Journal of Nutrition and Metabolism最新文献

{"title":"Therapeutic Effects of <i>Punica granatum</i> (Pomegranate): An Updated Review of Clinical Trials.","authors":"Samira Eghbali,&nbsp;Sayyedeh Fatemeh Askari,&nbsp;Razieh Avan,&nbsp;Amirhossein Sahebkar","doi":"10.1155/2021/5297162","DOIUrl":"https://doi.org/10.1155/2021/5297162","url":null,"abstract":"<p><p><i>Punica granatum</i> L. belongs to the <i>Punicaceae</i> family which is distributed around the world. Different parts of pomegranate like seed, peel, juice, and leaves are rich in potential bioactive compounds. These plants have found application in traditional medicine such as in treatment of gastrointestinal, cardiovascular, and endocrine diseases, among others. The present review aimed to summarize the current research on the traditional and scientific applications of <i>P. granatum</i> with regard to the phytochemical content and clinical applications that may be useful for future drug development. Information about <i>P. granatum</i> was obtained from local classic herbal literature and electronic databases, such as PubMed, Scopus, and ScienceDirect. Several phytochemical constituents including polyphenolics, flavonoids, anthocyanosides, alkaloids, lignans, and triterpenes have been reported from the plant. Randomized clinical trials have provided evidence as to the pharmacological activities of pomegranate in several diseases including diabetes, cardiovascular disease, oral cavity disorders, endocrine disorders, and cancer. The present review has provided an insight into the traditional applications of the plants, and some of them have been validated by scientific evidence, particularly their applications as treatment of cardiovascular and endocrine diseases.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"5297162"},"PeriodicalIF":2.2,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39638209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Uric Acid Is Associated with Metabolic Syndrome and Insulin Resistance among Health Personnel from Peru.","authors":"Brenda M Galindo-Yllu, Ricardo Rojas-Humpire, Carlos J Toro-Huamanchumo, Rosmery Gutierrez-Ajalcriña, Anderson N Soriano","doi":"10.1155/2021/9933319","DOIUrl":"10.1155/2021/9933319","url":null,"abstract":"<p><p>We explored the association between serum uric acid (SUA) and metabolic syndrome (MetS) and insulin resistance (IR) among health personnel from a public hospital in Peru in a cross-sectional study with data from the Plan for the Prevention and Surveillance of Communicable and Noncommunicable Diseases of Huaycán Hospital. MetS was defined according to Latin American Diabetes Association (ALAD) criteria and IR with surrogate IR markers, triglyceride-to-HDL-C ratio (TG/HDL-C), and triglyceride-to-glucose index (TyG). The association between SUA and MetS and IR was determined using Poisson regression models in a sample of 292 participants with an average age of 46.2 ± 10.6 years. The total prevalence of MetS was 38%, and the individuals with MetS presented mainly alterations in anthropometric parameters (obesity and body fat). Finally, the adjusted regression models showed that women with SUA in the highest tertile increased the prevalence of MetS (PR: 1.71, 95% CI: 1.07-2.74) compared to the lowest tertile of SUA in women, while SUA increased hypertriglyceridemia and IR (TG/HDL-C and TyG) in both sexes. We concluded that SUA is strongly associated with MetS in women, and SUA increases hypertriglyceridemia and IR in both sexes. On the contrary, more research is required regarding the female population.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"9933319"},"PeriodicalIF":2.2,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39909445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate and Severe Level of Food Insecurity Is Associated with High Calorie-Dense Food Consumption of Filipino Households.","authors":"Imelda Angeles-Agdeppa, Marvin B Toledo, Jezreel Ann T Zamora","doi":"10.1155/2021/5513409","DOIUrl":"10.1155/2021/5513409","url":null,"abstract":"<p><p>Food insecurity is often deeply rooted in poverty. Hence, accessibility and the quality of foods consumed may affect the dietary pattern. The study aims to assess the relationship between food insecurity and dietary consumption. This investigation analyzed the data from the 2015 Updating of Nutritional Nutrition Survey. The Household Food Insecurity Access Scale (HFIAS) was used to determine household food security status and the prevalence of food insecurity. Food weighing, food inventory, and food recall were the methods used to collect food consumption data of sampled households. The study revealed poor nutrient quality and a greater likelihood of inadequacy of nutrients among moderate and severe food insecure households. Mild, moderate, and severe levels of food insecurity were found to affect 12%, 32%, and 22% of the population, respectively. The test showed that both moderate and severe food insecure families have significantly lower mean consumption of meat, milk, and fats and oils in contrast to food secure households. In comparison with food secure households, moderate and severe food insecure households consume higher amounts of cereals and cereal products, rice, and vegetables. Moderate and severe food insecure households have higher consumption of total carbohydrates but have significantly lower average intake of vitamin A, riboflavin, niacin, and total fat related to food stable households. Moreover, the results of the multiple logistic regression revealed that food insecure households have a higher likelihood to be deficient in energy, protein, calcium, vitamin A, thiamin, riboflavin, niacin, and vitamin C intakes, but except for iron (<i>p</i> value <0.05). Indeed, household food insecurity was associated with the higher consumption of calorie-dense food among Filipino households. This explains a lower nutrient quality and a higher likelihood of inadequacy of nutrients among moderate and severe food insecure households.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"5513409"},"PeriodicalIF":2.3,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39712703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undernutrition and Associated Factors among Under-Five Orphan Children in Addis Ababa, Ethiopia, 2020: A Cross-Sectional Study.","authors":"Selam Shegaw Sewnet,&nbsp;Hunegnaw Almaw Derseh,&nbsp;Hanna Demelash Desyibelew,&nbsp;Netsanet Fentahun","doi":"10.1155/2021/6728497","DOIUrl":"https://doi.org/10.1155/2021/6728497","url":null,"abstract":"<p><strong>Background: </strong>Undernutrition contributes to the death of around 3 million children and threatens the futures of hundreds of millions, undermining healthy development and the strength of their societies by preventing children from achieving their full potential. Orphans are at greater risk of undernutrition because they are more likely to be extremely poor and receive less medical and social care. However, there is little information about the prevalence of undernutrition and associated factors among under-five orphan children.</p><p><strong>Objective: </strong>This study aimed to assess undernutrition and associated factors among under-five orphan children in orphanages in Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>An institution-based cross-sectional study was conducted in Addis Ababa from February 28 to March 28, 2020. A simple random sampling technique was employed to recruit a total of 275 orphan children. An interviewer-administered questionnaire and anthropometric measurements were used to collect data. Data were entered using EpiData version 3.1 and analysis was done by WHO Anthro version 3.2.2 and SPSS version 23. Multivariable logistic regression analysis was performed to identify determinants of undernutrition at a <i>p</i> value of less than 0.05 with an adjusted odds ratio of 95% confidence interval.</p><p><strong>Results: </strong>The prevalence of wasting, stunting, and underweight were 11.1%, 45.8%, and 25.5%, respectively. Presence of illness (AOR = 2.23; 95% CI: 1.41, 12.73), children who received less than three meals per day (AOR = 2.11; 95% CI: 1.58, 7.71), and children who were not vaccinated (AOR = 2.86; 95% CI: 2.07, 11.61) were significantly associated with stunting. Children who were not vaccinated (AOR = 2.04; 95% CI: 1.29, 9.71) and who had inadequate dietary diversity scores (AOR = 1.32, 95% CI: 1.16, 12.65) were significantly associated with wasting and underweight, respectively.</p><p><strong>Conclusion: </strong>The prevalence of undernutrition was very high compared to national data. Health status, meal frequency, and vaccination status were associated factors of stunting. Vaccination status and dietary diversity score were associated factors with wasting and underweight, respectively. Therefore, improving meal frequency, dietary diversity, and early treatment during childhood illness are important to reduce orphan undernutrition.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"6728497"},"PeriodicalIF":2.2,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39609216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Fermented Camel Milk Containing <i>Bifidobacterium longum</i> BB536 on Blood Lipid Profile in Hypercholesterolemic Rats.","authors":"Khaled M El-Zahar,&nbsp;Mohamed F Y Hassan,&nbsp;Suliman F Al-Qaba","doi":"10.1155/2021/1557945","DOIUrl":"https://doi.org/10.1155/2021/1557945","url":null,"abstract":"The present study aimed to investigate synergistic health effects of camel milk and Bif. longum BB536 in rats with diet-induced obesity, impaired lipid profile, and hypercholesterolemia. Wistar rats received a high-fat (HF) diet plus 2 ml/day of either cow's milk fermented with yogurt culture (CT), camel milk fermented with yogurt culture (CAT), camel milk fermented with Bif. longum BB536 (CAP), mixed cow's and camel milk fermented with yogurt culture (CCAT), or cow's milk and camel milk fermented with Bif. longum (CCAP). All fermented milk products significantly reduced HDL, albumin, and total protein. The percentage change in body weight gain was between −40% (CAP) and −24% (CT) and in serum triglycerides between −54% (CCAP) and −37% (CT); for the other parameters, changes caused by CCAP/CT were −40%/−22% (total cholesterol), +29%/+8% (HDL), −73%/−54% (LDL), −54%/−37% (VLDL), −52%/−14% (AST), −53%/−31% (ALT), +43%/+25% (albumin), +37%/+25% (total protein), −48%/−27% (urea), and −34%/−16% (creatinine). Camel or cow's milk fermented with yogurt culture or Bif. longum significantly improved negative effects of the HF diet on body weight, blood lipid profile, serum proteins, liver and kidney markers, and severity of the metabolic syndrome. Milk and fermentation culture acted synergistically with camel milk and Bif. longum generally showed stronger positive effects./","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"1557945"},"PeriodicalIF":2.2,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39597541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast-Food Dietary Pattern Is Linked to Higher Prevalence of Metabolic Syndrome in Older Canadian Adults.","authors":"Zeinab Hosseini,&nbsp;Mehdi Rostami,&nbsp;Susan J Whiting,&nbsp;Hassan Vatanparast","doi":"10.1155/2021/5712844","DOIUrl":"https://doi.org/10.1155/2021/5712844","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) is known to increase the risk of cardiovascular diseases and diabetes. Diet is a key factor in prevention and development of MetS. This study aimed to determine the association between dietary patterns and MetS among Canadians 12-79 years old using the Canadian Health Measures Survey (CHMS) combined Cycles 1 and 2 data from 2007-11. We hypothesized that MetS varies among different sociodemographic and lifestyle factors and that Canadians who have less healthy dietary patterns are more likely to have MetS.</p><p><strong>Methods: </strong>In the CHMS, MetS was determined using objective health measures. The principal component analysis method was used to determine the dietary patterns. Using logistic regression, the association between MetS and dietary patterns, controlling for potential covariates, was investigated for age groups of 12-19, 20-49, and 50-79 years. Survey data were weighted and bootstrapped to be representative at the national level.</p><p><strong>Results: </strong>The prevalence of MetS was 16.9% for ages 12-79 y (<i>n</i> = 4,272, males = 49.6%), representing 26,038,108 Canadians aged 12-79 years. MetS was significantly different across sociodemographic variables; Canadians with less education, income, and activity had higher MetS prevalence than their counterparts. In older adults (50-79 years of age), the \"fast-food\" dietary pattern was associated with 26% (odds ratio = 1.26; 95% CI: 1.04 to 1.54; <i>p</i>=0.0195) higher likelihood of having MetS.</p><p><strong>Conclusions: </strong>Among older Canadians, MetS is associated with a \"fast-food\" dietary pattern after adjustment for socioeconomic/lifestyle factors. Findings suggest the importance of diet quality/composition in the development of MetS among older Canadians and the need for further longitudinal studies on MetS and diet across the lifespan.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"5712844"},"PeriodicalIF":2.2,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39579823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude of Stunting and Associated Factors among Adolescent Students in Legehida District, Northeast Ethiopia.","authors":"Wassachew Ashebir Kebede,&nbsp;Belete Yimer Ayele","doi":"10.1155/2021/2467883","DOIUrl":"10.1155/2021/2467883","url":null,"abstract":"<p><strong>Background: </strong>Undernutrition including stunting particularly at an adolescent stage was not emphasized by various intervention strategies in the Ethiopian context. Assessing the magnitude and potential risk factors of undernutrition is thus helpful for policymakers to design appropriate intervention strategies. Hence, this study was aimed at assessing the magnitude of stunting and associated factors among adolescent students in Legehida district, Northeast Ethiopia.</p><p><strong>Methods: </strong>A school-based cross-sectional study was conducted among 424 adolescent students from February 15^th to March 15^th, 2018. A stratified sampling followed by a simple random sampling technique was used to select the study participants. A pretested, structured, and self-administered questionnaire was used to collect the required data. Height was measured by using a portable stadiometer and the height-for-age (HFA) z-score was calculated as an indicator of stunting. SPSS version 25 and WHO AnthroPlus software were applied to analyze the data. A multivariable logistic regression analysis was performed to identify factors associated with adolescent stunting. Statistical significance was determined at a <i>p</i> value of <0.05 and association was described by using an odds ratio at a 95% confidence interval.</p><p><strong>Results: </strong>A total of 406 adolescent students (with a response rate of 95.7%) participated in the study. The magnitude of stunting among adolescent students in this study was 24.9% (95% CI: 24.6%-35.3%).</p><p><strong>Conclusions: </strong>Stunting among adolescent students was significantly associated with being male [AOR = 2.1; 95% CI: 1.73-5.90], meal frequency (<3/day) [AOR = 4.6; 95% CI: 2.61-8.24], infrequent handwashing practice [AOR = 3.6; 95% CI: 1.30-9.40], absence of latrine facility (AOR = 5.51; 95% CI: 3.03-9.9), and consumption of unsafe water [AOR = 2.8; 95% CI: 1.35-6.19]. Hence, conducting routine nutrition screenings and assessments, promotion of proper food intake, and emphasis on nutrition education and counseling are needed to be strengthened.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"2467883"},"PeriodicalIF":2.2,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39554147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance of Mother-Child (6-23 Months) Dietary Diversity and Its Associated Factors in Kucha District, Gamo Zone, Southern Ethiopia: A Community-Based Cross-Sectional Study.","authors":"Tesfaye Guja,&nbsp;Yabsira Melaku,&nbsp;Eshetu Andarge","doi":"10.1155/2021/8819846","DOIUrl":"https://doi.org/10.1155/2021/8819846","url":null,"abstract":"<p><p>Meeting minimum standards of dietary quality in mothers and children is a challenge in many developing countries including Ethiopia. Emerging evidence suggests that maternal and child dietary diversity is associated, but little is known about the associated factors of concordance of mother-child dietary diversity in Ethiopia and none is documented in the study area. This study examines the concordance between mother-child (6-23 months) dyads dietary diversity and the associated factors in Kucha District, Gamo Zone, Southern Ethiopia. A community-based cross-sectional study was conducted among 791 mother-child (6-23 months) pairs from 11 selected kebeles on March 6 to April 13, 2017. Multistage cluster sampling technique was used to select the study subjects. The sampling frame was obtained from the family folder of health posts in each kebele. The mother-child pairs were selected by the simple random sampling method. The 7 food groups of the World Health Organization (WHO) for children and the 10 food groups of FANTA/FAO 2016 for mothers were used to analyze the dietary diversity. Cohen's kappa statistics was calculated to see the strength of concordance. The multivariable logistic regression model was fitted to determine factors affecting mother-child dietary diversity concordance. A good concordance was noted between mother-child dietary diversity scores (Kappa = 0.43). Only 56 (7.1%) mothers were negative deviants, and 133 (16.8%) mothers were positive deviants in dietary diversity consumption. Rural residence (AOR = 3.49; 95% CI: 1.90-6.41), having no formal education (AOR = 1.8; 95% CI: 1.08-3.05), not owning milking cow (AOR = 1.7; 95% CI: 1.10-2.56), children with low dietary diversity (AOR = 8.23; 95% CI: 5.17-13.08), and mothers with low dietary diversity (AOR = 0.46; 95% CI: 0.29-0.74) were found to be factors associated with mother-child dietary diversity concordance. An increase in the percentage of children reaching the minimum dietary diversity was greater with a successive increase in maternal dietary diversity. Despite interesting similarities between mothers and children dietary consumption, more than three-quarters of concordants did not achieve the recommended dietary diversity score (were low concordants). Interventions targeting on rural women's access to high school education, home-based milking cow rearing, and promoting nutrition-sensitive agriculture to meet the dietary requirements of mothers and children in a sustainable manner and public health efforts to improve child nutrition may be strengthened by promoting maternal dietary diversity due to its potential effect on the entire family.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"8819846"},"PeriodicalIF":2.2,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39554148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Assessment and Management in Paediatric Chronic Kidney Disease.","authors":"Jumanah Ziyad Azzouz,&nbsp;Osama Yousef Safdar,&nbsp;Farah Idriss Awaleh,&nbsp;Alya Abdullah Khoja,&nbsp;Ali Alawi Alattas,&nbsp;Abdulkarim Abbas Jawhari","doi":"10.1155/2021/8283471","DOIUrl":"10.1155/2021/8283471","url":null,"abstract":"<p><p>Nutrition in paediatrics has always been one of the most important factors for optimal growth. Children with chronic kidney disease (CKD) need special consideration for better long-term outcomes, including nutritional status, optimal height, and cognitive function. Nonetheless, there are many obstacles to overcome to attain optimal linear growth and nutritional status in children with CKD. This review highlights the need for tools to assess the growth parameters in CKD. In addition, recommendations for dietary intake play a major role in controlling electrolyte disturbances in patients with CKD. For example, it is still unclear whether it is better to restrict phosphate sources in inorganic, organic, or food additives. The review also summarises different factors such as fluid intake, route of feeding, and essential nutrients that require particular attention in paediatric patients with CKD. In summary, a multidisciplinary team is needed to devise individual nutritional plans to achieve the best outcome and improve the quality of life of patients.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"8283471"},"PeriodicalIF":2.2,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39539008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Third-Generation Beta Blockers on Weight Loss in a Population of Overweight-Obese Subjects in a Controlled Dietary Regimen.","authors":"Maria Alessandra Gammone,&nbsp;Konstantinos Efthymakis,&nbsp;Nicolantonio D'Orazio","doi":"10.1155/2021/5767306","DOIUrl":"https://doi.org/10.1155/2021/5767306","url":null,"abstract":"<p><strong>Background: </strong>Overweight and obesity often develop in individuals with genetic susceptibility and concomitant risk factors; however, medications can represent precipitating factors in some cases: evidence suggests that some antihypertensive drugs can adversely affect energy homeostasis and metabolism.</p><p><strong>Aim: </strong>The primary aim of this study was to investigate whether long-term therapy with a beta blocker impairs weight loss during a period of appropriate personalized hypocaloric diet and standardized physical activity in overweight and obese hypertensive patients in monotherapy and without comorbidities, compared to other antihypertensive drugs and to a control group not taking antihypertensive therapy. <i>Subjects and Methods</i>. We enrolled overweight and obese patients taking antihypertensive drugs; subjects were divided into 3 groups: those taking traditional beta blockers (bB group), those taking third-generation beta blockers (bB-3 group), and those taking other antihypertensive drugs (non-bB group). We also enrolled subjects receiving neither antihypertensive therapy nor other chronic medication in the prior 12 months as controls. All subjects underwent personalized hypocaloric diets for a period of 24 months with monthly follow-up. Anthropometric parameters were measured at enrollment and then monthly after diet prescription. Glucose and lipid values were assessed at baseline and at 12 and 24 months during dietary regimen.</p><p><strong>Results: </strong>We enrolled a total of 120 overweight and obese patients aged 50.30 ± 1.13 years (mean ± standard deviation) with a mean BMI of 31.79 ± 0.65 kg/m²; 90 were taking antihypertensive drugs (no comorbidity and no polytherapy), while 30 subjects receiving neither antihypertensive therapy nor other chronic medication in the prior 12 months were considered as controls. After 6 months, the percent total weight loss (TWL%) was lower in the bB group (3.62 ± 1.96 versus 5.27 ± 1.76 in the bB-3 group, versus 5.15 ± 1.30 in the non-bB group, and versus 4.70 ± 0.87 in the control group), as well as their BMI. After 24 months, we kept finding the worst result in the bB group (TWL% = 9.22 ± 2.19 versus 12.79 ± 1.72 in the non-bB group and 12.28 ± 1.97 in the control group) with the best trend in the bB-3 group (TWL% = 16.19 ± 2.67).</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2021 ","pages":"5767306"},"PeriodicalIF":2.2,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39482673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}