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Proceedings of the International Conference "Mathematical Biology and Bioinformatics"最新文献

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Optimal Valid Partitioning Method in Task of Evaluating Effect of Hemoglobin Oxygenation Levels Vessel Endothelial Growth Factor 血红蛋白氧合水平评价任务中血管内皮生长因子的最优有效分配方法
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.50
O. Senko, M. S. Kodryan, A. V. Kuznetsova, L. L. Klimenko
{"title":"Optimal Valid Partitioning Method in Task of Evaluating Effect of Hemoglobin Oxygenation Levels Vessel Endothelial Growth Factor","authors":"O. Senko, M. S. Kodryan, A. V. Kuznetsova, L. L. Klimenko","doi":"10.17537/ICMBB18.50","DOIUrl":"https://doi.org/10.17537/ICMBB18.50","url":null,"abstract":"Целью работы является исследование связи фактора роста эндотелия сосудов VEGF в сыворотке крови c гипоксией в группах пациентов, страдающих тяжёлыми неврологическими заболеваниями. Имеющиеся в литературе данные свидетельствуют об активации синтеза VEGF при гипоксии. Вместе с тем стандартный корреляционный анализ не позволил достоверно выявить по клиническим данным наличие связи между уровнем VEGF и параметрами оксиметрии, объективно характеризующими снабжение организма кислородом. В статье представлена методика, позволившая статистически достоверно доказать существование указанной связи, сводящейся к увеличению корреляции между VEGF и комплементом C4, а также между VEGF и белками S100 при снижении уровня оксигенации ниже некоторого порогового значения. Методика основывается на построении оптимальных разбиений интервалов значений показателей оксиметрии. Использовалась оригинальная методика статистической верификации, основанная на использовании перестановочных тестов, которая позволила совместно учесть отдельные эффекты по группе показателей оксиметрии, а также провести коррекцию значимости с целью учёта множественного тестирования.","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121630353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mathematical modeling of the metabolic activity of an isolated perfused rat liver under reduced oxygenation of the perfusion medium 在灌注介质缺氧条件下，大鼠离体灌注肝脏代谢活动的数学建模
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.36
K. V. Shadrin, V. Pakhomova, O. Kryukova, A. P. Rupenko
{"title":"Mathematical modeling of the metabolic activity of an isolated perfused rat liver under reduced oxygenation of the perfusion medium","authors":"K. V. Shadrin, V. Pakhomova, O. Kryukova, A. P. Rupenko","doi":"10.17537/ICMBB18.36","DOIUrl":"https://doi.org/10.17537/ICMBB18.36","url":null,"abstract":"","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131675328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moleculargenetic mechanisms of membrane potential formation in Escherichia coli at stationary growth on nitrite 大肠杆菌在亚硝酸盐上固定生长时膜电位形成的分子遗传学机制
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.18
N. Ree, T. Khlebodarova, V. Likhoshvai
{"title":"Moleculargenetic mechanisms of membrane potential formation in Escherichia coli at stationary growth on nitrite","authors":"N. Ree, T. Khlebodarova, V. Likhoshvai","doi":"10.17537/ICMBB18.18","DOIUrl":"https://doi.org/10.17537/ICMBB18.18","url":null,"abstract":"В кишечнике человека наиболее энергетически выгодным субстратом для бактерии Escherichia coli является нитрат, побочным продуктом восстановления которого является токсичный нитрит, используемый, хотя и с меньшей эффективностью, чем нитрат, в качестве акцептора электронов в дыхательной цепи. Нитрит восстанавливается до аммония периплазматической Nrf нитритредуктазой, кодируемой nrfABCD опероном, уровень эффективности транскрипции которого зависит от концентрации нитрита в среде Ранее нами была выдвинута гипотеза, что активность Nrf редуктазы при низких концентрациях нитрита в среде определяется не только механизмами регуляции экспрессии оперона nrfABCD, но и действием мембранного потенциала на процессы формирования активной формы фермента в периплазме. Эта возможность была теоретически доказана на математической модели, в которой мембранный потенциал представлен в виде феноменологической функции, зависящей от нитрита. Для окончательного подтверждения гипотезы была создана модель утилизации нитрита в хемостате, в которой величина мембранного потенциала была рассчитана на основе молекулярно-генетических механизмов его формирования. Поскольку структура дыхательной цепи на нитрите неизвестна, были реконструированы два гипотетических сценария формирования мембранного потенциала при культивировании клеток в хемостате и разработаны соответствующие модели. В сценариях рассматривается участие форматгидрогенлиазных комплексов FHL-1 и FHL-2, компонентами которых являются форматдегидрогеназа Fdh и гидрогеназы Hyd-3 и Hyd-4 соответственно. Было показано, что результаты математического моделирования не зависят от сценария формирования потенциала. Полученные результаты подтверждают, что мембранный потенциал играет важную роль в регуляции активности периплазматической Nrf редуктазы при низких концентрациях нитрита. Учитывая распространенность механизма, мы предполагаем, что мембранный потенциал может играть существенную роль в регуляции активностей других периплазматических белков.","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128325675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polaron in constant electric field. Generation of coherent lattice vibrations 恒电场中的极化子。相干晶格振动的产生
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.61
T. Astakhova, G. Vinogradov
{"title":"Polaron in constant electric field. Generation of coherent lattice vibrations","authors":"T. Astakhova, G. Vinogradov","doi":"10.17537/ICMBB18.61","DOIUrl":"https://doi.org/10.17537/ICMBB18.61","url":null,"abstract":"","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130374151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Silico modeling of microtubule tip dynamics and structure 微管尖端动力学和结构的计算机模拟
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.40
V. Mustyatsa, A. V. Kostarev, A. Tvorogova, F. Ataullakhanov, I. Vorobjev, N. Gudimchuk
{"title":"In Silico modeling of microtubule tip dynamics and structure","authors":"V. Mustyatsa, A. V. Kostarev, A. Tvorogova, F. Ataullakhanov, I. Vorobjev, N. Gudimchuk","doi":"10.17537/ICMBB18.40","DOIUrl":"https://doi.org/10.17537/ICMBB18.40","url":null,"abstract":"","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124666926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of active contractions on stress distribution in the wall of aresistance blood vessel 主动收缩对阻力血管壁应力分布的影响
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.19
N. Shadrina
{"title":"The influence of active contractions on stress distribution in the wall of aresistance blood vessel","authors":"N. Shadrina","doi":"10.17537/ICMBB18.19","DOIUrl":"https://doi.org/10.17537/ICMBB18.19","url":null,"abstract":"","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128227855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conceptual Approach to Clustering in the Study of Gene Expression 基因表达研究中的聚类概念方法
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.81
M. Bogatyrev, K. Samodurov
{"title":"Conceptual Approach to Clustering in the Study of Gene Expression","authors":"M. Bogatyrev, K. Samodurov","doi":"10.17537/ICMBB18.81","DOIUrl":"https://doi.org/10.17537/ICMBB18.81","url":null,"abstract":"The work contains an overview of clustering methods used in the study of gene expression and new results of application of Formal Concepts Analysis to clustering data extracted from the public functional genomics data repository GEO. Methods of Formal Concept Analysis allow clustering of multidimensional data under the single condition of partial ordering of such data sets. As a result, clusters are separate sublattices in the concept lattice, where each sublattice contains hierarchically related formal concepts. This solution of the clustering problem allows deep investigating both mutual influences of genes and their influence on other data obtained in experiments on gene expression. The paper describes a new information technology developed for the implementation of the proposed approach. The technology uses modern solutions in the field of Big Data processing, it has functions for communication with external data sources and other information systems. Preliminary results of the application of this technology to three-dimensional gene expression data obtained from the GEO system are presented.","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"293 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134205936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Tornadoes in the heart, its self-organization 龙卷风之心，其自组织
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.11
M. Mazurov, A. Gorodkov, G. Kiknadze
{"title":"Tornadoes in the heart, its self-organization","authors":"M. Mazurov, A. Gorodkov, G. Kiknadze","doi":"10.17537/ICMBB18.11","DOIUrl":"https://doi.org/10.17537/ICMBB18.11","url":null,"abstract":"","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114225034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosphere as a hierarchy of active media. Aspects of self-organization 生物圈作为活动媒介的层次结构。自组织的各个方面
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.95
A. Sidorova, V. Tverdislov
{"title":"Biosphere as a hierarchy of active media. Aspects of self-organization","authors":"A. Sidorova, V. Tverdislov","doi":"10.17537/ICMBB18.95","DOIUrl":"https://doi.org/10.17537/ICMBB18.95","url":null,"abstract":"","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"57 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114329783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognition of Latent Periodicity in DNA Sequences Based on Stochastic Models of Encoding 基于随机编码模型的DNA序列潜在周期性识别
Proceedings of the International Conference "Mathematical Biology and Bioinformatics" Pub Date : 2018-11-07 DOI: 10.17537/ICMBB18.8
V. Kutyrkin, M. Chaley
{"title":"Recognition of Latent Periodicity in DNA Sequences Based on Stochastic Models of Encoding","authors":"V. Kutyrkin, M. Chaley","doi":"10.17537/ICMBB18.8","DOIUrl":"https://doi.org/10.17537/ICMBB18.8","url":null,"abstract":"","PeriodicalId":168323,"journal":{"name":"Proceedings of the International Conference \"Mathematical Biology and Bioinformatics\"","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114496136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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