Journal of Pharmaceutical Health Care and Sciences最新文献

{"title":"Details of oral anticancer drug prescription audits by community pharmacists: a retrospective analysis of prescription inquiries.","authors":"Yuma Shibutani, Keito Ikou, Shinya Suzuki, Sayaka Nakajima, Akiko Hashimoto, Azumi Sako, Naoko Kumazawa, Yasuaki Ryusima, Masahito Yonemura, Naoki Kondo","doi":"10.1186/s40780-026-00580-4","DOIUrl":"https://doi.org/10.1186/s40780-026-00580-4","url":null,"abstract":"<p><strong>Background: </strong>Cancer pharmacotherapy has shifted to outpatient settings, making community pharmacists essential for ensuring medication safety. Although community pharmacist prescription audits are important, evidence regarding the clinical significance of their prescription audits for oral anticancer agents remains limited. This study aimed to analyze the content of inquiries regarding oral anticancer drugs and clarify the details of prescription audits conducted by community pharmacists.</p><p><strong>Methods: </strong>This single-institution retrospective a descriptive observational study included all records of inquiries regarding oral anticancer drugs submitted from community pharmacies to the National Cancer Center Hospital East between September 2023 and March 2025. Inquiry content was categorized based on treatment efficacy and safety concerns, while the level of pharmacist intervention was assessed based on the severity of the medication error and the clinical value of the pharmacist service. As the purpose of this study is to investigate prescription audits by community pharmacies, interventions unrelated to prescription auditing, such as telephone follow-ups or tracing reports, were excluded.</p><p><strong>Results: </strong>During the study period, 184,688 prescriptions were issued, of which 384 inquiries (0.2%) involved oral anticancer agents and were included in the analysis. Prescription modifications occurred in 295 cases (77%). The most common inquiry categories were incorrect treatment duration (23%), adjustment for leftover medication (20%), and dosage errors (16%). Overall, 49% of cases were classified as potentially lethal, serious, or significant medication-order errors, and 49% were assessed as having a value of service of significant or higher. High-severity and high-value interventions most frequently involved errors in treatment duration and dosage.</p><p><strong>Conclusions: </strong>Prescription inquiries regarding oral anticancer agents frequently identified clinically significant prescribing issues, and community pharmacists provided high-value interventions. These findings indicate that community pharmacists play a crucial role in conducting high-quality prescription audits and enhancing the safety of outpatient cancer drug therapy.</p>","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized tacrolimus therapy in allogeneic hematopoietic stem cell transplantation: from pharmacokinetic variability to novel control strategies.","authors":"Naoki Yoshikawa","doi":"10.1186/s40780-026-00581-3","DOIUrl":"https://doi.org/10.1186/s40780-026-00581-3","url":null,"abstract":"<p><strong>Background: </strong>Allogeneic hematopoietic stem cell transplantation is an established curative therapy for many hematological diseases, but graft-versus-host disease remains a major cause of morbidity and mortality. Tacrolimus, a calcineurin inhibitor, is widely used for prophylaxis because it suppresses T-cell activation. However, its clinical use is complicated by a narrow therapeutic window and marked pharmacokinetic variability. Therapeutic drug monitoring based on trough whole-blood concentrations is routinely used to guide dosing, but this approach has limitations, particularly in transplantation recipients who experience rapid physiological and hematological changes. This review summarizes recent insights into determinants of tacrolimus pharmacology in hematopoietic stem cell transplantation and discusses emerging perspectives for individualized dosing.</p><p><strong>Main body: </strong>Tacrolimus exerts its immunosuppressive effects by forming a complex with FK506-binding proteins that inhibits calcineurin and suppresses activation of nuclear factor of activated T cells. Beyond this canonical mechanism, interactions with FK506-binding proteins influence the distribution of tacrolimus within blood cells. Because tacrolimus strongly divides into erythrocytes and leukocytes, whole-blood concentrations reflect systemic exposure and drug binding within circulating blood components. In recipients of hematopoietic stem cell transplantation, marked fluctuations in blood cell counts during conditioning therapy and hematopoietic recovery can alter this distribution, potentially causing changes in concentrations without corresponding changes in pharmacologically active exposure. Genetic variation in drug-metabolizing enzymes further contributes to variability in tacrolimus pharmacokinetics. In particular, polymorphisms in the gene encoding cytochrome P450 3A5 influence tacrolimus metabolism and may affect early dose requirements during the post-transplant period. Additionally, temporal fluctuations in tacrolimus exposure within individual patients are increasingly recognized as clinically relevant. Measures that capture the proportion of time during which concentrations remain within the therapeutic range provide a useful indicator of exposure stability.</p><p><strong>Conclusion: </strong>Tacrolimus therapy after hematopoietic stem cell transplantation is influenced by molecular pharmacology, blood cell-dependent distribution, genetic determinants of metabolism, and temporal variability in drug exposure. Integrating these factors may improve understanding of therapeutic drug monitoring and promote more individualized strategies to maintain stable immunosuppression and improve transplant outcomes.</p>","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical stability study of diuretics in a concomitant simple suspension with magnesium oxide.","authors":"Ginjiro Kato, Hidemichi Mitome, Mayu Terada, Noriaki Hidaka, Mamoru Tanaka, Kazuki Akira","doi":"10.1186/s40780-026-00579-x","DOIUrl":"https://doi.org/10.1186/s40780-026-00579-x","url":null,"abstract":"<p><strong>Background: </strong>A simple suspension method has been widely used in Japan, however, chemical interactions among drugs in co-suspensions have not been fully clarified. Magnesium oxide (MgO), which is frequently prescribed as a laxative, can interact with various drugs. Eplerenone and spironolactone, potassium-sparing diuretics, are sometimes co-prescribed with MgO to older patients. In this study, we investigated the chemical stability of eplerenone and spironolactone in a co-suspension with MgO and characterized the structures of the degradation products that were formed under the conditions.</p><p><strong>Methods: </strong>An eplerenone or spironolactone tablet was soaked with or without an MgO tablet in warm water in a tube according to a standard simple suspension method. The contents in the tube were mixed by inversion after 10 min, 1 h or 5 h to prepare a simple suspension. In separate experiments, the suspension prepared after 10 min soaking was allowed to stand for 50 min or 4.8 h at room temperature. The suspensions were immediately analyzed by high-performance liquid chromatography. The recovery rates of the diuretics from the suspensions were calculated relative to the labeled amounts. The degradation products were isolated and the structures analyzed by high-resolution mass spectrometry.</p><p><strong>Results: </strong>The high-performance liquid chromatographic analysis showed that the diuretics were stable in their simple suspensions without MgO under any of the conditions. When co-suspended with MgO, a slight degradation was observed for eplerenone after just 10 min soaking and the degradation was statistically significant after 5 h soaking, whereas spironolactone was stable even after 5 h soaking. On the other hand, when the co-suspensions with MgO were left alone after mixing, eplerenone significantly degraded in 50 min, and spironolactone slightly degraded in the same period. Based on the mass spectra from the degradation products, hydrolysis of the lactone ring was shown to have occurred in both diuretics co-suspended with MgO. For spironolactone, hydrolysis and elimination of the thioester were also shown to have occurred in the co-suspensions.</p><p><strong>Conclusions: </strong>Eplerenone is more unstable than spironolactone in the simple co-suspension with MgO. As such, the simple co-suspensions of eplerenone are preferably prepared immediately before administration.</p>","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events.","authors":"Teruhisa Kinoshita, Yuki Kondo, Yuka Sakazaki, Norio Takimoto, Yoichi Ishitsuka","doi":"10.1186/s40780-026-00574-2","DOIUrl":"https://doi.org/10.1186/s40780-026-00574-2","url":null,"abstract":"","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacist-driven antimicrobial stewardship: evolving roles in clinical practice.","authors":"Naoto Okada","doi":"10.1186/s40780-026-00576-0","DOIUrl":"https://doi.org/10.1186/s40780-026-00576-0","url":null,"abstract":"","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Akathisia induced by concurrent use of mirogabalin and sulfamethoxazole-trimethoprim: a case report.","authors":"Takashi Nakashima, Kimitaka Suetsugu, Mina Nitta, Taichi Nagano, Makoto Yoshimitsu, Kenji Ishitsuka, Hideyuki Terazono","doi":"10.1186/s40780-026-00578-y","DOIUrl":"10.1186/s40780-026-00578-y","url":null,"abstract":"","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive analysis of community pharmacists' practices, barriers, and strategies in patient education on Saxenda®: a qualitative study.","authors":"Abdullah Saad Turki, Ehab Mudher Mikhael","doi":"10.1186/s40780-026-00575-1","DOIUrl":"https://doi.org/10.1186/s40780-026-00575-1","url":null,"abstract":"","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":"12 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of an HPLC-UV system (LM1010) and UPLC-MS/MS for plasma voriconazole measurement in routine clinical practice.","authors":"Junichi Nakagawa, Kayo Ueno, Katsuyoshi Osanai, Masahiro Ishiyama, Miyuki Matsushita, Satoru Morikawa, Hirofumi Tomita, Takenori Niioka","doi":"10.1186/s40780-026-00573-3","DOIUrl":"https://doi.org/10.1186/s40780-026-00573-3","url":null,"abstract":"","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of the effectiveness of virtual reality-based and text-based training in sterile preparation: pilot trial of early-stage clinical VR study.","authors":"Satoru Esumi, Sari Nakagawa, Mai Ikemura, Yui Takezawa, Rika Ebara, Miho Harada, Akitoshi Tatsumi, Akiko Kanmachi, Yasuhiko Hashimoto, Mariko Takeda-Morishita","doi":"10.1186/s40780-026-00571-5","DOIUrl":"https://doi.org/10.1186/s40780-026-00571-5","url":null,"abstract":"","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with peripheral neuropathy development during gemcitabine plus albumin-bound paclitaxel therapy as first-line treatment for unresectable pancreatic cancer: a retrospective evaluation.","authors":"Tomoya Ban, Makoto Miura","doi":"10.1186/s40780-026-00572-4","DOIUrl":"https://doi.org/10.1186/s40780-026-00572-4","url":null,"abstract":"","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}