大剂量静脉对乙酰氨基酚降低急性腹部疾病老年人谵妄风险:一项回顾性队列研究

IF 1.2 Q4 PHARMACOLOGY & PHARMACY
Masayuki Saito, Nanaha Nishiwaki, Yoshihito Nakashima, Eisei Hori, Tadashi Suzuki, Tomoya Tachi, Toshihiko Ichihara
{"title":"大剂量静脉对乙酰氨基酚降低急性腹部疾病老年人谵妄风险:一项回顾性队列研究","authors":"Masayuki Saito, Nanaha Nishiwaki, Yoshihito Nakashima, Eisei Hori, Tadashi Suzuki, Tomoya Tachi, Toshihiko Ichihara","doi":"10.1186/s40780-025-00462-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Delirium, a significant complication in older patients, often occurs during hospitalization and is associated with poor clinical outcomes. Effective strategies to prevent delirium are essential, particularly in emergency department (ED) settings where older patients frequently present with acute abdominal conditions. This study evaluated the impact of high-dose intravenous acetaminophen (≥ 1,000 mg) on the onset of delirium in older patients.</p><p><strong>Methods: </strong>This retrospective cohort study included 411 patients aged 70 years or older diagnosed with acute abdomen at the ED of Tosei General Hospital from October 2015 to December 2022. Patients were divided into high-dose (≥ 1,000 mg/administration) and low-dose (< 1,000 mg/administration) groups based on acetaminophen dosage. Multivariate logistic regression analysis was performed to adjust for confounding factors, including neurodegenerative diseases, sensory impairments, and serum albumin levels.</p><p><strong>Results: </strong>Of the 411 patients included in this study, 53 (12.9%) developed delirium during hospitalization, with the high-dose acetaminophen group demonstrating a significantly lower risk of delirium onset than that of the low-dose group (odds ratio: 0.391; 95% confidence interval: 0.193-0.791). Multivariate logistic regression analysis confirmed the protective effect of high-dose acetaminophen treatment after adjusting for potential confounding factors, suggesting this treatment protocol as a promising therapeutic approach for preventing delirium in older patients with acute abdominal conditions.</p><p><strong>Conclusions: </strong>High-dose intravenous acetaminophen may effectively reduce the risk of delirium onset in older patients hospitalized with acute abdomen. These findings suggest a valuable role for high-dose acetaminophen in improving patient outcomes and reducing the burden of delirium in emergency and hospital care.</p><p><strong>Trial registration: </strong>Retrospectively registered.</p>","PeriodicalId":16730,"journal":{"name":"Journal of Pharmaceutical Health Care and Sciences","volume":"11 1","pages":"56"},"PeriodicalIF":1.2000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High-dose IV acetaminophen reduces delirium risk in older adults with acute abdominal conditions: a retrospective cohort study.\",\"authors\":\"Masayuki Saito, Nanaha Nishiwaki, Yoshihito Nakashima, Eisei Hori, Tadashi Suzuki, Tomoya Tachi, Toshihiko Ichihara\",\"doi\":\"10.1186/s40780-025-00462-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Delirium, a significant complication in older patients, often occurs during hospitalization and is associated with poor clinical outcomes. Effective strategies to prevent delirium are essential, particularly in emergency department (ED) settings where older patients frequently present with acute abdominal conditions. This study evaluated the impact of high-dose intravenous acetaminophen (≥ 1,000 mg) on the onset of delirium in older patients.</p><p><strong>Methods: </strong>This retrospective cohort study included 411 patients aged 70 years or older diagnosed with acute abdomen at the ED of Tosei General Hospital from October 2015 to December 2022. Patients were divided into high-dose (≥ 1,000 mg/administration) and low-dose (< 1,000 mg/administration) groups based on acetaminophen dosage. Multivariate logistic regression analysis was performed to adjust for confounding factors, including neurodegenerative diseases, sensory impairments, and serum albumin levels.</p><p><strong>Results: </strong>Of the 411 patients included in this study, 53 (12.9%) developed delirium during hospitalization, with the high-dose acetaminophen group demonstrating a significantly lower risk of delirium onset than that of the low-dose group (odds ratio: 0.391; 95% confidence interval: 0.193-0.791). Multivariate logistic regression analysis confirmed the protective effect of high-dose acetaminophen treatment after adjusting for potential confounding factors, suggesting this treatment protocol as a promising therapeutic approach for preventing delirium in older patients with acute abdominal conditions.</p><p><strong>Conclusions: </strong>High-dose intravenous acetaminophen may effectively reduce the risk of delirium onset in older patients hospitalized with acute abdomen. These findings suggest a valuable role for high-dose acetaminophen in improving patient outcomes and reducing the burden of delirium in emergency and hospital care.</p><p><strong>Trial registration: </strong>Retrospectively registered.</p>\",\"PeriodicalId\":16730,\"journal\":{\"name\":\"Journal of Pharmaceutical Health Care and Sciences\",\"volume\":\"11 1\",\"pages\":\"56\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Health Care and Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s40780-025-00462-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Health Care and Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40780-025-00462-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

背景:谵妄是老年患者的一个重要并发症,常发生在住院期间,并与不良临床预后相关。预防谵妄的有效策略至关重要,特别是在急诊科(ED)设置中,老年患者经常出现急性腹部疾病。本研究评估了大剂量静脉注射对乙酰氨基酚(≥1000mg)对老年患者谵妄发作的影响。方法:本回顾性队列研究纳入2015年10月至2022年12月在东生总医院急诊科确诊的70岁及以上急腹症患者411例。患者被分为高剂量(≥1000mg /次)和低剂量(结果:纳入本研究的411例患者中,53例(12.9%)在住院期间出现谵妄,高剂量对乙酰氨基酚组谵妄发作的风险显著低于低剂量组(优势比:0.391;95%置信区间:0.193-0.791)。多因素logistic回归分析在校正潜在混杂因素后证实了大剂量对乙酰氨基酚治疗的保护作用,提示该治疗方案是预防老年急腹症患者谵妄的一种有前景的治疗方法。结论:大剂量静脉注射对乙酰氨基酚可有效降低老年急腹症住院患者谵妄发作的风险。这些发现表明,在急诊和医院护理中,大剂量对乙酰氨基酚在改善患者预后和减轻谵妄负担方面具有重要作用。试验注册:回顾性注册。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-dose IV acetaminophen reduces delirium risk in older adults with acute abdominal conditions: a retrospective cohort study.

Background: Delirium, a significant complication in older patients, often occurs during hospitalization and is associated with poor clinical outcomes. Effective strategies to prevent delirium are essential, particularly in emergency department (ED) settings where older patients frequently present with acute abdominal conditions. This study evaluated the impact of high-dose intravenous acetaminophen (≥ 1,000 mg) on the onset of delirium in older patients.

Methods: This retrospective cohort study included 411 patients aged 70 years or older diagnosed with acute abdomen at the ED of Tosei General Hospital from October 2015 to December 2022. Patients were divided into high-dose (≥ 1,000 mg/administration) and low-dose (< 1,000 mg/administration) groups based on acetaminophen dosage. Multivariate logistic regression analysis was performed to adjust for confounding factors, including neurodegenerative diseases, sensory impairments, and serum albumin levels.

Results: Of the 411 patients included in this study, 53 (12.9%) developed delirium during hospitalization, with the high-dose acetaminophen group demonstrating a significantly lower risk of delirium onset than that of the low-dose group (odds ratio: 0.391; 95% confidence interval: 0.193-0.791). Multivariate logistic regression analysis confirmed the protective effect of high-dose acetaminophen treatment after adjusting for potential confounding factors, suggesting this treatment protocol as a promising therapeutic approach for preventing delirium in older patients with acute abdominal conditions.

Conclusions: High-dose intravenous acetaminophen may effectively reduce the risk of delirium onset in older patients hospitalized with acute abdomen. These findings suggest a valuable role for high-dose acetaminophen in improving patient outcomes and reducing the burden of delirium in emergency and hospital care.

Trial registration: Retrospectively registered.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.80
自引率
0.00%
发文量
29
审稿时长
8 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信