Современные проблемы науки и образования (Modern Problems of Science and Education)最新文献_第2页

FINGER RECONSTRUCTION USING OSTEOCUTANEOUS COMPLEXES ON A PEDICLE IN CASE OF FROSTBITE AFTER-EFFECTS 冻伤后患用骨皮复合物在蒂上重建手指

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/SPNO.30543

N. Aleksandrov, I. Veshaev, D. A. Kuptsov

{"title":"FINGER RECONSTRUCTION USING OSTEOCUTANEOUS COMPLEXES ON A PEDICLE IN CASE OF FROSTBITE AFTER-EFFECTS","authors":"N. Aleksandrov, I. Veshaev, D. A. Kuptsov","doi":"10.17513/SPNO.30543","DOIUrl":"https://doi.org/10.17513/SPNO.30543","url":null,"abstract":"The purpose of the research was to study the effectiveness of the finger reconstruction using osteocutaneous complexes on a pedicle in case of hand frostbite after-effects. The reconstruction of 56 fingers on 40 hands was performed using different osteocutaneous complexes on the pedicle in 33 patients who had suffered a cold injury. The transposition of the fiinger stump and metacarpal bone of an injured hand was performed on typical (10) and distracted (32) permanent pedicles, a radial osteocutaneous complex on a distal pedicle (7) as well as the transplantation of tissue complexes (the finger stump of the opposite hand, a fragment of the second metatarsal bone, the lateral edge of the scapula with a skin flap, the second toe) on a microvascular pedicle (7). The clinical, radiological, morphological, biomechanical, biophysical and statistical research methods were applied therein. The technologies were elaborated for transplanting a radial osteocutaneous length of the bone graft did not significantly change. The performed study has shown the feasibility of using osteocutaneous complexes on a pedicle for the reconstruction of fingers in case of the cold injury after-effects.","PeriodicalId":167342,"journal":{"name":"Современные проблемы науки и образования (Modern Problems of Science and Education)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123133712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TOTAL ELBOW ARTHROPLASTY, REVIEW OF THE LITERATURE. PROSPECTS FOR USE IN CHILDREN 全肘关节置换术，文献回顾。儿童应用前景

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/spno.31425

D. Grankin, N. Avdeychik, S. I. Golyana, A.V. Safonov

引用次数: 0

MANIFESTATIONS OF THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME IN THE PATHOGENESIS OF PRETERM LABOR 全身性炎症反应综合征在早产发病机制中的表现

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/spno.32619

L. I. Dyatlova, T. Glukhova, E. Ponukalina, Y. Mikhaylova, L.V. Gorodetskaya, A.D. Zakurnaeva

引用次数: 0

MEDIA RESOURCES AS A MEANS OF PEDAGOGICAL SUPPORT FOR ADAPTATION OF FOREIGN STUDENTS IN HIGHER SCHOOL 媒体资源作为高等学校外国留学生适应的教学支持手段

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/spno.31110

O. Voskrekasenko, E. G. Syagaylo

引用次数: 0

THE EFFECT OF POLYMORPHIC GENES OF DETOXIFICATION SYSTEMS (CYP 1A1, CYP 1A2, CYP 2C9 (*2), CYP 2C9(*3), CYP 2C19, CYP 2E1(PSTI/RSAI), CYP 2E1(TAGI), CYP 3A4) ON THE THERAPEUTIC EFFICACY OF TREATMENT OF PATIENTS WITH LYMPHOPROLIFERATIVE DISEASES 解毒系统(cyp 1a1、cyp 1a2、cyp 2c9(*2)、cyp 2c9(*3)、cyp 2c19、cyp 2e1 (psti / rsai)、cyp 2e1 (tagi)、cyp 3a4)多态性基因对淋巴细胞增生性疾病患者治疗效果的影响

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/spno.29316

E. Kuznetsova, T. A. Sokolova-popova, A. Shulmin, A. V. Osedko, A. V. Khomichenko, T. I. Olkhovik, M. Mikhalev, E. Syrtseva, L. M. Savyak, E. P. Kuznetsova-Podzolkova

引用次数: 0

THE EXPRESSION ACTIVITY OF PROTEIN KINASE MΖ IN PILOCYTIC ASTROCYTOMAS CORRELATES WITH THE PROGNOSIS OF THE DISEASE 蛋白激酶mΖ在毛细胞星形细胞瘤中的表达活性与疾病预后相关

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/SPNO.28784

P. Nikitin, Marina Ryzhova, M. Muradyan, S. A. Galstyan, I. V. Zubova

{"title":"THE EXPRESSION ACTIVITY OF PROTEIN KINASE MΖ IN PILOCYTIC ASTROCYTOMAS CORRELATES WITH THE PROGNOSIS OF THE DISEASE","authors":"P. Nikitin, Marina Ryzhova, M. Muradyan, S. A. Galstyan, I. V. Zubova","doi":"10.17513/SPNO.28784","DOIUrl":"https://doi.org/10.17513/SPNO.28784","url":null,"abstract":"ФГАУ «НМИЦ нейрохирургии имени акад. Н.Н. Бурденко», Москва, e-mail: redseadog@gmail.com; ФГАУ ВО «Российский университет дружбы народов», Москва, e-mail: marymuradyan2605@mail.ru Пилоидные астроцитомы представляют собой актуальную проблему в современной нейроонкологии. Многие механизмы прогрессирования опухоли изучены недостаточно, в частности слабо охарактеризованы ключевые эффекторные звенья патогенеза. Подобные факторы могут играть важнейшую роль в процессе клинического прогрессирования опухолей. Поэтому мы изучили влияние активности экспрессии мозгоспецифичной атипической изоформы протеинкиназы С – протеинкиназы Mζ (ПК Mζ), одного из главных потенциальных эффекторных факторов – на прогноз безрецидивной выживаемости пациентов с установленным диагнозом пилоидной астроцитомы. Чтобы решить данную задачу, были сформированы две равные группы: с отсутствием рецидивов опухолевого процесса по крайней мере в течение пяти лет (БРГ) и с наличием рецидива (РГ). Выяснилось, что процент клеток, экспрессирующих ПК Mζ (ПКЭ Mζ), был статистически достоверно выше в РГ, нежели в БРГ (34.36±1.52% и 24.14±1.25% соответственно). Более того, и значения histoscore ПК Mζ были также статистически достоверно выше в РГ по сравнению с БРГ и составили 120.46±3.6% и 91.7±3.31%. Кроме того, было выявлено наличие обратной корреляции высокой степени между показателями ПКЭ Mζ и histiscore ПК Mζ и временем до возникновения рецидива. Данные результаты показывают наличие выраженной связи между активностью экспрессии ПК Mζ и прогрессированием опухолевого процесса, а также могут стать основой для формирования новых диагностических подходов и разработки средств таргетной терапии пилоидных астроцитом. Ключевые слова: пилоидная астроцитома, протеинкиназа M ζ, прогностический маркер.","PeriodicalId":167342,"journal":{"name":"Современные проблемы науки и образования (Modern Problems of Science and Education)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121808495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STUDY OF THE FREQUENCY AND SPECTRUM OF THE KRAS GENE MUTATION IN PATIENTS WITH COLORECTAL CANCER (CRC) DEPENDING ON THE EXTENT OF THE PROCESS 研究kras基因突变在结直肠癌(crc)患者中的频率和频谱，这取决于该过程的程度

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/SPNO.28909

K. Smagulova, D. Kaydarova, N. Chichua, E. Ishkinin

{"title":"STUDY OF THE FREQUENCY AND SPECTRUM OF THE KRAS GENE MUTATION IN PATIENTS WITH COLORECTAL CANCER (CRC) DEPENDING ON THE EXTENT OF THE PROCESS","authors":"K. Smagulova, D. Kaydarova, N. Chichua, E. Ishkinin","doi":"10.17513/SPNO.28909","DOIUrl":"https://doi.org/10.17513/SPNO.28909","url":null,"abstract":"Colorectal cancer (CRC) is one of the most common forms of malignant tumors in the world. Among the predictive response factors to treatment in patients with mCRC, the RAS genes (KRAS, NRAS and HRAS) are the most studied. Determining the status of RAS is the first step in the individual selection of drug therapy in patients with mCRC. We studied the frequency and spectrum of the KRAS gene mutation depending on the prevalence of the process in CRC patients in the Republic of Kazakhstan. The present work was based on the data of a study of 332 patients with CRC registered in regional oncologic dispensaries of the Republic of Kazakhstan, who have been determined the status of the KRAS gene on postoperative and / or biopsy material for the period from 2010 to 2014 by PCR. KRAS test was performed using BioLink kits by allele-specific PCR method, to detect mutations in 12 and 13 codons exon 2. Results: According to the obtained results, we can judge that there is no significant dependence of the KRAS mutation frequency in patients with CRC on the process stage, on the damage of regional lymph nodes and distant metastases. However, there was a tendency to an increase in the frequency of mutation in the presence of metastases in regional lymph nodes (p = 0.05), as well as a tendency to a decrease in the frequency of mutation at stage II of the tumor process (p = 0.05). Conclusions: 1.The frequency of wild type KRAS gene was observed slightly more often in all stages of the disease, compared to the mutated one. 2. There is a tendency to reduce the frequency of mutations in stage II of the tumor process (p = 0.05). 3. There is a tendency to increase the frequency of mutation in the presence of metastases in regional lymph nodes (p = 0.05). 4. In patients with CRC, who had distant metastases, mutations were detected more often compared to those patients who did not have distant metastases at initial treatment.","PeriodicalId":167342,"journal":{"name":"Современные проблемы науки и образования (Modern Problems of Science and Education)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124289891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A MODEL FOR ASSESSING THE QUALITY OF ACHIEVING EDUCATIONAL RESULTS OF STUDYING THE INTEGRATED COURSE «NATURAL SCIENCE» “自然科学”综合课程教学成果质量评估模型

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/spno.31546

I.Y. Aleksashina, O. Abdulaeva, Y. Kiselev

引用次数: 0

DOCTOR’S COMMUNICATIVE COMPETENCE AND ITS FORMATION IN MEDICAL RESIDENTS’ PERCEPTION: PROBLEM SETTING 医师沟通能力及其在住院医师知觉中的形成:问题设置

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/spno.29727

M. Chizhkova

{"title":"DOCTOR’S COMMUNICATIVE COMPETENCE AND ITS FORMATION IN MEDICAL RESIDENTS’ PERCEPTION: PROBLEM SETTING","authors":"M. Chizhkova","doi":"10.17513/spno.29727","DOIUrl":"https://doi.org/10.17513/spno.29727","url":null,"abstract":"This article analyzes the results of the pilot study conducted on medical residents in their 1st and 2nd years in order to study their ideas about the doctor’s communicative competence and conditions necessary for its full formation. Basing on the questionnaire compiled by the author of this study, we obtained the data attesting to the students’ fairly high assessment of the doctor's communicative skills, which, along with medical judgement and practical manipulations, ensure the effectiveness of the holistic treatment process. Using of statistical analysis methods allowed us to identify some significant differences inherent in second-year medical residents, which are due to the longer experience of their practical medical activities in hospitals. This group of respondents more often identify the ability to establish contact, to have a conversation and to fit into the set, normatively specified time, as well as to correctly formulate and ask questions to the patient when collecting anamnesis and making a preliminary diagnosis; at the same time they more restrainedly assess the presence of all the skills necessary for the formation of communicative competence at universit and more acutely feel the need for special communicative training precisely at the stage of residency. Underestimation of studying of the “Psychology” discipline in the system of the doctor’s professional training by the medical residents of both years actualizes the promising task to further develop the stated problem - the creation of a special course in the psychology of communication between a doctor and a patient that integrates clinical and psychological knowledge and promotes targeted, consistent and effective formation of communicative competence of future doctors in the educational process of a medical university.","PeriodicalId":167342,"journal":{"name":"Современные проблемы науки и образования (Modern Problems of Science and Education)","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116675367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CURRENT MARKERS OF INFLAMMATION IN CLINICAL PRACTICE 当前临床实践中的炎症标志物

Современные проблемы науки и образования (Modern Problems of Science and Education) Pub Date : 1900-01-01 DOI: 10.17513/spno.31653

A. Morozov, T. V. Sorokovikova, S. Zhukov, A. D. Morozova, T. S. Ryzhova, M. Muravlyantseva, A. Pichugova, Y. Minakova

{"title":"CURRENT MARKERS OF INFLAMMATION IN CLINICAL PRACTICE","authors":"A. Morozov, T. V. Sorokovikova, S. Zhukov, A. D. Morozova, T. S. Ryzhova, M. Muravlyantseva, A. Pichugova, Y. Minakova","doi":"10.17513/spno.31653","DOIUrl":"https://doi.org/10.17513/spno.31653","url":null,"abstract":"Inflammation is a physiological protective reaction of the body that occurs in response to damage by various biological, chemical and / or physical stimuli. As a general pathological process, inflammation is an indispensable pathogenetic component of many acute and chronic diseases. Understanding the mechanisms of inflammation development is essential for its timely detection and control, as well as diagnosis, treatment and prevention of relevant diseases. In this regard, the so-called inflammation markers are widely used in modern clinical practice. Primarily such inflammatory biomarkers are acute phase proteins such as C-reactive protein, fibrinogen, inflammatory mediators such as cytokines, including interleukins, and cell surface and cell adhesion receptors such as selectins and integrins. At the same time, blood cells remain indispensable markers of inflammation, which are activated in the acute phase of inflammation and directly produce and release a number of soluble mediators that stimulate and regulate the inflammatory response. However, all markers of inflammation widely used in modern clinical practice are non-specific; they make it possible to establish the presence of inflammation, but not to reveal its etiology.","PeriodicalId":167342,"journal":{"name":"Современные проблемы науки и образования (Modern Problems of Science and Education)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116778687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1