Journal of Pediatric Gastroenterology and Nutrition最新文献_第5页

Correction to "Upper and small bowel Crohn's disease in Brazilian children: Phenotypic characteristic and surgical risk". Journal of Pediatric Gastroenterology and Nutrition. 2026;83(1):87-95. 更正“巴西儿童上小肠克罗恩病：表型特征和手术风险”。儿科消化与营养杂志，2011;31(1):87-95。

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-10-01 Epub Date: 2026-08-11 DOI: 10.1002/jpn3.70526

引用次数: 0

Early discharge after paediatric liver biopsy: A prospective observational study. 儿童肝活检后早期出院：一项前瞻性观察研究。

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-10-01 Epub Date: 2026-07-14 DOI: 10.1002/jpn3.70507

Fie Brantbjerg Tinning, Jakob Stensballe, Birthe Henriksen, Marianne Hørby Jørgensen, Bente Utoft Andreassen

{"title":"Early discharge after paediatric liver biopsy: A prospective observational study.","authors":"Fie Brantbjerg Tinning, Jakob Stensballe, Birthe Henriksen, Marianne Hørby Jørgensen, Bente Utoft Andreassen","doi":"10.1002/jpn3.70507","DOIUrl":"10.1002/jpn3.70507","url":null,"abstract":"Objective: To evaluate the safety of early discharge after percutaneous liver biopsy (PLB) in children using prospective bleeding risk stratification.Methods: In this prospective observational cohort study, paediatric patients scheduled for PLB were stratified into low- and high-risk groups based on bleeding history and laboratory values. Low-risk patients were discharged after 6 h, while high-risk patients were observed for 24 h. Outcomes included bleeding complications, transfusion requirements and readmissions.Results: A total of 167 patients underwent PLB; 119 (71%) were classified as low-risk and 48 (29%) as high-risk. Two minor bleeding events occurred, both in the high-risk group. Only high-risk patients received blood products prior to PLB.Conclusion: Pre-procedural risk stratification effectively identifies paediatric patients bleeding risk and eligibility for early discharge after PLB. This approach appears safe and can reduce hospital admission time for low-risk patients.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"600-605"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reevaluating the rule of two's: Age and epidemiological variations in Meckel's diverticulum. 重新评估二法则：梅克尔憩室的年龄和流行病学变异。

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-10-01 Epub Date: 2026-07-22 DOI: 10.1002/jpn3.70521

Ashley Polachek, Megha S Mehta, Ahmed Shalaby, Aamirah Vadsariya, Wenjing Zong, David M Troendle

{"title":"Reevaluating the rule of two's: Age and epidemiological variations in Meckel's diverticulum.","authors":"Ashley Polachek, Megha S Mehta, Ahmed Shalaby, Aamirah Vadsariya, Wenjing Zong, David M Troendle","doi":"10.1002/jpn3.70521","DOIUrl":"10.1002/jpn3.70521","url":null,"abstract":"Objective: To evaluate the clinical characteristics, diagnostic modalities, and age-related variation of Meckel's diverticulum (MD) using data from a nationwide pediatric inpatient database and a single-center institutional cohort.Methods: The Kids' Inpatient Database (KID) for 2016 and 2019 was queried for patients with a principal diagnosis of MD. We additionally conducted a retrospective review of patients hospitalized with a primary diagnosis of MD at our institution over a 20-year period (January 1, 2005-May 1, 2025). Diagnosis was confirmed by surgical findings and pathology.Results: A total of 1004 patients with a primary diagnosis of MD were identified in KID. More than half were diagnosed after 5 years of age (n = 648, 64.8%). Similarly, among 147 patients identified in the single-center cohort, 63.2% (n = 93) were diagnosed after 5 years of age. Within this single-center cohort, patients ≤5 years more commonly presented with painless rectal bleeding (38.9%, p = 0.017) and underwent Meckel's scintigraphy more frequently (48.1%, p < 0.005). In contrast, patients >5 years more often presented with abdominal pain (61.3%) or vomiting (54.8%) and were more likely to undergo abdominal computed tomography (68.9%, p < 0.0001). Length of stay (LOS) was longer in patients <5 years and shortest in those >15 years (p = 0.04).Conclusion: More than half of pediatric patients with MD are diagnosed after 5 years of age. Presentation, LOS, and imaging patterns vary by age, with younger children more often presenting with bleeding and older children with obstructive symptoms and greater CT detection.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"658-664"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infliximab originator and biosimilars have similar efficacy in children with inflammatory bowel disease. 英夫利昔单抗原药和生物仿制药对儿童炎症性肠病的疗效相似。

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-10-01 Epub Date: 2026-07-31 DOI: 10.1002/jpn3.70508

Ross M Maltz, Jeremy Adler

{"title":"Infliximab originator and biosimilars have similar efficacy in children with inflammatory bowel disease.","authors":"Ross M Maltz, Jeremy Adler","doi":"10.1002/jpn3.70508","DOIUrl":"10.1002/jpn3.70508","url":null,"abstract":"Objectives: To evaluate whether children with inflammatory bowel disease (IBD) who initiate infliximab originator versus biosimilar experience similar clinical outcomes at 12 months.Methods: We conducted a retrospective cohort study evaluating prospectively collected data from the ImproveCareNow (ICN) Network registry. Children <18 years old initiating infliximab originator or biosimilar between January 2016 and September 2022 were eligible. Matched groups initiating originator and biosimilar were created with propensity score matching based on age at initiation, sex, race, year therapy initiated, and IBD type. Clinical disease activity, growth, and laboratory values were assessed at 12 months between the two groups using χ2, Fisher's exact test, or Wilcoxon rank sum test. Cox proportional hazard models were created to compare time to drug discontinuation, hospitalizations, and surgery between the two groups.Results: After propensity score matching, 428 children were included, 214 originator and 214 biosimilar starters. Efficacy at 12 months was similar as assessed by steroid-free clinical remission (p = 0.25), height-z-score (p = 0.68), hematocrit (p = 0.37), albumin (p = 0.40), and erythrocyte sedimentation rate (p = 0.06). Time to infliximab discontinuation (p = 0.21), time to surgery (p = 0.79), and time to hospitalization (p = 0.66) were comparable between infliximab originator and biosimilar users. Fecal calprotectin values were statistically higher (p = 0.032) at 12 months in patients started on the infliximab biosimilar versus originator, but only 30% of patients had values.Conclusion: This is one of the largest, multicenter studies to evaluate infliximab biosimilar use. Rigorous propensity score-matched methods demonstrated no differences in outcomes or treatment durability between children with IBD initiating infliximab originator or biosimilars.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"710-716"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are there age-related differences in the frequency of post-reflux peristaltic waves during impedance-pH monitoring? 在阻抗- ph监测期间，反流后蠕动波的频率是否存在与年龄相关的差异？

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-10-01 Epub Date: 2026-07-27 DOI: 10.1002/jpn3.70511

Judith Cohen Sabban, Jhoanna Valery Adauto Luizaga, Florencia Grisel Ursino, Maria Paula Manin, Vanina Laura Pagotto, Veronica Busoni, Marina Orsi

{"title":"Are there age-related differences in the frequency of post-reflux peristaltic waves during impedance-pH monitoring?","authors":"Judith Cohen Sabban, Jhoanna Valery Adauto Luizaga, Florencia Grisel Ursino, Maria Paula Manin, Vanina Laura Pagotto, Veronica Busoni, Marina Orsi","doi":"10.1002/jpn3.70511","DOIUrl":"10.1002/jpn3.70511","url":null,"abstract":"Objectives: The post-reflux swallow-induced peristaltic wave (PSPW) reflects esophageal chemical clearance. Pediatric data on this parameter remain limited. The aim of this study was to evaluate the behavior of the PSPW in children of different ages.Methods: We conducted a retrospective analysis of pediatric multichannel intraluminal pH/impedance, studies were performed for suspected gastroesophageal reflux (GER). We included those with a normal reflux index, symptom index <50%, symptom association probability <95% and a number of reflux episodes within normal parameters for age. Patients were divided into three groups according to their age: Group I (0-≤2 years), Group II (>2-≤10 years), and Group III (>10-≤18 years). The PSPW index was calculated manually.Results: Two hundred and sixty-one studies were analyzed, 195 were included (median age 6.3 years, 54% female). Group I showed significantly more reflux events (38 vs. 26 and 32 in Groups II-III, p = 0.004) with predominance of non-acid reflux (p < 0.001) and greater proximal extent (p = 0.005). PSPW index was significantly lower in Group I (42.1%) compared to Groups II (52.6%) and III (50.0%) (p = 0.009).Conclusions: In this pediatric cohort, a higher number of gastroesophageal reflux episodes, a predominance of non-acid reflux and greater proximal extent were observed in infants ≤2 years, as well as reduced chemical clearance, which is reflected in a lower PSPW index compared to the other groups analyzed. Age-specific interpretation of PSPW could improve the evaluation of pediatric GER and therapeutic management.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":"744-747"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal ultrasound versus magnetic resonance enterography for detecting small bowel Crohn's disease in children. 小肠超声与磁共振肠造影检测儿童小肠克罗恩病的比较

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-09-29 DOI: 10.1002/jpn3.70580

Johanna M B W Vos, Elsa A van Wassenaer, Anouk J Konert, Joost van Schuppen, Rick R van Rijn, Tim G J de Meij, Johan E van Limbergen, Krisztina B Gecse, Geert R A M D'Haens, Marc A Benninga, Bart G P Koot

{"title":"Intestinal ultrasound versus magnetic resonance enterography for detecting small bowel Crohn's disease in children.","authors":"Johanna M B W Vos, Elsa A van Wassenaer, Anouk J Konert, Joost van Schuppen, Rick R van Rijn, Tim G J de Meij, Johan E van Limbergen, Krisztina B Gecse, Geert R A M D'Haens, Marc A Benninga, Bart G P Koot","doi":"10.1002/jpn3.70580","DOIUrl":"10.1002/jpn3.70580","url":null,"abstract":"Objectives: In Crohn's disease (CD), magnetic resonance enterography (MRE) is used to assess small bowel disease activity. Intestinal ultrasound (IUS) is a less invasive, cheaper and more easily accessible imaging modality in CD. This study assesses the diagnostic accuracy of IUS versus MRE and defines an optimal bowel wall thickness (BWT) cut-off in children.Methods: Children with CD undergoing MRE as routine care had IUS within 7 days. MRE disease activity was assessed using the segmental grading system and compared to IUS BWT and IUS scores. The terminal ileum (TI), ileum and jejunum were analysed separately.Results: Seventy-eight paediatric CD patients (median age: 15 years; 49% female) were included. Based on MRE, 44 bowel segments had mild and 37 moderate-severe disease activity. The area under the receiver operating characteristic of IUS BWT for disease activity in the TI was 0.91 (95% confidence interval [CI] 0.84-0.98) with an optimal cut-off of 2.4 mm, 0.80 (95% CI 0.66-0.94) for the ileum with an optimal cut-off of 2.0 mm (sensitivity 76%; specificity 93%) and 0.69 (95% CI 0.52-0.86) for the jejunum. Due to the low number of affected segments in the jejunum, an accurate BWT cut-off value could not be determined. Previously developed IUS scores did not outperform BWT.Conclusions: IUS is an accurate tool to non-invasively assess CD activity in the TI and ileum. Based on our results, a BWT cut-off of 2.4 mm in the TI and 2.0 mm in the ileum in paediatric CD is optimal to distinguish active from inactive disease.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limosilactobacillus reuteri DSM 17938 in pediatric functional abdominal pain disorders and functional constipation: A systematic review and meta-analysis of randomized controlled trials. 罗伊氏乳杆菌DSM 17938在儿童功能性腹痛和功能性便秘中的作用：随机对照试验的系统回顾和荟萃分析。

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-09-29 DOI: 10.1002/jpn3.70565

Giovanna Quatrale, Marco Bianchi, Luigi Colecchia, Valentina Giorgio, Maurizio Mennini, Sara Sergio, Marco Graziani, Giorgia Gallo, Silvia Furio, Laura Tiberia, Giovanni Barbara, Giovanni Marasco, Giovanni Di Nardo

{"title":"Limosilactobacillus reuteri DSM 17938 in pediatric functional abdominal pain disorders and functional constipation: A systematic review and meta-analysis of randomized controlled trials.","authors":"Giovanna Quatrale, Marco Bianchi, Luigi Colecchia, Valentina Giorgio, Maurizio Mennini, Sara Sergio, Marco Graziani, Giorgia Gallo, Silvia Furio, Laura Tiberia, Giovanni Barbara, Giovanni Marasco, Giovanni Di Nardo","doi":"10.1002/jpn3.70565","DOIUrl":"10.1002/jpn3.70565","url":null,"abstract":"Objectives: Functional abdominal pain (FAP) and functional constipation (FC), are common in children and affect quality of life. Dysfunction of the microbiota-gut-brain axis may contribute to their pathophysiology, with growing interest in probiotic interventions. Limosilactobacillus reuteri (L. reuteri) DSM 17938 has been widely studied, but its efficacy remains unclear. This systematic review and meta-analysis aimed to evaluate the efficacy of L. reuteri DSM 17938 in pediatric FAP and FC.Methods: Randomized controlled trials (RCTs) published up to October 2025 were identified from major databases. Eligible studies included children diagnosed by Rome criteria and treated with L. reuteri DSM 17938 as a single strain. Primary outcomes were responder rates for FAP and normalization of stool frequency for FC, with abdominal pain frequency and intensity assessed as secondary outcomes for FAP.Results: Five RCTs, including 302 children with FAP, and five RCTs, including 276 children with FC, were analyzed. In FAP, L. reuteri DSM 17938 did not significantly improve responder rates (risk ratio [RR] 1.11, 95% confidence interval [CI] 0.83-1.47, p = 0.49), abdominal pain frequency (p = 0.91; 95% CI -0.42 to 0.38), or pain intensity (p = 0.14, 95% CI -1.07 to 0.15) compared with placebo in meta-analysis. In FC, the pooled analysis showed no significant difference in stool frequency (RR 1.1, 95% CI 0.94-1.27, p = 0.27).Conclusions: In this systematic review and meta-analysis, L. reuteri DSM 17938 did not demonstrate clinically significant benefits in pediatric FAP or FC. Further well-powered, strain-specific RCTs with standardized outcome measures are warranted to clarify its role.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The case for understanding rather than overlooking the overlap between rumination syndrome and eosinophilic esophagitis. 了解而不是忽视反刍综合征和嗜酸性粒细胞性食管炎之间重叠的情况。

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-09-28 DOI: 10.1002/jpn3.70577

Dennis Yang, Peter L Lu, Janice S Khoo, Raul E Sanchez, Rajitha D Venkatesh, John M Russo, Neetu Bali, Karla Vaz, Desale Yacob, Carlo Di Lorenzo, Ashley M Kroon Van Diest

引用次数: 0

Correction to "Safety and efficacy of weekly adalimumab 80 mg therapy in pediatric Crohn's disease". 更正“阿达木单抗80mg每周治疗小儿克罗恩病的安全性和有效性”。

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-09-28 DOI: 10.1002/jpn3.70598

引用次数: 0

Urine diagnostics in paediatric intestinal failure: A prospective cohort study of alternative sampling methods. 儿童肠衰竭的尿液诊断：一项替代抽样方法的前瞻性队列研究。

IF 3.1 3区医学

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2026-09-25 DOI: 10.1002/jpn3.70597

Anna Sakaeva, Andreas Busch, Johannes Holle, Hendrik Bartolomaeus, Bernd Fode, Ilias Tsiflikas, Ekkehard Sturm, Christoph Slavetinsky, Simon Scherer, Jörg Fuchs, Justus Lieber, Steven W Warmann, Johannes Hilberath

{"title":"Urine diagnostics in paediatric intestinal failure: A prospective cohort study of alternative sampling methods.","authors":"Anna Sakaeva, Andreas Busch, Johannes Holle, Hendrik Bartolomaeus, Bernd Fode, Ilias Tsiflikas, Ekkehard Sturm, Christoph Slavetinsky, Simon Scherer, Jörg Fuchs, Justus Lieber, Steven W Warmann, Johannes Hilberath","doi":"10.1002/jpn3.70597","DOIUrl":"10.1002/jpn3.70597","url":null,"abstract":"Objectives: Regular monitoring of urinary electrolyte excretion and kidney function is essential in children with intestinal failure (IF) receiving long-term parenteral nutrition (PN). This study evaluated alternative urine sampling methods against 24-h urine collection (UC) and assessed the prevalence of chronic kidney disease (CKD) and renal abnormalities.Methods: In this prospective single-centre cohort study, 31 paediatric IF patients underwent 24-h UC, spot urine (SU) sampling, and shorter timed collections at predefined intervals. Urinary electrolytes and derived ratios were analysed. Kidney function was evaluated using cystatin C (CysC)- and creatinine (Cr)-based estimated glomerular filtration rate (eGFR) and 24-h urinary Cr clearance (CrCl). Agreement between alternative sampling methods and 24-h UC was assessed using Bland-Altman and regression analyses. Renal abnormalities were evaluated by ultrasound.Results: Shorter timed UCs, particularly those corresponding to the PN infusion interval, showed the closest agreement with 24-h UC for sodium, magnesium, calcium, and phosphate excretion. Certain SU samples detected electrolyte deficiencies, particularly sodium and magnesium depletion, and low sodium-to-potassium ratios, highlighting cyclic dehydration at the end of the PN-free interval. CKD was detected in 15/30 patients (50%) by creatinine-cysC-based eGFR. Proteinuria was present in 17/29 patients (58.6%) in 24-h UC, and albuminuria in 13/26 SU samples (50%). Nephrocalcinosis was found in 37% of patients.Conclusions: Shorter timed UC and targeted SU samples may provide practical alternatives to 24-h UC for monitoring urinary electrolyte status and hydration. CKD and renal abnormalities are prevalent in children with IF receiving PN.","PeriodicalId":16694,"journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0