Journal of Prosthetic Dentistry最新文献

{"title":"A multifunctional scannable mounting device for computer guided implant surgery: An in vitro study.","authors":"Daniel Rotenberg, Yaniv Mayer, Jacob Horwitz, Yuval Nov, Hadar Zigdon-Giladi, Eran Gabay","doi":"10.1016/j.prosdent.2024.09.027","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.027","url":null,"abstract":"<p><strong>Statement of problem: </strong>As part of the growing digitization of the dental field, clinicians are looking for ways to simplify digital workflow, reduce chairside time, and provide new work patterns for future applications. Whether scanning with a multifunctional apparatus (MFA) scan body results in improved scanning is unclear.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to compare the horizontal, vertical, and angular deviations with the MFA scan body with a commercially available scan body (SBIO).</p><p><strong>Material and methods: </strong>Sixteen identically printed edentulous maxillary models were used to plan two Ø3.8×11.5-mm implants in the right maxillary first molar and left maxillary central incisor locations. Two implants in each model were installed using a surgical guide. The models were scanned using an intraoral scanner with MFA and then rescanned twice, with SBIO using the intraoral scanner and a laboratory 3D scanner. The implants were digitally positioned according to the scanned MFA and SBIO locations in standard tessellation language (STL) files. These STL files were superimposed on the reference laboratory 3D scanner STL files. Linear measurements included implant apex/cervical horizontal/vertical deviations, as well as implant axis angular deviations. Normality was evaluated with the Shapiro-Wilk test. Paired samples t tests (2 sided) were used for the mean SBIO-MFA deviation difference. To compare the molar/incisor sites, paired samples Wilcoxon tests were used (α=.05 for all tests).</p><p><strong>Results: </strong>No statistically significant differences were found between the MFA/ SBIO deviations, for each of the 10 sites × deviation combinations (P>.05). Overall, the lowest endpoint of the 95% confidence intervals among the 8 linear measurement comparisons was -0.107 mm (coronal vertical deviation, right maxillary first molar site) and -0.30 degrees between the 2 angular measurement comparisons.</p><p><strong>Conclusions: </strong>The current in vitro study demonstrated high accuracy for the novel MFA device, similar to that of the standard SBIO scan body. Furthermore, the current study offers an alternative technique to evaluate the accuracy of implant placement by using scanning and back programming over the traditional postplacement cone beam computed tomography (CBCT) scanning.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabricating crowns that fit both an implant and an existing removable partial denture.","authors":"Saud S Alajmi, Charles J Goodacre","doi":"10.1016/j.prosdent.2024.09.024","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.024","url":null,"abstract":"<p><p>Fabricating a crown to fit both a tooth and an existing removable partial denture (RPD) using many different techniques has been described. However, in the event of abutment loss, information regarding the clinical and laboratory steps used to fabricate a crown that fits both an implant and an RPD is lacking. This report describes the use of either an impression coping or an interim abutment attached to the implant to which a composite resin interim restoration material is flowed and the RPD then seated to form a resin pattern of the required crown form. The process allows the implant crown to be made without retaining the patient's RPD during crown fabrication.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limits of prosthetic rehabilitation of cocaine-induced midline destructive lesions: Time to change the paradigm.","authors":"Chloé Mense, Vincent Romao, Frédéric Silvestri, Romain Lan","doi":"10.1016/j.prosdent.2024.09.023","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.023","url":null,"abstract":"<p><p>The steady rise in cocaine consumption, particularly in its snorted form, has led to the increased incidence of cocaine-induced midline destructive lesions (CIMDLs), a severe condition resulting from chronic cocaine use that leads to significant tissue destruction in the nasal and palatal regions. Four patients with CIMDLs are presented, all characterized by nasopalatine perforation. Each patient reported a spontaneous onset of tissue loss in the hard palate near the midline, with the affected area ranging from 2.3 to 5.1 cm². All patients had a history of psychiatric conditions, including depressive episodes but without other significant medical conditions, which contributed to an average delay of 9 months before seeking initial medical consultation. Treatment, which included the use of palatal obturators to improve quality of life, remains nonstandardized and, combined with the patients' continued cocaine use and refusal of addiction care, led to poor follow-up and persistent tissue damage. This clinical report underscores the need for a paradigm shift in managing CIMDLs, emphasizing the integration of addiction treatment and psychological support with prosthetic rehabilitation to optimize long-term outcomes and prevent relapse.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor regarding, \"Influence of occlusal collision corrections completed by two intraoral scanners or a dental design program on the accuracy of the maxillomandibular relationship\".","authors":"Marta Revilla-León, Miguel Gómez-Polo, Abdul B Barmak, John C Kois, Burak Yilmaz, Jorge Alonso Pérez-Barquero","doi":"10.1016/j.prosdent.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.002","url":null,"abstract":"","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of 3D neural networks and explainable AI to classify ICDAS detection system on mandibular molars.","authors":"Taseef Hasan Farook, Saif Ahmed, Farah Rashid, Faisal Ahmed Sifat, Preena Sidhu, Pravinkumar Patil, Sumaya Yousuf Zai, Nafij Bin Jamayet, James Dudley, Umer Daood","doi":"10.1016/j.prosdent.2024.09.014","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.014","url":null,"abstract":"<p><strong>Statement of problem: </strong>Considerable variations exist in cavity preparation methods and approaches. Whether the extent and depth of cavity preparation because of the extent of caries affects the overall accuracy of training deep learning models remains unexplored.</p><p><strong>Purpose: </strong>The purpose of this study was to investigate the difference in 3-dimensionsal (3D) model cavity preparations after International Caries Detection and Assessment System (ICDAS) classification performed by different practitioners and the subsequent influence on the ability of a deep learning model to predict cavity classification.</p><p><strong>Material and methods: </strong>Two operators prepared 56 restorative cavities on simulated mandibular first molars according to 4 ICDAS classifications, followed by 3D scanning and computer-aided design processing. The surface area, virtual volume, Hausdorff distance (HD), and Dice Similarity Coefficients were computed. Multivariate analysis of variance was used to assess cavity size and operator proficiency interactions, and 1-way ANOVA was used to evaluate HD differences across 4 cavity classifications (α=.05). The 3D convolutional neural network (CNN) predicted the ICDAS class, and Saliency Maps explained the decisions of the models.</p><p><strong>Results: </strong>Operator 1 exhibited a cavity preparation surface area of 360.55 ±15.39 mm², and operator 2 recorded 355.24 ±10.79 mm². Volumetric differences showed operator 1 with 440.41 ±35.29 mm³ and operator 2 with 441.01 ±35.37 mm³. Significant interactions (F=2.31, P=.01) between cavity size and operator proficiency were observed. A minimal 0.13 ±0.097 mm variation was noted in overlapping preparations by the 2 operators. The 3D CNN model achieved an accuracy of 94.44% in classifying the ICDAS classes with a 66.67% accuracy when differentiating cavities prepared by the 2 operators.</p><p><strong>Conclusions: </strong>Operator performance discrepancies were evident in the occlusal cavity floor, primarily due to varying cavity depths. Deep learning effectively classified cavity depths from 3D intraoral scans and was less affected by preparation quality or operator skills.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elastic and fatigue properties of additively manufactured and milled Ti-6Al-4V removable partial denture clasps.","authors":"Minrui Xu, Yan Lin, Zhenxiang Lin, Hui Cheng","doi":"10.1016/j.prosdent.2024.09.017","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.017","url":null,"abstract":"<p><strong>Statement of problem: </strong>The use of additive manufacturing Ti-6Al-4V (AM Ti64) in removable partial denture (RPD) frameworks has become increasingly prevalent in clinical practice. However, the elastic and fatigue properties of AM Ti64 clasps are not well understood.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to investigate the elastic and fatigue properties of AM Ti64 clasps by comparing them with milled Ti64 (Milled TC4) clasps.</p><p><strong>Material and methods: </strong>Dumbbell specimens of AM Ti64 and Milled TC4 were prepared for tensile tests following the International Organization for Standardization (ISO) 22674 standard (n=6). Raw (R) and mechanically polished (P) clasp-shaped specimens were prepared for elastic and fatigue tests and divided into 4 groups: AM Ti64R, AM Ti64P, Milled TC4R, and Milled TC4P. The clasp intaglio surface roughness was measured before testing (n=10). The elastic deformation limit (EDL) of the clasp was determined through incremental displacement loading (n=10). Fatigue tests were conducted on 160 clasps (40 specimens per group) at displacements from 0.30 mm to 1.00 mm for 10⁵ cycles (n=5 per displacement). The fracture surfaces of failed clasps were observed using a scanning electron microscope (SEM), and the microstructures were analyzed using optical microscopy. Statistical analyses were conducted using t tests and Kruskal-Wallis tests (α=.05).</p><p><strong>Results: </strong>AM Ti64 exhibited higher 0.2% offset yield strength and ultimate tensile strength than Milled TC4 (P<.001), with no significant difference in percentage elongation (P=.298) or elastic modulus (P=.151). No significant differences in intaglio surface roughness were found between AM Ti64 and Milled TC4 clasps in both the raw (P=.306) and polished (P>.999) groups. AM Ti64 clasps demonstrated greater EDL values than Milled TC4 clasps in both the raw and polished groups (P<.001). The fatigue life of AM Ti64 clasps was significantly shorter than that of Milled TC4 clasps (P<.001), with no significant difference between the raw and polished groups in both AM Ti64 (P=.611) and Milled TC4 clasps (P>.999). SEM observation revealed fatigue cracks originating from surface defects in AM Ti64 clasps. Microstructural analysis showed lamellar α phase dominance in AM Ti64, while Milled TC4 exhibited primarily equiaxed α phase.</p><p><strong>Conclusions: </strong>The AM Ti64 clasp showed better elasticity but inferior fatigue performance compared with Milled TC4 clasps. Mechanical polishing did not significantly affect the elasticity or fatigue properties of the titanium clasp.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding, \"Antimycotic prophylaxis with multispecies probiotics against oral candidiasis in new complete denture wearers: A randomized clinical trial\".","authors":"Wei-Zhen Tang, Xue-Bing Chen, Tai-Hang Liu","doi":"10.1016/j.prosdent.2024.09.018","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.018","url":null,"abstract":"","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of optimal gingival displacement widths, finish line depths, and preparation designs for digitally scanned single crowns: An in vitro study.","authors":"Wei-Jyun Ciou, Wei-Hung He","doi":"10.1016/j.prosdent.2024.08.024","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.08.024","url":null,"abstract":"<p><strong>Statement of problem: </strong>Digital scans for single crowns have been reported to achieve accuracy similar to that of traditional impressions in certain patients, but criteria for acquiring high-quality scans are lacking.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to determine the optimal gingival displacement widths, finish line depths, and preparation designs for single crowns when using intraoral scanners (IOSs) to achieve clinically acceptable and high-quality recordings.</p><p><strong>Material and methods: </strong>Three different preparation designs of computer-aided design and computer-aided manufacturing (CAD-CAM) polymethyl methacrylate (PMMA) abutments (round shoulder, shoulder, and sloped shoulder) were fitted with titanium sleeves of 4 different thicknesses (0.2 mm, 0.3 mm, 0.4 mm, and 0.5 mm) and magnetically attracted onto the spindle of an electronic spiral micrometer. Occlusal registration material was injected around the abutment to simulate gingival tissue. After setting, the titanium sleeves were removed to create gaps as different gingival displacement widths. The spiral micrometer was rotated to create 5 different finish line depths (supragingival 0.5 mm, equal gingiva, subgingival 0.5 mm, subgingival 1.0 mm, and subgingival 1.5 mm). Two IOSs (CEREC Primescan [PS] and TRIOS 3 [TS]) were used to scan 3 preparation designs with a combination of 4 gingival displacement widths and 5 finish line depths 5 times each (N=600). The files were imported into an engineering software program and superimposed with the corresponding reference scanned files of the original abutments. Tangent distances (TD) and marginal angle differences (MAD) between the testing groups and references were measured and analyzed using the Kolmogorov-Smirnov, Kruskal-Wallis, and Jonckheere-Terpstra tests (α=.05).</p><p><strong>Results: </strong>A significant linear trend of decreasing TD and MAD with increasing gingival displacement widths and shallower finish line depths was found. Statistically significant differences (P<.05) were found in TD and MAD between different preparation designs at finish line depths that were equigingival and 0.5-mm subgingival.</p><p><strong>Conclusions: </strong>Clinically acceptable scans generally required a gingival displacement width of at least 0.3 mm and a finish line depth within subgingival 1.0 mm. Both IOSs produced high-quality scans for supragingival finish lines. Both IOSs required at least 0.4-mm gingival displacement width to achieve high-quality scans under equal gingival conditions. Only PS with at least 0.4-mm gingival displacement width was able to achieve high-quality scans for subgingival margins. The accuracy ranking of preparation designs was round shoulder (highest), shoulder, and sloped shoulder (lowest).</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy, fit, and marginal quality of advanced additively manufactured and milled zirconia 3-unit fixed dental prostheses.","authors":"Yujie Wang, Yi Zhou, Han Zhu, Jimin Jiang, Fuming He","doi":"10.1016/j.prosdent.2024.09.016","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.016","url":null,"abstract":"<p><strong>Statement of problem: </strong>Advanced additive manufacturing (AM) of zirconia is an emerging technology that can explore the limitations of traditional computer-aided design and computer-aided manufacturing (CAD-CAM) milling techniques. However, a comprehensive evaluation of their differences in producing zirconia restorations, especially multi-unit restorations, is lacking.</p><p><strong>Purpose: </strong>The purpose of this in vitro study was to compare the accuracy, fit, marginal quality, and surface roughness of zirconia 3-unit fixed dental prostheses (FDPs) by using advanced AM and 2 CAD-CAM milling materials.</p><p><strong>Material and methods: </strong>Based on the same CAD model, 30 3-unit posterior FDPs (n=10) were manufactured by using AM and 2 CAD-CAM milling materials (VT and UP). The accuracies of the total, intaglio, occlusal, axial, and marginal regions were calculated separately by comparing the scanned model with the design model by using 3-dimensional (3D) deviation analysis. The silicone layer was scanned to evaluate the marginal and intaglio fit in 3 dimensions. A 3D laser microscope was used for surface roughness detection, marginal quality assessment, and marginal defect measurement. The data were analyzed using ANOVA and the Tukey post hoc test (α=.05).</p><p><strong>Results: </strong>Compared with CAD-CAM milling, the AM group had higher accuracy and smaller positive deviations on the axial and intaglio regions (P<.001). Different manufacturing methods showed no statistically significant effect on the mean intaglio fit (P>.05), and all were within the clinically acceptable range (<100 µm). The intaglio gap was significantly higher than the target parameter in the occlusal regions. AM-fabricated FDPs had significantly higher surface roughness than milled ones, yet showed better margin quality with fewer marginal defects CONCLUSIONS: Compared with CAD-CAM milling, the advanced additively manufactured zirconia 3-unit FDPs provided better accuracy, improved margin quality, and clinically acceptable fit, but higher surface roughness, and may be a promising alternative for clinical applications.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indicator of tongue pressure to estimate the mastication pattern in an aging population.","authors":"Chung-Ta Chang, Yi-Fang Huang, Yu-Fang Liao","doi":"10.1016/j.prosdent.2024.09.012","DOIUrl":"https://doi.org/10.1016/j.prosdent.2024.09.012","url":null,"abstract":"<p><strong>Statement of problem: </strong>The mastication ability of the elderly greatly affects their health-related quality of life. However, studies investigating the impact of peri-oral muscular strength on the performance of mastication in older adults are lacking.</p><p><strong>Purpose: </strong>The purpose of this cross-sectional clinical study in older adults was to formulate an equation relating to the mastication pattern and tongue pressure to estimate the correlation between tongue pressure and habitual mastication patterns, including mastication strokes and mastication time.</p><p><strong>Material and methods: </strong>A total of 98 healthy adults over 65 years old who were independent in daily activities and had no swallowing difficulties were enrolled. Tongue pressure was measured with the Iowa Oral Performance Instrument (IOPI), which assesses pressure generated by squeezing a bulb between the tongue and palate. The mastication pattern was evaluated by counting strokes and measuring the time required to consume a cornstarch cookie. Statistical analysis used linear regression (α=.05).</p><p><strong>Results: </strong>The sample included 48 women and 50 men with an average age of 71.7 years. Tongue pressure demonstrated a significant correlation with both mastication time and mastication strokes (P=.03 and.04, respectively). The findings led to a linear regression model linking tongue pressure (x) to mastication time (y₁) and mastication strokes (y₂), expressed as y₁=-0.2976x + 33.907 and y₂=-0.4134x + 45.624.</p><p><strong>Conclusions: </strong>In older adults, a correlation was found between tongue pressure and both mastication time and mastication strokes. Based on this correlation, measuring tongue pressure might provide insight into mastication patterns, while estimating mastication time and mastication strokes could help gauge tongue strength in an aging population. Mastication ability could then be assessed and appropriate food textures chosen for elderly individuals. This formula could also help determine the optimal tongue pressure value for enhancing the mastication pattern by serving as a guide for tongue training or rehabilitation initiatives.</p>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}