Journal of Pharmaceutical Research最新文献_第7页

Design and Characterization of Buccal Films of Benzocaine for Mouth Ulcer 苯佐卡因口腔溃疡膜的设计与表征

Journal of Pharmaceutical Research Pub Date : 2021-09-15 DOI: 10.18579/jopcr/v20i3.ms21062

J. Jose, M. V. Sisira, M. Prasanth, C. Prasanth, P. Pradeep

{"title":"Design and Characterization of Buccal Films of Benzocaine for Mouth Ulcer","authors":"J. Jose, M. V. Sisira, M. Prasanth, C. Prasanth, P. Pradeep","doi":"10.18579/jopcr/v20i3.ms21062","DOIUrl":"https://doi.org/10.18579/jopcr/v20i3.ms21062","url":null,"abstract":"Mouth ulcer is very common in recent years, which occurs due to the damage of epithelial tissue and/or lamina propria that finally leads to tissue necrosis. Benzocaine has been used to treat the mouth ulcers due to its excellent local anaesthetic effect that relieves the pain associated with mouth ulcer. Hence an attempt was made to develop and characterize the buccal films of Benzocaine to treat mouth ulcers with an aim of prolonging the drug release and improving the patient convenience. The films were fabricated using the mucoadhesivepolymerblendofchitosanandHPMCbysolventcastingmethodandthephysico-mechanical, in vitro drug release and ex vivo buccal mucosal permeation characteristics of the films were studied. All fabricated film formulations prepared were smooth and almost opaque, with good flexibility. The weight and thickness of all the formulations were found to be uniform. Drug content in the films ranged from 97–99%, indicating favorable drug loading and uniformity. The inclusion of HPMC, significantly reduced the bioadhesive strength and in vitro mucoadhesion time of chitosan films, although the degree of swelling increased. In vitro drug release and permeation studies in simulated saliva showed a prolonged release for a period of 6 h for all formulations. The formulation with Chitosan: HPMC ratio 1:1, 10% w/w polysorbate 80 and 10% w/w propylene glycol as plasticizers showed the best results which exhibited the cumulative percentagedrugreleaseof87.9%andthecumulativeamountofdrugpermeationof7.62mg/cm 2 acrossgoat buccal mucosa in 6 h. Drug-excipient interaction studies were carried out using DSC and FT-IR technique; films indicated no chemical interaction between drug and polymers used.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46654900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Screening and Comparative Anthelmintic Activity of Psidium guajava L. Leaves extract against Pheretima posthuma 番石榴叶提取物的植物化学筛选及对柱状假脱机的比较杀虫活性

Journal of Pharmaceutical Research Pub Date : 2021-09-15 DOI: 10.18579/jopcr/v20i3.ms21042

D. K. Pradhan, M. Mishra, Abhishek Hota

{"title":"Phytochemical Screening and Comparative Anthelmintic Activity of Psidium guajava L. Leaves extract against Pheretima posthuma","authors":"D. K. Pradhan, M. Mishra, Abhishek Hota","doi":"10.18579/jopcr/v20i3.ms21042","DOIUrl":"https://doi.org/10.18579/jopcr/v20i3.ms21042","url":null,"abstract":"Objective: Psidium guajava L. (Family: Myrtaceae.), commonly known as Guava, is a well-known traditional medicinal plant used in treatment of vomiting, diarrhea, dysentery, flatulence, gastroenteritis, abdominal distention and hyperglycemia. The present study was carried out to evaluate Phytochemical and Comparative in vitro anthelmintic activity of P. guajava leave extracts against Indian adult earthworm Pheretima posthuma . Methods: The traditional medicinal plant is used to control gastrointestinal infections. The phytochemical analysis and anthelmintic effects of extracts (Chloform, aqueous & methanol) and the standard drug (Piperazine citrate) were tested against Indian adult earthworm. The time taken to paralyze and death time of earthworm was considered for anthelmintic effects. Results: The phytochemical analysis revealed the presence of flavanoids, glycosides, alkaloids, steroids, and tannins. Methanolic extract of P. guajava leave extract was showed significant anthelmintic activity among all extracts. Methanolic extract havebeenfoundthehighestrateofparalysis(1.820 (cid:6) 0.242min)anddeath(5.573 (cid:6) 0.315min)ofearthworm againstthestandarddrugPiperazinecitrate.Conclusion:Thewormicidalactivityof P.guajava leavesextract suggests that it could be effective against parasitic infections of humans and validate the traditional use of P. guajava as a natural therapy for treatment of anthelmintic infection.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48834215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Micro and Macrovascular Complications and Assessment of Risk Factors in Diabetic patients: a Prospective Observational Study 糖尿病患者微血管和大血管并发症患病率及危险因素评估:一项前瞻性观察研究

Journal of Pharmaceutical Research Pub Date : 2021-09-15 DOI: 10.18579/jopcr/v20i3.ms21056

D. Jothieswari, R. M. Soniya, R. S. Vinuthna, P. Venkatesh, V. Hari

{"title":"Prevalence of Micro and Macrovascular Complications and Assessment of Risk Factors in Diabetic patients: a Prospective Observational Study","authors":"D. Jothieswari, R. M. Soniya, R. S. Vinuthna, P. Venkatesh, V. Hari","doi":"10.18579/jopcr/v20i3.ms21056","DOIUrl":"https://doi.org/10.18579/jopcr/v20i3.ms21056","url":null,"abstract":"Diabetes is a chronic metabolic disorder of heterogenous type. Diabetic complications are mostly associated with condition of vascular penetrability that affects different tissues & kidneys, retina, nerves which involve the body organs.The aim of study was to assess the prevalence of micro and macro diabetic complications and risk factors of diabetic patients. The prospective observational study was conducted in Raghu Diabetes and general clinic, Chittoor, Andhra Pradesh. A sample size of 200 subjects was recruited for the study. The study was conducted from December 2020 to May 2021. Patients with age group of 30-90 years and diabetic complications were included in the study. Patients below 30 years of age were excluded from study. The patient details were collected using questionnaire form. It contains sociodemographic data and medical history including smoking, alcohol, family history of diabetes mellitus, and treatment and management of diabetes. The statistical analysis was carried out using SPSS version 25.0. The study results showed 1.5% of patients had more than two co-morbidities, which was significantly higher among elderly (5.04%), females (5.2%) and urban residence (6.31%), physical inactivity (3.15%) and house wife (2.1%). The statins prescribed patients were 160 (80%) whereas patients on other medications, insulin in combination with OHA38(19%),andmultivitaminsprescribedpatients181(90.5%).Thestudyshowedthepatient’sageof51-70yearswasmostlyaffectedbydiabetes.Regularexercise,intakeofmorevegetablesandfruitsandadoptingahealthierlife-stylecanreducetheprevalenceofdiabetes.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46378261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study on the Knowledge and Attitude of the Ayurvedic and Dental Undergraduates of Central India towards ACLS and BLS 印度中部阿育吠陀和牙科本科生对ACLS和BLS的知识和态度研究

Journal of Pharmaceutical Research Pub Date : 2021-09-14 DOI: 10.9734/JPRI/2021/V33I43B32569

Anjali Bankar, Amit Reche, K. Chhabra, P. Madhu, Mehek Batra, Radhika kannake, Ramani Mandale

引用次数: 0

Occurrence of Hemorrhoids and Anal Fissures through Pregnancy and Postpartum 妊娠和产后痔疮和肛裂的发生

Journal of Pharmaceutical Research Pub Date : 2021-09-07 DOI: 10.9734/JPRI/2021/V33I43A32497

Esmatullah, Baseera

{"title":"Occurrence of Hemorrhoids and Anal Fissures through Pregnancy and Postpartum","authors":"Esmatullah, Baseera","doi":"10.9734/JPRI/2021/V33I43A32497","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I43A32497","url":null,"abstract":"Objective: To recognize occurrence also danger issues of hemorrhoids and fissures throughout pregnancy and afterwards childbirth. \u0000Population: The overall 180 pregnant females trailed up till 1 month after delivery. \u0000Methods: Females remained inspected 4 times via pregnancy and after delivery; those that developed perianal diseases were compared with those that did not. Main outcome measures Incidence, time and risk factors of hemorrhoids and fissures. Our current research was done in Nangarhar Reginal Hospital Gyn/ Obs ward from June -2020 to June -2021. \u0000Results: In total 90 (50%) female patients have developed perineal diseases (Hemorrhoid, Anal Fissure. The most vulnerable times were 3rd trimester about 60 (66.6%), Second trimester 20(22.2%) and in the first month after deliver 10(11.11%). \u0000From these Patients Investigation shows that 65(72.2%) only suffering from hemorrhoid and 15(13.5%) has both hemorrhoid and anal fissure. 80 female undergone Vaginal delivery and 10 remind has undergone of caesarean section. Risk Factors for Perineal illness during pregnancy was Constipation, Straining throughout delivery for more than 20 mins and baby weight >3900gr. \u0000Conclusions: Hemorrhoids and fissures remain mutual throughout last trimester of pregnancy and one month afterwards delivery, through constipation, individual past of hemorrhoids or fissures, birth weight of new >3900 g, straining throughout delivery for extra than 20 mins being self-sufficiently related risk factors.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"357-360"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45688377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Antioxidant Property of Moringa Oleifera Leaves and its Effectiveness Against Rheumatoid Arthritis 辣木叶抗氧化性能及其对类风湿性关节炎的疗效评价

Journal of Pharmaceutical Research Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32358

M. J. Kapil, D. Deka, M. Lahkar, N. Sharma

引用次数: 2

Effects of Solvents and Extraction Methods on Naringenin, LC-MS Based Quantitative Studies and Major Metabolite of Cochlospermum gossypium 溶剂和提取方法对棉蚜Naringenin、LC-MS定量研究及主要代谢产物的影响

Journal of Pharmaceutical Research Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32361

Y. Rajendra, K. Sunitha

{"title":"Effects of Solvents and Extraction Methods on Naringenin, LC-MS Based Quantitative Studies and Major Metabolite of Cochlospermum gossypium","authors":"Y. Rajendra, K. Sunitha","doi":"10.9734/JPRI/2021/V33I41B32361","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I41B32361","url":null,"abstract":"Aim: The present study was aimed to investigate “Effects of Solvents and Extraction Methods on Naringenin, LC-MS Based Quantitative Studies and major Metabolite of Cochlospermum Gossypium”. \u0000Study Design: LC-MS based Quantification Studies. \u0000Place and Duration of Study: Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, Visakhapatnam, Andhra Pradesh between April 2019 and July 2020. \u0000Methodology: Rapid and Quantitative efficient extraction methods were used by using soxhlet and Ultrasound mediated extraction techniques for a range of polar solvents and Isolation of Naringenin by gradient elution technique, In the present study Naringenin was isolated in abundance (1%) by repetitive chromatographic purifications of the ethyl acetate extract of the bark part of C.gossypium. In view of high therapeutic potential, detailed HPLC based quantitative studies was carried out on C. gossypium bark, which contains significant levels of Naringenin. \u0000Results: The chromatographic separation was performed on the stationary phase, based on different retention mechanisms due to hydrophilic and hydrophobic interactions between compounds and stationary phase. In total, 24 different polar extracts were generated by soxhlet and ultrasound extraction methods from the two bark samples which were collected from Jaipur town (Telangana state) and Trichur town (Kerala state). \u0000Conclusion: The highest Naringenin content (0.59%) was found in the methanol + chloroform (1:1) extract (E8) generated by direct Soxhlet extraction of C.gossypium bark collected from Jaipur (Telangana state).Naringenin was isolated from a non-citrus plant for first time from Cochlospermum gosspyium and more significantly it is isolated in large quantity. It was obtained in 99.9% purity as shown by LCMS.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"217-228"},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44038847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Metformin in Pediatric Type-1 Diabetes Mellitus in Addition to Insulin Therapy; Literature Review 二甲双胍与胰岛素治疗对儿童1型糖尿病的影响文献综述

Journal of Pharmaceutical Research Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32357

Mohammed Abdullah Alzahimah, Khalid Mohammed S. Al Sleem, Hatem Ahmed Albenawy, Albara Abdullah Mohammed Al Mushham

引用次数: 0

Studies of Serum Calcium, Inorganic Phosphate and Magnesium Levels in Lactating Mothers in Owerri Owerri哺乳期母亲血清钙、无机磷和镁水平的研究

Journal of Pharmaceutical Research Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32360

A. Edward, E. Obeagu, H. Okorie, C. Vincent, Yakubu Sunday Bot

引用次数: 4

Comparative Analysis of Differentially Expressed Genes in Oral Leukoplakia and Oral Submucous Fibrosis Using Bioinformatics Approach 应用生物信息学方法比较分析口腔白斑和口腔黏膜下纤维化差异表达基因

Journal of Pharmaceutical Research Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32356

Akansha Budakoti, C. More, A. Seth, Priyanka Sharma

引用次数: 0