Journal of oral sciencePub Date : 2026-10-16Epub Date: 2026-08-10DOI: 10.2334/josnusd.26-0043
Aysenur Oncu, Ecem Ozgur, Arda Buyuksungur, Berkan Celikten, Kaan Orhan
{"title":"Computational fluid dynamics analysis of root canal irrigation flow using XP-Endo Finisher, sonic, and ultrasonic activation systems.","authors":"Aysenur Oncu, Ecem Ozgur, Arda Buyuksungur, Berkan Celikten, Kaan Orhan","doi":"10.2334/josnusd.26-0043","DOIUrl":"10.2334/josnusd.26-0043","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate and compare the flow characteristics and wall shear stress (WSS) generated by the XP-Endo Finisher, sonic, and ultrasonic activation systems using computational fluid dynamics (CFD) analysis.</p><p><strong>Methods: </strong>A three-dimensional model of a resin-based prepared mandibular premolar was generated from a high-resolution micro-computed tomography (Micro-CT) scan and used for CFD analysis of different irrigation activation systems. Following image segmentation and stereolithography (STL) reconstruction, high-quality tetrahedral meshes with inflation layers were generated and imported into ANSYS Fluent. Irrigant flow during needle irrigation was simulated under steady-state laminar conditions. For the sonic, ultrasonic, and mechanical activation systems, dynamic mesh techniques and user-defined functions were employed to model device-specific oscillatory tip motions based on their respective frequencies and amplitudes. Deterministic CFD outputs, including velocity magnitude and WSS, were compared descriptively among the activation systems.</p><p><strong>Results: </strong>The highest intracanal flow velocity was observed with the EDDY system, followed by ultrasonic activation, EndoActivator, XP-Endo Finisher, and side-vented needle irrigation. A similar trend was observed for maximum WSS, with the EDDY system producing the highest values. Ultrasonic activation ranked second, while EndoActivator, XP-Endo Finisher, and side-vented needle generated progressively lower WSS values.</p><p><strong>Conclusion: </strong>All activation techniques demonstrated improved flow dynamics compared to conventional side-vented needle irrigation.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"193-197"},"PeriodicalIF":1.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of oral sciencePub Date : 2026-07-16Epub Date: 2026-06-15DOI: 10.2334/josnusd.25-0300
Fatih Bedir, Muhammet Karadas
{"title":"How do increased irradiance and exposure time affect the repair bond strength of universal adhesives to CAD-CAM composite material?","authors":"Fatih Bedir, Muhammet Karadas","doi":"10.2334/josnusd.25-0300","DOIUrl":"10.2334/josnusd.25-0300","url":null,"abstract":"<p><strong>Purpose: </strong>This study was designed to investigate the effects of increased exposure time and different levels of irradiance on the repair bond strength (µTBS) and degree of conversion (DoC) of two universal adhesives.</p><p><strong>Methods: </strong>Computer-aided design-computeraided manufacturing (CAD-CAM) composite blocks were prepared and subjected to thermal cycling. They were randomly divided into two groups based on the adhesive agent used: Clearfil S<sup>3</sup> Bond Universal (CSU) or Gluma Bond Universal (GBU). Within each group, the specimens were further classified into six subgroups (n = 6 blocks) according to irradiance (1,000 or 1,400 mW/cm<sup>2</sup>) and exposure time (10, 15, or 20 s). The bonded specimens were then repaired using nano-hybrid resin composite. Sticks measuring 0.9 mm<sup>2</sup> were obtained from the repaired blocks and subsequently tested in a micro-tensile testing machine. Additionally, the DoC was assessed using micro-Raman spectroscopy.</p><p><strong>Results: </strong>The 1400*10 group of GBU and CSU demonstrated higher µTBS than the 1000*10 and 1400*15 groups, regardless of thermal cycling (P = 0.000). For CSU, the 1400*10 group showed the highest DoC (P < 0.05). However, the DoC of GBU did not differ significantly among the various irradiation/exposure times (P > 0.05).</p><p><strong>Conclusion: </strong>The polymerization of adhesives at an irradiance level of 1,400 mW/cm<sup>2</sup> for 10 s (14 J/cm<sup>2</sup>) increases the repair µTBS and DoC regardless of thermal cycling.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"119-123"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of oral sciencePub Date : 2026-07-16Epub Date: 2026-06-16DOI: 10.2334/josnusd.26-0028
Young-Bum Song, Jin-Woo Park
{"title":"Effect of smoking intensity on clinical outcomes of implants placed with simultaneous guided bone regeneration: a 5-year retrospective study.","authors":"Young-Bum Song, Jin-Woo Park","doi":"10.2334/josnusd.26-0028","DOIUrl":"10.2334/josnusd.26-0028","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the dose-dependent impact of smoking intensity on marginal bone loss (MBL) and the rates of implant survival and failure in patients undergoing implant placement with simultaneous guided bone regeneration (GBR) over a 5-year follow-up period.</p><p><strong>Methods: </strong>A retrospective cohort analysis was performed on 55 patients (130 implants) who were stratified by smoking intensity (10 or 20 cigarettes/day). MBL was assessed radiographically, and clinical outcomes were analyzed using Kaplan-Meier survival curves and multivariate logistic regression.</p><p><strong>Results: </strong>At 5 years, smokers consuming >10 cigarettes/day exhibited significantly greater MBL than did non-smokers and light smokers (2.67 mm vs. 1.34-1.40 mm; P < 0.001). Heavy smokers (>20 cigarettes/day) showed the highest MBL (2.88 mm). Multivariate analysis identified smoking ≥20 cigarettes/day (odds ratio = 16.7) and the use of non-resorbable membranes (odds ratio = 10.4) as primary independent risk factors for failure. The 5-year survival rate remained 100% for non-smokers and light smokers (≤10 cigarettes/day) but decreased significantly to 88.1% for those exceeding 10 cigarettes/day.</p><p><strong>Conclusion: </strong>Smoking intensity has a profound, dose-dependent negative effect on GBR-supported implants. Consumption of more than 10 cigarettes/day significantly accelerates bone loss and diminishes implant survival, identifying heavy smoking as a critical risk factor for long-term biological complications in patients receiving implants along with concurrent GBR.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"158-163"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of oral sciencePub Date : 2026-07-16Epub Date: 2026-06-26DOI: 10.2334/josnusd.26-0113
Rina Ohtani, Kana Kawai-Ozasa, Keita Takizawa, Ryosuke Shintani, Ko Dezawa, Noboru Noma
{"title":"Toothache and temporomandibular disorder-like symptoms as red flags for maxillary sinus carcinoma.","authors":"Rina Ohtani, Kana Kawai-Ozasa, Keita Takizawa, Ryosuke Shintani, Ko Dezawa, Noboru Noma","doi":"10.2334/josnusd.26-0113","DOIUrl":"10.2334/josnusd.26-0113","url":null,"abstract":"<p><p>A case of a patient with left maxillary molar pain unresponsive to standard dental treatment is presented. Advanced imaging revealed an aggressive lesion in the maxillary sinus with associated bone destruction, soft tissue extension, and diffusion restriction suggestive of malignancy. The lesion was subsequently confirmed as maxillary sinus carcinoma. This case highlights the diagnostic challenges associated with nonspecific temporomandibular disorder-like symptoms and emphasizes the importance of recognizing red flags as prompts for cross-sectional imaging and specialist referral, which are essential for ensuring an accurate diagnosis and improving clinical outcomes in patients with atypical or refractory orofacial pain.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"184-187"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of oral sciencePub Date : 2026-07-16Epub Date: 2026-06-16DOI: 10.2334/josnusd.25-0348
Şükrü C Akmansoy, Erkut Kahramanoğlu
{"title":"In vitro evaluation of marginal and internal gaps of materials used for onlay and occlusal veneer restorations.","authors":"Şükrü C Akmansoy, Erkut Kahramanoğlu","doi":"10.2334/josnusd.25-0348","DOIUrl":"10.2334/josnusd.25-0348","url":null,"abstract":"<p><strong>Purpose: </strong>This study compares the marginal and internal gaps for four restorative materials produced by two fabrication methods in both minimally invasive occlusal veneer and conventional onlay cavities.</p><p><strong>Methods: </strong>Eighty mandibular molars prepared as occlusal veneer and mesial-occlusal-distal-lingual onlays and restorations were produced using lithium disilicate glass ceramic, hybrid ceramic, nanohybrid composite, and laboratory composite materials. A silicone replica method was used to examine the marginal gap and internal gap with a stereomicroscope. Two-way analysis of variance (ANOVA) was used to analyze the effects of the material and design, and one-way ANOVA was used to analyze the effect of the fabrication method.</p><p><strong>Results: </strong>The marginal gap significantly differed in relation to the material, and the internal gap significantly differed in relation to the material and design. Gaps were significantly smaller for the laboratory composite groups than for the other groups. Comparison of fabrication methods showed that internal and marginal gaps were significantly smaller for the conventional procedure.</p><p><strong>Conclusion: </strong>The less complicated designs yielded a better fit. In particular, because of the greater number of intaglio surfaces, internal gap values were worse when cavity design complexity increased.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"147-151"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synergistic biomineralization of dentin driven by polar amino acids for dentin tubule occlusion.","authors":"Lijun Wei, Feixiang Wang, Qinglian Wang, Churen Zhang","doi":"10.2334/josnusd.26-0067","DOIUrl":"10.2334/josnusd.26-0067","url":null,"abstract":"<p><strong>Purpose: </strong>Dentin hypersensitivity, caused by exposed dentinal tubules, remains a significant clinical challenge. Conventional biomineralization using hydroxyapatite (HAP) often fails to achieve rapid nucleation and durable tubule occlusion. This study aims to develop a biomimetic mineralization strategy that leverages the synergistic interplay of specific polar amino acids to actively direct HAP deposition and enhance dentin occlusion efficacy.</p><p><strong>Methods: </strong>Mineralization kinetics of isolated and combined polar amino acids were quantitatively evaluated to identify the optimal templating conditions for HAP nucleation. The optimized combination of (tyrosine and lysine) with HAP was applied in vitro to demineralized dentin models for 1 to 7 days. The efficacy of tubule occlusion, structural integration, and chemical stability was systematically characterized using scanning electron microscopy, focused ion beam-transmission electron microscopy, and rigorous acid-challenge assays.</p><p><strong>Results: </strong>The combination of positively charged and neutral polar amino acids synergistically accelerated HAP nucleation kinetics. In vitro application promoted rapid, dense, and deep occlusion of dentinal tubules. Crystallographic analysis confirmed the formation of a structurally integrated mineralized layer with strong chemical homology to native dentin (Ca/P ratio: 1.67 vs. 1.72). Moreover, the layer maintained significant occlusion integrity following prolonged acid challenges.</p><p><strong>Conclusion: </strong>This biomimetic mineralization paradigm, driven by a synergistic combination of polar amino acids, overcomes the limitations of passive HAP filling by achieving rapid, deeply integrated, and chemically stable dentinal tubule occlusion. It provides a highly translatable foundation for the development of advanced desensitizing biomaterials.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"164-169"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of oral sciencePub Date : 2026-07-16Epub Date: 2026-06-10DOI: 10.2334/josnusd.25-0383
Selin Atay, Ayşegül Kurt, Onur Doğan Dağ, Ahmet İlter Atay
{"title":"Effects of scan body splinting material types and heights on scanning accuracy and duration.","authors":"Selin Atay, Ayşegül Kurt, Onur Doğan Dağ, Ahmet İlter Atay","doi":"10.2334/josnusd.25-0383","DOIUrl":"10.2334/josnusd.25-0383","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effects of scan body splinting material types and heights on scanning accuracy and duration for a completely edentulous mandible.</p><p><strong>Methods: </strong>Scan bodies on multi-unit abutments were splinted at heights of 2 mm and 6 mm using orthodontic elastic ligatures (OELs) and three-dimensionally printed attachments (3D-As). Forty scans were obtained (n = 10 per combination) and analyzed with Geomagic Control X software. The Shapiro-Wilk test was used to assess normality, and nonparametric data were analyzed using the Kruskal-Wallis and Mann-Whitney U tests (P < 0.05).</p><p><strong>Results: </strong>Scanning time varied significantly among groups (P = 0.000), being longest in the 2-mm-OEL and shortest in the 6-mm-3D-A group. Greater splinting height significantly reduced scan time (P < 0.001), and 3D-A showed shorter durations than OELs (P = 0.008). Angular deviation differed significantly among the groups (P = 0.012), although height and material alone had no significant effect (P > 0.05). Linear deviation did not differ significantly overall (P = 0.062), but lower values were observed in OEL groups (P = 0.018).</p><p><strong>Conclusion: </strong>Splint height and material type significantly influence scanning time. The potential impact of splinting material type and height on accuracy should be carefully considered when planning digital impression protocols.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"129-134"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of oren on IL-6 production in cultured human airway epithelial cells stimulated with the SARS-CoV-2 envelope protein.","authors":"Hourei Oh, Yoshimasa Makita, Kazuya Masuno, Yasuhiro Imamura","doi":"10.2334/josnusd.25-0334","DOIUrl":"10.2334/josnusd.25-0334","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to establish an in vitro model using Calu-3 human lung adenocarcinoma cells stimulated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein to evaluate the anti-inflammatory effects of oren (Coptis rhizome), a traditional Kampo medicine.</p><p><strong>Methods: </strong>Calu-3 cells were treated with the E protein in the presence or absence of oren extract. Interleukin (IL)-6 production was quantified using ELISA. Reporter gene assays were used to measure IL-6 promoter activity and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. The involvement of Toll-like receptor (TLR) signaling pathways was also investigated.</p><p><strong>Results: </strong>The E protein increased IL-6 production in Calu-3 cells by approximately fourfold; however, co-treatment with oren significantly suppressed this effect (P < 0.001). In 293-TLR2/CD14 cells, the E protein enhanced IL-6 promoter activity by approximately 2.8-fold, but this activation was significantly inhibited by oren (P < 0.001). The E protein also increased NF-κB-dependent transcriptional activity by approximately fourfold in 293-TLR2/CD14 and 2.4-fold in Calu-3 cells, and these effects were significantly suppressed by oren (P < 0.001).</p><p><strong>Conclusion: </strong>Oren significantly suppressed SARS-CoV-2 E protein-induced IL-6 production and NF-κB pathway activation, with effects extending to the transcriptional level through inhibition of IL-6 promoter activity.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"135-139"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced corrosion resistance of Ti-6Al-7Nb and Ti-6Al-4V alloys through electrochemical surface treatment for biomedical applications.","authors":"Hiroyasu Koizumi, Haruto Hiraba, Kosuke Takehana, Takayuki Yoneyama","doi":"10.2334/josnusd.26-0108","DOIUrl":"10.2334/josnusd.26-0108","url":null,"abstract":"<p><p>Electrochemical surface treatment (ET) was applied to Ti-6Al-7Nb and Ti-6Al-4V alloys to enhance their corrosion resistance for biomedical applications. Disk-shaped specimens were treated in a water-glycerin-lactic acid electrolyte under a constant voltage of 50 V. Corrosion behavior was evaluated by anodic polarization in 0.9% saline, and the surface chemistry was analyzed using X-ray photoelectron spectroscopy (XPS). ET shifted the corrosion potential toward more noble values and reduced the passive current density for both alloys. XPS revealed a marked increase in the Ti<sup>4+</sup> fraction, indicating the formation of a TiO<sub>2</sub>-enriched surface layer. Overall, ET enhanced the passivation of high-strength titanium alloys used in medical and dental prostheses.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"181-183"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of oral sciencePub Date : 2026-07-16Epub Date: 2026-06-10DOI: 10.2334/josnusd.25-0378
Natsumi Sakamoto, Yusuke Matsuyama, Sakura Kiuchi, Jun Aida
{"title":"Difference in inequalities in routine oral health behaviors among older Japanese: a cross-sectional study.","authors":"Natsumi Sakamoto, Yusuke Matsuyama, Sakura Kiuchi, Jun Aida","doi":"10.2334/josnusd.25-0378","DOIUrl":"10.2334/josnusd.25-0378","url":null,"abstract":"<p><strong>Purpose: </strong>From a life-course perspective, adolescent socioeconomic status (SES) can have long-term effects. This study investigated the association between SES in adolescence and older age SES, as well as their mobility, and routine oral health behaviors among older adults.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data of individuals aged 65 years or older from the 2019 wave of the Japan Gerontological Evaluation Study (JAGES). SES mobility from adolescence to old age was defined based on combinations of economic status at age 15 and in older adulthood. Oral health behaviors, such as tooth brushing, toothpaste use, and flossing or interdental brushing, were also assessed. Poisson regression analysis was used to estimate prevalence ratios (PRs).</p><p><strong>Results: </strong>Among 21,197 participants with a mean age of 74.0 years (SD = 5.9), 47.2% were male. Compared to individuals with consistently low SES, those with upward SES mobility and consistently high SES were more likely to use dental floss or interdental brushes (PR = 1.21, 95% CI: 1.12-1.30 and 1.22, 95% CI: 1.14-1.31, respectively). In contrast, neither tooth brushing nor toothpaste use was significantly associated with SES mobility.</p><p><strong>Conclusion: </strong>Inequalities in the use of dental floss and interdental brushes based on SES and SES mobility were observed.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"124-128"},"PeriodicalIF":1.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}