The Detection of HDL receptor on platelet surface in patients with Coronary artery disease (CAD)

Abstract

The human scavenger receptor B1 (hSR-B1/CLA) is a HDL receptor with various anti-atherogenic functions which is expressed on the platelet surface. The anti thrombotic function of HDL includes the modulation of platelet reactivity, coagulation, and endothelial function. The goal of this study is to detect the level of HDL receptor on platelets of CAD patients with atherosclerotic disease. Expressions of the hSRB1 receptor on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls was detected using flow cytometry. Moreover, the lipid panel tests were assayed by Chemistry auto analyzer and compared with healthy controls. Our findings show that abundance of hSR-B1/CLA-1 was significantly reduced on the surface of platelets from CAD patients with atherosclerotic disease compared with healthy control (6/8 % vs. 13/6 %), (P <0,001). The HDL receptor (hSR-B1/CLA-1) expression on platelets inversely correlates with the risk of coronary heart disease.  Our findings suggest that determining the level of hSR-B1/CLA-1 on the platelets may be a useful laboratory marker for CAD investigation.