Journal of nuclear medicine technology最新文献

{"title":"The Importance of Peer Review: It's All in the Details.","authors":"Jennifer Prekeges","doi":"10.2967/jnmt.126.272579","DOIUrl":"10.2967/jnmt.126.272579","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"113"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Detection of Persistent Left Superior Vena Cava During Lung Perfusion Scan.","authors":"Sanket Karangutkar, Lajos Szabados, Athar Haroon, Ghulam Mustafa Shah Syed","doi":"10.2967/jnmt.125.270991","DOIUrl":"10.2967/jnmt.125.270991","url":null,"abstract":"<p><p>Lung perfusion scintigraphy is a cornerstone for evaluating pulmonary embolism but may reveal unexpected vascular anomalies. Persistent left superior vena cava, a congenital anomaly, can cause a right-to-left shunt when draining into the left atrium, bypassing pulmonary circulation. We report the incidental detection of persistent left superior vena cava during lung perfusion scintigraphy in a patient with post-COVID-19 hypoxia. Dual-site radiotracer injections and SPECT/CT confirmed the diagnosis, highlighting the need for adaptive imaging techniques to accurately interpret atypical findings in nuclear medicine.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"212-213"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Reconstruction Methods on Regional Wall Motion Abnormalities During Gated SPECT Myocardial Perfusion Imaging.","authors":"Mehrdad Jabbari, Tohid Mortezazadeh, Alireza Motamedi, Sajad Samadi, Sahar Rezaei, Esmaeil Gharepapagh","doi":"10.2967/jnmt.125.271265","DOIUrl":"10.2967/jnmt.125.271265","url":null,"abstract":"<p><p>Accurate assessment of regional wall motion abnormalities (RWMA) is essential for diagnosing coronary artery disease. The quality of image reconstruction in gated SPECT myocardial perfusion imaging (MPI) can significantly influence diagnostic accuracy. <b>Methods:</b> We retrospectively analyzed 100 patients who underwent gated SPECT MPI, including 25 normal and 75 abnormal cases stratified into mild, moderate, and severe defects groups. Images were reconstructed using filtered backprojection (FBP) and iterative reconstruction (IR) with varying iteration-subset settings. RWMA was visually assessed using a 20-segment model. Statistical agreement between methods was analyzed. <b>Results:</b> No significant differences were found between FBP and IR in normal and mild MPI groups. However, in moderate and severe cases, IR with 4 iterations × 6 subsets and 4 iterations × 8 subsets reclassified multiple patients into more severe RWMA categories, demonstrating higher diagnostic sensitivity compared with FBP (<i>P</i> < 0.0001). <b>Conclusion:</b> Optimized IR parameters (particularly 4 iterations × 6 subsets and 4 iterations × 8 subsets) improve the detection of RWMA in moderate to severe coronary artery disease compared with FBP. Incorporating IR into routine MPI protocols may enhance clinical decision-making and patient outcomes.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"192-198"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Tumor Absorbed Dose with Progression-Free Survival in Metastatic Castration-Resistant Prostate Cancer Treated with ¹⁷⁷Lu-PSMA.","authors":"Yung Hsiang Kao, David Pook, Jeremy Shapiro, Mark Frydenberg, Dinesh Sivaratnam","doi":"10.2967/jnmt.125.270563","DOIUrl":"10.2967/jnmt.125.270563","url":null,"abstract":"<p><p>Today's common practice of empiric activity prescription in radiopharmaceutical therapy is inconsistent with the modern philosophy of personalized medicine. We investigate the radiobiologic relationship between tumor mean absorbed dose (<i>D</i> _mean) and progression-free survival (PFS) in ¹⁷⁷Lu-PSMA I&T therapy guided by personalized predictive dosimetry in metastatic castration-resistant prostate cancer. <b>Methods:</b> We conducted a single-center retrospective study of the first 20 patients treated with ¹⁷⁷Lu-PSMA I&T at our institution. PFS was calculated from the day a patient was assessed by a nuclear medicine physician in the clinic until treatment cessation (due to progression or toxicity) or death. <i>D</i> _mean was estimated by predictive dosimetry. Correlation with PFS was performed on the following baseline characteristics: age, Gleason score, Eastern Cooperative Oncology Group performance status, estimated glomerular filtration rate, prostate-specific antigen (PSA) doubling time, injected activity per treatment, <i>D</i> _mean and <i>D</i> _mean per gigabecquerel. <b>Results:</b> Twenty patients naïve to ¹⁷⁷Lu-PSMA were treated over a 2-y period, totaling 65 infusions. The median PSA doubling time was 1.6 mo at baseline. The median follow-up time was 8.4 mo (interquartile range [IQR], 4.6-14.5 mo). Each patient received 3 ± 1 treatments (range, 1-5), with a mean injected activity of 7.74 ± 0.66 GBq per treatment. The mean injected activity for the first treatment was 7.85 ± 0.71 GBq. The median <i>D</i> _mean for the first treatment was 23 Gy (IQR, 15-36 Gy). The median PFS was 10.6 mo for a <i>D</i> _mean of 23 Gy or greater and was 3.1 mo for a <i>D</i> _mean of less than 23 Gy (hazard ratio, 0.39; 95% CI, 0.22-0.68; <i>P</i> < 0.01). There were statistically significant correlations between PFS, PSA doubling time, and <i>D</i> _mean (<i>P</i> < 0.05). However, there was no statistically significant correlation between the injected activity per treatment versus PFS or <i>D</i> _mean (<i>P</i> > 0.05). <b>Conclusion:</b> We found a strong direct correlation between <i>D</i> _mean and PFS in patients with metastatic castration-resistant prostate cancer treated with ¹⁷⁷Lu-PSMA in a real-world setting. We identified a <i>D</i> _mean of 23 Gy as a possible threshold for significantly better PFS in our cohort with median PSA doubling time of 1.6 mo. Our findings support radiobiologically sound prescription based on the radiation absorbed dose by personalized predictive dosimetry.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"149-152"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Earlobe Inferior Margin as a Landmark for Cerebellar Visualization in Brain Perfusion SPECT.","authors":"Daichi Moriyama, Akihiro Furuta, Ritsuko Nishida, Yasuhiko Ueno, Yousuke Okada, Hirokazu Takemoto","doi":"10.2967/jnmt.125.271806","DOIUrl":"10.2967/jnmt.125.271806","url":null,"abstract":"<p><p>Consistent inclusion of the cerebellum is essential for accurate interpretation of brain perfusion SPECT. However, the anatomic validity of external head landmarks for patient positioning has not been quantitatively evaluated. This study assessed spatial relationships between external landmarks and the cerebellar inferior margin using CT images. <b>Methods:</b> We retrospectively analyzed 100 preoperative brain tumor CT studies and measured <i>z</i>-coordinates of the eyeball center, inferior margin of the earlobe, nasal base, external auditory meatus, and inferior margin of the cerebellum. Differences between <i>z</i>-coordinates of landmarks and a tilt index were calculated. <b>Results:</b> The inferior margin of the earlobe was consistently located caudal to the cerebellum with low variability and showed the weakest association with neck posture. <b>Conclusion:</b> The inferior margin of the earlobe is a stable landmark for reproducible craniocaudal head positioning and may support consistent cerebellar coverage in brain perfusion scintigraphy.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"173-176"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key Concepts in Prostate Cancer Imaging and Theranostics: A Practical Terminology Guide for Nuclear Medicine Professionals.","authors":"Geoffrey M Currie, C David Gilmore, Patrick Colletti, Victoria West","doi":"10.2967/jnmt.126.272482","DOIUrl":"10.2967/jnmt.126.272482","url":null,"abstract":"<p><p>Key terminology related to theranostics in prostate cancer has been consolidated into concise reference tables. The definitions are simplified to emphasize practical clinical understanding and working language. Enhanced understanding and familiarity with this shared language supports ongoing professional development and the practical translation of scientific concepts into safe and effective clinical practice.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"144-148"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Amyloid Images Using a Generative Adversarial Network from 2-Dimensional ¹⁸F-FDG Images and Evaluation for Clinical Use.","authors":"Misa Honda, Takahiro Yamada, Shogo Watanabe, Aya Watanabe, Takashi Nagaoka, Mitsutaka Nemoto, Katsuhiro Mikami, Kohei Hanaoka, Hayato Kaida, Hisashi Handa, Kazunari Ishii, Yuichi Kimura","doi":"10.2967/jnmt.125.270154","DOIUrl":"10.2967/jnmt.125.270154","url":null,"abstract":"<p><p>The use of amyloid PET to assess patient suitability of disease-modifying drugs for Alzheimer disease is increasing. This study aimed to synthesize amyloid PET images from ¹⁸F-FDG PET images using a generative artificial intelligence algorithm to reduce unnecessary amyloid PET scans. <b>Methods:</b> A 2-dimensional pix2pix algorithm was used. The algorithm was evaluated across 4 domains: image quality, voxel values, contrast between white and gray matter, and diagnostic performance for detecting the presence or absence of β-amyloid (Aβ) deposition. Pairs of ¹⁸F-FDG PET and amyloid PET images from 55 Aβ-negative and -positive cases were evaluated. A 6-fold cross-validation was conducted. <b>Results:</b> Synthetic images were visually consistent, producing plausible negative and positive patterns while preserving continuity in the sagittal plane. Voxel values of the synthetic images showed a significant linear relationship with the real images. The contrast correlated well with the real images, and the differences between the negative and positive cases were significant as well as those in the real images. The performance of the positive or negative 2-class classifier exceeded 85% for the synthetic images. <b>Conclusion:</b> The synthetic images successfully captured features of Aβ deposition, and evaluation with a 2-class classifier achieved an acceptable accuracy of 85%. These results suggest that amyloid images can potentially be generated from ¹⁸F-FDG PET images for use in clinical practice.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"177-182"},"PeriodicalIF":1.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Venous Atresia as a Mimicker of Chronic Thromboembolic Pulmonary Disease: Diagnostic Utility of Ventilation/Perfusion Scanning.","authors":"Jehad Azar, Alaa Hamad, Nagham Joudeh, Lema Jaber, Alaa Hmeedan","doi":"10.2967/jnmt.125.270526","DOIUrl":"10.2967/jnmt.125.270526","url":null,"abstract":"<p><p>A man in his 60s was referred to our institution for evaluation of suspected chronic thromboembolic pulmonary disease in the context of progressive exertional dyspnea and a mismatched ventilation/perfusion defect on scintigraphy. The ventilation/perfusion scan revealed complete absence of perfusion to the left hemithorax with preserved ventilation. CT pulmonary angiography demonstrated unilateral pulmonary vein atresia, characterized by absent left pulmonary venous drainage, a hypoplastic pulmonary arterial tree on the affected side, and compensatory hyperinflation of the contralateral lung. This case highlights the distinctive scintigraphic pattern of unilateral pulmonary vein atresia, in which global absent perfusion in the affected hemithorax results from the reversal of pulmonary arterial flow due to elevated pulmonary venous pressures. Additionally, perfusion is further impaired by retrograde bronchial collateralization, compounding the hemodynamic compromise.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"210-211"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Evaluation of Automatic Pipeline for Patient-Specific Registration to a Bronchopulmonary Segment Atlas for Planar Perfusion Scintigraphy.","authors":"Mohsen Ansari, Amir Jabbarpour, Jochen Lang, Eric Moulton, Ran Klein","doi":"10.2967/jnmt.125.270998","DOIUrl":"10.2967/jnmt.125.270998","url":null,"abstract":"<p><p>Relating planar lung scintigraphic image features to bronchopulmonary anatomy is a mental task requiring specialized medical experience. This study aimed to accurately normalize spatial data to overlay patient images onto a bronchopulmonary segment atlas (BSA), enhancing image interpretation for nonexperts and enabling quantification. <b>Methods:</b> This study evaluates the efficacy of 3 spatial normalization techniques: naïve registration, cost function masking, and perfusion defect removal with convolutional autoencoders. Autoencoders were trained for each of 6 projection angles using a large cohort of healthy patients (<i>n</i> = 660). Perfusion planar population templates for each projection, with its corresponding BSA, were constructed using a random subset sample of these patients (<i>n</i> = 149). Synthetic perfusion defects were applied on 60 projections from 10 patients with normal perfusion, allowing a comprehensive assessment of each spatial normalization technique's performance and effect on defect size in the template space. <b>Results:</b> The results reveal that autoencoder preprocessing significantly outperforms the naïve method and exhibits comparable or superior performance to cost function masking, particularly in preserving defect size and minimizing registration error to the population template within the defect. Visual comparisons further support the efficacy of autoencoder preprocessing in preserving anatomic features. <b>Conclusion:</b> Autoencoder preprocessing is a fully automatic and reliable method for reducing distortions during spatial normalization in perfusion scintigraphy, highlighting its potential for enhancing registration accuracy in clinical practice for BSA overlay and defect quantification.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"183-191"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Evaluation of a Virtual Reality Teaching Program for Myocardial Perfusion Imaging in Nuclear Medicine Education.","authors":"Jui-Yin Kung, Chih-Wei Chang, Yao-Wen Chen, Pu-Jung Huang, Shih-Chuan Tsai, Jin-Long Huang, Chen-Jung Chang","doi":"10.2967/jnmt.125.271203","DOIUrl":"10.2967/jnmt.125.271203","url":null,"abstract":"<p><p>In nuclear medicine, simulation-based instruction offers a safer alternative to traditional training, yet no studies have specifically applied virtual reality (VR) to clinical education and training within nuclear medicine departments. This study aimed to investigate whether a VR-based teaching module enhances students' perceived understanding of myocardial perfusion imaging (MPI) procedures and overall learning satisfaction. <b>Methods:</b> Between July and December 2023, we enrolled a group of 19 internship students, who were asked to complete a survey on their learning expectations regarding MPI. Survey analysis revealed that 73.7% of students were unfamiliar with the MPI procedure and 57.9% indicated that they required over 2 h of learning and hands-on practice to achieve proficiency. To address these needs, the research team produced a 10-min simulation video, covering learning objectives, training duration, evaluation criteria, patient education, procedural steps, and key safety considerations. Using the survey results, we designed a teaching video to capture realistic clinical scenes that involved MPIs. After students completed the simulation-based module, they viewed the teaching video and completed a satisfaction survey to evaluate the effectiveness of our teaching. <b>Results:</b> All students agreed that the video length was appropriate, the quiz questions facilitated understanding, and the interactive design supported understanding. Furthermore, 89.5% of students found the contents clear and easy to understand, with an overall mean satisfaction score of 8.95 (of 10 possible points). <b>Conclusion:</b> The VR teaching program for MPI was successful and serves as an effective preparatory resource for students completing nuclear medicine internships.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"199-206"},"PeriodicalIF":1.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}