Journal of Neurogastroenterology and Motility最新文献

{"title":"Resolution of Refractory Gastroparesis Symptoms Following Benzodiazepine Treatment for Catatonic Depression.","authors":"Benjamin M Moy, Mark A Solinski, Joy J Liu","doi":"10.5056/jnm25160","DOIUrl":"10.5056/jnm25160","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 2","pages":"298-299"},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Impact on Quality of Life in Adult Patients With Chronic Intestinal Pseudo-obstruction: A Multicenter, Cohort Study.","authors":"Kota Takahashi, Takaomi Kessoku, Hidenori Ohkubo, Yo Ishihara, Kosuke Tanaka, Tomoki Ogata, Tsumugi Jono, Atsushi Yamamoto, Anna Ozaki, Yuki Kasai, Michihiro Iwaki, Akiko Fuyuki, Takayuki Kato, Yasunari Sakamoto, Takeo Kurihashi, Hirotoshi Ebinuma, Atsushi Nakajima","doi":"10.5056/jnm25103","DOIUrl":"10.5056/jnm25103","url":null,"abstract":"<p><strong>Background/aims: </strong>: To evaluate the quality of life (QOL) of patients with chronic intestinal pseudo-obstruction (CIPO) before and after treatment.</p><p><strong>Methods: </strong>: This study enrolled 50 adult patients diagnosed with CIPO at 4 institutions, of whom 42 underwent therapy. Patient background, body mass index, treatment, palliative care intervention, numerical rating scale for abdominal pain or bloating, the medical outcomes study 36-item short-form health survey (SF-36) and summary scores (physical component summary, mental component summary, and role/social component summary), Japanese version of the Patient Assessment of Constipation Quality of Life (JPAC-QOL) and subscales (physical discomfort, psychosocial discomfort, worries and concerns, and satisfaction), and Patient Assessment of Constipation Symptoms (PAC-SYM) and subscales (stool, rectal, and abdominal symptoms) were prospectively sampled and collected.</p><p><strong>Results: </strong>: The patients (n = 50; 35 females and 15 males) had an average age of onset of 44.7 years and, body mass index of 17.3 kg/m², and 38 (76%) required palliative care intervention. Effective therapeutic interventions included intestinal sterilization (19/42), decompression therapy with percutaneous endoscopic gastrojejunostomy (PEG-J) (6/42), and dietary restriction (6/42). The numerical rating scale for abdominal distension and pain decreased significantly after treatment. All SF-36 summary scores showed improvements. The JPAC-QOL and PAC-SYM both showed improvement overall and in all subscales.</p><p><strong>Conclusions: </strong>: Patients with CIPO have a lower physical, psychological and social QOL, which is equivalent to or lower than that of adult patients with inflammatory bowel disease or psychiatric disorders. Sterilization of the intestinal tract and PEG-J decompression effectively improve the QOL of patients.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 2","pages":"244-253"},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asia Is Not the West: Mean Nocturnal Baseline Impedance Must Be Interpreted in a Device- and Region-specific Context.","authors":"Tae Hee Lee","doi":"10.5056/jnm25201","DOIUrl":"10.5056/jnm25201","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":" ","pages":"302-303"},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Belching and Reflux: The Relationship and the Underlying Mechanism.","authors":"Songfeng Chen, Xingyu Jia, Dianxuan Jiang, Mengyu Zhang, Niandi Tan, Qianjun Zhuang, Yinglian Xiao","doi":"10.5056/jnm25189","DOIUrl":"10.5056/jnm25189","url":null,"abstract":"<p><strong>Background/aims: </strong>: Belching can occur either independently or concurrently with reflux symptoms. This study aims to explore the relationship between belching and reflux and explore the underlying mechanisms involved.</p><p><strong>Methods: </strong>: Firstly, patients with isolated belching symptoms or concurrent belching and reflux symptoms were retrospectively enrolled. High-resolution esophageal impedance manometry (HRIM) and 24-hour pH impedance monitoring were used to assess belching types and temporal relationship between belching and reflux. Secondly, subjects with belching disorder were prospectively recruited. Postprandial HRIM monitoring was used to clarify the relationship and underlying mechanisms between belching and reflux.</p><p><strong>Results: </strong>: In the initial phase, 139 subjects were enrolled. Regardless of patients' symptom spectrum (with or without gastroesophageal reflux symptoms), the proportion of preceding-reflux belching was significantly higher in those with objective evidence of gastroesophageal reflux disease, compared to those without (both <i>P</i> < 0.05), which indicated that belching could trigger reflux events and led to more severe reflux burden. To clarify the potential mechanisms involved, 44 belching subjects were prospectively enrolled in the second phase of this study. HRIM analysis demonstrated that maximum intragastric pressure, gastric-lower esophageal sphincter pressure gradient and gastric-esophageal pressure gradient were significantly higher in preceding-reflux belching than those in independent belching.</p><p><strong>Conclusions: </strong>: This study demonstrated that belching might trigger reflux by increasing intragastric pressure, elevating the gastric-sphincter pressure gradient, which enables gastric contents to pass through the esophagogastric junction. These findings have crucial clinical significance, suggesting that reducing the occurrence of belching might be a potential treatment for refractory reflux.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 2","pages":"254-266"},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' Knowledge, Attitudes, and Practices Regarding Non-pharmacological Treatments for Irritable Bowel Syndrome.","authors":"Chengwen Li, Qiong Liu, Jianan Cao, Xuan Xu, Haolong He, Yingchun Huang, Xinye Liu, Rong Luo, Xiaorong Chang, Mi Liu","doi":"10.5056/jnm25147","DOIUrl":"10.5056/jnm25147","url":null,"abstract":"<p><strong>Background/aims: </strong>: Non-pharmacological treatments are crucial for managing irritable bowel syndrome (IBS), yet patient engagement remains a challenge. Understanding patients' knowledge, attitudes, and practices regarding these treatments is essential for improving care.</p><p><strong>Methods: </strong>: A cross-sectional study was conducted across 5 hospitals, from October 2023 to February 2024. A self-designed knowledge, attitudes, and practices questionnaire along with the IBS quality of life and IBS severity scoring system was administered, and 496 valid responses were analyzed. Statistical analyses included correlation tests, multivariate linear regression, and mediation effect analysis.</p><p><strong>Results: </strong>: The median scores for knowledge, attitude, and practice were 28, 25.5, and 21, respectively. Significant positive correlations were found between knowledge-attitude (<i>r</i> = 0.195), knowledge-practice (<i>r</i> = 0.364), and attitude-practice (<i>r</i> = 0.151). The multivariate linear regression analysis further indicated that knowledge (β = 0.399, <i>P</i> < 0.001) and attitude (β = 0.219, <i>P</i> = 0.022) positively correlated with the practical performance. SEM revealed that knowledge had a significant direct effect on both attitude (β = 0.186, <i>P</i> = 0.013) and practice (β = 0.356, <i>P</i> = 0.006). However, the direct effect of attitude on practice was not significant, and attitude did not mediate the relationship between knowledge and practice.</p><p><strong>Conclusions: </strong>: IBS patients exhibit a significant gap between their positive attitudes and their actual practices concerning non-pharmacological treatments. Knowledge is a direct driver of practice, but positive attitudes alone are insufficient to translate into behavior. Healthcare providers must move beyond simply fostering positive attitudes and focus on targeted educational interventions that provide actionable knowledge and skills to improve patient outcomes.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 2","pages":"276-289"},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide Induces Changes in Gastric Electrical Activity in Patients With Overweight and Obesity: A Pilot Study.","authors":"Ryan Abraham, Daphne Foong, Milan Piya, Kathy Grudzinskas, Vincent Ho","doi":"10.5056/jnm25156","DOIUrl":"10.5056/jnm25156","url":null,"abstract":"<p><strong>Background/aims: </strong>: Semaglutide is associated with gastroduodenal symptoms, such as nausea and vomiting. This pilot study used body surface gastric mapping (BSGM) to measure the effect of semaglutide on gastric function and associated symptoms.</p><p><strong>Methods: </strong>: Patients without gastrointestinal symptoms (n = 8) underwent BSGM at baseline and on 1 mg semaglutide, as per standard subcutaneous dosing. Spectral metrics included Principal Gastric Frequency, Gastric Alimetry Rhythm Index (GA-RI), body mass index-adjusted amplitude, fed:fasted amplitude ratio, and meal response ratio. Symptoms were assessed using validated questionnaires. Data were compared using paired t tests.</p><p><strong>Results: </strong>: Body mass index-adjusted amplitude showed a significant decrease on the drug (<i>P</i> = 0.04). Five patients (63%) developed spectral abnormalities on the drug, with 2 displaying a low or undetectable GA-RI (< 0.25). The patient assessment of upper gastrointestinal disorders-symptom severity index fullness/early satiation subscale significantly increased on the drug (<i>P</i> = 0.005).</p><p><strong>Conclusions: </strong>: Semaglutide appears to alter gastric electrical activity on BSGM and increase early satiation, offering potential biomarkers for detecting drug effects. Further studies are needed.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 2","pages":"237-243"},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pylorus Endoluminal Functional Luminal Imaging Probe Measurements in Children Are Determined by Age and Are Distinctly Different From Adult Values.","authors":"Jaime Chan, Noeni Austin, Miri Taneichi, William Kong, Mohamed Mutalib","doi":"10.5056/jnm25102","DOIUrl":"10.5056/jnm25102","url":null,"abstract":"<p><strong>Background/aims: </strong>: The pylorus muscles are known to play a vital role in the process of gastric emptying and are directly implicated in symptom associated with delayed gastric drainage. Endoluminal functional luminal imaging probe (EndoFLIP) can predict clinical response to pylorus directed therapy in symptomatic children and adults. Normal pylorus EndoFLIP values are available for adult but not in children. We aim to assess the impact of age on pediatric pyloric EndoFLIP values.</p><p><strong>Methods: </strong>: Retrospective review of all children who underwent pylorus EndoFLIP in Evelina London Children's Hospital from July 2022 to March 2025.</p><p><strong>Results: </strong>: One hundred and sixty-nine EndoFLIP values were collected from 29 children, 35% females. Mean age was 8.5 ± SD (± 4.1), children reported at least 1 symptom of impaired gastric emptying. EndoFLIP values appeared to cluster in age ranges 0-4, 4-8 and > 8 years with diameter significantly different. There was no correlation with weight range. At balloon volume of 40 mL, abdominal distension after feeding positively correlated with distensibility (<i>r</i> = 0.45, <i>P</i> = 0.018 and negatively with pressure (<i>r</i> = -0.41, <i>P</i> = 0.036). Intolerance to gastric feeding with pressure (<i>r</i> = 0.45, <i>P</i> = 0.019) and pain after feeding with pressure (<i>r</i> = 0.5, <i>P</i> = 0.009). High balloon pressure can lead to unwarranted dilatation.</p><p><strong>Conclusion: </strong>: Pediatric pylorus EndoFLIP values are determined by age but not weight and they correlate with symptoms of impaired gastric emptying. Adults normal values are not applicable to children. There is a need to set up a separate pediatric protocol for pylorus EndoFLIP.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 1","pages":"46-51"},"PeriodicalIF":3.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Leuven Postprandial Distress Scale According to the Rome IV Criteria for Functional Dyspepsia.","authors":"Cedric Van de Bruaene, Florencia Carbone, Karen Van den Houte, Jolien Schol, Bert Broeders, Michael P Jones, Alain Vandenberghe, Tim Vanuytsel, Jan Tack","doi":"10.5056/jnm25108","DOIUrl":"10.5056/jnm25108","url":null,"abstract":"<p><strong>Background/aims: </strong>: The Leuven Postprandial Distress Scale (LPDS) is a validated patient reported outcome (PRO) measure for functional dyspepsia (FD)/postprandial distress syndrome (PDS) patients according to Rome III criteria. However, meal-related nausea or epigastric pain, part of PDS in Rome IV, were not addressed in this construct. Also, focus groups identified fatigue as a frequently reported complaint for which the European Medicines Agency requested further analysis. Our aim is to validate the LPDS in FD/PDS as defined by Rome IV criteria and to optimize the model by assessing the value of adding extra items to this questionnaire.</p><p><strong>Methods: </strong>: The questionnaire was validated in 3 different Rome IV FD/PDS patient cohorts recruited for controlled clinical trials. Additional questions in the diary regarding symptom relationship to meal and fatigue were evaluated. Anchor scores were the patient assessment of gastrointestinal symptom severity index, Short-form Nepean dyspepsia index, the overall treatment evaluation and overall symptom severity questionnaires.</p><p><strong>Results: </strong>: The LPDS Construct validity was confirmed for Rome IV-defined PDS. Psychometric analysis did not support inclusion of fatigue, nausea, meal-related or meal-unrelated, and meal-related epigastric pain, due to low loading or poor model fit.</p><p><strong>Conclusions: </strong>: The LPDS questionnaire showed good reliability and responsiveness, and can be confidently used as a validated tool in Rome IV PDS populations. Data did not support adding accessory symptoms to the construct, due to low loading or poor model fit.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 1","pages":"99-108"},"PeriodicalIF":3.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Gastric Electrical Stimulation: Future Prospects in Managing Gastric Emptying Disorders.","authors":"Jonathan Sivakumar, John B Furness, David B Grayden, James Fallon, Jeremy Cottrell, Cuong Phu Duong","doi":"10.5056/jnm25106","DOIUrl":"10.5056/jnm25106","url":null,"abstract":"<p><p>Neural gastric electrical stimulation (NGES) is a multi-channel high-energy gastrointestinal stimulation technique that directly activates cholinergic motor neurons to evoke contractions that improve gastric emptying. NGES stimulation superimposes on spontaneous electromechanical activity to generate coordinated propagating contractions. In contrast, the most commonly applied form of gastric electrical stimulation (Enterra), employs paired pulses that stimulate vagal afferent pathways to reduce symptoms of nausea and vomiting, but does not enhance emptying. This review examines the evolution and implementation of NGES, focusing on its potential role as a treatment option to enhance gastric propulsion in gastroparesis and delayed gastric conduit emptying. While initial acute animal studies have shown promising results, continued development of the technology and refinement of stimulation protocols through chronic experiments remains essential for successful clinical translation.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 1","pages":"19-29"},"PeriodicalIF":3.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Gastric Alimetry and Gastric Emptying Scintigraphy Testing Increases Clinician Certainty in the Diagnosis and Management of Suspected Gastroparesis.","authors":"Ryan Abraham, Daphne Foong, Vincent Ho","doi":"10.5056/jnm25094","DOIUrl":"10.5056/jnm25094","url":null,"abstract":"<p><strong>Background/aims: </strong>: Gastric emptying scintigraphy (GES) is the reference standard test for diagnosing gastroparesis. Body surface gastric mapping (BSGM) via Gastric Alimetry is a new test of gastric function that combines non-invasive assessment of gastric electrophysiology and validated symptom profiling. This randomized, prospective pilot study evaluated the impact of GES vs BSGM test results on clinical decision-making.</p><p><strong>Methods: </strong>: Patients with chronic gastroduodenal symptoms from a tertiary center referred for GES were recruited. Subjects separately underwent baseline assessment with GES and BSGM testing. Two motility-specialists were first asked to devise a management plan after reviewing a test result (GES or BSGM, in random order). They were then asked to repeat the management plan after reviewing the other test result (BSGM or GES). Clinician-perceived certainty measures were assessed.</p><p><strong>Results: </strong>: Sixteen patients, 13 (81.0%) female, median age 30 years, median body mass index 22.5 kg/m², were recruited. At baseline, a diagnosis was established in 2/16 (12.5%) and increased to 8/16 (50.0%) with both tests. Abnormal test results were found in 11 patients. In patients with normal results, BSGM symptom profiling phenotyped 5 additional patients. All patients received an intervention following the first unblinding, with subsequent management changes made in 75.0% (BSGM) and 62.5% (GES) of patients. The combined GES and BSGM results significantly increased diagnostic and management certainty (<i>P</i> < 0.05), with both tests having similar influence on management (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>: The combined GES and BSGM test results significantly enhanced diagnostic and management confidence in patients with suspected gastroparesis within a tertiary center.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":" ","pages":"61-70"},"PeriodicalIF":3.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}