Journal of Neuropathology and Experimental Neurology最新文献_第9页

Multidimensional analysis of matched primary and recurrent glioblastoma identifies contributors to tumor recurrence influencing time to relapse. 对匹配的原发性和复发性胶质母细胞瘤进行多维分析，找出影响复发时间的肿瘤复发因素。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2025-01-01 DOI: 10.1093/jnen/nlae108

Tala Shekarian, Marie-Françoise Ritz, Sabrina Hogan, Tomás A Martins, Philip Schmassmann, Alexandra Gerber, Julien Roux, Deniz Kaymak, Célia Durano, Bettina Burger, Matthias Matter, Gregor Hutter

{"title":"Multidimensional analysis of matched primary and recurrent glioblastoma identifies contributors to tumor recurrence influencing time to relapse.","authors":"Tala Shekarian, Marie-Françoise Ritz, Sabrina Hogan, Tomás A Martins, Philip Schmassmann, Alexandra Gerber, Julien Roux, Deniz Kaymak, Célia Durano, Bettina Burger, Matthias Matter, Gregor Hutter","doi":"10.1093/jnen/nlae108","DOIUrl":"10.1093/jnen/nlae108","url":null,"abstract":"Glioblastoma (GBM) is a lethal brain tumor without effective treatment options. This study aimed to characterize longitudinal tumor changes in order to find potentially actionable targets to prevent GBM relapse. We extracted RNA and proteins from fresh frozen tumor samples from patient-matched IDHwt WHO grade 4 primary (pGBM) and recurrent (rGBM) tumors for transcriptomics and proteomics analysis. A tissue microarray containing paired tumor samples was processed for spatial transcriptomics analysis. Differentially expressed genes and proteins between pGBM and rGBM were involved in synapse development and myelination. By categorizing patients into short (STTR) and long (LTTR) time-to-lapse, we identified genes/proteins whose expression levels positively or negatively correlated with TTR. In rGBM, expressions of Fcγ receptors (FCGRs) and complement system genes were negatively correlated with TTR, whereas expression of genes involved in DNA methylation was positively correlated with TTR. Spatial transcriptomics of the tumor cells showed enrichment of oligodendrocytes in rGBM. Besides, we observed changes in the myeloid compartment such as a switch from quiescent to activated microglia and an enrichment in B and T cells in rGBM with STTR. Our results uncover a role for activated microglia/macrophages in GBM recurrence and suggest that interfering with these cells may hinder GBM relapse.","PeriodicalId":16682,"journal":{"name":"Journal of Neuropathology and Experimental Neurology","volume":" ","pages":"45-58"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of a (not so) diffuse leptomeningeal glioneuronal tumor with an unusual clinical history. 一例临床病史不寻常的弥漫性脑膜胶质细胞瘤。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2025-01-01 DOI: 10.1093/jnen/nlae087

Christina Abi Faraj, Ian E McCutcheon, Donald F Schomer, Kenneth Aldape, Martha Quezado, Zied Abdullaev, Maria A Gubbiotti

引用次数: 0

CTDSP2::GLI1 fusion in glioblastoma: A diagnostic challenge through tumor heterogeneity. 胶质母细胞瘤中的 CTDSP2::GLI1 融合：肿瘤异质性带来的诊断挑战。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-12-01 DOI: 10.1093/jnen/nlae073

Manita Kanathanavanich, Shunsuke Koga, Sara Lynn Stone, Jacquelyn Roth, Zied Abdullaev, Donald M O'Rourke, Stephen Bagley, Robert M Kurtz, Michelle Alonso-Basanta, Kenneth Aldape, MacLean P Nasrallah, Guang Yang

引用次数: 0

Very low levels of ABCA7 in the cerebrum and Alzheimer's disease onset between the ages of 60 and 80 independently of APOE. 大脑中极低水平的 ABCA7 与阿尔茨海默病的发病年龄（60 至 80 岁）无关，与 APOE 无关。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-10-01 DOI: 10.1093/jnen/nlae060

Viktor Garliyev, Catherine A Lyssenko, Joel P Wiener, Domenico Praticò, Nicholas N Lyssenko

{"title":"Very low levels of ABCA7 in the cerebrum and Alzheimer's disease onset between the ages of 60 and 80 independently of APOE.","authors":"Viktor Garliyev, Catherine A Lyssenko, Joel P Wiener, Domenico Praticò, Nicholas N Lyssenko","doi":"10.1093/jnen/nlae060","DOIUrl":"10.1093/jnen/nlae060","url":null,"abstract":"This cross-sectional study addressed the ABCA7-Alzheimer's disease (AD) association. ABCA7 protein levels were quantified in 3 cerebral regions of brain donors with Braak neurofibrillary tangle (NFT) stages 0-V. Ordinal regression models were implemented to estimate the effect of ABCA7 on stopping in an earlier Braak NFT stage versus progressing to the later stages in 2 prespecified age segments. In the final model, high ABCA7 levels in the parietal cortex increased the odds of remaining cognitively healthy (ie, in stages 0/I) versus experiencing AD onset (ie, progressing to stages II-V) in the 61-80 age segment (OR = 2.87, adj 95% CI = 1.41-7.86, adj P = .007, n = 109), after controlling for APOE and other covariates. No ABCA7-AD association was found in the 81-98 age segment (n = 113). Parietal ABCA7 levels in 61-80-year-old with stages II-V were very low, even significantly lower than in 81-98-year-old with stages II-V. ABCA7 levels in the prefrontal cortex and hippocampus predicted AD onset in the 61-80 age segment after adjustment for APOE. ABCA7 levels were also the lowest in 61-80-year-old with frequent neuritic plaques. Thus, very low ABCA7 levels in the cerebrum are associated with AD onset in the 7th-8th decade of life.","PeriodicalId":16682,"journal":{"name":"Journal of Neuropathology and Experimental Neurology","volume":" ","pages":"808-821"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FH-mutant glioma displaying the epigenetic signature of IDH-mutant astrocytomas. FH突变胶质瘤显示出IDH突变星形细胞瘤的表观遗传学特征。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-10-01 DOI: 10.1093/jnen/nlae064

Valentina Zschernack, Christian Thomas, Christina Schaub, Glen Kristiansen, Andreas Waha, Tobias Goschzik, Ulrich Herrlinger, Torsten Pietsch

引用次数: 0

Cerebral amyloid-β-related angiitis and iatrogenic cerebral amyloid angiopathy-related vasculitis: Implications for amyloid-related imaging abnormalities. 脑淀粉样蛋白-β相关血管炎和先天性脑淀粉样血管病相关血管炎：淀粉样蛋白相关成像异常的意义。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-10-01 DOI: 10.1093/jnen/nlae068

Rudy J Castellani, Pouya Jamshidi

引用次数: 0

Primary CNS histiocytic sarcoma: Two case reports highlighting a novel MIGA2::BRAF gene fusion and genome-wide DNA methylation profiling results. 原发性中枢神经系统组织细胞肉瘤：两份病例报告突显新型 MIGA2::BRAF 基因融合和全基因组 DNA 甲基化分析结果。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-10-01 DOI: 10.1093/jnen/nlae061

Ryan Cecchi, Doré Guptil, Nicholas Haslett, Alexandra Hristov, Jacob R Bledsoe, Harrison Tsai, John DeWitt, Sean P Ferris

引用次数: 0

In situ seeding assay: A novel technique for direct tissue localization of bioactive tau. 原位播种试验：生物活性 tau 的直接组织定位新技术。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-10-01 DOI: 10.1093/jnen/nlae059

Romain Perbet, Anastasie Mate de Gerando, Calina Glynn, Cameron Donahue, Angelica Gaona, Raquel N Taddei, Teresa Gomez-Isla, Aurelien Lathuiliere, Bradley T Hyman

{"title":"In situ seeding assay: A novel technique for direct tissue localization of bioactive tau.","authors":"Romain Perbet, Anastasie Mate de Gerando, Calina Glynn, Cameron Donahue, Angelica Gaona, Raquel N Taddei, Teresa Gomez-Isla, Aurelien Lathuiliere, Bradley T Hyman","doi":"10.1093/jnen/nlae059","DOIUrl":"10.1093/jnen/nlae059","url":null,"abstract":"Proteins exhibiting prion-like properties are implicated in tauopathies. The prion-like traits of tau influence disease progression and correlate with severity. Techniques to measure tau bioactivity such as RT-QuIC and biosensor cells lack spatial specificity. Therefore, we developed a histological probe aimed at detecting and localizing bioactive tau in situ. We first induced the recruitment of a tagged probe by bioactive Tau in human brain tissue slices using biosensor cell lysates containing a fluorescent probe. We then enhanced sensitivity and flexibility by designing a recombinant probe with a myc tag. The probe design aimed to replicate the recruitment process seen in prion-like mechanisms based on the cryo-EM structure of tau aggregates in Alzheimer disease (AD). Using this novel probe, we observed selective staining of misfolded tau in pre- and post-synaptic structures within neurofibrillary tangles and neurites, whether or not associated with neuritic plaques. The probe specifically targeted AD-associated bioactive tau and did not recognize bioactive tau from other neurodegenerative diseases. Electron microscopy and immunolabeling further confirmed the identification of fibrillar and non-fibrillar tau. Finally, we established a correlation between quantifying bioactive tau using this technique and gold standard biosensor cells. This technique presents a robust approach for detecting bioactive tau in AD tissues and has potential applications for deciphering mechanisms of tau propagation and degradation pathways.","PeriodicalId":16682,"journal":{"name":"Journal of Neuropathology and Experimental Neurology","volume":" ","pages":"870-881"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Abstracts of the 100th Annual Meeting June 6-9, 2024 Olympic Valley, California. 更正：第 100 届年会摘要，2024 年 6 月 6-9 日，加利福尼亚州奥林匹克谷。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-09-16 DOI: 10.1093/jnen/nlae102

引用次数: 0

Epithelioid angiosarcoma arising from pleomorphic xanthoastrocytoma, CNS WHO grade 3. 上皮样血管肉瘤源于多形性黄细胞瘤，中枢神经系统 WHO 3 级。

IF 3.2 3区医学

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-09-13 DOI: 10.1093/jnen/nlae101

Austin J Helmink,Kanish Mirchia,Frank M Mezzacappa,Samir Atiya,Calixto-Hope Lucas,Rufei Lu,Daniel Surdell,Nicole A Shonka,Sahara J Cathcart,Zhenya Tang,Dominick DiMaio,Arie Perry,Jie Chen

引用次数: 0