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Journal of Pharmaceutical Investigation最新文献

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Recent advancements of nitric oxide-releasing hydrogels for wound dressing applications 伤口敷料用一氧化氮释放水凝胶的研究进展
4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-10-30 DOI: 10.1007/s40005-023-00636-9
Nurhasni Hasan, Cao Jiafu, Apon Zaenal Mustopa, Achmad Himawan, Rifqiyah Nur Umami, Muneeb Ullah, Nasrul Wathoni, Jin-Wook Yoo
{"title":"Recent advancements of nitric oxide-releasing hydrogels for wound dressing applications","authors":"Nurhasni Hasan, Cao Jiafu, Apon Zaenal Mustopa, Achmad Himawan, Rifqiyah Nur Umami, Muneeb Ullah, Nasrul Wathoni, Jin-Wook Yoo","doi":"10.1007/s40005-023-00636-9","DOIUrl":"https://doi.org/10.1007/s40005-023-00636-9","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function 基于CYP3A5基因型和肝功能的非那雄胺个体化方案的人群药代动力学模型
4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-10-30 DOI: 10.1007/s40005-023-00638-7
Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee
{"title":"A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function","authors":"Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee","doi":"10.1007/s40005-023-00638-7","DOIUrl":"https://doi.org/10.1007/s40005-023-00638-7","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"480 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136070412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent developments in dry powder inhalation (DPI) formulations for lung-targeted drug delivery 用于肺靶向药物递送的干粉吸入(DPI)制剂的最新发展
4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-10-30 DOI: 10.1007/s40005-023-00635-w
Min-Seok Yang, Ji-Hyun Kang, Dong-Wook Kim, Chun-Woong Park
{"title":"Recent developments in dry powder inhalation (DPI) formulations for lung-targeted drug delivery","authors":"Min-Seok Yang, Ji-Hyun Kang, Dong-Wook Kim, Chun-Woong Park","doi":"10.1007/s40005-023-00635-w","DOIUrl":"https://doi.org/10.1007/s40005-023-00635-w","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"21 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136103799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent progress and drug delivery applications of surface-functionalized inorganic nanoparticles in cancer therapy 表面功能化无机纳米颗粒在癌症治疗中的研究进展及给药应用
4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-09-16 DOI: 10.1007/s40005-023-00632-z
Alam Zeb, Maleeha Gul, Thi-Thao-Linh Nguyen, Han-Joo Maeng
{"title":"Recent progress and drug delivery applications of surface-functionalized inorganic nanoparticles in cancer therapy","authors":"Alam Zeb, Maleeha Gul, Thi-Thao-Linh Nguyen, Han-Joo Maeng","doi":"10.1007/s40005-023-00632-z","DOIUrl":"https://doi.org/10.1007/s40005-023-00632-z","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135307121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcutaneous injection sites impact brain uptake of blood-brain barrier impermeable paclitaxel 皮下注射部位对血脑屏障不可渗透紫杉醇脑摄取的影响
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-09-08 DOI: 10.1007/s40005-023-00634-x
O. Lee, Ji Hee Kang, Y. Ko
{"title":"Subcutaneous injection sites impact brain uptake of blood-brain barrier impermeable paclitaxel","authors":"O. Lee, Ji Hee Kang, Y. Ko","doi":"10.1007/s40005-023-00634-x","DOIUrl":"https://doi.org/10.1007/s40005-023-00634-x","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"1 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44234873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in Alzheimer’s disease pathogenesis and therapeutics from an immune perspective 从免疫角度研究阿尔茨海默病的发病机制和治疗方法的最新进展
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-09-01 DOI: 10.1007/s40005-023-00631-0
Thai-Duong Nguyen, Loi Nguyen Dang, Jung-Hee Jang, Soyeun Park
{"title":"Recent advances in Alzheimer’s disease pathogenesis and therapeutics from an immune perspective","authors":"Thai-Duong Nguyen, Loi Nguyen Dang, Jung-Hee Jang, Soyeun Park","doi":"10.1007/s40005-023-00631-0","DOIUrl":"https://doi.org/10.1007/s40005-023-00631-0","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"667 - 684"},"PeriodicalIF":5.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46131805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics 无定形鼻粉的先进性能:体外/离体研究及与体内药代动力学的相关性
4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-09-01 DOI: 10.1007/s40005-023-00630-1
Patrícia Henriques, Joana Bicker, Andreia Carona, Margarida Miranda, Carla Vitorino, Slavomíra Doktorovová, Ana Fortuna
{"title":"Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics","authors":"Patrícia Henriques, Joana Bicker, Andreia Carona, Margarida Miranda, Carla Vitorino, Slavomíra Doktorovová, Ana Fortuna","doi":"10.1007/s40005-023-00630-1","DOIUrl":"https://doi.org/10.1007/s40005-023-00630-1","url":null,"abstract":"Abstract Purpose Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of the present study was to apply this solubility enhancement technique to a poorly soluble drug for nasal delivery, while comparing two particle engineering strategies, namely spray dried microparticles and chimeral agglomerates, with the corresponding physical blends with crystalline drug. Methods Formulations of piroxicam were manufactured using varied polymer and particle engineering strategies and evaluated through in vitro drug release and ex vivo permeation studies, as well as nasal deposition and in vivo pharmacokinetic studies. Results ASD with hydroxypropyl methylcellulose (HPMC) showed enhanced drug release and permeation, compared to polyvinylpyrrolidone/vinyl acetate formulations and blends. Nasal deposition of HPMC chimeral agglomerates suggested off-target deposition. In vivo pharmacokinetic studies revealed that spray-dried HPMC-containing microparticles exhibited the highest maximum plasma concentration (C max ) and the lowest time to attain it (t max ). In vitro release rate and in vivo absorption rate were correlated as well as t max and in vitro performance. When excluding the formulation with least nasal targeted deposition, in vitro release and ex vivo permeation performance were also correlated with C max and area under the drug concentration-time curve (AUC) from 0 to 1 h, with R 2 > 0.89. Conclusion ASD for nasal delivery provide fast drug absorption, which depends on the supersaturation ability of the polymer employed. In vitro-in vivo correlations suggested that in vitro release and ex vivo permeation studies are predictive tools regarding nasal absorption.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pattern recognition receptors and their nano-adjuvants for cancer immunotherapy 模式识别受体及其纳米佐剂用于癌症免疫治疗
4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-09-01 DOI: 10.1007/s40005-023-00633-y
Zhen Li, Isra Rana, Gyungdeuk Park, Jinwoo Lee, Chae Eun Park, Jutaek Nam
{"title":"Pattern recognition receptors and their nano-adjuvants for cancer immunotherapy","authors":"Zhen Li, Isra Rana, Gyungdeuk Park, Jinwoo Lee, Chae Eun Park, Jutaek Nam","doi":"10.1007/s40005-023-00633-y","DOIUrl":"https://doi.org/10.1007/s40005-023-00633-y","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135388934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current application of dexamethasone-incorporated drug delivery systems for enhancing bone formation 地塞米松联合给药系统促进骨形成的应用现状
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-08-09 DOI: 10.1007/s40005-023-00629-8
T. P. Mai, Jun-Beom Park, Huu Duc Nguyen, K. Min, Cheol Moon
{"title":"Current application of dexamethasone-incorporated drug delivery systems for enhancing bone formation","authors":"T. P. Mai, Jun-Beom Park, Huu Duc Nguyen, K. Min, Cheol Moon","doi":"10.1007/s40005-023-00629-8","DOIUrl":"https://doi.org/10.1007/s40005-023-00629-8","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"643 - 665"},"PeriodicalIF":5.5,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44206262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial strategies for topical biofilm-based wound infections: past, present, and future 基于生物膜的局部伤口感染的抗菌策略：过去、现在和未来
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-07-27 DOI: 10.1007/s40005-023-00628-9
R. Thapa, Jong Oh Kim, Jeonghwan Kim
{"title":"Antimicrobial strategies for topical biofilm-based wound infections: past, present, and future","authors":"R. Thapa, Jong Oh Kim, Jeonghwan Kim","doi":"10.1007/s40005-023-00628-9","DOIUrl":"https://doi.org/10.1007/s40005-023-00628-9","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"627 - 641"},"PeriodicalIF":5.5,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48541402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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