Journal of Prosthetic Dentistry最新文献

{"title":"Analysis of the risk of interproximal contact loss between adjacent teeth and implant-supported fixed prostheses: A retrospective cross-sectional study.","authors":"Jiaping Wang, Juan Lin, Yan Chen, Xin Wu","doi":"10.1016/j.prosdent.2025.02.047","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.047","url":null,"abstract":"<p><strong>Statement of problem: </strong>Food impaction following the placement of an implant-supported restoration is most frequently associated with a high incidence of interproximal contact loss (ICL). Food packing is unpleasant and can cause gingival inflammation and even peri-implant bone resorption. Studies on the various factors that may contribute to the occurrence of ICL are lacking.</p><p><strong>Purpose: </strong>This retrospective cross-sectional study aimed to collect and analyze data from participants to investigate the incidence of ICL between implant-supported prostheses and adjacent teeth. The study further sought to identify factors influencing ICL, evaluate participants' subjective perceptions of ICL, and explore the relationship between ICL and peri-implant tissue health.</p><p><strong>Material and methods: </strong>A total of 107 participants with 133 implant-supported fixed prostheses (ISFPs) and 172 interproximal contact relationships, all verified at the time of insertion, were included in this study. A total of 27 factors were assessed in 4 dimensions: participant, ISFP, adjacent tooth, and antagonist. The Spearman correlation analysis, linear-by-linear association chi-squared test, Pearson chi-squared test, and Fisher exact test were used to analyze the factors influencing the ICL (α=.05).</p><p><strong>Results: </strong>ICL was found to occur as early as 3 months after delivery of an ISFP, with a mean onset of 24 months after delivery. The prevalence of ICL at the participant level was 66.4% and 53.4% at the ISFP level, and the incidence of ICL was higher on the mesial side than on the distal, at 50.5% and 36.9%. Statistically significant differences were found in relation to the contralateral side, root configuration of the distal adjacent tooth, a plunger cusp, and participants' awareness of food impaction (P<.05). Additionally, a significant correlation was found with the delivery time (P<.05).</p><p><strong>Conclusions: </strong>Delivery time, the contralateral side, root configuration, and an opposing plunger cusp can influence the development of mesial ICL. However, no significant relationship was found between ICL and peri-implant tissue health. Additionally, participants' awareness of food impaction was found to be associated with the occurrence of mesial ICL.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scanning accuracy of abutment level scan body according to insertion angles and depths of dental implants.","authors":"Sumin Kwon, Eun-Jin Park","doi":"10.1016/j.prosdent.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.015","url":null,"abstract":"<p><strong>Statement of problem: </strong>Abutment level scanning using an abutment base-scan body is a convenient option for obtaining digital implant scans. However, few studies have investigated the effects of implant angulation and depth on intraoral scanning accuracy.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to explore ways to improve the accuracy of implant prostheses by comparing intraoral scans at conventional fixture and abutment levels under various implant conditions (angle and depth).</p><p><strong>Material and methods: </strong>An implant was placed in the maxillary right first molar position of a partially edentulous dentiform at 3 different depths (bone crest level and 3 mm and 6 mm below the crest), and at 3 different angles (0 degrees, 25 degrees, and 35 degrees toward the palatal side). Digital scans were made using a high precision extraoral 3-dimensional (3D) scanner (E4) for the master reference model and an intraoral scanner (i700) for the test model. A conventional scan body was used in the control group, and an abutment base-scan body was used in the experimental group. Each scan was performed 10 times by a single clinician. The standard tessellation language (STL) files of the scans were analyzed using a 3D metrology software program (Gom Inspect) and superimposed on the occlusal surfaces, and the root mean square (RMS) error discrepancies were calculated at 5 specific points on the scan body. The accuracy of the control and experimental groups was compared by converting the deviation values to absolute values and averaging them based on the depth and angle conditions. Statistical analysis included independent samples t tests, Welch t tests, and 1-way analysis of variance (ANOVA) with a Scheffé post hoc test to compare mean differences among groups based on the implant angle and depth (α=.05).</p><p><strong>Results: </strong>The experimental group showed significantly higher accuracy (P<.05) than the control group under most conditions. A significant correlation between the implant angulation and depth was observed in the control group. One-way ANOVA, followed by a Scheffé post hoc test, revealed that the control group showed significantly higher accuracy at the 0-mm depth condition and 0-degree condition (P<.05). However, the experimental group showed significantly higher accuracy in the 3-mm depth condition (P<.05). The experimental group also demonstrated higher accuracy (P<.05) with shorter visible supramucosal lengths.</p><p><strong>Conclusions: </strong>The accuracy of intraoral scanning using the abutment base-scan body system was comparable with that of the conventional fixture level digital scans with scan bodies. Additionally, when the implant is angled toward the palatal side or is deeply placed, the abutment-level scan body can be a useful option during digital scanning.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of silicone impressions with intraoral 3D scans in newborns with cleft lip and palate.","authors":"Olga Košková, Libor Borák, Wanda Urbanová, Alena Bryšová, Magda Nováková, Michaela Richtrová, Libor Streit, Petr Štourač, Petr Marcián","doi":"10.1016/j.prosdent.2025.02.054","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.054","url":null,"abstract":"<p><strong>Statement of problem: </strong>Intraoral scanning is currently becoming the standard method for imaging the maxilla in patients with cleft lip and palate. However, the reliability of intraoral scans compared with traditional conventional impression methods has not yet been sufficiently described and examined in detail in newborns with severe types of cleft lip and palate.</p><p><strong>Purpose: </strong>The purpose of this clinical study was to assess the reliability and agreement between intraoral scanning and traditional impression methods for maxillary measurements in newborns with unilateral and bilateral cleft lip and palate (U/BCLP). A secondary aim was to evaluate the consistency of maxillary measurements obtained with and without general anesthesia.</p><p><strong>Material and methods: </strong>Six newborns with cleft lip and palate underwent 4 maxillary impression methods (silicone impression and 3-dimensional (3D) scan, with and without anesthesia). Intra- and inter-observer reliability was assessed by 3 clinicians using intraclass correlation coefficient, median absolute deviation, and median relative deviation (α=.05).</p><p><strong>Results: </strong>The intraclass correlation coefficient values for both inter-observer and intra-observer reliability indicated excellent agreement (ICC>.90, P<.05) for maxillary dimension measurements. Acceptable variability was observed because of differences in reference point identification by clinicians and across data collection methods.</p><p><strong>Conclusions: </strong>When assessing the maxilla in U/BCLP patients, both intraoral scanner and traditional impression techniques showed excellent reliability and agreement in measurements, whether performed while the newborns were awake or under general anesthesia.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of citric acid and conventional denture cleansers on surface properties and antimicrobial performance of conventionally heat-processed acrylic resin: An in vitro study.","authors":"Samuel Santana Malheiros, Cícero Andrade Sigilião Celles, Maria Helena Rossy Borges, Mirtes Maria Ferreira Corrêa, Catia Sufia Alves Freire de Andrade, João Vicente Calazans Neto, Valentim Adelino Ricardo Barão, Bruna Egumi Nagay","doi":"10.1016/j.prosdent.2025.02.063","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.063","url":null,"abstract":"<p><strong>Statement of problem: </strong>Effective decontamination of denture base acrylic resin is essential for biofilm removal but can compromise the integrity of the material. Citric acid has shown promise as a potent antimicrobial agent, though its effectiveness as a denture cleanser is unknown.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to evaluate the effect of citric acid on the surface properties and efficacy of biofilm removal on denture base acrylic resin compared with commonly used denture cleansers.</p><p><strong>Material and methods: </strong>A total of 130 conventional, heat-processed denture base acrylic resin disks were randomly allocated into 1 of 5 groups based on the decontamination solution applied: control 0.9% sodium chloride (NaCl), 0.1% sodium hypochlorite (SH), Periogard (chlorhexidine digluconate), effervescent denture cleansing tablets (Corega Tabs), and 10% citric acid (CA). Surface properties (roughness, hydrophilicity, microhardness, and color stability) were assessed at 3 time points: baseline (T0), after 5 minutes of exposure (T1), and after 1 week of exposure (T2) to the respective solution. A microcosm biofilm was formed on specimen surfaces to evaluate antimicrobial efficacy of the decontamination solution groups, through assessment of microbial viability, metabolic activity, biofilm dry weight, and morphology. A 2-way repeated measures ANOVA was performed for surface properties evaluations and for microbiological analysis, 1-way ANOVA was used (α=.05).</p><p><strong>Results: </strong>No significant differences in average surface roughness (Ra) were observed between T0, T1, and T2 across all groups (P>.05). CA significantly increased surface hydrophilicity at T2 (P<.001) compared with the other groups. No significant differences in ΔE₀₀ were seen among the groups: all values near the 50% perceptibility threshold. Compared with the control group, all denture cleansers significantly reduced the viability of total microorganisms and Candida species, with no viable colonies detected after treatment (P<.001). However, CA demonstrated a robust antimicrobial effect, with a significant reduction in biofilm dry weight and metabolic activity (P<.001), suggesting superior biofilm disruption compared with the other groups.</p><p><strong>Conclusions: </strong>Citric acid effectively increased hydrophilicity of conventional, heat-processed acrylic resin without negatively impacting surface roughness, microhardness, or color stability.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital imaging for an effective tooth color match for zirconia restorations: The eLAB protocol.","authors":"Thais Marques Simek Vega Gonçalves, Zuila Maria Lobato Wanghon, Artur Yamamoto, Henrique César Schimitz Gassen, Isabela Kendra Rodrigues Oliveira, Analucia Gebler Phillippi","doi":"10.1016/j.prosdent.2025.02.050","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.050","url":null,"abstract":"<p><p>Tooth color matching for ceramic restorations can be challenging, especially for teeth with vertical fracture lines or different color nuances. The dental laboratory technician's expertise in layering ceramic is essential for achieving a good esthetic result. However, accurately reproducing the correct color in the definitive dental restoration requires effective communication with the dental laboratory technician and an understanding of color science. This report illustrates the use of the eLAB protocol, a photocolorimetric technique for recording and conveying the color of adjacent teeth. It also demonstrates how this method can improve communication with dental laboratory technicians, ultimately improving predictable esthetic outcomes.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aligning intraoral scans and cone beam computed tomography scans with beam hardening artifacts: A dental technique.","authors":"Omar Hms Moustafa, Christian Loo, Jacqueline Chow, Damian J Lee","doi":"10.1016/j.prosdent.2025.02.058","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.058","url":null,"abstract":"<p><p>The alignment of patient intraoral scans to cone beam computed tomography (CBCT) scans is often complicated by beam hardening artifacts from multiple dental restorations. Various methods requiring an appliance to be fabricated or flowable composite resin to be added have been described. However, in this straightforward technique, scan alignment with a CBCT scan was achieved in a single visit using only fiducial markers.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of dental implant fracture following loading: A retrospective clinical study.","authors":"Mahmood Abu Ruja, Babak Shokati, Vanessa C Mendes, Amir Azarpazhooh, David Chvartszaid","doi":"10.1016/j.prosdent.2025.02.046","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.046","url":null,"abstract":"<p><strong>Statement of problem: </strong>Fracture of an osseointegrated implant (FOI) is a rare complication that occurs primarily after loading and may lead to other complications including failure or fracture of the implant-supported prosthesis. Risk factors for FOI are not well understood.</p><p><strong>Purpose: </strong>The purpose of this retrospective clinical study was to determine the frequency of occurrence of FOI among participants treated with dental implants in an academic setting and to identify and analyze the possible risk indicators and contributing factors.</p><p><strong>Material and methods: </strong>A retrospective analysis was performed using dental records of participants who received dental implant treatment at the Faculty of Dentistry, University of Toronto, from January 1979 until January 2020, and experienced post-loading FOI. A systematic search of the dental records was conducted, and clinical situations with FOI were identified. Data related to patient factors, implant factors, and prosthesis factors were collected from the identified clinical situations with FOI. The data were analyzed to determine the incidence of FOI. A descriptive analysis was used to identify the possible risk indicators for FOI.</p><p><strong>Results: </strong>A total of 7712 implants had been placed at the Faculty of Dentistry, University of Toronto, from January 1979 until January 2020. During the 41-year period, a total of 27 fractured implants were identified. The incidence of FOI following loading was 0.35%. Overall, the mean ±standard deviation time between loading and occurrence of implant fracture was 10.6 ±7 years. Implant fractures occurred in 23 different study participants; 16 men, and 7 women, with a mean ±standard deviation age of 65.4 ±8.0 years at the time of FOI. Factors associated with implant fracture include narrow-diameter implants (≤3.75 mm), implants placed in posterior mandible (molar or premolar regions), presence of a long cantilever, and unfavorable implant design (such as the Tri-Channel design). Among the 27 fractured implants, 19 were removed, 6 were buried, and 2 were adjusted or smoothed and restored with a new prosthesis.</p><p><strong>Conclusions: </strong>The incidence rate of FOI was very low, but might have been increased by an increased presence of predisposing risk factors.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding, \"Screw loosening in angulation-correcting single implant restorations: A systematic review of in vitro studies\" by Pitman et al.","authors":"Robert Dobrin","doi":"10.1016/j.prosdent.2024.12.033","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.12.033","url":null,"abstract":"","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a robot system to prepare guiding planes for removable partial dentures: An in vitro study.","authors":"Yi Li, Chuyue Yang, Xunning Cao, Yin Zhou, Jianguo Tan, Xiaoqiang Liu","doi":"10.1016/j.prosdent.2025.02.053","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.053","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Statement of problem: &lt;/strong&gt;Ensuring that guiding planes are parallel and that they maintain alignment with the path of insertion are essential for the success of a removable partial denture (RPD). However, freehand preparation and the use of digital guides have shortcomings, while the feasibility of using a robot system to prepare the guiding planes is unknown.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The purpose of this in vitro study was to evaluate the effect of robot-assisted guiding plane preparation for an RPD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;Fifteen mandibular typodonts, each without first molars bilaterally, were custom designed, and an indicator rod was placed on the lingual side of the anterior teeth. A split-mouth design was used, and the partially edentulous areas on the left and right sides of typodonts were randomly assigned to 2 groups based on the preparation technique: the robot or freehand. The guiding planes for the distal surface of the second premolar and the mesial surface of the second molar were prepared by a robot or freehand. For the robot group, the intraoral scan data of the typodonts were imported into a software program, and the trajectory of the handpiece was drawn in the edentulous area. The handpiece orientation in the software program was adjusted to align with the direction of the indicator rod on the typodont. Subsequently, a robotic arm equipped with a high-speed handpiece was used to perform the preparation procedures. For the freehand group, a dentist prepared the guiding planes by referring to the indicator rod with the naked eye. Postoperatively, the typodonts were scanned to evaluate the angles between the 2 guiding planes and the angular deviation between the guiding planes and indicator rod. The independent samples t test was used to analyze the angle between the 2 guiding planes, and 2-way analysis of variance (ANOVA) and the least significant difference (LSD) post hoc test were used to compare the angular deviation between the guiding planes and the indicator rod (α=.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The data are presented as mean ±standard deviation [minimum, maximum]. The angles between the 2 guiding planes prepared by the robot and freehand were 1.93 ±1.04 degrees (0.70 degrees, 3.93 degrees) and 13.41 ±8.86 degrees (2.91 degrees, 33.84 degrees), respectively (P&lt;.001). The angular deviation between the guiding planes and indicator rod prepared by the robot in the second premolar and molar were 2.81 ±1.78 degrees (0.55 degrees, 5.70 degrees) and 2.48 ±2.21 degrees (0.28 degrees, 8.80 degrees), respectively (P=.715). The angular deviation of the freehand group in the second premolar and molar was 8.18 ±5.71 degrees (0.98 degrees, 25.53 degrees) and 15.37 ±8.55 degrees (3.26 degrees, 32.86 degrees), respectively (P&lt;.001). The angular deviation between the guiding plane and indicator rod prepared by the robot was significantly lower than that of freehand (P&lt;.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Co","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual zone color anodization for fabricating an interim implant restoration: A step-by step technique.","authors":"Omar Hms Moustafa, Jacqueline Chow, Ariana Rodriguez, Damian J Lee","doi":"10.1016/j.prosdent.2025.02.032","DOIUrl":"https://doi.org/10.1016/j.prosdent.2025.02.032","url":null,"abstract":"<p><p>Anodization is an electrochemical process that modifies the oxide layer on the surface of a metal, typically aluminum or titanium. In dentistry, the process has been used on titanium implant abutments to modify color for esthetic purposes. An interim implant restoration was fabricated that combined dual zone color anodization with esthetic and biologic contour concepts. The voltages in the anode were varied in 2 locations on an implant titanium abutment, resulting in a pink gingival portion and a gold body.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}