with the ISO 7491:2000 standard, with 10 disks per subgroup. The comparison of the optical properties and the mechanical flexural strength between the speed and standard protocol was analyzed using an unpaired t test (α=.05).</p><p><strong>Results: </strong>Speed sintering reduced biaxial flexural strength in all ZP layers (P<.05) and in ZPE-Gr (P<.05). A statistically significant difference in the CR was observed in the ZP-Tr, ZP-Gr, and ZPE-Gr layers (P<.05). The TP of the ZP-Gr, ZP-De, and ZPE-Gr layers was significantly lower when using the speed sintering protocol. Tt% was significantly lower with speed sintering for both materials (P<.05).</p><p><strong>Conclusions: </strong>Speed sintering statistically changed both the optical (CR, TP, Tt%) and mechanical (flexural strength) properties of multilayered zirconia materials, but the differences may not be clinically relevant.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of toothbrushing on surface roughness and gloss of CAD-CAM versus conventional interim materials with different surface treatments.","authors":"Sarasinee Sattawatthamrong, Krid Kamonkhantikul, Woraporn Homsiang, Mansuang Arksornnukit","doi":"10.1016/j.prosdent.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.10.003","url":null,"abstract":"<p><strong>Statement of problem: </strong>Characterizing interim restorations promotes esthetics. However, studies on the effects of characterization materials on the surface roughness and gloss of interim materials after toothbrushing are lacking.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to evaluate the surface roughness and gloss of 5 different interim materials with different surface treatments after 1 year of simulated toothbrushing.</p><p><strong>Material and methods: </strong>Cuboid specimens (10×12×2 mm) were fabricated from each interim material: autopolymerized polymethyl methacrylate (UNIFAST Trad), autopolymerized bis-acryl composite resin (Protemp 4), light-activated composite resin (REVOTEK LC), milled polymethyl methacrylate block (DD provi P HI), and 3-dimensionally printed methacrylate oligomer (Nextdent C&B MFH). Each material was divided into 3 groups based on surface treatment (n=10): polishing, application of Lite Art and Resin Glaze, and application of OPTIGLAZE color. The specimens were subjected to 5000 and 10 000 cycles of toothbrushing. The surface roughness and gloss were measured and separately analyzed by using 3-way repeated measures ANOVA (α=.05).</p><p><strong>Results: </strong>Significant interactions of the surface roughness and gloss among interim materials, surface treatments, and toothbrushing durations were found (P<.001). After 5000 and 10 000 cycles, each polished material showed no significant difference in surface roughness compared with baseline: Protemp 4 (P>.999), REVOTEK LC (P>.999, P=.922), and Nextdent C&B MFH (P>.999), except for UNIFAST Trad and DD provi P HI (P<.001). Coating with Lite Art and Resin Glaze, as well as OPTIGLAZE color, significantly reduced surface roughness after both 5000 and 10 000 cycles for all materials (application of Lite Art and Resin Glaze with UNIFAST TRAD (P<.001), Protemp 4 (P<.001), REVOTEK LC (P<.001), DD provi P HI (P<.001), and Nextdent C&B MFH (P<.001, P=.002), and application of OPTIGLAZE color with UNIFAST TRAD (P<.001), Protemp 4 (P<.001), REVOTEK LC (P<.001, P=.002), DD provi P HI (P<.001), and Nextdent C&B MFH (P<.001, P=.008)). Specimens with these treatments also exhibited significantly better gloss compared with the polished specimens (P<.001).</p><p><strong>Conclusions: </strong>After 5000 to 10 000 cycles of toothbrushing, Protemp 4, REVOTEK LC, and Nextdent C&B MFH, interim materials containing fillers, exhibited smoother surfaces compared with UNIFAST Trad and DD provi P HI, interim materials without fillers. Coating of all materials reduced surface roughness and increased gloss. After 5000 to 10 000 cycles of toothbrushing, the surface roughness of each material remained stable; while the gloss decreased slightly, it remained within clinically acceptable levels.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between implant angulation and crestal bone changes: A 5-year retrospective study.","authors":"Donghyun Kim, Kihyun Kim, Joo-Young Ohe, Seung Jun Song, Janghyun Paek","doi":"10.1016/j.prosdent.2024.09.015","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.015","url":null,"abstract":"<p><strong>Statement of problem: </strong>The effects of nonaxial forces on peri-implant bone loss have been investigated, mostly in reference to buccal mesiodistal implant angulations as potential risk indicators. However, when implant angulations are multidirectional, including the buccolingual aspect, evaluations of peri-implant bone loss based solely on mesiodistal measurements may skew the correlation.</p><p><strong>Purpose: </strong>The purpose of this retrospective study was to evaluate the correlation between the magnitudes of multidirectional implant angulations and peri-implant crestal bone loss.</p><p><strong>Material and methods: </strong>Data were retrospectively collected and analyzed from clinical records, periapical radiographic images, and computer-aided design (CAD) files of custom abutments. The study included 288 patients with 506 dental implants, and the mean follow-up duration after the placement of definitive prostheses was 5.1 years. Patients with uncontrolled systemic disease were excluded. Variables such as age, sex, type of unit (single-unit or multi-unit), location (maxillary or mandibular and anterior, premolar, or molar), and antagonist (natural tooth, implant-supported prosthesis, or removable prosthesis) were evaluated. The angulation of the implant (mesiodistal and buccolingual) and status of attrition (normal, localized, or generalized) were assessed using the CAD file. The angulation of the implant was then derived from the mesiodistal and buccolingual angle measurements by using a mathematical formula. Peri-implant bone loss was measured from periapical radiographs. A comparison of peri-implant bone loss between axial and nonaxial implants was performed using the Student t test (α=.05). Additional comparative evaluations were performed according to the type of unit, location, antagonist, and status of attrition in reference to the angulation categories.</p><p><strong>Results: </strong>The mean ±standard deviation peri-implant bone loss over 5 years was 0.10 ±0.39 mm in the axial implants and 0.22 ±0.48 mm in the nonaxial implants. Statistical analysis showed that nonaxial implants had a significantly greater bone loss (P<.05), which was more pronounced when the antagonists were implant-supported prostheses (P<.05) and when the implants were located in the mandible (P<.05).</p><p><strong>Conclusions: </strong>A significant correlation was observed between implant angulation and peri-implant bone loss. Nonaxially positioned implants exhibited greater bone loss compared with axially positioned implants. Additionally, the location of the implant and the type of antagonist were found to influence the extent of bone loss. These findings suggest that careful consideration of implant angulation, as well as the position and type of antagonist, is crucial in minimizing peri-implant bone loss.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifunctional scannable mounting device for computer guided implant surgery: An in vitro study.","authors":"Daniel Rotenberg, Yaniv Mayer, Jacob Horwitz, Yuval Nov, Hadar Zigdon-Giladi, Eran Gabay","doi":"10.1016/j.prosdent.2024.09.027","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.027","url":null,"abstract":"<p><strong>Statement of problem: </strong>As part of the growing digitization of the dental field, clinicians are looking for ways to simplify digital workflow, reduce chairside time, and provide new work patterns for future applications. Whether scanning with a multifunctional apparatus (MFA) scan body results in improved scanning is unclear.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to compare the horizontal, vertical, and angular deviations with the MFA scan body with a commercially available scan body (SBIO).</p><p><strong>Material and methods: </strong>Sixteen identically printed edentulous maxillary models were used to plan two Ø3.8×11.5-mm implants in the right maxillary first molar and left maxillary central incisor locations. Two implants in each model were installed using a surgical guide. The models were scanned using an intraoral scanner with MFA and then rescanned twice, with SBIO using the intraoral scanner and a laboratory 3D scanner. The implants were digitally positioned according to the scanned MFA and SBIO locations in standard tessellation language (STL) files. These STL files were superimposed on the reference laboratory 3D scanner STL files. Linear measurements included implant apex/cervical horizontal/vertical deviations, as well as implant axis angular deviations. Normality was evaluated with the Shapiro-Wilk test. Paired samples t tests (2 sided) were used for the mean SBIO-MFA deviation difference. To compare the molar/incisor sites, paired samples Wilcoxon tests were used (α=.05 for all tests).</p><p><strong>Results: </strong>No statistically significant differences were found between the MFA/ SBIO deviations, for each of the 10 sites × deviation combinations (P>.05). Overall, the lowest endpoint of the 95% confidence intervals among the 8 linear measurement comparisons was -0.107 mm (coronal vertical deviation, right maxillary first molar site) and -0.30 degrees between the 2 angular measurement comparisons.</p><p><strong>Conclusions: </strong>The current in vitro study demonstrated high accuracy for the novel MFA device, similar to that of the standard SBIO scan body. Furthermore, the current study offers an alternative technique to evaluate the accuracy of implant placement by using scanning and back programming over the traditional postplacement cone beam computed tomography (CBCT) scanning.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}