Journal of paediatrics and child health最新文献

{"title":"Post-Covid-19 Symptoms in Children: A Cross-Sectional Survey.","authors":"Julie Bennett, Mona Jeffreys, Andrew Waa, Jane Zhang, Anna E S Brooks, Larisa Hockey, Amanda Kvalsvig, Michael G Baker","doi":"10.1111/jpc.70104","DOIUrl":"https://doi.org/10.1111/jpc.70104","url":null,"abstract":"<p><strong>Aim: </strong>To assess children's self or parental-rated health following Aotearoa New Zealand's (NZ) first widespread community transmission of SARS-CoV-2 in February 2022.</p><p><strong>Methods: </strong>This cross-sectional study recruited participants aged 3-20 years who had consented to be contacted after taking part in the NZ Health Survey. Participants over 15 years or guardians of younger children were surveyed by telephone between November 2022 and April 2023. Ordinal logistic regression was used to estimate the effect of Covid-19 infection on self-reported health.</p><p><strong>Results: </strong>The study included 4264 children and young adults, with 70.6% reporting having tested positive for Covid-19 at least once (via PCR or RAT test). Almost one-quarter (24.5%) reported more frequent coughs, colds and stomach bugs after Covid-19 infection. One-fifth reported headaches (21.7%), fatigue (20.6%) or stomach aches (14.6%) and 13.1% reported anxiety that was new since having Covid-19. At baseline, there were no significant differences between the self-rated health status of those children who later had Covid-19 and those who did not (p = 0.5274). Following widespread SARS-CoV-2 transmission, those who reported having had Covid-19 were significantly more likely to report a poorer health status than those who did not (p < 0.0001).</p><p><strong>Conclusions: </strong>Greater than one-fifth of NZ children reported persisting symptoms after Covid-19 infection. Post-Covid-19 symptoms impacted the quality of children's day-to-day lives. Preventing infection is key to preventing post-Covid-19 symptoms.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentially Overlooked Risk for Neuropsychiatric Symptoms in Children: Montelukast Treatment.","authors":"Seda Tunca, Ozge Yilmaz, Merve Ocalan, Mustafa Arga, Ozlem Cavkaytar, Deniz Ozceker, Mehmet Kiliç, Fatma Duksal, Demet Can, Ozlem Sancakli, Mehmet Şirin Kaya, Nazli Ercan, Nursen Cigerci Gunaydin, Metin Aydogan, Esen Demir, Recep Sancak, Sefika İlknur Kökcü Karadag, Nihat Sapan, Ahmet Ugur Demir, Oznur Bilac, Emine Dibek Misirlioglu, Ahmet Turkeli, Hasibe Artac, Hatice Eke Gungor, Haluk Cokugras, Fazil Orhan, Aysen Bingol, Pinar Uysal, Sennur Keles, Aylin Kont Ozhan, Tuba Tuncel, Ozlem Keskin, Elif Arik, Öner Özdemir, Ceren Can, Nazan Altinel, Koray Harmanci, Yurda Simsek, Derya Ufuk Altintas, Serap Ozmen, Nevin Uzuner, Yakup Canıtez, Hasan Yüksel","doi":"10.1111/jpc.70092","DOIUrl":"https://doi.org/10.1111/jpc.70092","url":null,"abstract":"<p><strong>Background: </strong>Montelukast is a leukotriene receptor antagonist commonly used in allergic diseases. In this study, we investigated the frequency, severity and risk factors for neuropsychiatric side effects and sleep disorders associated with montelukast in children.</p><p><strong>Method: </strong>Children aged 6 months to 17 years prescribed montelukast for allergic rhinitis or asthma at 31 Paediatric Allergy and Immunology centres were enrolled in this cohort study. At enrollment, sociodemographic characteristics, prior diagnoses of neuropsychiatric diseases or sleep disorders, and indications for montelukast treatment were recorded, and the primary caregivers completed a baseline questionnaire about neuropsychiatric symptoms (insomnia, nightmares and depressed mood) of their children. All participants were followed up for 1 month, and a post-treatment follow-up questionnaire on neuropsychiatric symptoms was completed at the end of this period. Moreover, caregivers were instructed to contact the clinic if neuropsychiatric side effects or sleep disorders were observed during this period.</p><p><strong>Results: </strong>Total of 1163 children were enrolled. There was a significant increase in the frequency of insomnia, nightmares, night terrors, drowsiness, behavioural problems, irritability, depressive mood, agitation, anxiety, hyperactivity, learning difficulties and headache during the 1 month period after montelukast treatment compared to the previous 1 month (p < 0.001 for all). Overall, caregiver reports of neuropsychiatric symptoms in children increased from 172 (14.8%) to 399 (34.3%) after 1 month of montelukast treatment (p < 0.001).</p><p><strong>Conclusions: </strong>Montelukast treatment increases the risk of neuropsychiatric symptoms and sleep disorders in children with allergic diseases, especially if there is concomitant use of antihistamines.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Toddler With New Onset Poor Sleep, Irritability and Head Banging.","authors":"Nicholas Beng Hui Ng, Velda Xinying Han, Jeremy Bingyuan Lin","doi":"10.1111/jpc.70109","DOIUrl":"https://doi.org/10.1111/jpc.70109","url":null,"abstract":"","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Acute Kidney Injury and Diabetic Ketoacidosis on Subsequent HbA1c in the First 36 Months in Children and Adolescents With New-Onset Type 1 Diabetes Mellitus.","authors":"Timothy Hopgood, Dug Yeo Han, Benjamin B Albert, Craig Jefferies","doi":"10.1111/jpc.70106","DOIUrl":"https://doi.org/10.1111/jpc.70106","url":null,"abstract":"<p><strong>Background: </strong>Children and adolescents with new-onset Type 1 Diabetes Mellitus (T1D) experience high rates of both Acute Kidney Injury (AKI) and Diabetic Ketoacidosis (DKA). However, their relative impact on subsequent HbA1c is not well understood.</p><p><strong>Objectives: </strong>To evaluate the relative effects of DKA and AKI on HbA1c levels within the first 36 months following diagnosis.</p><p><strong>Methods: </strong>Data was collected from a cohort of all children and adolescents presenting to a regional paediatric diabetes centre with new onset T1D between 2006 and 2016.</p><p><strong>Results: </strong>585 children were included, with a mean age of 8.9 years (SD 3.8) at diagnosis. 257 children (44%) had AKI, classified as 181 (70%) KDIGO stage 1, 61 (24%) stage 2, and 15 (6%) stage 3. 167 children (29%) presented with Diabetic Ketoacidosis (DKA). Overall, AKI at diagnosis was not associated with HbA1c at any time point. However, more severe AKI was associated with lower HbA1c at 6 months (p = 0.04). DKA at diagnosis was linked to higher HbA1c levels at 6, 12, and 24 months (p < 0.05), but there was no difference at 36 months.</p><p><strong>Conclusions: </strong>Although both AKI and DKA are common at diagnosis in children and adolescents with T1D, it is DKA at diagnosis that is associated with higher HbA1c levels in follow-up. This highlights the importance of efforts to identify T1D early and prevent DKA. While more severe AKI was linked to lower HbA1c levels 6 months after diagnosis, replication is required in other cohorts.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Outcomes of Paediatric Patients With Severe Acute Asthma in Retrieval.","authors":"Kuangjun Li, Emily R Le Fevre, Tiffany Pizzuto, Marino Festa, Stuart Haggie","doi":"10.1111/jpc.70101","DOIUrl":"https://doi.org/10.1111/jpc.70101","url":null,"abstract":"<p><strong>Aim: </strong>To describe the characteristics, management, and outcomes of a paediatric cohort with severe acute asthma or wheeze retrieved to tertiary care.</p><p><strong>Methods: </strong>A retrospective cohort study of children ≥ 1 year old with severe acute asthma or wheeze retrieved to tertiary paediatric centres by a statewide paediatric retrieval service, January 2017 to May 2023. Data of clinical characteristics, pharmacotherapy, respiratory support, and outcomes were collected.</p><p><strong>Results: </strong>We included 325 patients, median age 6.8 years (IQR 3.8-10.5) and 61% male. High rates of nebulised bronchodilators, systemic corticosteroids, intravenous magnesium sulphate, and adjunct aminophylline use were observed. Ketamine was the preferred sedative agent among cases managed with mechanical or non-invasive ventilation. Intravenous salbutamol use declined significantly during the study (p = 0.04). Intubation rates were low (6.8%), non-invasive ventilation was the most common respiratory support (37.2%), and high-flow nasal cannula use increased over the study (p < 0.01). Overall, 65.5% of patients were admitted to intensive care. We report two deaths (0.9%) following intensive care admission and infrequent complications, including air leak (2.2%) and haemodynamic instability (2.8%). Variables associated with intensive care admission include pre-existing asthma diagnosis, preventer prescription, and previous intensive care admission (p < 0.05).</p><p><strong>Conclusion: </strong>Contemporary severe acute asthma management frequently includes adjunct aminophylline and non-invasive ventilation. Clinical outcomes were overall good with short intensive care and hospital stays, low mortality rates, and infrequent complications. Children with pre-existing asthma diagnosis, preventer prescription, or prior PICU admission for asthma were more likely to require PICU care.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indications and Techniques for Ultrasonography of the Paediatric Orthopaedic Hip.","authors":"Allison Kelliher, Erin Welby, Elyse Jensen, Mark Seeley","doi":"10.1111/jpc.70095","DOIUrl":"https://doi.org/10.1111/jpc.70095","url":null,"abstract":"<p><p>Ultrasound of the paediatric hip has vast utility. The purpose of this paper is to outline the clinical indications for infantile hip ultrasound, describe the method by which it can be implemented, and describe the benefits of implementing such technology into orthopaedic paediatric practice. Indications for the use of paediatric ultrasound in the acute setting include infectious and inflammatory processes such as transient synovitis and septic arthritis, whereas indications in the chronic setting include developmental dysplasia, juvenile arthropathies, and Perthes disease. The following technique guide outlines the static (Classic Graf Method) assessment of the infantile hip while adding further development and instruction on the implementation of additional dynamic techniques promoted by Harcke et al. Ultrasound accurately identifies early stages of pathology; however, it also clearly outlines the anatomy of the paediatric hip without the disadvantage of radiologic exposure. As ultrasound techniques evolve, their utility also continues to expand. This paper is a useful tool for the paediatric orthopaedic surgeon to understand their diagnostic application.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycoplasma-Induced Rash and Mucositis: Ocular Manifestations, Treatment and Outcomes in a Paediatric Population.","authors":"Daniel Cool, Vivien Nguyen, Susan Zhang, Shiney Seo, Shuan Dai","doi":"10.1111/jpc.70103","DOIUrl":"https://doi.org/10.1111/jpc.70103","url":null,"abstract":"<p><strong>Background: </strong>There has been an increase in Mycoplasma pneumoniae infections. This can present with extra-pulmonary manifestations including mycoplasma-induced rash and mucositis (MIRM). This paper aims to describe the ocular features in MIRM at a paediatric tertiary referral hospital in Queensland, Australia, and review the treatment and outcomes of these patients.</p><p><strong>Methods: </strong>A case series of 14 patients presenting to the Queensland Children's Hospital was included in this study. Patient demographics, ocular examination findings, and treatment methods were obtained from retrospective chart review.</p><p><strong>Results: </strong>The mean age was 11.2 years (range 8-15 years) and was mostly male (73%). All patients had conjunctival injection or ulceration. No patients had corneal involvement. One patient underwent amniotic membrane graft and glue tarsorrhaphy for one eye. All others were managed non-surgically with cautious use of topical steroid, as well as multidisciplinary care. Most patients (80%) achieved full recovery with no symblepharon formation or forniceal shortening.</p><p><strong>Conclusion: </strong>Conservative management with preservative-free antibiotics and lubricants should be considered as initial first-line treatment for patients presenting with MIRM. Topical corticosteroid therapy should be guided by an ophthalmology service. This should be in conjunction with systemic therapy and multidisciplinary care for extra-ocular complications. This case series suggests a treatment guideline for future patients presenting with possible MIRM. Paediatric and primary care physicians should be aware of ocular features of MIRM to facilitate early referral to and intervention by ophthalmologists to allow for the best outcome.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragmatic Ultrasonography in Preterm Newborns With Respiratory Distress Syndrome on Invasive Mechanical Ventilation: An Observational Study.","authors":"Cleuma Oliveira Soares, Caroline Almeida Campbell, Mariana Souza Azevedo Moura, Rodrigo Santiago Barbosa Rocha","doi":"10.1111/jpc.70102","DOIUrl":"https://doi.org/10.1111/jpc.70102","url":null,"abstract":"<p><strong>Aim: </strong>In preterm newborns, Respiratory Distress Syndrome (RDS) is one of the leading causes of mortality. Treatment often requires invasive mechanical ventilation (IMV), which can cause diaphragmatic dysfunction. Ultrasonography is a promising tool for assessing diaphragmatic function in neonates. This study analyses changes in the diaphragm muscle of preterm newborns with RDS undergoing IMV.</p><p><strong>Methods: </strong>A longitudinal study was conducted with preterm newborns diagnosed with RDS and subjected to IMV. Clinical data were collected, and ultrasonographic evaluations of diaphragm thickness and diaphragmatic thickening fraction (DTF) were performed at two time points: within the first 48 h of life and up to 48 h after extubation.</p><p><strong>Results: </strong>There was a significant reduction in diaphragmatic thickness (p < 0.0001), DTF index (p = 0.01), and diaphragmatic excursion (p = 0.02) during the intubation period. A moderate correlation was observed between DTF and IMV duration (R = 0.62), hospitalisation time (R = 0.52), and the risk of reintubation (R = 0.55). A moderate correlation was also identified between IMV duration and hospitalisation time (R = 0.64) and between diaphragmatic thickness and gestational age (R = 0.58). However, the correlation between DTF and gestational age was weak (R = 0.48).</p><p><strong>Conclusion: </strong>IMV leads to diaphragmatic deterioration with increased muscle atrophy in preterm newborns with respiratory distress syndrome.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Survey of the Current Practice for Testing for Neonatal Hypoglycaemia in Aotearoa, New Zealand.","authors":"C M Ulyatt, J E Harding, V Clapham, J M Alsweiler, L Lin","doi":"10.1111/jpc.70097","DOIUrl":"https://doi.org/10.1111/jpc.70097","url":null,"abstract":"<p><strong>Aims: </strong>Neonatal hypoglycaemia is the most common metabolic disturbance in newborns and can lead to brain injury. However, the feasibility of implementing a national recommendation to use accurate testing methods to avoid under- and over-diagnosis depends on current practise, preferences, and resources. We therefore sought to identify current testing practises for neonatal hypoglycaemia to inform recommendations for testing, including devices and timing.</p><p><strong>Methods: </strong>An online survey was sent to relevant clinical unit leaders across the 19 health regions of New Zealand, and to members of the New Zealand College of Midwives who provide home birth services. These individuals were asked to complete the survey themselves or identify the appropriate practitioner in their unit to complete it.</p><p><strong>Results: </strong>From 28th August to 12th December 2023, we obtained 71 responses, which came from more than one profession from all but one health region. The most commonly used devices for measuring glucose concentrations in capillary blood samples were blood gas analysers (20/65, 31%) and i-STAT (12/65, 18%). Devices used did not differ among professions, but the use of blood gas analysers was not reported in primary units. i-STAT (22/80, 28%) and blood gas analyser (19/80, 24%) were also the most preferred testing devices. The timing of blood sampling was reported to be similar for > 70% of respondents.</p><p><strong>Conclusions: </strong>Most healthcare professionals use and prefer accurate blood sampling devices, suggesting implementing a recommendation to use these is likely feasible. However, guidance on the timing of testing is needed.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalizations in Children With Optic Nerve Hypoplasia and Septo-Optic-Pituitary Dysplasia.","authors":"Michael S Salman, Chelsea A Ruth, Marina S Yogendran, Lisa M Lix","doi":"10.1111/jpc.70094","DOIUrl":"https://doi.org/10.1111/jpc.70094","url":null,"abstract":"<p><strong>Background and objectives: </strong>Optic nerve hypoplasia (ONH) causes congenital impaired vision. The diagnosis of septo-optic-pituitary dysplasia (SOD) is made when ONH occurs in conjunction with hypopituitarism or absent septum pellucidum or abnormal corpus callosum. Our objectives were to describe differences in hospitalisation rates, length of hospital stay (LOS), and the primary reasons for hospitalisations among children with ONH/SOD in comparison to controls.</p><p><strong>Methods: </strong>A population-based retrospective study with a case-control design was conducted. Cases were 124 ONH/SOD patients (mean age: 13 years, SD: 7.2 years), matched to 620 unrelated population-based controls (mean age: 12.4 years, SD: 7.2 years) on area of residence, year of birth, and sex. Non-parametric statistics were used to test for differences between cases and controls on number of hospital admissions, crude rates of admissions, and LOS. Relative rates (RR) with 95% confidence intervals (CIs) were estimated. Primary (most responsible) diagnoses were described for hospitalisations.</p><p><strong>Results: </strong>ONH/SOD cases had the highest percentage of hospitalisations (26.6%-32.3%) in comparison to the control group (10.2%-12.6%), especially in the SOD subgroup with hypopituitarism (42.9%-54.3%) who were also at risk of multiple hospitalisations. ONH/SOD cases had a significantly higher crude hospitalisation rate in comparison to the control group (RR range:2.3-2.8, 95% CI range:1.6-4.2), and was highest in infants < 1-year-old and in the SOD subgroup with hypopituitarism. The median LOS was significantly higher in ONH/SOD cases in comparison to the controls [median (interquartile range):7-8 (3-21) versus 3-4 (2-9) days respectively, p ≤ 0.004]. Diseases of the respiratory system were the primary reasons for hospitalisation in all groups, but they were highest in the ONH/SOD group accounting for 25.3% of their hospitalisations versus 9.5% in the unrelated controls.</p><p><strong>Conclusion: </strong>Children with ONH/SOD have a higher rate of hospitalisation and LOS in comparison to controls, especially in the SOD subgroup with hypopituitarism. Diseases of the respiratory system were primarily responsible for hospitalisations in all groups, but disproportionately affected the ONH/SOD group.</p>","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}