Journal of Nutrition and Metabolism最新文献

{"title":"Associations between Components of Metabolic Syndrome and Demographic, Nutritional, and Lifestyle Factors.","authors":"Layne Christina Benedito de Assis Lima, Séphora Louyse Silva Aquino, Aline Tuane Oliveira da Cunha, Talita do Nascimento Peixoto, Severina Carla Vieira Cunha Lima, Karine Cavalcanti Maurício Sena-Evangelista, Josivan Gomes Lima, Lucia Fátima Campos Pedrosa","doi":"10.1155/2024/8821212","DOIUrl":"10.1155/2024/8821212","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the associations between individuals with and without changes in components of metabolic syndrome (MetS) and demographic, nutritional, and lifestyle factors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 224 individuals followed-up at a public hospital in Northeast Brazil. We used National Cholesterol Education Program-Adult Treatment Panel III (NCEP) criteria to diagnose MetS. We assessed components of MetS as dependent variables, while sex, age, food consumption, smoking, alcohol intake, physical activity, anthropometric parameters, and sleep hours were independent variables.</p><p><strong>Results: </strong>Comparing individuals with and without changes in components of MetS, the logistic regression models revealed that female sex was predictive of increased waist circumference and low HDL-c levels while advanced age was predictive of increased blood pressure and blood glucose levels. BMI emerged as a predictor for waist circumference and a protective factor for triglyceride levels. In addition, potassium intake, physical activity, and sleep duration were protective against decreased HDL-c, elevated triglyceride, and elevated blood pressure levels, respectively.</p><p><strong>Conclusion: </strong>This study demonstrated that sex, age, BMI, dietary potassium intake, physical activity, and hours of sleep are factors to be targeted in public health actions for prevention and treatment of MetS.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2024 ","pages":"8821212"},"PeriodicalIF":2.3,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Modified Atkins Ketogenic Diet on Children with Intractable Epilepsy: A Pilot Study from Indonesia","authors":"Achmad Rafli, S. Handryastuti, M. Karyanti, Yoga Devaera, Cut Nurul Hafifah, I. Mangunatmadja, Muzal Kadim, E. Herini, Lora Sri Nofi, Ariek Ratnawati, Suci Fitrianti","doi":"10.1155/2023/9222632","DOIUrl":"https://doi.org/10.1155/2023/9222632","url":null,"abstract":"Background. The ketogenic diet has recently been explored as a potential treatment approach for intractable epilepsy in children and has been applied in various parts of the world. The ketogenic diet is also effective for the treatment of mood disorders, especially for adolescent and young adults with epilepsy. The Modified Atkins Diet (MAD) is the less restrictive type of ketogenic diet with similar principles as the classic type. However, no study has been conducted to evaluate the use of MAD in children with severe epilepsy in Indonesia. This study aims to assess the effectiveness, tolerance, compliance, and the adverse effects of MAD in children with intractable epilepsy during a 6-month monitoring period. Methods. This is a pilot experimental study involving children aged 2–18 years old with intractable epilepsy at the Pediatric Neurology and the Pediatric Nutrition & Metabolic Diseases Clinics at the Dr. Cipto Mangunkusumo Hospital Jakarta between November 2021 and June 2022. Results. A total of 31 subjects met the inclusion criteria and received the MAD in the first month, followed by 13 (41.9%) subjects in the third month, and 9 (29%) subjects in the sixth month. The MAD reduced the seizure frequency by 50% (p=0.144), 62% (p=0.221), and 83.3% (p=0.028) in the first, third, and sixth months, respectively. The most frequent adverse effects are vomiting and diarrhea. Noncompliance was observed in 18 (58.1%) subjects. A sample of the MAD food menu guidebook was developed to make it easier for parents to adhere to the diet. Conclusions. The MAD reduces the mean seizure frequency in children with intractable epilepsy in the first, third, and sixth months, with a statistical significance in the sixth month. A further randomized, controlled, and multicenter clinical trial with a larger sample size and longer observation period is required. This trial is registered with Protocol ID 20-10-1323.","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"17 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Answers between ChatGPT and Human Dieticians to Common Nutrition Questions","authors":"Daniel Kirk, Elise van Eijnatten, Guido Camps","doi":"10.1155/2023/5548684","DOIUrl":"https://doi.org/10.1155/2023/5548684","url":null,"abstract":"Background. More people than ever seek nutrition information from online sources. The chatbot ChatGPT has seen staggering popularity since its inception and may become a resource for information in nutrition. However, the adequacy of ChatGPT to answer questions in the field of nutrition has not been investigated. Thus, the aim of this research was to investigate the competency of ChatGPT in answering common nutrition questions. Methods. Dieticians were asked to provide their most commonly asked nutrition questions and their own answers to them. We then asked the same questions to ChatGPT and sent both sets of answers to other dieticians (N = 18) or nutritionists and experts in the domain of each question (N = 9) to be graded based on scientific correctness, actionability, and comprehensibility. The grades were also averaged to give an overall score, and group means of the answers to each question were compared using permutation tests. Results. The overall grades for ChatGPT were higher than those from the dieticians for the overall scores in five of the eight questions we received. ChatGPT also had higher grades on five occasions for scientific correctness, four for actionability, and five for comprehensibility. In contrast, none of the answers from the dieticians had a higher average score than ChatGPT for any of the questions, both overall and for each of the grading components. Conclusions. Our results suggest that ChatGPT can be used to answer nutrition questions that are frequently asked to dieticians and provide encouraging support for the role of chatbots in offering nutrition support.","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"344 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135475159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Anthropometric Indices as Screening Tools for Obesity: A Study on Healthy Iranians.","authors":"Toktam Alirezaei, Hamid Soori, Rana Irilouzadian, Hadis Najafimehr","doi":"10.1155/2023/6612411","DOIUrl":"10.1155/2023/6612411","url":null,"abstract":"<p><strong>Background and aims: </strong>Upper body fat distribution is more related to cardiometabolic diseases than central obesity. Neck circumference (NC) and neck-to-height ratio (NHtR) are two indicators of upper body obesity that are affordable, easy to obtain, highly reproducible, and more practical in the crowded health centers than the classic anthropometric indices.</p><p><strong>Methods: </strong>18-65-year-old individuals with no past medical history were included. After obtaining written informed consent, they were screened for hypertension, high blood glucose, and other abnormal laboratory results. Data were analyzed using SPSS and Mann-Whitney <i>U</i> test, Chi square test, Spearman's correlation coefficient, and ROC curve.</p><p><strong>Results: </strong>In our 2,812 participants, NC had the lowest area under the curve (AUC) in both male and female obese and overweight subjects. NHtR and hip circumference (HC) had the highest AUC in men and women with obesity, respectively. The highest sensitivity for overweight men and women belonged to waist circumference (WC) and waist-to-height ratio (WHtR), respectively, and for both males and females with obesity, NHtR had the highest sensitivity. The cutoff point of NHtR had the same value for males and females. HC and NHtR had the highest positive likelihood ratio (PLR) for obesity in men. In addition, HC and WC had the highest PLR for obesity in women.</p><p><strong>Conclusion: </strong>In this study, we revealed that NC had the lowest and NHtR and HC had the highest predictive value for obesity. Furthermore, for both males and females with obesity, NHtR had the highest sensitivity. HC had the highest PLR for obesity in both genders. Our results warrant prospective studies to evaluate the role of NHtR and other novel anthropometric indices in the risk of cardiometabolic diseases.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2023 ","pages":"6612411"},"PeriodicalIF":2.3,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions.","authors":"Franco Cavaleri,&nbsp;Sukalpa Chattopadhyay,&nbsp;Vrushalee Palsule,&nbsp;Pradip Kumar Kar,&nbsp;Ritam Chatterjee","doi":"10.1155/2023/9599744","DOIUrl":"10.1155/2023/9599744","url":null,"abstract":"<p><strong>Background: </strong>Ashwagandha extracts play a significant role in traditional Indian medicine to help treat a wide range of disorders from amnesia, erectile dysfunction, neurodegenerative and cardiovascular diseases, cancer, stress, anxiety, and many more. Ashwagandha root is enriched with bioactive plant metabolites of which withanolides are the most important ones. The concentration and constitution of withanolides primarily determine ashwagandha's potency and pharmacology. Various factors modulate the withanolide constitution in the plant-derived extracts, rendering inconsistent therapeutic efficacy. Standardisation of the extraction protocol and a better understanding of the pharmacology mechanism of different extracts with varied withanolide constitutions is therefore critical for developing reliable, repeatable, and effective ashwagandha-based treatment.</p><p><strong>Objectives: </strong>Here, we work toward defining indication mechanisms for two varieties of ashwagandha extract-ASHWITH (ASH-Ext1) and Regenolide (ASH-Ext2)-with different proprietary withanolide proportions.</p><p><strong>Methods: </strong>ASH-Ext1 was studied for antioxidant signaling modulation using HEK293, HeLa, and A549 cells, and ASH-Ext2 was studied for subcellular drug targets associated with the reactivation and longevity of human hair follicles, using primary human hair follicle dermal papilla cells (HFDPCs).</p><p><strong>Results: </strong>Study findings support the antioxidant activity and Nrf2 signaling modulation by ASH-Ext1 in various cell models. Of note, ASH-Ext2 was found to increase <i>β</i>-catenin and telomerase reverse transcriptase (TERT) protein expression levels in HFDPCs.</p><p><strong>Conclusion: </strong>The results of drug target modulation show us that the withanolide constitution associated with different extraction protocols influences the pharmacological potential of the extract significantly and points to the value of standardisation not only of total withanolide content but also of internal withanolide proportions.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2023 ","pages":"9599744"},"PeriodicalIF":2.2,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41133203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Crucial Role of Diet Therapy and Selenium on the Evolution of Clinical and Paraclinical Parameters in Patients with Metabolic Syndrome.","authors":"Adrian Marius Danciu,&nbsp;Timea Claudia Ghitea,&nbsp;Alexa Florina Bungau,&nbsp;Cosmin Mihai Vesa","doi":"10.1155/2023/6632197","DOIUrl":"10.1155/2023/6632197","url":null,"abstract":"<p><p>Oxidative stress (OS) is associated with metabolic syndrome (MS) and represents a complex disease association that has become a major challenge in the field of public health. The aim of this study was to investigate the effectiveness of introducing selenium in the management of OS, while considering a balanced diet based on a healthy lifestyle and dietary therapy. A total of 206 individuals participated voluntarily in the study, divided into three groups: the control group with 35 individuals (17.0%) designated as control lot (LC), the group undergoing diet therapy with 119 individuals (57.8%) designated as diet therapy lot (LD), and the group undergoing diet therapy supplemented with selenium consisting of 52 individuals (25.2%) designated as diet therapy with selenium lot (LD + Se). The study assessed various clinical parameters (such as body mass index (BMI), body weight status, fat mass, visceral fat, and sarcopenic index), paraclinical parameters (including HOMA index, cholesterol, triglycerides, C-reactive protein, and glycosylated haemoglobin (HGS)), as well as OS parameters (measured using the FORD test, FORT test, and MIXED test). The LD + Se group demonstrated the most favourable results in terms of BMI reduction, decreased fat and visceral mass, reduced levels of C-reactive protein, and improved glycosylated haemoglobin levels. By implementing a balanced diet therapy and supplementing the diet with selenium, it was possible to achieve a reduction in adipose tissue and glycosylated haemoglobin levels, ultimately contributing to the reduction of OS in the body.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2023 ","pages":"6632197"},"PeriodicalIF":2.2,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats.","authors":"Hery D Purnomo,&nbsp;Refani A Kusuma,&nbsp;Elfrida Sianturi,&nbsp;Ryan F Haroen,&nbsp;Muchamad R Solichin,&nbsp;Choirun Nissa,&nbsp;Adriyan Pramono,&nbsp;Endang Mahati,&nbsp;Etika R Noer","doi":"10.1155/2023/2313503","DOIUrl":"https://doi.org/10.1155/2023/2313503","url":null,"abstract":"<p><p>Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BCAAs) and middle-chain triglycerides (MCTs), which could repair liver tissue damage, improve the inflammatory status, and modulate SCFA in liver damage. The study aimed to determine the effect of hepatogomax on liver tissue repair, inflammation (TNF-<i>α</i> and IL-6), and SCFA levels in thioacetamide (TAA)-induced rats. The induction of TAA causes liver steatosis, increasing TNF-<i>α</i> and IL-6, and decreasing SCFA levels. Hepatogomax at a dose of 14.6 g/200 gBW significantly reduces TNF-<i>α</i> and IL-6 levels and increases SCFA levels (<i>p</i> < 0.05). The number of steatosis between groups P2 and P3 was lower as compared to a group of negative control [K2] (<i>p</i> < 0.05). Hepatogomax, in a dose-dependent manner, may repair liver tissue and improve inflammatory response and SCFA levels in TAA-induced rats.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2023 ","pages":"2313503"},"PeriodicalIF":2.2,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral Nutrition Safety and Outcomes of Patients with COVID-19 on Continuous Infusion of Neuromuscular Blockers: A Retrospective Study.","authors":"Hasan M Al-Dorzi,&nbsp;Reem Yaqoub,&nbsp;Reema Alalmaee,&nbsp;Ghafran Almutairi,&nbsp;Allulu Almousa,&nbsp;Leen Aldawsari","doi":"10.1155/2023/8566204","DOIUrl":"10.1155/2023/8566204","url":null,"abstract":"<p><strong>Background: </strong>Intravenous infusions of neuromuscular blocking agents (NMBAs) and prone positioning are recommended for acute respiratory distress syndrome (ARDS) due to COVID-19. The safety of enteral nutrition (EN) during these treatments is unclear. This study assessed EN tolerance and safety during NMBA infusion in proned and nonproned patients with ARDS due to COVID-19.</p><p><strong>Methods: </strong>This retrospective study evaluated patients who were admitted to a tertiary-care ICU between March and December 2020, had ARDS due to COVID-19, and received NMBA infusion. We assessed their EN data, gastrointestinal events, and clinical outcomes. The primary outcome was gastrointestinal intolerance, defined as a gastric residual volume (GRV) ≥500 ml or 200-500 ml with vomiting. We compared proned and nonproned patients.</p><p><strong>Results: </strong>We studied 181 patients (mean age 61.2 ± 13.7 years, males 71.1%, and median body mass index 31.4 kg/m²). Most (63.5%) patients were proned, and 94.3% received EN in the first 48 hours of NMBA infusion at a median dose <10 kcal/kg/day. GRV was mostly below 100 ml. Gastrointestinal intolerance occurred in 6.1% of patients during NMBA infusion and 10.5% after NMBA discontinuation (similar rates in proned and nonproned patients). Patients who had gastrointestinal intolerance during NMBA infusion had a higher hospital mortality (90.9% versus 60.0%; <i>p</i>=0.05) and longer mechanical ventilation duration and ICU and hospital stays compared with those who did not.</p><p><strong>Conclusion: </strong>In COVID-19 patients on NMBA infusion for ARDS, EN was provided early at low doses for most patients, and gastrointestinal intolerance was uncommon in proned and nonproned patients, occurred at a higher rate after discontinuing NMBAs and was associated with worse outcomes. Our study suggests that EN was tolerated and safe in this patient population.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2023 ","pages":"8566204"},"PeriodicalIF":2.2,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Zinc Supplementation in Taste Disorder Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Boshra Mozaffar, Arash Ardavani, Hisham Muzafar, Iskandar Idris","doi":"10.1155/2023/6711071","DOIUrl":"10.1155/2023/6711071","url":null,"abstract":"<p><strong>Introduction: </strong>Food taste and flavour affect food choice and acceptance, which are essential to maintain good health and quality of life. Reduced circulating zinc levels have been shown to adversely affect the taste, but the efficacy of zinc supplementation to treat disorders of taste remains unclear. In this systematic review and meta-analysis, we aimed to examine the efficacy of zinc supplementation in the treatment of taste disorders.</p><p><strong>Methods: </strong>We searched four electronic bibliographical databases: Ovid MEDLINE, Ovid Embase, Ovid AMAD, and PubMed. Article bibliographies were also searched, which yielded additional relevant studies. There were no restrictions on the publication date to facilitate the collection and identification of all available and relevant articles published before 7 February 2021. We performed a systematic review and meta-analysis according to the PRISMA Statement. This review was registered at PROSPERO and given the identification number CRD42021228461.</p><p><strong>Results: </strong>In total, we included 12 randomized controlled trials with 938 subjects. The intervention includes zinc (sulfate, gluconate, picolinate, polaprezinc, and acetate), and the pooled results of the meta-analysis of subjects with idiopathic and zinc-deficient taste disorder indicate that improvements in taste disorder occurred more frequently in the experimental group compared to the control group (RR = 1.38; 95% CI: 1.16, 1.64, <i>p</i>=0.0002). Zinc supplementation appears to confer a greater improvement in taste perception amongst those with chronic renal disease using zinc acetate (overall RR = 26.69, 95% CI = 5.52-129.06, <i>p</i> < 0.0001). The doses are equivalent to 17 mg-86.7 mg of elemental zinc for three to six months.</p><p><strong>Conclusion: </strong>Zinc supplementation is an effective treatment for taste disorders in patients with zinc deficiency, idiopathic taste disorders, and in patients with taste disorders induced by chronic renal failure when given in high doses ranging from 68 to 86.7 mg/d for up to six months.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2023 ","pages":"6711071"},"PeriodicalIF":2.3,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9146897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Deworming on Health Outcomes among Children Aged 12-59 Months in Tanzania: A Multilevel Mixed Effects Analysis.","authors":"Cypriana Cyprian Moshi,&nbsp;Penina Joseph Sebastian,&nbsp;Kaunara Ally Azizi,&nbsp;Erick Killel,&nbsp;Devotha Gabriel Mushumbusi,&nbsp;Wessy Pirbhai Meghji,&nbsp;Malimi Emmanuel Kitunda,&nbsp;Francis Karl Millinga,&nbsp;Hancy Adam,&nbsp;Ladislaus Manaku Kasankala","doi":"10.1155/2023/9529600","DOIUrl":"https://doi.org/10.1155/2023/9529600","url":null,"abstract":"<p><strong>Introduction: </strong>Mass deworming of preschool children is a strategy suggested to prevent soil-transmitted helminth infections in most developing countries. Nonetheless, there is a scarcity of data showing the contribution of mass deworming to a child's nutritional status. The purpose of this study was to assess the effect of deworming on nutritional health outcomes (stunting, underweight, and anemia) in children aged 12 to 59 months.</p><p><strong>Methods: </strong>A secondary analysis of data extracted from the Tanzania Demographic and Health Survey (TDHS) 2015-16 data was carried out. A total of 7,962 children were included in this study. A multilevel logistic regression was used at a 5% level of significance to determine the individual- and community-level determinants of deworming on health outcomes among children.</p><p><strong>Results: </strong>The prevalence of underweight (62.6%), stunting (61.0%), and anemia (61.8%) was higher in children who were not dewormed than those who were dewormed. Female children were more likely to suffer from poor health outcomes (OR = 1.01 and 95% CI = 0.95-1.07) than male children. Children aged 24-35 months and 36-47 months were significantly less likely to suffer from poor health outcomes (OR = 0.89; 95% CI = 0.82-0.97 and OR = 0.88; 96% CI = 0.81-0.96, respectively; <i>p</i> < 0.01). Children from households with unimproved toilets (OR = 1.38 and 95% CI = 1.25-1.52), unimproved water sources (OR = 1.08 and 95% CI = 1.01-1.16), and living in rural areas (OR = 1.02 and 95% CI = 0.91-1.14) had higher odds for poor health outcomes.</p><p><strong>Conclusion: </strong>Deworming may be an effective technique for preventing poor health outcomes in children and the risks associated with them, such as poor growth and development.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2023 ","pages":"9529600"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}