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Tracer kinetic modeling of a 14 kDa anti-CD8 PET tracer (2C8v144) for in vivo estimation of CD8 expression in tissue and blood, binding affinity, and total body receptor occupancy. 14kda抗CD8 PET示踪剂（2C8v144）的动力学建模，用于体内估计CD8在组织和血液中的表达、结合亲和力和全身受体占用率。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-04-21 DOI: 10.1007/s10928-026-10029-8
Ruediger E Port, C Andrew Boswell, Annie Ogasawara, Herman Gill, Jan Marik, Alice F Tarantal, Eric Berg, Simon P Williams, Gregory Z Ferl
{"title":"Tracer kinetic modeling of a 14 kDa anti-CD8 PET tracer (2C8v144) for in vivo estimation of CD8 expression in tissue and blood, binding affinity, and total body receptor occupancy.","authors":"Ruediger E Port, C Andrew Boswell, Annie Ogasawara, Herman Gill, Jan Marik, Alice F Tarantal, Eric Berg, Simon P Williams, Gregory Z Ferl","doi":"10.1007/s10928-026-10029-8","DOIUrl":"https://doi.org/10.1007/s10928-026-10029-8","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A structure-preserving hybrid learning framework for compartmental pharmacokinetic models. 一个保留结构的混合学习框架的室室药代动力学模型。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-04-10 DOI: 10.1007/s10928-026-10031-0
Hanan Al Lawati, Mohamed Al-Lawatia
{"title":"A structure-preserving hybrid learning framework for compartmental pharmacokinetic models.","authors":"Hanan Al Lawati, Mohamed Al-Lawatia","doi":"10.1007/s10928-026-10031-0","DOIUrl":"https://doi.org/10.1007/s10928-026-10031-0","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitigating antibiotic resistance from missed doses. 减轻因漏服剂量造成的抗生素耐药性。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-04-10 DOI: 10.1007/s10928-026-10027-w
J Alexander Gilsoul, Hwai-Ray Tung, Sean D Lawley
{"title":"Mitigating antibiotic resistance from missed doses.","authors":"J Alexander Gilsoul, Hwai-Ray Tung, Sean D Lawley","doi":"10.1007/s10928-026-10027-w","DOIUrl":"https://doi.org/10.1007/s10928-026-10027-w","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a population pharmacokinetics model and an R-Shiny simulation platform for moxifloxacin pharmacokinetics in non-human primates. 莫西沙星在非人类灵长类动物体内的群体药代动力学模型和R-Shiny模拟平台的建立。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-04-01 DOI: 10.1007/s10928-026-10030-1
Arnay Garhyan, Derek Leishman
{"title":"Development of a population pharmacokinetics model and an R-Shiny simulation platform for moxifloxacin pharmacokinetics in non-human primates.","authors":"Arnay Garhyan, Derek Leishman","doi":"10.1007/s10928-026-10030-1","DOIUrl":"https://doi.org/10.1007/s10928-026-10030-1","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early exposure-response modeling of an interferon-beta monoclonal antibody (dazukibart) in adults with dermatomyositis. 成人皮肌炎患者干扰素- β单克隆抗体（dazukibart）的早期暴露反应模型
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-03-24 DOI: 10.1007/s10928-026-10022-1
John P Prybylski, Jing 'Daisy' Zhu, Christopher Banfield, Arnab Mukherjee, Vivek Purohit
{"title":"Early exposure-response modeling of an interferon-beta monoclonal antibody (dazukibart) in adults with dermatomyositis.","authors":"John P Prybylski, Jing 'Daisy' Zhu, Christopher Banfield, Arnab Mukherjee, Vivek Purohit","doi":"10.1007/s10928-026-10022-1","DOIUrl":"10.1007/s10928-026-10022-1","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling, Simulation, and Extrapolation to Optimize Pediatric Development Plan: Sarilumab Polyarticular-Course juvenile arthritis Application. 建模，模拟和外推，以优化儿童发展计划：赛利单抗多关节病程青少年关节炎的应用。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-03-24 DOI: 10.1007/s10928-026-10024-z
Christine Xu, Mei Zhang, Ying Liu, Lydie Baret-Cormel, Fabrizio De Benedetti, Hisham Abdallah, Vanaja Kanamaluru, Zhaoling Meng
{"title":"Modeling, Simulation, and Extrapolation to Optimize Pediatric Development Plan: Sarilumab Polyarticular-Course juvenile arthritis Application.","authors":"Christine Xu, Mei Zhang, Ying Liu, Lydie Baret-Cormel, Fabrizio De Benedetti, Hisham Abdallah, Vanaja Kanamaluru, Zhaoling Meng","doi":"10.1007/s10928-026-10024-z","DOIUrl":"10.1007/s10928-026-10024-z","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of a physiologically-based pharmacokinetic model for investigating time-dependent variability in the fetal-to-maternal plasma concentration ratio of digoxin. 利用基于生理的药代动力学模型来研究地高辛胎儿与母体血浆浓度比的时间依赖性变异性。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-03-24 DOI: 10.1007/s10928-026-10028-9
Kanoko Okuba, Kenji Ikeda
{"title":"Utility of a physiologically-based pharmacokinetic model for investigating time-dependent variability in the fetal-to-maternal plasma concentration ratio of digoxin.","authors":"Kanoko Okuba, Kenji Ikeda","doi":"10.1007/s10928-026-10028-9","DOIUrl":"10.1007/s10928-026-10028-9","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hybrid PKPD agent-based model of the tumour immune interaction: effects of anti-cancer combination therapy. 基于混合PKPD试剂的肿瘤免疫相互作用模型：抗癌联合治疗的效果。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-03-24 DOI: 10.1007/s10928-026-10021-2
Van Thuy Truong, Grant Lythe, Paolo Vicini, James W T Yates, Vincent F S Dubois
{"title":"A hybrid PKPD agent-based model of the tumour immune interaction: effects of anti-cancer combination therapy.","authors":"Van Thuy Truong, Grant Lythe, Paolo Vicini, James W T Yates, Vincent F S Dubois","doi":"10.1007/s10928-026-10021-2","DOIUrl":"10.1007/s10928-026-10021-2","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the impact of bacterial heterogeneity on bacteriophage population dynamics. 评估细菌异质性对噬菌体种群动态的影响。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-03-09 DOI: 10.1007/s10928-026-10025-y
Massinissa Beldjenna, Jérémie Guedj, J G Coen van Hasselt, Tingjie Guo
{"title":"Assessing the impact of bacterial heterogeneity on bacteriophage population dynamics.","authors":"Massinissa Beldjenna, Jérémie Guedj, J G Coen van Hasselt, Tingjie Guo","doi":"10.1007/s10928-026-10025-y","DOIUrl":"10.1007/s10928-026-10025-y","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the existence conditions of interaction indices in response surface models. 响应面模型中相互作用指标的存在条件。
IF 2.8 4区 医学
Journal of Pharmacokinetics and Pharmacodynamics Pub Date : 2026-03-02 DOI: 10.1007/s10928-026-10026-x
Erhan Yumuk, Clara Ionescu
{"title":"On the existence conditions of interaction indices in response surface models.","authors":"Erhan Yumuk, Clara Ionescu","doi":"10.1007/s10928-026-10026-x","DOIUrl":"10.1007/s10928-026-10026-x","url":null,"abstract":"","PeriodicalId":16851,"journal":{"name":"Journal of Pharmacokinetics and Pharmacodynamics","volume":"53 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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