Journal of pain and symptom management最新文献

{"title":"A Beacon of Wisdom: Tribute to Dr. Betty Ferrell as a Devoted Mentor","authors":"Tamryn F. Gray PhD, RN, MPH , Natalie S. McAndrew PhD, RN, ACNS-BC, CCRN-K , Karen O. Moss PhD, RN, CNL, FNAP , Virginia Sun PhD, MSN, RN","doi":"10.1016/j.jpainsymman.2024.10.002","DOIUrl":"10.1016/j.jpainsymman.2024.10.002","url":null,"abstract":"","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages e12-e16"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative Care in Hematology: A Systematic Review of the Components, Effectiveness, and Implementation","authors":"Sophie Hochrath M.Sc. ,&nbsp;Naomi Dhollander PhD ,&nbsp;Luc Deliens PhD ,&nbsp;Rik Schots M.D. & PhD ,&nbsp;Frederick Daenen PhD ,&nbsp;Tessa Kerre M.D. & PhD ,&nbsp;Kim Beernaert PhD ,&nbsp;Koen Pardon PhD","doi":"10.1016/j.jpainsymman.2024.08.025","DOIUrl":"10.1016/j.jpainsymman.2024.08.025","url":null,"abstract":"<div><h3>Context</h3><div>While the evidence supporting the benefits of integration of palliative care into cancer care for patients and informal caregivers is growing, it poses challenges for hematological cancer patients due to rapidly changing disease trajectories, uncertain prognosis, and diverse care needs.</div></div><div><h3>Objectives</h3><div>This systematic review aims to provide an overview of the intervention components, the targeted outcomes, the effectiveness in improving patient and informal caregiver outcomes, and the implementation into clinical practice.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed (MEDLINE), EMBASE, CENTRAL, PsycINFO, and CINAHL in March 2023. The studies included described interventions in palliative care, with multiple components, targeting patients with hematological cancer and/or their informal caregivers, and producing primary data on effectiveness or implementation. Quality was assessed using the QualSyst tool.</div></div><div><h3>Results</h3><div>We identified 19 reports on 16 different palliative care interventions, including four quasi-randomized controlled trials. These interventions were provided by secondary and tertiary palliative care providers in a hospital setting. Tertiary interventions significantly improved the most common patient outcomes, including pain, quality of life, symptom burden, depression, and anxiety. Meanwhile, secondary interventions were feasible and well-accepted by healthcare professionals and patients. Despite limited inclusion of informal caregivers, the results indicated significant improvements in quality of life and depression.</div></div><div><h3>Conclusion</h3><div>While palliative care interventions are found to improve patient outcomes, future research is needed on the effectiveness of secondary palliative care interventions, integrating primary palliative care, and more reliable and frequent implementation measurements. More focus on informal caregivers and resource allocation based on patient needs is warranted.</div></div>","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages 114-133.e2"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for Psychosocial Support for Long-Distance Caregivers of Terminally Ill Patients","authors":"Franziska A. Herbst PhD,&nbsp;Nils Schneider MD, MPH,&nbsp;Stephanie Stiel PhD","doi":"10.1016/j.jpainsymman.2024.10.020","DOIUrl":"10.1016/j.jpainsymman.2024.10.020","url":null,"abstract":"<div><h3>Context</h3><div>The provision of appropriate psychosocial support has a significant impact on quality of life for informal caregivers of terminally ill patients. Long-distance caregivers have specific wishes and needs for psychosocial support.</div></div><div><h3>Objectives</h3><div>To date, no formal support measures for long-distance caregivers of terminally ill patients have been developed in Germany. The national Delphi study aimed at systematically and empirically generating recommendations for psychosocial support measures, tailored to this population.</div></div><div><h3>Methods</h3><div>Recommendations were formulated on the basis of qualitative interviews exploring the support experiences and unmet needs of long-distance caregivers of terminally ill patients. Experts from hospice and palliative care rated the relevance and feasibility of 10 recommendations using two 4-point Likert-type scales. Additionally, suggestions for improvement were captured via free text fields. Recommendations were deemed to have achieved consensus when ≥ 80% of participants indicated “strongly agree” or “somewhat agree” for both relevance and feasibility.</div></div><div><h3>Results</h3><div>A total of 26 experts completed two Delphi rounds. Following the first round, eight of the 10 recommendations were revised according to participant feedback. After the second round, consensus was achieved for five of these revised recommendations. Three recommendations were rejected, as participants regarded them unfeasible due to a perceived lack of personnel resources.</div></div><div><h3>Conclusion</h3><div>The consensus-based recommendations represent the first empirically grounded guidelines in Germany aimed at addressing the psychosocial needs of long-distance caregivers of terminally ill patients. The recommendations seek to raise awareness among both professional and voluntary workers regarding the specific support requirements of this understudied population.</div></div>","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages 10-22.e1"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leadership in Action—Betty Ferrell's Influence on Individuals’ Leadership Paths","authors":"Lynn F. Reinke PhD, ANP-BC, FAAN ,&nbsp;Patricia M. Davidson PhD, Med, RN, FAAN","doi":"10.1016/j.jpainsymman.2024.10.006","DOIUrl":"10.1016/j.jpainsymman.2024.10.006","url":null,"abstract":"","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages e21-e22"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Pregabalin and Gabapentin for Pruritus: A Systematic Review and Meta-Analysis","authors":"Wenting Xu MD ,&nbsp;Hanyue Dong MD ,&nbsp;Haolong Ran MD ,&nbsp;Huan Liu MD ,&nbsp;Lin Wang MD ,&nbsp;Hongmin Li MD, PhD ,&nbsp;Cheng Tan MD, PhD","doi":"10.1016/j.jpainsymman.2024.08.028","DOIUrl":"10.1016/j.jpainsymman.2024.08.028","url":null,"abstract":"<div><h3>Context</h3><div>Limited data existed on the efficacy and safety of novel antiepileptic drugs (pregabalin and gabapentin) in treating pruritus.</div></div><div><h3>Objectives</h3><div>To assess their role in managing either acute or chronic pruritus.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in PubMed, EMBASE, the Cochrane Library, and Web of Science databases for relevant randomized controlled trials. Pooled odd ratio (OR) with 95% CI were performed using RevMan5.4 and R4.3.1.</div></div><div><h3>Results</h3><div>Analysis of 27 articles involving 2,016 patients showed significant reduction in pruritus incidence (OR, 0.30 [CI, 0.22–0.4]; I²=1%) and improvements in VAS (MD, 2.76 [CI, 0.95–4.57]; I²=98%) and 5-D scores (MD, 3.42 [CI, 2.10–4.75]; I²=92%) with pregabalin/gabapentin compared to controls. Adverse effects mainly included dizziness, somnolence, nausea and vomiting, dry mouth, constipation, and anxiety, with no significant difference between the groups (OR, 1.08 [CI, 0.32–3.59]; I²=76%).</div></div><div><h3>Conclusion</h3><div>The novel antiepileptic drugs pregabalin and gabapentin demonstrated significant therapeutic value in the treatment of pruritus, with a favorable safety profile. Compared to commonly used pruritus treatments such as antihistamines and antidepressants, these medications offered a promising alternative.</div></div>","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages 65-81"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Family Financial Toxicity Across Serious Illnesses","authors":"Rod Carlo Columbres DO ,&nbsp;Puneeth Iyengar MD, PhD ,&nbsp;Edward Christopher Dee MD","doi":"10.1016/j.jpainsymman.2024.09.013","DOIUrl":"10.1016/j.jpainsymman.2024.09.013","url":null,"abstract":"","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages e90-e92"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gabapentinoids Rotation to Duloxetine in Palliative Care Patients With Cancer Receiving Concurrent Opioids","authors":"Matthew D. Clark PharmD ,&nbsp;Patricia Bramati MD ,&nbsp;Grecia Singleton MD ,&nbsp;James Troyer MD ,&nbsp;Paresa Alizadeh APRN ,&nbsp;Annie Berly RN ,&nbsp;Bryan Fellman MS ,&nbsp;David Hui MD ,&nbsp;Eduardo Bruera MD","doi":"10.1016/j.jpainsymman.2024.09.016","DOIUrl":"10.1016/j.jpainsymman.2024.09.016","url":null,"abstract":"","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages e97-e99"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing the WHO Indicators for Assessing Palliative Care Development in Three Countries: A Do-It-Yourself Approach","authors":"Vilma A. Tripodoro MD, PhD ,&nbsp;Anna Ray MD ,&nbsp;Eduardo Garralda BA ,&nbsp;Fernanda Bastos MD ,&nbsp;Álvaro Montero MSc ,&nbsp;Ana Cristina Béjar MD ,&nbsp;Juan José Pons PhD ,&nbsp;Marie-Charlotte Bouësseau MD ,&nbsp;Carlos Centeno MD, MSc, PhD","doi":"10.1016/j.jpainsymman.2024.09.017","DOIUrl":"10.1016/j.jpainsymman.2024.09.017","url":null,"abstract":"<div><h3>Context</h3><div>Palliative care is an essential health service, with over 56.8 million people needing it yearly, particularly in low- and middle-income countries. The World Health Assembly has recognized palliative care as an ethical responsibility and called for comprehensive primary health care. The World Health Organization has published a technical report titled \"Assessing the Development of Palliative Care Worldwide,\" as a crucial first step in addressing palliative care. The report includes 14 indicators to help decision-makers identify service provision gaps and inform health priorities, piloted by WHO's ATLANTES in Benin, Morocco, and Uruguay as part of a global assessment.</div></div><div><h3>Objectives</h3><div>To describe, for the three countries, the primary outcomes and lessons learned to enable replication in further countries.</div></div><div><h3>Methods</h3><div>A step-by-step description of the assessment project, a summary of the main results obtained through evaluations, and a description of how the selected countries effectively implemented the WHO indicators through a six-step process, including a phase of action plan design. We advocated a 'Do-it-yourself' approach.</div></div><div><h3>Results</h3><div>The summary data from three country reports reveals national development at a national level. A SWOT analysis involving consultants and program managers was conducted. A stakeholder guide was developed, providing trigger questions and practical recommendations for assessing development using specific indicators. Full information can be found in the specific published reports.</div></div><div><h3>Conclusion</h3><div>The WHO approach has proven effective in identifying health system deficiencies and disseminating information about palliative care evaluation processes. The report provides a 'Do-it-yourself' approach, encouraging self-management without expert guidance.</div></div>","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages e61-e69"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racism in Pediatric Serious Illness and Palliative Care: A Scoping Review of Qualitative Research","authors":"J'Mag Karbeah PhD, MPH ,&nbsp;Camille R. Murray MPH, CHES ,&nbsp;Corelle Nakamura MPH ,&nbsp;Haley Brahmbhatt MSPH ,&nbsp;Elena Cattaneo BS ,&nbsp;Hailey Frye BS ,&nbsp;Erin Shen BS ,&nbsp;Dio Kavalieratos PhD, FAAHPM ,&nbsp;Khaliah A. Johnson MD","doi":"10.1016/j.jpainsymman.2024.09.021","DOIUrl":"10.1016/j.jpainsymman.2024.09.021","url":null,"abstract":"<div><h3>Context</h3><div>Racial disparities in health outcomes have historically impacted Black and Native American children with serious illness, yet little is known about how racism shapes the healthcare experiences of these families. To improve care experiences for this population, we must understand the myriad of ways that racism may impact their experiences with serious illness.</div></div><div><h3>Objectives</h3><div>1) To assess the extent to which the experiences of Black and Native American families have been captured in existing serious illness and palliative care literature and 2) explore how experiences of racism uniquely impact this population.</div></div><div><h3>Methods</h3><div>We conducted a scoping review and qualitative meta-synthesis of peer-reviewed articles from 1980 to 2022 that included Black and/or Native American parents’ or caregivers’ experiences of serious illness care. We abstracted study characteristics, and forms of racism mentioned.</div></div><div><h3>Results</h3><div>Searches yielded 2762 articles, of which six were reviewed based on inclusion criteria. Three key themes emerged from the literature on the experiences of Black families navigating pediatric serious illness that highlight how parents navigate their future after a serious illness diagnosis; how relationships and support networks change after diagnosis; and the challenges associated with navigating grief and suffering after a diagnosis. Institutionalized racism and interpersonal racism were the most identified forms of racism experienced by Black families. None of the articles identified included Native American families.</div></div><div><h3>Conclusion</h3><div>Our findings highlight the pressing need for further qualitative research to explore the lived experiences of racially minoritized families—especially studies focusing on the experiences of Native American families.</div></div>","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":"69 1","pages":"Pages 44-52"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cigarette Smoking and Symptom Burden: Baseline Results From Nine ECOG-ACRIN Cancer Clinical Trials.","authors":"Sarah N Price, Ju-Whei Lee, Ilana F Gareen, Sheetal M Kircher, Shaji K Kumar, Ingrid A Mayer, Nabil F Saba, Timothy S Fenske, Michael B Atkins, F Stephen Hodi, Christos E Kyriakopoulos, Clare M Tempany-Afdhal, Tait D Shanafelt, Elyse R Park, Lynne I Wagner","doi":"10.1016/j.jpainsymman.2024.12.021","DOIUrl":"10.1016/j.jpainsymman.2024.12.021","url":null,"abstract":"<p><strong>Context: </strong>Approximately 11% of cancer survivors smoke postdiagnosis.</p><p><strong>Objectives: </strong>Understanding the relationship between smoking and perceived cancer-related symptoms may inform tobacco treatment interventions for this population.</p><p><strong>Methods: </strong>From 2017 to 2021, 740 adults in 9 ECOG-ACRIN trials provided baseline data. The effects of smoking status on symptoms were evaluated using logistic regression, adjusting for age, gender, race, performance status, treatment setting, and anxiety. Fisher's exact test was used to compare the prevalence of patients reporting that smoking helps/worsens each symptom by smoking status (current vs. former).</p><p><strong>Results: </strong>Among participants (mean age = 58.8, 93.9% white, 30.3% female, most common cancer types: leukemia [35.5%], lymphoma [19.1%], and prostate [17.7%]), smoking statuses were: 81 current (10.9%), 257 former (34.7%), and 402 (54.3%) never. Patients currently smoking were more likely to experience cough compared to those who formerly (OR = 3.25, P < .0001) or never (OR = 3.70, P < .0001) smoked. Current smoking was associated with greater severity of cough and pain and greater pain interference compared to former and never smoking (OR's > 2.26, P's < .005). Patients currently smoking were more likely to report that smoking helps with nausea (29.4% vs. 1.3%, P < .0001), insomnia (16.4% vs. 0.6%, P < .0001), and pain (16.1% vs. 2.8%, P = .002) compared to those who formerly smoked.</p><p><strong>Conclusion: </strong>Patients currently smoking report greater severity of cancer-related symptoms (i.e., cough, pain) yet were also more likely to believe that smoking helps with nausea, insomnia, and pain. Symptom management should include tobacco cessation, education on smoking and its relationship to symptoms, and strategies to reduce reliance on smoking for symptom relief.</p>","PeriodicalId":16634,"journal":{"name":"Journal of pain and symptom management","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}