Journal of Neural Transmission最新文献_第8页

From parents to children: associations of traffic risks with impulsivity, family relationships and serotonin transporter genotype. 从父母到孩子：交通风险与冲动、家庭关系和血清素转运体基因型的关系。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 Epub Date: 2024-06-20 DOI: 10.1007/s00702-024-02798-8

Tõnis Tokko, Diva Eensoo, Jaanus Harro

{"title":"From parents to children: associations of traffic risks with impulsivity, family relationships and serotonin transporter genotype.","authors":"Tõnis Tokko, Diva Eensoo, Jaanus Harro","doi":"10.1007/s00702-024-02798-8","DOIUrl":"10.1007/s00702-024-02798-8","url":null,"abstract":"Road traffic injuries are the leading cause of death for young adults, and parents play a major role in shaping their traffic behaviour. Higher impulsivity (predictor of higher traffic risk) has been shown to be dependent on family relations and the serotonin transporter gene promoter polymorphism (5-HTTLPR). The specific mechanisms for the inheritance of risky traffic behaviour from parents to children are not clear, and the genetic aspect has not been studied before. We used data of Estonian Children Personality Behaviour and Health Study subjects (n = 596, mean age = 25.2 ± 0.6) and their parents (mothers, n = 460, mean age = 52.1 ± 5.8; fathers, n = 339, mean age = 54.1 ± 6.5). Family relationships scale, traffic risk questionnaires and Adaptive and Maladaptive Impulsivity Scale were filled out. The increased risk-taking behaviour of parents and worse quality of family relationship were significant predictors of higher traffic risk among subjects. Family support and impulsivity of fathers significantly predicted the subjects' traffic risk score in interaction with 5-HTTLPR genotype: l'/l' homozygous subjects with adaptively impulsive fathers had higher traffic risk, whereas for s'-allele carrying subjects family support was more significant. Parental role modelling and family relationships are significant predictors of future traffic behaviour of the child. Whether the behavioural example of the father or the influence of family relationships is more important in predicting future risky traffic behaviour, depends on the 5-HTTLPR genotype of the child.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1095-1103"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Role of dopamine agonists in Parkinson's disease therapy. 更正：多巴胺受体激动剂在帕金森病治疗中的作用。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 DOI: 10.1007/s00702-023-02695-6

D Woitalla, C Buhmann, R Hilker-Roggendorf, G Höglinger, J Koschel, T Müller, D Weise

引用次数: 0

Correction: Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson's disease patients. 更正：意大利语版额叶评估测试（FAB）在非痴呆帕金森病患者中的临床测量和可行性。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 DOI: 10.1007/s00702-023-02690-x

Edoardo Nicolò Aiello, Alfonsina D'Iorio, Federica Solca, Silvia Torre, Ruggero Bonetti, Francesco Scheveger, Eleonora Colombo, Alessio Maranzano, Luca Maderna, Claudia Morelli, Alberto Doretti, Marianna Amboni, Carmine Vitale, Federico Verde, Roberta Ferrucci, Sergio Barbieri, Eleonora Zirone, Alberto Priori, Gabriella Pravettoni, Gabriella Santangelo, Vincenzo Silani, Nicola Ticozzi, Andrea Ciammola, Barbara Poletti

引用次数: 0

Timing and cortical region matter: theta power differences between teenagers affected by Major Depression and healthy controls. 时间与皮层区域物质：受重度抑郁症影响的青少年与健康对照组之间的θ功率差异。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1007/s00702-024-02810-1

Gideon Gradwohl, Sophia Snipes, Susanne Walitza, Reto Huber, Miriam Gerstenberg

{"title":"Timing and cortical region matter: theta power differences between teenagers affected by Major Depression and healthy controls.","authors":"Gideon Gradwohl, Sophia Snipes, Susanne Walitza, Reto Huber, Miriam Gerstenberg","doi":"10.1007/s00702-024-02810-1","DOIUrl":"10.1007/s00702-024-02810-1","url":null,"abstract":"In adults affected by Major Depressive Disorder (MDD), most findings point to higher electroencephalographic (EEG) theta power during wake compared to healthy controls (HC) as a potential biomarker aiding the diagnostic process or subgrouping for stratified treatment. Besides these group differences, theta power is modulated by time of day, sleep/wake history, and age. Thus, we aimed at assessing if the time of recording alters theta power in teenagers affected by MDD or HC. Standardized wake EEG power was assessed with high-density EEG in 15 children and adolescents with MDD and in 15 age- and sex-matched HC in the evening and morning. Using a two-way ANOVA, group, time, and their interaction were tested. In patients, the current severity of depression was rated using the Children's Depression Rating Scale. Broadband EEG power was lower in the morning after sleep, with a significant interaction (group x time) in central regions in the 4-6 Hz range. In MDD relative to HC, theta power was decreased over occipital areas in the evening and increased over frontal areas in the morning. A higher frontal theta power was correlated with more severe depressive mood in the morning but not in the evening. This was a cross-sectional study design, including patients on antidepressant medication. In conclusion, depending on time of recording, region-specific opposite differences of theta power were found between teenagers with MDD and HC. These findings stress the importance of the time of the recording when investigating theta power's relationship to psychopathology.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1105-1115"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in metabolites in the anterior cingulate cortex and thalamus and their associations with pain and empathy in patients with chronic mild pain: a preliminary study. 慢性轻度疼痛患者前扣带回皮层和丘脑代谢物的变化及其与疼痛和移情的关系：一项初步研究。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 Epub Date: 2024-06-19 DOI: 10.1007/s00702-024-02791-1

Tomonori Shigemura, Fumio Osone, Akira Hara, Kanako Miyano, Akihiro Okada, Tokuzou Yokokawa, Yukihiko Shirayama

{"title":"Alterations in metabolites in the anterior cingulate cortex and thalamus and their associations with pain and empathy in patients with chronic mild pain: a preliminary study.","authors":"Tomonori Shigemura, Fumio Osone, Akira Hara, Kanako Miyano, Akihiro Okada, Tokuzou Yokokawa, Yukihiko Shirayama","doi":"10.1007/s00702-024-02791-1","DOIUrl":"10.1007/s00702-024-02791-1","url":null,"abstract":"Proton magnetic resonance spectroscopy (1H-MRS) has shown inconsistent alterations in the brain metabolites of individuals with chronic pain. We used 3T 1H-MRS to investigate the brain metabolites in the anterior cingulate cortex and thalamus of 22 patients with chronic mild pain and no gait disturbance and 22 healthy controls. The chronic-pain group included patients with chronic low back pain and/or osteoarthritis but none suffering from hypersensitivity. There were no significant between group-differences in glutamate, glutamate plus glutamine (Glx), N-acetylaspartate, glycerophosphorylcholine (GPC), glutamine, creatine plus phosphocreatine, or myo-inositol in the anterior cingulate cortex, but the patients showed a significant decrease in GPC, but not other metabolites, in the thalamus compared to the controls. The GPC values in the patients' thalamus were significantly correlated with pain components on the Short-Form McGill Pain Questionnaire (SF-MPQ-2) and affective empathy components on the Questionnaire of Cognitive and Affective Empathy (QCAE). The GPC in the patients' anterior cingulate cortex showed significant correlations with cognitive empathy components on the QCAE. Myo-inositol in the controls' anterior cingulate cortex and Glx in the patients' thalamus each showed significant relationships with peripheral responsivity on the QCAE. These significances were not significant after Bonferroni corrections. These preliminary findings indicate important roles of GPC, myo-inositol, and Glx in the brain of patients with chronic mild pain.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1079-1094"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of transient receptor potential (TRP) channels in psychiatric disorders. 瞬态受体电位（TRP）通道在精神疾病中的治疗潜力。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI: 10.1007/s00702-024-02803-0

Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh

引用次数: 0

The neural structures of theory of mind are valence-sensitive: evidence from three tDCS studies. 心智理论的神经结构对情绪敏感：来自三项 tDCS 研究的证据。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 Epub Date: 2024-07-17 DOI: 10.1007/s00702-024-02808-9

Vahid Nejati, Maryam Sharifian, Zahra Famininejad, Mohammad Ali Salehinejad, Shahab Mahdian

{"title":"The neural structures of theory of mind are valence-sensitive: evidence from three tDCS studies.","authors":"Vahid Nejati, Maryam Sharifian, Zahra Famininejad, Mohammad Ali Salehinejad, Shahab Mahdian","doi":"10.1007/s00702-024-02808-9","DOIUrl":"10.1007/s00702-024-02808-9","url":null,"abstract":"Several cortical structures are involved in theory of mind (ToM), including the dorsolateral prefrontal cortex (dlPFC), the ventromedial prefrontal cortex (vmPFC), and the right temporo- parietal junction (rTPJ). We investigated the role of these regions in mind reading with respect to the valence of mental states. Sixty-five healthy adult participants were recruited and received transcranial direct current stimulation (tDCS) (1.5 mA, 20 min) with one week interval in three separate studies. The stimulation conditions were anodal tDCS over the dlPFC coupled with cathodal tDCS over the vmPFC, reversed stimulation conditions, and sham in the first study, and anodal tDCS over the vmPFC, or dlPFC, and sham stimulation, with an extracranial return electrode in the second and third study. During stimulation, participants underwent the reading mind from eyes/voice tests (RMET or RMVT) in each stimulation condition. Anodal left dlPFC/cathodal right vmPFC stimulation increased the accuracy of negative mental state attributions, anodal rTPJ decreased the accuracy of negative and neutral mental state attributions, and decreased the reaction time of positive mental state attributions. Our results imply that the neural correlates of ToM are valence-sensitive.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1067-1078"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acceptance of psychosocial bridging measures in context of dementia. 痴呆症患者对社会心理过渡措施的接受程度。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1007/s00702-024-02814-x

Barbara Leicher, Verena Buschert, Jens Benninghoff, Norbert Scherbaum

{"title":"Acceptance of psychosocial bridging measures in context of dementia.","authors":"Barbara Leicher, Verena Buschert, Jens Benninghoff, Norbert Scherbaum","doi":"10.1007/s00702-024-02814-x","DOIUrl":"10.1007/s00702-024-02814-x","url":null,"abstract":"Participants from an outpatient treatment program for cognitive disorders have been offered bridging measures because of limited access to the outpatient clinic during a Covid-19-caused lock-down. The aim of this study was to assess perceived stress, acceptance, and appreciation of the measures among patients and their caregivers compared to the previous bridging measure. Forty participants were offered treatment in person or online depending on their cognitive performance level. To evaluate acceptance, data collected from clinical routine was incorporated into a treatment observation. The evaluation of bridging measures by 25 participants was positive. Perceived stress was moderate to high among participants and has increased significantly compared to previous special treatment. Perceived stress in older patients had increased over the course of the pandemic. Bridging measures represented a treatment alternative and may offer previously untapped potential for location-independent psychosocial treatments in order to ameliorate both the patients' and their caregivers' convenience.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1135-1142"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clozapine-associated adverse drug reactions in 38,349 psychiatric inpatients: drug surveillance data from the AMSP project between 1993 and 2016. 38349 名精神病住院患者中与氯氮平相关的药物不良反应：1993 年至 2016 年 AMSP 项目的药物监测数据。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI: 10.1007/s00702-024-02818-7

Lene Bleich, Renate Grohmann, Waldemar Greil, Dominik Dabbert, Andreas Erfurth, Sermin Toto, Johanna Seifert

{"title":"Clozapine-associated adverse drug reactions in 38,349 psychiatric inpatients: drug surveillance data from the AMSP project between 1993 and 2016.","authors":"Lene Bleich, Renate Grohmann, Waldemar Greil, Dominik Dabbert, Andreas Erfurth, Sermin Toto, Johanna Seifert","doi":"10.1007/s00702-024-02818-7","DOIUrl":"10.1007/s00702-024-02818-7","url":null,"abstract":"Clozapine is a second-generation antipsychotic drug that offers superior treatment results in patients with schizophrenia but is also associated with significant risks. This study analyzes data on pharmacotherapy with clozapine and the associated adverse drug reactions (ADRs) in an inpatient setting including 38,349 patients. Data about the use of clozapine and reports of severe ADRs within the period 1993-2016 were obtained from the multicentered observational pharmacovigilance program \"Arzneimittelsicherheit in der Psychiatrie\" (AMSP). In total, 586 severe clozapine-associated ADRs were documented (1.53% of all patients exposed). Patients aged ≥65 years had a higher risk of ADRs than patients aged <65 years (1.96 vs. 1.48%; p = 0.021). Significantly more ADRs were attributed to clozapine alone (396; 67.6% of all 586 ADRs) than to a combination with other drugs. The most frequent ADRs were grand mal seizures (0.183% of all 38,349 patients exposed), delirium (0.180%), increased liver enzymes (0.120%), and agranulocytosis (0.107%). We detected 24 cases (0.063%) of clozapine-induced extrapyramidal symptoms, of which 8 (0.021%) were attributed to clozapine alone. Five ADRs resulted in death (0.013%): 2 due to agranulocytosis (41 cases total) (mortality = 4.88%) and 3 due to paralytic (sub)ileus (16 cases) (mortality = 18.75%). The median dose of clozapine in all patients treated was 300 mg/day, in patients who developed ADRs 250 mg/day. The main risk factor for an ADR was pre-existing damage of the affected organ system. Overall, the results of this study highlight the importance of alertness-especially of frequently overlooked symptoms-and appropriate monitoring during treatment with clozapine, even at low doses.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1117-1134"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-dependent associations of serum BDNF, glycolipid metabolism and cognitive impairments in Parkinson's disease with depression: a comprehensive analysis. 帕金森病合并抑郁症患者血清 BDNF、糖脂代谢和认知障碍的性别依赖关系：一项综合分析。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-09-01 Epub Date: 2024-07-05 DOI: 10.1007/s00702-024-02802-1

Xinxu Wang, Chi Zhou, Yanzhe Li, Hechao Yang, Xiaoxiao Sun, Shen Li, Jie Li

{"title":"Sex-dependent associations of serum BDNF, glycolipid metabolism and cognitive impairments in Parkinson's disease with depression: a comprehensive analysis.","authors":"Xinxu Wang, Chi Zhou, Yanzhe Li, Hechao Yang, Xiaoxiao Sun, Shen Li, Jie Li","doi":"10.1007/s00702-024-02802-1","DOIUrl":"10.1007/s00702-024-02802-1","url":null,"abstract":"Brain-derived neurotrophic factor (BDNF) and glycolipid metabolism have been implicated in cognitive impairments and depression among Parkinson's disease (PD). However, the role of sex differences in this relationship remains elusive. This study aimed to investigate the potential sex differences in the link between serum BDNF levels, glycolipid metabolism and cognitive performance among depressive PD patients. PD patients comprising 108 individuals with depression and 108 without depression were recruited for this study. Cognitive function was assessed using the Montreal Cognitive Assessment Beijing version (MOCA-BJ). The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HAMD-17), while motor symptoms were evaluated using the Revised Hoehn and Yahr rating scale (H-Y) and the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III). Laboratory testing and enzyme-linked immunosorbent assay (ELISA) are used to measure serum levels of glycolipid metabolism and BDNF. Females showed superior performance in delayed recall (all p < 0.05), male PD patients exhibited higher scores in naming tasks compared to females in non-depression group. There was no sex differences in serum BDNF levels between depression and non-depression groups. Liner regression analysis indicated BDNF as an independent risk factor for language deficits in male PD patients with depression (p < 0.05), while cholesterol (CHOL) emerged as a cognitive influencing factor, particularly in delayed recall among male PD patients with depression (p < 0.05). Our study reveals extensive cognitive impairments in PD patients with depression. Moreover, BDNF and CHOL may contribute to the pathological mechanisms underlying cognitive deficits, particularly in male patients with depression.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1047-1057"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0