Vishwanath P. Singh, S. Shirmardi, R. Bagheri, R. Adeli, M. Tatari
{"title":"A case study of energy absorption buildup factors in some human bones for gamma energies 30 keV to 1.5 MeV","authors":"Vishwanath P. Singh, S. Shirmardi, R. Bagheri, R. Adeli, M. Tatari","doi":"10.22037/JPS.V8I2.15108","DOIUrl":"https://doi.org/10.22037/JPS.V8I2.15108","url":null,"abstract":"Human body consists of some tissues among which bone is one of the important living and growing tissue . In this research, energy absorption buildup factor (EABF) values of 27 types of bone have been computed for photon energy 0.03 to 1.5 MeV up to 40 mean free path (40mfp) penetration depths. The Inner bone tissue, Spongiosa and Male sternum had the largest values of EABF in low photon energies, and great differences below 150 keV photon energy were noted relative to the other bones. This study would be of utmost importance for estimation of the effective dose to the human bones, radiation therapy and various medical applications.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"4 1","pages":"37-49"},"PeriodicalIF":0.0,"publicationDate":"2017-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79514373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Kalaki, R. Safaeijavan, Masumeh Mahdavi Ortakand
{"title":"Biosynthesis of Silver Nanoparticles Using Mentha longifolia (L.) Hudson Leaf Extract and Study its Antibacterial Activity","authors":"Z. Kalaki, R. Safaeijavan, Masumeh Mahdavi Ortakand","doi":"10.22037/JPS.V8I2.14432","DOIUrl":"https://doi.org/10.22037/JPS.V8I2.14432","url":null,"abstract":"In the present study, a simple, fast and eco-friendly biosynthesis of silver nanoparticles (AgNPs) using Mentha langifolia leaf extract as the reducing agent was investigated. Nanoparticles forming were indicated by the color changes in solution and were confirmed by UV-Vis spectrum, FT-IR analysis and Scanning Electron Microscopic (SEM) micrograph. The average particle size of produced AgNPs was determined by dynamic light scattering (DLS) technique. Further, the antibacterial activity of synthesized AgNPs was evaluated against Streptococcus pneumonia and staphylococcus epidermidis as Gram-positive bacteria and Salmonella enterica and enterobacter aerogenes as Gram-negative bacteria. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of biosynthesized silver nanoparticles were determined. UV-Visible spectrophotometer showed absorbance peak in 340 nm. DLS analysis indicated that the average size of AgNPs is 21.1nm. The results of SEM showed that synthesized AgNPs are spherical in shape. The antibacterial activities of the silver nanoparticles were studied against subject bacteria. The present report explores a rapid, simple and economical route, without any hazardous chemicals as reducing or stabilizing agents to synthesis AgNPs and describes the antimicrobial activities of synthetized silver nanoparticles.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"8 1","pages":"24-30"},"PeriodicalIF":0.0,"publicationDate":"2017-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73356178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Shaveisi-Zadeh, Kimia Davarian, A. Movafagh, R. Mirfakhraie, Z. Rostami-Far, R. Alibakhshi, H. Abdi, M. Bakhtiari
{"title":"Cytogenetic Abnormalities and Y Chromosome Microdeletions in Azoospermic and Oligospermic Infertile Males from West of Iran","authors":"F. Shaveisi-Zadeh, Kimia Davarian, A. Movafagh, R. Mirfakhraie, Z. Rostami-Far, R. Alibakhshi, H. Abdi, M. Bakhtiari","doi":"10.22037/JPS.V8I2.15022","DOIUrl":"https://doi.org/10.22037/JPS.V8I2.15022","url":null,"abstract":"About 15% of couples have infertility problems, half of which are related to male factors. Cytogenetic and genetic disorders account for about 10% of the male infertility problems. The aim of this study was to determine the frequency and types of both cytogenetic abnormalities and AZF microdeletions of Y chromosome in idiopathic azoospermic and oligospermic infertile men in west of Iran. In this case-control study, a total of 108 infertile men including 62 azoospermic and 46 oligospermic men were studied for the cytogenetic and AZF microdeletions. Moreover, 90 fertile men served as a control group. Detailed clinical and laboratory examination was done for all participants. Karyotyping was done on peripheral blood lymphocytes to detect the cytogenetic abnormalities; likewise, multiplex-PCR method was performed to identify the presence of microdeletion in AZFa, AZFb or AZFc regions. Chromosomal abnormalities were detected in 6.5% (7/108) of cases, including two oligospermic men with balanced autosomal rearrangements, one oligospermic and four azoospermic men with Klinefelter syndrome. Y chromosome microdeletions were detected in 4.6% (5/108) of infertile men (AZFc: 3.7%, AZFbc: 0.9%). No AZFa deletion was detected in any of the patients. No chromosomal abnormality and Y chromosome microdeletion was detected in control group. The prevalence of chromosomal abnormalities and Y chromosome microdeletions shows the importance of genetic factors in male infertility. The analysis of karyotype and Y microdeletions in infertile men provide a proper understanding about the causes of infertility, the choice of the appropriate assisted reproduction technique and reducing the risk of transmission of these genetic defects to the future generation.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"5 1","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2017-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87480956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scientometric Analysis of Medical and Non-Medical Highly Cited Papers of Iran in Essential Science Indicator (ESI)","authors":"Azade Haseli mofrad, M. Shekofteh, M. Kazerani","doi":"10.22037/JPS.V8I2.13762","DOIUrl":"https://doi.org/10.22037/JPS.V8I2.13762","url":null,"abstract":"The aim of the present research is to study scientometric indicators (the number of articles and citations, the mean citation per paper, H-index, Y-index, and the national and international collaboration) of medical and non-medical highly cited papers of Iran in the Essential Science Indicators (ESI). The research population is all highly cited articles of Iran in ESI during 2005 to 2015. Data was retrieved from ESI and was analyzed using descriptive statistics. Findings show that Iran has achieved the 35 th global rank in terms of the number of highly cited articles. This rank encompasses % 0.1 of the highly cited medical subject areas and % 0.6 of the global portion in non-medical areas. The growth of highly cited papers in non-medical subject areas is more than medical subject ones. Y-index indicates that the role of authors in most highly cited articles in both medical and non-medical subject areas is either as the corresponding or the first author, with an inclination towards the first author. Most of Iran’s highly cited articles in the medical subject areas are based on international collaborations, but in the non-medical areas, they are based on national collaborations. The most international collaborations are with U.S, Canada and England, respectively. H-index of Iran is 141. As a whole, in quantitative and qualitative assessment, non-medical subject areas have a better status than medical subject areas. In general, it can be said that the status of scientific products and the international status of Iran is not satisfactory. Professional planning and policy should be taken into consideration by Iran .","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"29 1","pages":"6-15"},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83333811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-proliferative Effects Curcumin in Human Acute Lymphoblastic leukemia Cell Line","authors":"M. Entezari, Sepideh Khatamsaz, H. Dehghani","doi":"10.22037/jps.v8i2.15685","DOIUrl":"https://doi.org/10.22037/jps.v8i2.15685","url":null,"abstract":"Acute lymphoblastic leukemia (ALL) is one of the most common cancers among children. Although there have been tremendous treatments, none of them have led to a precise cure. The use of herbal medicines which are safe and non-toxic have been demonstrated in this study. Curcumin is a polyphenol, hydrophobic product that is derived from turmeric plant. Curcumin has anti-toxic, anti-bacterial, anti-inflammatory, anti-cancer and anti-apoptosis properties. In recent years, extensive researches have been performed over the use of curcumin on cancers. In this study, CCRF-CEM cell line has been treated by curcumin. Rate of cytotoxicity of curcumin and the viability of the cells after treatment were evaluated by MTT assay and flow cytometry analysis. When different concentrations of curcumin were used upon the CCRF-CEM cell line at different times, it was found that curcumin effect depended on dose and time pattern. The results revealed that curcumin could induce apoptosis in CCRF-CEM cell line of acute lymphoblastic leukemia.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"143 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80309701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bacteria as a vehicle in cancer therapy and drug delivery","authors":"F. Sabzehali, H. Azimi, M. Goudarzi","doi":"10.22037/JPS.V8I1.13574","DOIUrl":"https://doi.org/10.22037/JPS.V8I1.13574","url":null,"abstract":"Although the conventional therapies have obviously improved the conditions of patients with cancer, some mechanisms of resistance have led scientists to use alternative agents that can penetrate in most solid tumors. Furthermore, the success of cancer therapies depends on limiting the uptake of toxins to normal tissues and their selectivity to malignant cells. The involvement of natural and genetically modified non-pathogenic bacterial species, as potential antitumor agents, has led scientists to study bacteria and their products as an ideal vector for delivering therapeutic components to tumors. Moreover, bacterial ghosts, microbots, and bactofection are the other strategies to destruct the malignant tissues. Although it has shown to achieve successful results in vivo, further investigations on the targeting mechanisms of the bacteria are needed to make it a complete therapeutic approach in cancer treatment.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"12 1","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2017-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86853732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Salarpour, K. Goudarzipour, A. Ahmadzadeh, M. Mohammadi, M. A. Farsani
{"title":"Changes of AML 1 and P53 tumor suppressor gene expression in patients de novo acute myeloid leukemia","authors":"F. Salarpour, K. Goudarzipour, A. Ahmadzadeh, M. Mohammadi, M. A. Farsani","doi":"10.22037/JPS.V8I1.15416","DOIUrl":"https://doi.org/10.22037/JPS.V8I1.15416","url":null,"abstract":"P53 and AML1are two important tumor suppressor genes in regulation of hematopoiesis with a critical role in keeping balance between proliferation and differentiation. Alternations in the expression of these genes can be resulted in malignancy. The present study investigated the expression levels of P53 and AML1 genes in 82 de novo AML patient specimens against normal control group using Real-Time-PCR. The results presented in this study revealed that AML1 gene expression was significantly higher and P53 gene expression levels was significantly lower in patients with AML in comparison with the normal control group (P = 0.016 and P = 0.002). Furthermore, the correlation between P53 and AML1 was significant and positive (P= 0.037 and r= 0.231). The lower levels of P53 expression were expected and in line with the normal role of this gene as a tumor suppressor gene, however AML1 over expression was in contrast with of its well-known role in myeloid maturation. However, This findings suggest that despite the current established role this genes in myeloid cell differentiation, oncogenic form of AML1 (AML1a) has possibly increased and high expression of this isoform may act as an inhibitor for other normal AML1 isoforms and P53 as well.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"22 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2017-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78592728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Salmani, A. Abadi, Seyyed Meisam Taheri, H. Majd, A. Abbaszadeh, Hakimeh Sheikhasadi
{"title":"Effect of Beloved Person’s Voice on Chest Tube Removal Pain in Patients undergoing Open Heart Surgery: Fuzzy Logistic Regression Model","authors":"F. Salmani, A. Abadi, Seyyed Meisam Taheri, H. Majd, A. Abbaszadeh, Hakimeh Sheikhasadi","doi":"10.22037/JPS.V8I1.11921","DOIUrl":"https://doi.org/10.22037/JPS.V8I1.11921","url":null,"abstract":"Chest tube removal pain is one of the important complications after open heart surgery. The removal of a chest tube is a painful and frightening experience and should be managed with as little pain and distress as possible. The aim of this study is to assess the effect of beloved person’s voice on chest tube removal pain in patients undergoing open heart surgery. 128 patients were randomly assigned to two groups: one group listened to beloved person’s voice during the procedure, and the other did not. Since pain was measured by linguistic terms, a fuzzy logistic regression was applied for modeling. After controlling for the potential confounders, based on fuzzy logistic regression, the beloved person’s voice reduced the risk of pain. Therefore, using beloved person’s voice could be effective, inexpensive and safe for distraction and reduction of pain.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"13 1","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2017-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81633713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parisa Nehzati, M. Hamidpour, Davod Bashash, Mahin Nikoogoftar, M. Hedari, Ali Akbar Khadem mabodi
{"title":"The Detection of HDL receptor on platelet surface in patients with Coronary artery disease (CAD)","authors":"Parisa Nehzati, M. Hamidpour, Davod Bashash, Mahin Nikoogoftar, M. Hedari, Ali Akbar Khadem mabodi","doi":"10.22037/JPS.V8I1.15310","DOIUrl":"https://doi.org/10.22037/JPS.V8I1.15310","url":null,"abstract":"The human scavenger receptor B1 (hSR-B1/CLA) is a HDL receptor with various anti-atherogenic functions which is expressed on the platelet surface. The anti thrombotic function of HDL includes the modulation of platelet reactivity, coagulation, and endothelial function. The goal of this study is to detect the level of HDL receptor on platelets of CAD patients with atherosclerotic disease. Expressions of the hSRB1 receptor on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls was detected using flow cytometry. Moreover, the lipid panel tests were assayed by Chemistry auto analyzer and compared with healthy controls. Our findings show that abundance of hSR-B1/CLA-1 was significantly reduced on the surface of platelets from CAD patients with atherosclerotic disease compared with healthy control (6/8 % vs. 13/6 %), (P <0,001). The HDL receptor (hSR-B1/CLA-1) expression on platelets inversely correlates with the risk of coronary heart disease. Our findings suggest that determining the level of hSR-B1/CLA-1 on the platelets may be a useful laboratory marker for CAD investigation.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"3 1","pages":"33-38"},"PeriodicalIF":0.0,"publicationDate":"2017-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81926612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahla Naeemi, Mohsen Bakhshandeh, Hojatolah Sabouri, M. Ahmadi, D. Roshani
{"title":"Prospective evaluation of acute radiation – induced skin reactions in patients after head and neck radiotherapy","authors":"Shahla Naeemi, Mohsen Bakhshandeh, Hojatolah Sabouri, M. Ahmadi, D. Roshani","doi":"10.22037/JPS.V8I1.11883","DOIUrl":"https://doi.org/10.22037/JPS.V8I1.11883","url":null,"abstract":"Acute Radiation- induced Skin reaction (ARISR) is a common side effect in the majority of patients receiving radiotherapy. ARISR is often characterized by swelling, redness, pigmentation, dry and moist desquamation, edema, ulceration, bleeding and necrosis of the Skin. This study was carried out to evaluate prevalence and severity of ARISR in patients with head and neck cancer undergoing radiotherapy and determining skin dose–response relationship. From December 2014 to September 2015, we evaluated 88 patients with head and neck cancer. The acute skin toxicity was scored based on RTOG toxicity criteria. Analysis of data using statistical software SPSS (version20) and ANOVA or chi- square test was done, with P 0.05 considered as significant. 98.86% of patients experienced dermatitis, but were mild in most cases.There was no significant differences in age, sex, stage, and field size between patients with dermatitis.","PeriodicalId":16663,"journal":{"name":"Journal of paramedical sciences","volume":"3 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2017-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89090937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}