Journal of Perinatal Medicine最新文献

{"title":"Analysis of changes in serum VEGF, β-hCG, and sFlt-1 levels in women with placenta accreta spectrum and the impact on prognosis.","authors":"Pan Shang, DongMei Pang, YinLing Zhao","doi":"10.1515/jpm-2025-0291","DOIUrl":"10.1515/jpm-2025-0291","url":null,"abstract":"<p><strong>Objectives: </strong>To explore serum vascular endothelial growth factor (VEGF), β-subunit human chorionic gonadotropin (β-hCG), and soluble Fms-like tyrosine kinasereceptor 1 (sFlt-1) levels in pregnant women with placenta accreta spectrum (PAS) and their prognostic implications.</p><p><strong>Methods: </strong>Serum levels were measured in PAS patients and non-PAS controls. Depending on the depth of placental penetration into the uterine wall, PAS patients were further classified into placenta accreta, placenta increta and placenta percreta subgroups. Diagnostic efficacy of individual biomarkers and combined indices was evaluated using receiver operating characteristic curves. Correlations between biomarker levels, disease severity, and prognosis were analyzed.</p><p><strong>Results: </strong>Serum levels of VEGF and β-hCG showed significant positive correlations with the extent of PAS invasion, whereas sFlt-1 levels were inversely associated with disease progression. Combined pregnancy complications, elevated serum VEGF levels and decreased serum sFlt-1 levels were risk factors for poor prognosis in patients with PAS. The AUC values of the indicators combined to predict the diagnosis and prognosis of patients with PAS were greater than serum VEGF, hCG, and sFlt-1 levels alone.</p><p><strong>Conclusions: </strong>Serum levels of VEGF, β-hCG, and sFlt-1 demonstrate the potential to differentiate between women with and without PAS, and further exhibit a correlation with the depth of myometrial invasion in PAS cases. The combined use of these serum markers enhances both the sensitivity and specificity of prenatal diagnosis and prognostic assessment for PAS compared to individual markers, thereby offering valuable guidance for clinical diagnosis and management of PAS.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"493-499"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of chromosomal microarray and whole exome sequencing in evaluating genetic causes for pregnancy loss using products of conception specimens.","authors":"Kanaka Durga Devi Yadam Reddy, Suresh Kumaraswamy, Palanichamy Palanikumar, Tajamul Hussain, Shaik Mohammad Naushad","doi":"10.1515/jpm-2025-0240","DOIUrl":"10.1515/jpm-2025-0240","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the genetic causes of miscarriage by analyzing products of conception (POC).</p><p><strong>Methods: </strong>Chromosomal microarray (CMA) using the Affymetrix Cytoscan HD array was performed in 172 POC specimens from women experiencing spontaneous miscarriage before 20 weeks of gestation to detect aneuploidies, copy number variants (CNVs), and loss of heterozygosity (LOH). Whole exome sequencing (WES) with Roche KAPA HyperExome V2 probes was used for cases where CMA results were normal.</p><p><strong>Results: </strong>Common clinical indications included recurrent pregnancy loss, first-time miscarriage, absence of cardiac activity, intrauterine death, and fetal growth restriction (FGR), making up 72.55 % of cases. CMA identified chromosomal abnormalities in 38.37 % of samples, with numerical anomalies in 16.86 % and structural anomalies in 21.51 %. Turner syndrome (5.8 %) and various trisomies (5.8 %) were frequent numerical anomalies. Mosaicism and LOH were observed in 11.04 and 2.91 % of cases. WES detected pathogenic or likely pathogenic mutations in 21 genes (e.g., KCNQ1, KCNE1, COL1A2, ROBO1) in 18 cases, adding a 10.46 % diagnostic yield. K-means clustering grouped 17 of these genes into three pathways: chondrocyte differentiation, fibrin clot formation, and Ehlers-Danlos syndrome.</p><p><strong>Conclusions: </strong>Combining CMA and WES provides a diagnostic yield of 48.83 %, offering a powerful approach to uncover genetic causes of pregnancy loss and guide clinical care.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"507-514"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we conduct a trial of labor in women with a macrosomic fetus?","authors":"Luís Carlos Machado Junior, Emy Kikugawa, Patricia de Carvalho Jacobsen, Josikwylkson Costa Brito, João Mateus Junior, Heráclito Barbosa de Carvalho","doi":"10.1515/jpm-2025-0359","DOIUrl":"10.1515/jpm-2025-0359","url":null,"abstract":"<p><strong>Objectives: </strong>There is much debate about the best mode of delivery for the macrosomic fetus. This study compares maternal and neonatal outcomes of macrosomic in prelabor cesareans (PLC) vs. in trials of labor (TOL).</p><p><strong>Methods: </strong>Retrospective cohort including neonates with birthweight of 4,000 g or more delivered in a public teaching hospital between October 2019 and December 2024. Exclusions: preterm, non cephalic, multiples, fetal death and malformed. Created three composite outcomes: \"any serious adverse neonatal outcome\", \"any adverse maternal outcome\", \"neonatal respiratory morbidity\". Considered significant a value of p<0.05.</p><p><strong>Results: </strong>Included 611 births. There was no maternal death and, in the group of TOL, one neonatal death; 37.7 % had vaginal births and 62.3 % had cesareans. Were conducted 341 (56 %) TOL's; from these, 32.8 % failed. Among 231 vaginal births, we had 61 (26.4 %) cases of shoulder dystocia, among which 9 neonates were discharged with brachial plexus injury (3.9 % of vaginal births; 1/25). We found a greater frequency of \"any neonatal adverse outcome\" in TOL, adjusted Odss Ratio (aOR) 6.68; p=0.037. No significant difference in \"respiratory morbidity\". In TOL, the frequency of \"any maternal adverse outcome\" was higher: aOR 3.53; p=0.009. A sensivity analysis excluding birthweights of 4,500 g or more had basically the same results.</p><p><strong>Conclusions: </strong>We had a high frequency of infants discharged with brachial plexus injury. Higher maternal morbidity in TOL could be because of the high rate of failed TOL. Not accessed in this work, there is still some difficulty in correctly identifiying the macrosomic antenatally.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"208-215"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of virtual reality on fear of birth, length of labor, and fetal well-being: a randomized controlled trial.","authors":"Mine Oruç, Kamile Kabukcuoglu","doi":"10.1515/jpm-2025-0462","DOIUrl":"10.1515/jpm-2025-0462","url":null,"abstract":"<p><strong>Objectives: </strong>The use of technological methods in childbirth is becoming increasingly common. This study aimed to evaluate the effects of virtual reality (VR) glasses on fear of childbirth, duration of labor, and fetal well-being in women undergoing term vaginal delivery.</p><p><strong>Methods: </strong>This single-blind randomized controlled trial included 144 pregnant women, equally divided into VR and control groups, stratified by parity. The intervention group watched nature videos via VR glasses in two sessions during the active phase of labor. Data were collected using clinical record forms, a nonstress test (NST) monitoring form, and the Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ-A/B).</p><p><strong>Results: </strong>The use of VR significantly reduced fear of childbirth and shortened the active phase of labor among both primiparous and multiparous women (p<0.05). No significant differences were found in the total duration of labor or other phases. While significant differences were observed in fetal movements and accelerations between groups, no clinically adverse effects on fetal well-being were reported. No side effects or complications related to the VR intervention were observed.</p><p><strong>Conclusions: </strong>VR appears to be a safe and effective non-pharmacological method to reduce childbirth fear and shorten the active phase of labor. Further studies are recommended to confirm its effects on labor physiology and neonatal outcomes.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"522-532"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The FAIR framework: ethical hybrid peer review.","authors":"Amos Grünebaum, Joachim Dudenhausen, Frank A Chervenak","doi":"10.1515/jpm-2025-0658","DOIUrl":"https://doi.org/10.1515/jpm-2025-0658","url":null,"abstract":"","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":"54 2","pages":"435-436"},"PeriodicalIF":1.4,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of prelabour midwifery consultation in enhancing maternal satisfaction and preparedness for birth.","authors":"Nina Badić, Martina Potisek, Mirjam Druškovič, Gorazd Kavšek, Miha Lučovnik","doi":"10.1515/jpm-2025-0355","DOIUrl":"10.1515/jpm-2025-0355","url":null,"abstract":"<p><strong>Objectives: </strong>Individual prelabour midwifery consultations were introduced at the Ljubljana Maternity Hospital to provide pregnant women with personalized information and support regarding childbirth. This study evaluated women's satisfaction, perceived preparedness, and trust in the care team.</p><p><strong>Methods: </strong>We conducted a two-part cross-sectional study. In the first part, routine hospital records were analysed to compare obstetric intervention rates between women who attended and those who did not attend the consultation. In the second part, a questionnaire survey assessed women's satisfaction with the consultation and their perceptions of its impact on childbirth.</p><p><strong>Results: </strong>Of 760 respondents (66.5 % response rate), 91 % reported a positive impact on their birth experience. The consultations enhanced preparedness, confidence, and trust in healthcare providers. The individual format was highly valued, helping women set realistic expectations for childbirth. Areas for improvement included breastfeeding support and postnatal follow-up. No significant differences were observed in obstetric intervention rates between consultation attendees and non-attendees.</p><p><strong>Conclusions: </strong>Prelabour midwifery consultations are highly valued by pregnant women and contribute to psychological preparation, trust, and satisfaction with childbirth. While they do not influence clinical outcomes, these consultations represent an effective supportive practice that can be integrated into maternity care, with potential enhancements in breastfeeding guidance and postnatal follow-up.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"201-207"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of antiphospholipid syndrome under medical treatment with adverse pregnancy outcomes.","authors":"Huilin Tang, Mingjie Xiang","doi":"10.1515/jpm-2025-0156","DOIUrl":"10.1515/jpm-2025-0156","url":null,"abstract":"<p><strong>Objectives: </strong>We aim to clarify the association and strength of association between antiphospholipid syndrome (APS) and adverse pregnancy outcomes.</p><p><strong>Methods: </strong>Our study included an analysis of 191 hospitalized singleton pregnant women with APS and 984 healthy singleton pregnant women at Obstetrics and Gynecology Hospital Affiliated to Fudan University from July 2017 to September 2023. The exposure factor was diagnosed as antiphospholipid syndrome, and the main outcomes were adverse pregnancy outcomes, including miscarriage, preterm birth, low birth weight, gestational hypertension, and eclampsia.</p><p><strong>Results: </strong>Our analysis indicated that the odds ratio (OR) for miscarriage in APS patients was 2.50 (95 % CI, 1.025 ± 15.794; p=0.046), for preterm birth was 2.8 (95 % CI, 1.025 ± 15.794; p=0.046), for low birth weight was 2.28 (95 % CI, 1.025 ± 15.794; p=0.046), and for fetal growth restriction was OR=2.48 (1.45, 4.23) p<0.05. The OR for preeclampsia was 1.00, and for gestational hypertension was 0.96, p>0.05. After adjustment for confounders of age and BMI confounders, the odds ratio (OR) for miscarriage was 2.50 (95 % CI: 1.52-4.11) p<0.05. Preterm birth was 2.89 (95 % CI: 1.79-4.65) p<0.05, low birth weight was 2.28 (95 % CI: 1.52-3.55) p<0.05, intrauterine growth restriction was 2.48 (95 % CI: 1.45-4.23) p<0.05. The OR of preeclampsia was 1.00 (95 % CI: 0.59-1.71) p>0.05, and that of pregnancy-induced hypertension was 0.96 (95 % CI: 0.53-1.75) p>0.05. After adjustment for confounders of age, BMI, eclampsia and diabetes, the OR for preterm infants were 3.06 (95 % CI: 1.87-5.00) p<0.05, and those of low birth weight infants were 2.55 (95 % CI: 1.49-4.37) p<0.05. After adjustment for confounders of age, BMI, diabetes, eclampsia, and gestational week, the OR for low birth weight infants was 2.02 (95 % CI: 1.26-3.26) p<0.05.</p><p><strong>Conclusions: </strong>Antiphospholipid syndrome was significantly associated with the risk of miscarriage, preterm birth, low birth weight, and intrauterine growth restriction as adverse pregnancy outcomes.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"515-521"},"PeriodicalIF":1.4,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145604732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamin D and inflammatory markers in SARS-CoV-2 positive pregnant women.","authors":"Vita Andreja Mesarič, Tanja Premru Sršen, Gorazd Kavšek, Ivan Verdenik, Aleksandra Štrukelj, Mirjam Druškovič","doi":"10.1515/jpm-2025-0356","DOIUrl":"10.1515/jpm-2025-0356","url":null,"abstract":"<p><strong>Objectives: </strong>The SARS-CoV-2 pandemic was declared by World Health Organisation (WHO) in March 2020, causing health and economic disruptions and millions of deaths. Pregnant women represent a vulnerable group, as COVID-19 during pregnancy increases the risk of preterm birth, preeclampsia, and severe maternal illness. Nutritional status, such as vitamin D deficiency, may influence these outcomes, yet data on its status in the cohort of SARS-CoV-2 positive pregnant women as well as its association with inflammatory and angiogenic markers is scarce. The aim of this study was to evaluate the levels of vitamin D in the cohort of SARS-CoV-2 positive pregnant women and its association with inflammatory and angiogenic markers.</p><p><strong>Methods: </strong>Prospective cohort study at Ljubljana Maternity Hospital (Oct 1, 2020-Mar 30, 2021) enrolled singleton pregnancies with PCR-confirmed SARS-CoV-2 within the last 14 days, delivering at our institution.</p><p><strong>Results: </strong>Among 235 SARS-CoV-2-positive pregnant women 62.1 % had adequate and 21.3 % insufficient level of vitamin D and 13.6 % were vitamin D deficient. Statistical analysis revealed no significant correlations between 25-OH-vitamin D and C-reactive protein (CRP), procalcitonin (PCT), leukocyte count, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), the sFlt-1/PlGF ratio, or body mass index (BMI).</p><p><strong>Conclusions: </strong>Our prospective cohort study revealed that high proportion of pregnant women has inadequate levels of vitamin D. Although maternal insufficiency is linked to adverse outcomes, its association with inflammatory and angiogenic markers remains unclear. Rigorous studies in pregnancy are essential to clarify vitamin D's role in COVID-19 complications in pregnancy.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"183-188"},"PeriodicalIF":1.4,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of fetal adrenal gland and thymothoracic ratio in preterm premature membrane rupture: a prospective case-control study.","authors":"Burcu Bozkurt Ozdal, Atakan Tanacan, Betul Akgun Aktas, Huseyin Kayaalp, Gulnihal Reyhan Toptas, Esra Karatas, Ozgur Kara, Dilek Sahin","doi":"10.1515/jpm-2025-0261","DOIUrl":"10.1515/jpm-2025-0261","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the role of fetal thymus and adrenal medulla dimensions in the pathogenesis of preterm prelabor rupture of membranes (PPROM).</p><p><strong>Methods: </strong>A prospective, case-control study was conducted involving 45 pregnant women with PPROM between 28 and 37 weeks of gestation and 45 matched healthy controls. Ultrasonographic measurements of fetal thymus (width, length, thymothoracic ratio (TTR)) and adrenal glands (length, width, depth, volume), including the adrenal medulla, were performed. Biochemical markers (WBC, CRP) and neonatal outcomes were recorded. Statistical analyses included comparisons between groups, correlation assessments, and ROC curve analysis to evaluate predictive parameters.</p><p><strong>Results: </strong>The fetal thymus dimensions and TTR ratio were significantly smaller in the PPROM group. The adrenal medulla volume, length, and depth were notably reduced, while total adrenal gland size showed no significant difference. Moderate negative correlations were observed between inflammatory markers and TTR. ROC analysis indicated that TTR and adrenal medulla volume could predict NICU admission with moderate sensitivity and specificity.</p><p><strong>Conclusions: </strong>The findings suggest that alterations in fetal thymus and adrenal medulla sizes are associated with PPROM and may serve as potential biomarkers for its diagnosis and prognosis. Further large-scale studies are warranted to validate these parameters and explore their clinical applications.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"575-581"},"PeriodicalIF":1.4,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145588047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureaplasma parvum detected in umbilical cord tissues diagnosed with funisitis associated with adverse pregnancy outcomes and neonatal pneumonia.","authors":"Wen Lei, Leijun Huo, Qiuping Chen, Yanxia Liao, Mi Li, Xiangcheng Zhou, Jiali Zhang, Shuai Zhou, Liang Zhang, Hongyi Gao, Hua Deng","doi":"10.1515/jpm-2025-0321","DOIUrl":"10.1515/jpm-2025-0321","url":null,"abstract":"<p><strong>Objectives: </strong>Existing studies yielded conflicting evidence regarding the associations between genital tract microbial and funisitis, chorioamnionitis and adverse pregnancy outcomes. This study aims to provide additional evidence for their association through systematic investigation.</p><p><strong>Methods: </strong>A total of 98 FFPE umbilical cord specimens confirmed as funisitis and chorioamnionitis through histopathological examination were tested for seven genital tract microorganisms using quantitative polymerase chain reaction (qPCR). Electronic medical records of mothers and neonates were retrieved to analyze the risk associations between microorganism-positive cases and chorioamnionitis as well as adverse pregnancy outcomes. The umbilical cord samples with <i>Ureaplasma parvum</i> positive had been sequenced for serovars analysis.</p><p><strong>Results: </strong><i>Ureaplasma parvum</i> (UP), <i>Ureaplasma urealyticum</i> (UU), Group B <i>Streptococcus</i> (GBS) and <i>Mycoplasma homini s</i> (MH) were all detected in the study with prevalence of 36.5 %, 7.9 %, 18.6 %, and 5.8 %, respectively, while <i>Mycoplasma genitalium</i> (MG), <i>Chlamydia trachomatis</i> (CT) and <i>Neisseria gonorrhoeae</i> (NG) were not detected. <i>Ureaplasma</i> spp. were identified as the predominant microorganisms detected in 98 umbilical cord cases by using qPCR, demonstrating concordance with clinical vaginal swab findings from pregnant women. Genital microorganisms infection was associated with high stage chorioamnionitis (p = 0.0254) and adverse pregnant outcomes (p = 0.0053). In addition, the prevalence of <i>U. parvum</i> demonstrated a strong significant association with neonatal pneumonia (p = 0.0037).</p><p><strong>Conclusions: </strong>Umbilical cord specimens tested positive for <i>U. parvum</i> demonstrated a significant association with adverse perinatal outcomes and neonatal pneumonia. Additional studies are warranted to investigate the determinants enabling commensal <i>U. parvum</i> in the genital tract to ascend and induce intrauterine infection, thereby leading to adverse clinical outcomes.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"273-281"},"PeriodicalIF":1.4,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145541056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}